publicdata/nih-gov
2
0
Fork 0
Code Issues Pull requests Projects Releases Packages Wiki Activity Actions
nih-gov/medlineplus.gov/genetics/condition/fibromyalgia/index.html
Scott Williams 7bcb500d37 Initial commit.
2025-02-26 13:17:41 -05:00

699 lines
37 KiB
HTML
Raw Blame History

This file contains ambiguous Unicode characters

This file contains Unicode characters that might be confused with other characters. If you think that this is intentional, you can safely ignore this warning. Use the Escape button to reveal them.

<!DOCTYPE html>
<html lang="en" id="genetic_condition" class="nojs us" data-root="https://medlineplus.gov/">
<head>
<meta charset="utf-8" />
<meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1" />
<meta http-equiv="window-target" content="_top" />
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8" />
<meta name="viewport" content="width=device-width, initial-scale=1" />
<link rel="canonical" href="https://medlineplus.gov/genetics/condition/fibromyalgia/" />
<link href="https://medlineplus.gov/genetics/condition/fibromyalgia/" hreflang="x-default" rel="alternate">
<meta name="ac-dictionary" content="medlineplus-ac-dictionary" />
<meta name="description" content="Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. Explore symptoms, inheritance, genetics of this condition." />
<link rel="shortcut icon" href="https://medlineplus.gov/images/favicon.ico" type="image/x-icon" />
<link rel="apple-touch-icon" href="https://medlineplus.gov/images/touch-icon.png" />
<meta property="fb:app_id" content="1042245625821448" />
<meta property="og:title" content="Fibromyalgia: MedlinePlus Genetics" />
<meta property="og:url" content="https://medlineplus.gov/genetics/condition/fibromyalgia/" />
<meta property="og:image" content="https://medlineplus.gov/images/GeneticCondition_Share.jpg" />
<meta property="og:description" content="Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. Explore symptoms, inheritance, genetics of this condition." />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:site" content="@medlineplus" />
<meta name="twitter:creator" content="@medlineplus" />
<meta name="twitter:title" content="Fibromyalgia: MedlinePlus Genetics" />
<meta name="twitter:description" content="Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. Explore symptoms, inheritance, genetics of this condition." />
<meta name="twitter:image" content="https://medlineplus.gov/images/GeneticCondition_Share.jpg" />
<meta name="twitter:image:alt" content=""/>
<meta property="og:image:alt" content="" />
<title>Fibromyalgia: MedlinePlus Genetics</title>
<link rel="stylesheet" href="https://medlineplus.gov/css/common_new.css?1738956844613" />
<!--[if IE 8]> <link rel="stylesheet" href="https://medlineplus.gov/css/ie8/common.css"> <![endif]-->
<link rel="stylesheet" href="https://medlineplus.gov/uswds/css/uswds_styles.css" />
<script type="text/javascript">document.getElementsByTagName('html')[0].className = document.getElementsByTagName('html')[0].className.replace( /(?:^|\s)nojs(?!\S)/g , '').trim();</script>
<script src="https://medlineplus.gov/uswds/js/uswds-init.min.js" type="text/javascript"></script>
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':
new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],
j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=
'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);
})(window,document,'script','dataLayer','GTM-MMVM77');</script>
</head>
<body>
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MMVM77"
height="0" width="0" style="display:none;visibility:hidden" title="googletagmanager"></iframe></noscript>
<a name="top" id="top"></a>
<a class="hide-offscreen" href="#start">Skip navigation</a>
<section
class="usa-banner"
aria-label="Official website of the United States government"
>
<div class="usa-accordion">
<header class="usa-banner__header">
<div class="usa-banner__inner">
<div class="grid-col-auto">
<img
aria-hidden="true"
class="usa-banner__header-flag"
src="https://medlineplus.gov/uswds/img/us_flag_small.png"
alt=""
/>
</div>
<div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true">
<p class="usa-banner__header-text">
An official website of the United States government
</p>
<p class="usa-banner__header-action">Here’s how you know</p>
</div>
<button
type="button"
class="usa-accordion__button usa-banner__button"
aria-expanded="false"
aria-controls="gov-banner-default-default"
>
<span class="usa-banner__button-text">Here’s how you know</span>
</button>
</div>
</header>
<div
class="usa-banner__content usa-accordion__content"
id="gov-banner-default-default"
>
<div class="grid-row grid-gap-lg">
<div class="usa-banner__guidance tablet:grid-col-6">
<img
class="usa-banner__icon usa-media-block__img"
src="https://medlineplus.gov/uswds/img/icon-dot-gov.svg"
role="img"
alt=""
aria-hidden="true"
/>
<div class="usa-media-block__body">
<p>
<strong>Official websites use .gov</strong><br />A
<strong>.gov</strong> website belongs to an official government
organization in the United States.
