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<span>Obstructive sleep apnea</span>
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<span class="page-url print-only">URL of this page: https://medlineplus.gov/genetics/condition/obstructive-sleep-apnea/</span>
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<h1>Obstructive sleep apnea</h1>
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<div class="mp-exp exp-full" data-bookmark="description">
<h2>Description</h2>
<section><div class="mp-content"><p>Obstructive sleep apnea is a condition in which individuals experience pauses in breathing (apnea) during sleep, which are associated with partial or complete closure of the throat (pper airway). Complete closure can lead to apnea while partial closure allows breathing but decrease the intake of oxygen (hypopnea).</p><p>Individuals with obstructive sleep apnea may experience interrupted sleep with frequent awakenings and loud snoring. Repeated pauses in breathing lead to episodes of lower-than-normal oxygen levels (hypoxemia) and a buildup of carbon dioxide (hypercapnia) in the bloodstream. Interrupted and poor quality sleep can lead to daytime sleepiness and fatigue, impaired attention and memory, headaches, <a data-pid="16877" href="https://medlineplus.gov/genetics/condition/depression/">depression</a>, and sexual dysfunction. Daytime sleepiness leads to a higher risk of motor vehicle accidents in individuals with obstructive sleep apnea. Obstructive sleep apnea is also associated with an increased risk of developing insulin resistance, which is an inability to regulate blood sugar (glucose) levels effectively; high blood pressure (<a data-pid="16961" href="https://medlineplus.gov/genetics/condition/hypertension/">hypertension</a>); heart disease; and stroke.</p></div>
</section>
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<div class="mp-exp exp-full" data-bookmark="frequency">
<h2>Frequency</h2>
<section><div class="mp-content"><p>Obstructive sleep apnea is a common condition. It is estimated to affect 2 to 4 percent of children and at least 10 percent of adults worldwide. Malea are twice as likely as females to have obstructive sleep apnea.</p></div>
</section>
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<div class="mp-exp exp-full" data-bookmark="causes">
<h2>Causes</h2>
<section><div class="mp-content"><p>The causes of obstructive sleep apnea are often complex. This condition results from a combination of genetic, health, and lifestyle factors, many of which have not been identified. Studies suggest that variations in multiple genes, each with a small effect, combine to increase the risk of developing the condition. However, it is unclear what contribution each of these genetic changes makes to disease risk. Most of the variations have been identified in single studies, and subsequent research has not verified them.</p><p>Genes thought to be associated with the development of obstructive sleep apnea are involved in many body processes. These include communication between nerve cells, breathing regulation, control of inflammatory responses by the immune system, development of tissues in the head and face (craniofacial development), the sleep-wake cycle, and appetite control.</p><p>Obesity is a major risk factor for obstructive sleep apnea as 60 to 70 percent of individuals with this condition have obesity. It is thought that excess fatty tissue in the head and neck constricts airways and abdominal fat may prevent the chest and lungs from fully expanding and relaxing. Other risk factors for obstructive sleep apnea include alcohol use; frequent nasal congestion; and blockages of <a class="image-modal" data-alt="Anatomy of the pharynx (throat). The three parts of the pharynx are the nasopharynx, oropharynx, and hypopharynx." data-caption="Anatomy of the pharynx (throat). The three parts of the pharynx are the nasopharynx, oropharynx, and hypopharynx." data-credit="© 2012 Terese Winslow LLC for the National Cancer Institute" data-filepath="images/PX00026R_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX00026R" data-sourceurl="https://visualsonline.cancer.gov/details.cfm?imageid=9254" data-title="Upper respiratory tract, pharynx" href="https://medlineplus.gov/images/PX00026R_PRESENTATION.jpeg" id="PX00026R_1" title="Show image">the airways<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a>, such as by enlarged tonsils.</p><p>Obstructive sleep apnea often occurs on its own, without signs and symptoms affecting other parts of the body. However, it can also occur as part of a syndrome, such as <a data-pid="15051" href="https://medlineplus.gov/genetics/condition/mucopolysaccharidosis-type-i/">mucopolysaccharidosis type I</a> or <a data-pid="16867" href="https://medlineplus.gov/genetics/condition/polycystic-ovary-syndrome/">polycystic ovary syndrome</a>.</p></div>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="inheritance">
<h2>Inheritance</h2>
<section><div class="mp- mp-content"><p>The inheritance pattern of obstructive sleep apnea is unclear. Overall, the risk of developing this condition is about 50 percent greater for <a class="image-modal" data-alt="First degree relatives include parents, offspring, and siblings." data-caption="A first degree relative is a family member who shares about 50 percent of their genes with a particular individual in a family. First degree relatives include parents, offspring, and siblings." data-credit="Darryl Leja, NHGRI" data-filepath="images/PX0000I8_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0000I8" data-sourceurl="" data-title="First-degree relatives" href="https://medlineplus.gov/images/PX0000I8_PRESENTATION.jpeg" id="PX0000I8_1" title="Show image">first-degree relatives<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> (such as siblings or children) of affected individuals as compared to the general public.</p></div>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="synonyms">