</p>
</div>
</div>
<div class="usa-banner__guidance tablet:grid-col-6">
<img
class="usa-banner__icon usa-media-block__img"
src="https://medlineplus.gov/uswds/img/icon-https.svg"
role="img"
alt=""
aria-hidden="true"
/>
<div class="usa-media-block__body">
<p>
<strong>Secure .gov websites use HTTPS</strong><br />A
<strong>lock</strong> (
<span class="icon-lock"
><svg
xmlns="http://www.w3.org/2000/svg"
width="52"
height="64"
viewBox="0 0 52 64"
class="usa-banner__lock-image"
role="img"
aria-labelledby="banner-lock-description-default"
focusable="false"
>
<title id="banner-lock-title-default">Lock</title>
<desc id="banner-lock-description-default">Locked padlock icon</desc>
<path
fill="#000000"
fill-rule="evenodd"
d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z"
/>
</svg> </span
>) or <strong>https://</strong> means you’ve safely connected to
the .gov website. Share sensitive information only on official,
secure websites.
</p>
</div>
</div>
</div>
</div>
</div>
</section>
<div id="mplus-wrap">
<header>
<div id="mplus-header">
<div id="mplus-orgs">
<a href="https://www.nih.gov/" class="nih-org" target="_blank" title="National Institutes of Health">
<img class="nihlogo" src="https://medlineplus.gov/images/nihlogo.png" alt="National Institutes of Health"/>
</a><a href="https://www.nlm.nih.gov/" target="_blank"> National Library of Medicine</a>
</div>
<div id="mplus-logo" class="years-25">
<a href="https://medlineplus.gov/">
<img alt="MedlinePlus Trusted Health Information for You" title="MedlinePlus Trusted Health Information for You" src="https://medlineplus.gov/images/m_logo_25.png"/>
</a>
</div>
<div id="mplus-nav">
<div aria-live="polite" class="sm-live-area hide-offscreen"></div>
<button id="sm-menu-btn" class="navmenu-btn" title="Menu" role="button" aria-controls="mplus-menu-list" type="submit">Menu<span class="icon icon-nav-menu"></span></button>
<ul id="mplus-menu-list" class="nav-list">
<li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li>
<li><a href="https://medlineplus.gov/druginformation.html">Drugs & Supplements</a></li>
<li><a href="https://medlineplus.gov/genetics/">Genetics</a></li>
<li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li>
<li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li>
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
</ul><button id="sm-search-btn" class="navmenu-btn" title="Search" role="button" aria-controls="mplus-search" type="submit"><span class="hide-offscreen"></span>Search<span class="icon icon-nav-search"></span></button>
<div class="top-1">
<form id="mplus-search" method="get" action="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta" title="Search MedlinePlus" target="_self">
<input type="hidden" name="v:project" value="medlineplus"/>
<input type="hidden" name="v:sources" value="medlineplus-bundle"/>
<div class="form-box text-combo">
<div class="form-area"><label class="hide-offscreen" for="searchtext_primary">Search MedlinePlus</label>
<input id="searchtext_primary" class="form-text" type="text" placeholder="Search MedlinePlus" alt="#Site Search input" title="Site Search input" maxlength="400" size="40" name="query" autocomplete="off" role="textbox" aria-autocomplete="list" aria-haspopup="true"/>
</div>
<div class="button-area">
<button class="form-btn" title="Search MedlinePlus" alt="Search MedlinePlus" type="submit">GO</button>
</div>
</div>
</form>
<div class="secondarynav">
<ul class="nav-list">
<li><a href="https://medlineplus.gov/about/"><span>About MedlinePlus</span></a></li>
<li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li>
<li><a href="https://medlineplus.gov/sitemap.html"><span>Site Map</span></a></li>
<li><a href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&category=medlineplus&from=https%3A//medlineplus.gov/genetics/condition/fibromyalgia/" target="_blank"><span>Customer Support</span></a></li>
</ul>
</div>
</div>
<div id="mplus-nav-bar">
<ul class="nav-list">
<li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li><li><a href="https://medlineplus.gov/druginformation.html">Drugs & Supplements</a></li><li><a href="https://medlineplus.gov/genetics/">Genetics</a></li><li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li><li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li>
</ul>
</div>
</div>
</div>
</header>
<div id="mplus-content">
<div id="breadcrumbs">
<div itemprop="breadcrumb" itemscope="" itemtype="http://schema.org/BreadcrumbList">
<span class="hide-offscreen">You Are Here:</span>
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
<a href="https://medlineplus.gov/" itemprop="item"><span itemprop="name">Home</span></a>
&rarr;
<meta itemprop="position" content="1"/>
</div>
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
<a href="https://medlineplus.gov/genetics/" itemprop="item"><span itemprop="name">Genetics</span></a>
&rarr;
<meta itemprop="position" content="2"/>
</div>
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
<a href="https://medlineplus.gov/genetics/condition/" itemprop="item"><span itemprop="name">Genetic Conditions</span></a>
&rarr;
<meta itemprop="position" content="3"/>
</div>
<div>
<span>Fibromyalgia</span>
</div>
</div>
</div>
<span class="page-url print-only">URL of this page: https://medlineplus.gov/genetics/condition/fibromyalgia/</span>
<div >
<article>
<div class="page-info">
<div class="page-title">
<a name="start" id="start"></a>
<h1>Fibromyalgia</h1>
</div>
<div class="page-actions"></div>
<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript>
</div>
<div class="main">
<div class="mp-exp exp-full" data-bookmark="description">
<h2>Description</h2>
<section><div class="mp-content"><p>Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. The pain is associated with tenderness that occurs with touch or pressure on the muscles, joints, or skin. Some affected individuals also report numbness, tingling, or a burning sensation (paresthesia) in the arms and legs.</p><p>Other signs and symptoms of fibromyalgia include excessive tiredness (exhaustion); sleep problems, such as waking up feeling unrefreshed; and problems with memory or thinking clearly. People with fibromyalgia often report additional types of pain, including headaches, back and neck pain, sore throat, pain or clicking in the jaw (<a class="image-modal" data-alt="Profile view of a face with the parts of the temporormandibular joint labeled." data-caption="" data-credit="National Institute of Dental and Craniofacial Research/National Institutes of Health" data-filepath="images/PX000004_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX000004" data-sourceurl="https://www.nidcr.nih.gov" data-title="The temporomandibular joint" href="https://medlineplus.gov/images/PX000004_PRESENTATION.jpeg" id="PX000004_1" title="Show image">temporomandibular<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> joint dysfunction), and stomach pain or digestive disorders such as irritable bowel syndrome. They have an increased likelihood of developing mood or psychiatric disorders including <a data-pid="16877" href="https://medlineplus.gov/genetics/condition/depression/">depression</a>, anxiety, and <a data-pid="16943" href="https://medlineplus.gov/genetics/condition/obsessive-compulsive-disorder/">obsessive-compulsive disorder</a>. However, many people with fibromyalgia do not have a mental health condition.</p><p>The major signs and symptoms of fibromyalgia can occur by themselves or together with another chronic pain condition such as <a data-pid="16837" href="https://medlineplus.gov/genetics/condition/osteoarthritis/">osteoarthritis</a>, <a data-pid="16181" href="https://medlineplus.gov/genetics/condition/rheumatoid-arthritis/">rheumatoid arthritis</a>, <a data-pid="14713" href="https://medlineplus.gov/genetics/condition/ankylosing-spondylitis/">ankylosing spondylitis</a>, or <a data-pid="16327" href="https://medlineplus.gov/genetics/condition/systemic-lupus-erythematosus/">systemic lupus erythematosus</a>.</p></div>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="frequency">