<h2>Other Names for This Condition</h2>
<section>
<ul class="bulletlist">
<li>Apnea, obstructive</li> <li>Obstructive apnea</li> <li>Obstructive sleep apnea syndrome</li> <li>OSA</li> <li>OSAHS</li> <li>OSAS</li> <li>SAHS</li> <li>Sleep apnea hypopnea syndrome</li> <li>Sleep apnea syndrome, obstructive</li> <li>Sleep apnea, obstructive</li> <li>Sleep apnea/hypopnea syndrome</li> <li>Upper airway resistance sleep apnea syndrome</li>
</ul>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="resources">
<h2>Additional Information & Resources</h2>
<section>
<div class="mp-content">
<h2>Genetic Testing Information</h2>
<ul>
<li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C0520679/" target="TheNewWin">Genetic Testing Registry: Obstructive sleep apnea syndrome</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
</ul>
</div>
</section>
<section>
<div class="mp-content">
<h2>Patient Support and Advocacy Resources</h2>
<ul>
<li><a href="https://rarediseases.org/" target="TheNewWin">National Organization for Rare Disorders (NORD)</a></li>
</ul>
</div>
</section>
<section>
<div class="mp-content">
<h2>Clinical Trials</h2>
<ul>
<li><a href="https://clinicaltrials.gov/search?cond=%22Obstructive sleep apnea%22" target="TheNewWin">ClinicalTrials.gov</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
</ul>
</div>
</section>
<section>
<div class="mp-content">
<h2>Catalog of Genes and Diseases from OMIM</h2>
<ul>
<li><a href="https://omim.org/entry/107650" target="TheNewWin">APNEA, OBSTRUCTIVE SLEEP</a></li>
</ul>
</div>
</section>
<section>
<div class="mp-content">
<h2>Scientific Articles on PubMed</h2>
<ul>
<li><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%28Sleep+Apnea,+Obstructive%5BMAJR%5D%29+AND+%28obstructive+sleep+apnea%5BTI%5D%29+AND+review%5Bpt%5D+AND+english%5Bla%5D+AND+human%5Bmh%5D+AND+%22last+720+days%22%5Bdp%5D" target="TheNewWin">PubMed</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
</ul>
</div>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="references">
<h2>References</h2>
<section>
<div class="mp-content">
<ul>
<li>de Lima FF, Mazzotti DR, Tufik S, Bittencourt L. The role inflammatory
response genes in obstructive sleep apnea syndrome: a review. Sleep Breath. 2016
Mar;20(1):331-8. doi: 10.1007/s11325-015-1226-7. Epub 2015 Jul 23. <a href="https://pubmed.ncbi.nlm.nih.gov/26201496" target="TheNewWin">Citation on PubMed</a></li>
<li>Feliciano A, Torres VM, Vaz F, Carvalho AS, Matthiesen R, Pinto P, Malhotra A,
Barbara C, Penque D. Overview of proteomics studies in obstructive sleep apnea.
Sleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb
14. <a href="https://pubmed.ncbi.nlm.nih.gov/25770042" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402077/" target="TheNewWin">Free article on PubMed Central</a></li>
<li>Larkin EK, Patel SR, Goodloe RJ, Li Y, Zhu X, Gray-McGuire C, Adams MD,
Redline S. A candidate gene study of obstructive sleep apnea in European
Americans and African Americans. Am J Respir Crit Care Med. 2010 Oct
1;182(7):947-53. doi: 10.1164/rccm.201002-0192OC. Epub 2010 Jun 10. <a href="https://pubmed.ncbi.nlm.nih.gov/20538960" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970865/" target="TheNewWin">Free article on PubMed Central</a></li>
<li>Parish JM. Genetic and immunologic aspects of sleep and sleep disorders.
Chest. 2013 May;143(5):1489-1499. doi: 10.1378/chest.12-1219. Erratum In: Chest.
2013 Aug;144(2):721. <a href="https://pubmed.ncbi.nlm.nih.gov/23648914" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734884/" target="TheNewWin">Free article on PubMed Central</a></li>
<li>Patel SR, Goodloe R, De G, Kowgier M, Weng J, Buxbaum SG, Cade B, Fulop T,
Gharib SA, Gottlieb DJ, Hillman D, Larkin EK, Lauderdale DS, Li L, Mukherjee S,
Palmer L, Zee P, Zhu X, Redline S. Association of genetic loci with sleep apnea
in European Americans and African-Americans: the Candidate Gene Association
Resource (CARe). PLoS One. 2012;7(11):e48836. doi: 10.1371/journal.pone.0048836.
Epub 2012 Nov 14. <a href="https://pubmed.ncbi.nlm.nih.gov/23155414" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498243/" target="TheNewWin">Free article on PubMed Central</a></li>
<li>Xu H, Guan J, Yi H, Yin S. A systematic review and meta-analysis of the
association between serotonergic gene polymorphisms and obstructive sleep apnea
syndrome. PLoS One. 2014 Jan 27;9(1):e86460. doi: 10.1371/journal.pone.0086460.
eCollection 2014. <a href="https://pubmed.ncbi.nlm.nih.gov/24475124" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903532/" target="TheNewWin">Free article on PubMed Central</a></li>
</ul>
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<li><a href="https://medlineplus.gov/sleepapnea.html">Sleep Apnea</a></li>
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<h2>MEDICAL ENCYCLOPEDIA</h2>
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<li><a href="https://medlineplus.gov/ency/article/002048.htm">Genetics</a></li>
<li><a href="https://medlineplus.gov/ency/article/000811.htm">Obstructive sleep apnea - adults</a></li>
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<li><a href="https://medlineplus.gov/genetics/understanding/consult/prognosis/">What is the prognosis of a genetic condition?</a></li>
<li><a href="https://medlineplus.gov/genetics/understanding/mutationsanddisorders/mutationscausedisease/">How can gene variants affect health and development?</a></li>
<li><a href="https://medlineplus.gov/genetics/understanding/inheritance/runsinfamily/">What does it mean if a disorder seems to run in my family?</a></li>
<li><a href="https://medlineplus.gov/genetics/understanding/inheritance/inheritancepatterns/">What are the different ways a genetic condition can be inherited?</a></li>
<li><a href="https://medlineplus.gov/genetics/understanding/consult/treatment/">How are genetic conditions treated or managed?</a></li>
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