<h2>Frequency</h2>
<section><div class="mp-content"><p>Fibromyalgia occurs in an estimated 2 to 8 percent of the general population worldwide. Because its signs and symptoms are nonspecific and overlap with those of many other conditions, it can be challenging to diagnose. The condition seems to affect women more than men, and its prevalence increases with age.</p></div>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="causes">
<h2>Causes</h2>
<section><div class="mp-content"><p>Fibromyalgia is known to run in families, suggesting that genetic factors contribute to the risk of developing this disease. However, little is known for certain about the genetic basis of fibromyalgia. It is likely that variations in many genes, each with a small effect, combine to increase the risk of developing this condition.</p><p>The signs and symptoms of fibromyalgia are related to the way the brain recognizes and interprets pain signals. People with fibromyalgia have an increased sensitivity to pain; they feel pain more acutely than others would in response to a given stimulus. Researchers describe this phenomenon as the "volume" of pain sensations being turned up too high (pain amplification). Studies of the genetics of fibromyalgia have focused on genes with roles in the way the brain processes pain. For example, several genes that may influence the condition are involved in the production and breakdown of certain chemical messengers called <a class="image-modal" data-alt="Diagram showing parts of a neuron and structure of a typical chemical synapse. Neurotransmitters are shown packaged into synaptic vesicles and transmitting signals from a neuron to a target cell across the synapse." data-caption="" data-credit="Designua/Shutterstock.com" data-filepath="images/PX00011G_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX00011G" data-sourceurl="" data-title="Release and uptake of neurotransmitters at a nerve cell synapse" href="https://medlineplus.gov/images/PX00011G_PRESENTATION.jpeg" id="PX00011G_1" title="Show image">neurotransmitters<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a>. These chemicals relay signals between nerve cells that can increase or decrease the sensation of pain, a process known as pain modulation.</p><p>Nongenetic (environmental) factors also play critical roles in a person's risk of developing fibromyalgia. The disorder can be triggered by infection or illness that would not otherwise cause chronic pain, injury, and other physical stress. Psychological and social factors such as a history of childhood abuse or neglect, exposure to war or other catastrophic events, and low job or life satisfaction have also been associated with an increased risk of fibromyalgia. Additionally, physical inactivity, obesity, and sleep disturbances seem to increase risk. However, many people who develop this condition do not have any recognized triggers or risk factors. It is likely that environmental conditions interact with genetic factors to determine the overall risk of developing this disorder.</p></div>
</section>
<section>
<div class="related-genes mp-exp exp-full">
<h3>Learn more about the gene associated with Fibromyalgia</h3>
<ul class="relatedmp">
<li><a href="https://medlineplus.gov/genetics/gene/comt/">COMT</a></li>
</ul>
<p><strong>Additional Information from NCBI Gene:</strong></p>
<ul class="relatedmp">
<li><a href="https://www.ncbi.nlm.nih.gov/gene/154" target="TheNewWin">ADRB2</a></li>
<li><a href="https://www.ncbi.nlm.nih.gov/gene/3356" target="TheNewWin">HTR2A</a></li>
<li><a href="https://www.ncbi.nlm.nih.gov/gene/6532" target="TheNewWin">SLC6A4</a></li>
<li><a href="https://www.ncbi.nlm.nih.gov/gene/134864" target="TheNewWin">TAAR1</a></li>
</ul>
</div>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="inheritance">
<h2>Inheritance</h2>
<section><div class="mp- mp-content"><p>Fibromyalgia does not have a clear pattern of inheritance in families. Overall, the risk of developing this condition is about eight times higher for <a class="image-modal" data-alt="Parents, siblings, and children are first-degree relatives." data-caption="An individual shares half his/her genes with each parent and each offspring. An individual shares an on average half his/her genes with each sibling" data-credit="GeneReviews, University of Washington, Seattle" data-filepath="images/PX0002I7_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0002I7" data-sourceurl="https://www.ncbi.nlm.nih.gov/books/NBK5191/box/further_illus-59/" data-title="First-degree relative" href="https://medlineplus.gov/images/PX0002I7_PRESENTATION.jpeg" id="PX0002I7_1" title="Show image">first-degree relatives<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> of affected individuals (such as siblings or children) as compared to the general public. Many people with fibromyalgia also have relatives with headaches, irritable bowel syndrome, temporomandibular joint dysfunction, and other conditions that cause chronic pain. These disorders may cluster in families in part because they share some genetic risk factors with fibromyalgia.</p></div>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="synonyms">
<h2>Other Names for This Condition</h2>
<section>
<ul class="bulletlist">
<li>Diffuse myofascial pain syndrome</li> <li>Fibromyalgia syndrome</li> <li>Fibromyalgia-fibromyositis syndrome</li> <li>Fibromyositis</li> <li>Fibrositis</li> <li>FMS</li> <li>Myofascial pain syndrome</li>
</ul>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="resources">
<h2>Additional Information & Resources</h2>
<section>
<div class="mp-content">
<h2>Patient Support and Advocacy Resources</h2>
<ul>
<li><a href="https://rarediseases.org/" target="TheNewWin">National Organization for Rare Disorders (NORD)</a></li>
</ul>
</div>
</section>
<section>
<div class="mp-content">
<h2>Clinical Trials</h2>
<ul>
<li><a href="https://clinicaltrials.gov/search?cond=%22Fibromyalgia%22" target="TheNewWin">ClinicalTrials.gov</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
</ul>
</div>
</section>
<section>
<div class="mp-content">
<h2>Scientific Articles on PubMed</h2>
<ul>
<li><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%28Fibromyalgia%5BMAJR%5D%29+AND+%28fibromyalgia%5BTI%5D%29+AND+%28%28gene%5BTIAB%5D%29+OR+%28genes%5BTIAB%5D%29+OR+%28genetic*%5BTIAB%5D%29+OR+%28GWAS%5BTIAB%5D%29%29+AND+english%5Bla%5D+AND+human%5Bmh%5D" target="TheNewWin">PubMed</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
</ul>
</div>
</section>
</div>
<div class="mp-exp exp-full" data-bookmark="references">
<h2>References</h2>
<section>
<div class="mp-content">
<ul>
<li>Ablin JN, Buskila D. Update on the genetics of the fibromyalgia syndrome. Best
Pract Res Clin Rheumatol. 2015 Feb;29(1):20-8. doi: 10.1016/j.berh.2015.04.018.
Epub 2015 May 18. <a href="https://pubmed.ncbi.nlm.nih.gov/26266996" target="TheNewWin">Citation on PubMed</a></li>
<li>Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55.
doi: 10.1001/jama.2014.3266. <a href="https://pubmed.ncbi.nlm.nih.gov/24737367" target="TheNewWin">Citation on PubMed</a></li>
<li>Docampo E, Escaramis G, Gratacos M, Villatoro S, Puig A, Kogevinas M, Collado
A, Carbonell J, Rivera J, Vidal J, Alegre J, Estivill X, Rabionet R. Genome-wide
analysis of single nucleotide polymorphisms and copy number variants in
fibromyalgia suggest a role for the central nervous system. Pain. 2014
Jun;155(6):1102-1109. doi: 10.1016/j.pain.2014.02.016. Epub 2014 Feb 26. <a href="https://pubmed.ncbi.nlm.nih.gov/24582949" target="TheNewWin">Citation on PubMed</a></li>
<li>Hauser W, Ablin J, Fitzcharles MA, Littlejohn G, Luciano JV, Usui C, Walitt B.
Fibromyalgia. Nat Rev Dis Primers. 2015 Aug 13;1:15022. doi:
10.1038/nrdp.2015.22. <a href="https://pubmed.ncbi.nlm.nih.gov/27189527" target="TheNewWin">Citation on PubMed</a></li>
<li>Hauser W, Ablin J, Perrot S, Fitzcharles MA. Management of fibromyalgia:
practical guides from recent evidence-based guidelines. Pol Arch Intern Med. 2017
Jan 4;127(1):47-56. doi: 10.20452/pamw.3877. Epub 2017 Jan 4. <a href="https://pubmed.ncbi.nlm.nih.gov/28075425" target="TheNewWin">Citation on PubMed</a></li>
<li>Lee YH, Choi SJ, Ji JD, Song GG. Candidate gene studies of fibromyalgia: a
systematic review and meta-analysis. Rheumatol Int. 2012 Feb;32(2):417-26. doi:
10.1007/s00296-010-1678-9. Epub 2010 Dec 1. <a href="https://pubmed.ncbi.nlm.nih.gov/21120487" target="TheNewWin">Citation on PubMed</a></li>
<li>Park DJ, Lee SS. New insights into the genetics of fibromyalgia. Korean J
Intern Med. 2017 Nov;32(6):984-995. doi: 10.3904/kjim.2016.207. Epub 2017 Oct 23. <a href="https://pubmed.ncbi.nlm.nih.gov/29056037" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668398/" target="TheNewWin">Free article on PubMed Central</a></li>
<li>Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Hauser W, Katz RL, Mease PJ,
Russell AS, Russell IJ, Walitt B. 2016 Revisions to the 2010/2011 fibromyalgia
diagnostic criteria. Semin Arthritis Rheum. 2016 Dec;46(3):319-329. doi:
10.1016/j.semarthrit.2016.08.012. Epub 2016 Aug 30. <a href="https://pubmed.ncbi.nlm.nih.gov/27916278" target="TheNewWin">Citation on PubMed</a></li>
</ul>
</div>
</section>
</div>
</div>
<div class="side">
<aside>
<section><div class="side-section">
<div class="mp-img">
<img class="scale-with-grid" src="https://medlineplus.gov/images/GeneticCounseling.jpg" alt="Genetic Counseling">
</div>
</div></section>
<section><div class="side-section">
</div></section>
<section><div class="side-section">
<div class="section-header">
<h2>Related Health Topics</h2>
</div>
<div class="section-body">
<ul class="relatedmp">
<li><a href="https://medlineplus.gov/ankylosingspondylitis.html">Ankylosing Spondylitis</a></li>
<li><a href="https://medlineplus.gov/fibromyalgia.html">Fibromyalgia</a></li>
<li><a href="https://medlineplus.gov/geneticdisorders.html">Genetic Disorders</a></li>
<li><a href="https://medlineplus.gov/lupus.html">Lupus</a></li>
<li><a href="https://medlineplus.gov/osteoarthritis.html">Osteoarthritis</a></li>
<li><a href="https://medlineplus.gov/rheumatoidarthritis.html">Rheumatoid Arthritis</a></li>
</ul>
</div>
</div></section>
<section><div class="side-section">
<div class="section-header red">
<h2>MEDICAL ENCYCLOPEDIA</h2>
</div>
<div class="section-body" id="more_encyclopedia">
<ul class="relatedmp" style="list-style: none; padding: 0;">
<li><a href="https://medlineplus.gov/ency/article/000427.htm">Fibromyalgia</a></li>
<li><a href="https://medlineplus.gov/ency/article/002048.htm">Genetics</a></li>
</ul>
</div>
</div></section>
<section><div class="side-section">
<div class="section-header">
<h2>Understanding Genetics</h2>
</div>
<div class="section-body">
<ul class="relatedmp">
<li><a href="https://medlineplus.gov/genetics/understanding/consult/prognosis/">What is the prognosis of a genetic condition?</a></li>
<li><a href="https://medlineplus.gov/genetics/understanding/mutationsanddisorders/mutationscausedisease/">How can gene variants affect health and development?</a></li>
<li><a href="https://medlineplus.gov/genetics/understanding/inheritance/runsinfamily/">What does it mean if a disorder seems to run in my family?</a></li>
<li><a href="https://medlineplus.gov/genetics/understanding/inheritance/inheritancepatterns/">What are the different ways a genetic condition can be inherited?</a></li>
<li><a href="https://medlineplus.gov/genetics/understanding/consult/treatment/">How are genetic conditions treated or managed?</a></li>
</ul>
</div>
</div></section>
<section><div class="side-section">
<div class="section-header hide-offscreen">
<h2>Disclaimers</h2>
</div>
<div class="section-body no-header">
MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. MedlinePlus also links to health information from non-government Web sites. See our <a href="https://medlineplus.gov/disclaimers.html">disclaimer</a> about external links and our <a href="https://medlineplus.gov/criteria.html">quality guidelines</a>.
</div>
</div></section>
</aside>
</div>
<div class="bottom">
<section>
<!--
<div class="from-ghr">
<img src="https://medlineplus.gov/images/fromGHR.png" alt="From Genetics Home Reference" />
<p>Genetics Home Reference has merged with MedlinePlus. Genetics Home Reference content now can be found in the "Genetics" section of MedlinePlus. <a href="https://medlineplus.gov/about/general/genetics/newhome/">Learn more</a></p>
</div>
-->
<p>The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.</p>
</section>
</div>
</article>
</div>
<div id="citation-how-to">
<button><span>Learn how to cite this page</span></button>
</div>
</div>
<footer>
<div id="mplus-footer">
<div class="footer1">
<ul class="secondarynav">
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
<li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li>
<li><a href="https://medlineplus.gov/sitemap.html">Site Map</a></li>
<li><a href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&category=medlineplus&from=https%3A//medlineplus.gov/genetics/condition/fibromyalgia/" target="_blank"><span>Customer Support</span></a></li>
</ul>
<ul class="follow-footer">
<li>
<a href="https://medlineplus.gov/rss.html" class="follow-item">Subscribe to RSS<img src="https://medlineplus.gov/images/feed.png" class="social-media-toolkit-icon" alt="RSS" title="RSS"></a>
</li>
<li>
<span class="follow-label">Follow us</span>
<a href="https://twitter.com/medlineplus" class="follow-item" target="_blank">
<img src="https://medlineplus.gov/images/i_share_twitter.png" class="follow-icon" alt="X" title="X">
</a>
<a href="https://facebook.com/Mplus.gov/" class="follow-item" target="_blank">
<img src="https://medlineplus.gov/images/i_share_fb.png" class="follow-icon" alt="Facebook" title="Facebook">
</a>
<a href="https://www.instagram.com/mplusgov/" class="follow-item" target="_blank">
<img src="https://medlineplus.gov/images/Instagram_Glyph_Gradient_RGB.png" class="follow-icon" alt="Instagram" title="Instagram">
</a>
</li>
<li>
<a href="https://medlineplus.gov/social-media-toolkit/" class="social-media-toolkit-item">Social Media Toolkit<img src="https://medlineplus.gov/images/i_social_media_toolkit.png" class="social-media-toolkit-icon" alt="Social Media Toolkit" title="Social Media Toolkit"></a>
</li>
</ul>
</div>
<div class="footer2">
<ul>
<li><a href=" https://www.nlm.nih.gov/web_policies.html" target='_blank'>NLM Web Policies</a></li>
<li><a href="https://medlineplus.gov/about/using/usingcontent/" >Copyright</a></li>
<li><a href="https://medlineplus.gov/accessibility.html">Accessibility</a></li>
<li><a href="https://medlineplus.gov/about/using/criteria/">Guidelines for Links</a></li>
<li><a href="https://medlineplus.gov/plugins.html">Viewers & Players</a></li>
<li><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank">HHS Vulnerability Disclosure</a></li>
<li><a href="https://medlineplus.gov/medlineplus-connect/">MedlinePlus Connect for EHRs</a></li>
<li><a href="https://medlineplus.gov/about/developers/">For Developers</a></li>
</ul>
<div class="address">
<a href="https://www.nlm.nih.gov" target="_blank">National Library of Medicine</a>
<span>8600 Rockville Pike, Bethesda, MD 20894</span>
<a href="https://www.hhs.gov" target="_blank">U.S. Department of Health and Human Services</a>
<a href="https://www.nih.gov" target="_blank">National Institutes of Health</a>
</div>
<div class="date">
<span id="lastupdate">Last updated June 1, 2018</span>
</div>
<div class="return-top"><a href="#top" title="Return to top"><img class="return-top-icon" alt="Return to top" src="https://medlineplus.gov/images/return-top.png"></a></div>
</div>
</div>
</footer>
</div>
<script src="https://medlineplus.gov/jslib/jquery-3.6.0.min.js" type="text/javascript"></script>
<script src="https://medlineplus.gov/jslib/mplus-frontend-controls-new.js" type="text/javascript"></script>
<script src="https://medlineplus.gov/jslib/mplus-share.js?id=1112022" type="text/javascript"></script>
<!--[if lte IE 9]><script src="//www.nlm.nih.gov/medlineplus/jslib/jquery.placeholder.js" type="text/javascript"></script><![endif]-->
<script src="https://medlineplus.gov/jslib/control.js" type="text/javascript"></script>
<script src="https://medlineplus.gov/uswds/js/uswds.min.js" type="text/javascript"></script>
</body>
</html>
Reference in a new issue View git blame Copy permalink