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<span>Dupuytren contracture</span>
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<h1>Dupuytren contracture</h1>
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<h2>Description</h2>
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<section><div class="mp-content"><p>Dupuytren contracture is characterized by a deformity of the hand in which the joints of one or more fingers <a class="image-modal" data-alt="Photo of a right hand with bent fingers due to Dupuytren contracture" data-caption="" data-credit="British Dupuytren's Society" data-filepath="images/PX0002RR_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0002RR" data-sourceurl="http://dupuytrens-society.org.uk/" data-title="Dupuytren contracture in right hand" href="https://medlineplus.gov/images/PX0002RR_PRESENTATION.jpeg" id="PX0002RR_1" title="Show image">cannot be fully straightened<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> (extended); their mobility is limited to a range of bent (flexed) positions. The condition is a disorder of <a class="image-modal" data-alt="Components of connective tissue, labelled, including collagen fibers, elastic fibers, reticular fibers, capillaries, fat cells and other cell types." data-caption="" data-credit="Designua/Shutterstock.com" data-filepath="images/PX0000S4_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0000S4" data-sourceurl="" data-title="Connective tissues" href="https://medlineplus.gov/images/PX0000S4_PRESENTATION.jpeg" id="PX0000S4_2" title="Show image">connective tissue<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a>, which supports the body's muscles, joints, organs, and skin and provides strength and flexibility to structures throughout the body. In particular, Dupuytren contracture results from shortening and thickening of connective tissues in the hand, including fat and bands of fibrous tissue called fascia; the skin is also involved.</p><p>In men, Dupuytren contracture most often occurs after age 50. In women, it tends to appear later and be less severe. However, Dupuytren contracture can occur at any time of life, including childhood. The disorder can make it more difficult or impossible for affected individuals to perform manual tasks such as preparing food, writing, or playing musical instruments.</p><p>Dupuytren contracture often first occurs in only one hand, affecting the right hand twice as often as the left. About 80 percent of affected individuals eventually develop features of the condition in both hands.</p><p>Dupuytren contracture typically first appears as one or more small hard nodules that can be seen and felt under the skin of the palm. In some affected individuals the nodules remain the only sign of the disorder, and occasionally even go away without treatment, but in most cases the condition gradually gets worse. Over months or years, tight bands of tissue called cords develop. These cords gradually draw the affected fingers downward so that they curl toward the palm. As the condition worsens, it becomes difficult or impossible to extend the affected fingers. The fourth (ring) finger is most often involved, followed by the fifth (little), third (middle), and second (index) fingers. Occasionally the <a class="image-modal" data-alt="Photo of a left hand with bent fingers due to Dupuyten contracture" data-caption="" data-credit="British Dupuytren Society" data-filepath="images/PX0002Q4_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0002Q4" data-sourceurl="http://dupuytrens-society.org.uk/" data-title="Dupuytren contracture in left hand" href="https://medlineplus.gov/images/PX0002Q4_PRESENTATION.jpeg" id="PX0002Q4_3" title="Show image">thumb is involved<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a>. The condition is also known as Dupuytren disease, and "Dupuytren contracture" most accurately refers to later stages when finger mobility is affected; however, the term is also commonly used as a general name for the condition.</p><p>About one-quarter of people with Dupuytren contracture experience uncomfortable inflammation or sensations of tenderness, burning, or itching in the affected hand. They may also feel pressure or tension, especially when attempting to straighten affected joints.</p><p>People with Dupuytren contracture are at increased risk of developing other disorders in which similar connective tissue abnormalities affect other parts of the body. These include <a class="image-modal" data-alt="photo of the back of a hand with dark circles surrounding the middle knuckle of the index, middle, and ring fingers" data-caption="" data-credit="British Dupuytren's Society" data-filepath="images/PX0002P1_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0002P1" data-sourceurl="http://dupuytrens-society.org.uk/" data-title="Garrod pads associated with Dupuytren contracture" href="https://medlineplus.gov/images/PX0002P1_PRESENTATION.jpeg" id="PX0002P1_4" title="Show image">Garrod pads<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a>, which are nodules that develop on the knuckles; Ledderhose disease, also called plantar fibromatosis, which affects the feet; scar tissue in the shoulder that causes pain and stiffness (adhesive capsulitis or frozen shoulder); and, in males, Peyronie disease, which causes abnormal curvature of the penis.</p></div>
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<div class="mp-exp exp-full" data-bookmark="frequency">
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<h2>Frequency</h2>
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<section><div class="mp-content"><p>Dupuytren contracture occurs in about 5 percent of people in the United States. The condition is 3 to 10 times more common in people of European descent than in those of non-European descent.</p></div>
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</section>
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<div class="mp-exp exp-full" data-bookmark="causes">
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<h2>Causes</h2>
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<section><div class="mp-content"><p>While the cause of Dupuytren contracture is unknown, changes in one or more genes are thought to affect the risk of developing this disorder. Some of the genes associated with the disorder are involved in a biological process called the <a class="image-modal" data-alt="Diagrams of the Wnt signaling pathway in the absence and presence of ligand" data-caption="" data-credit="Meletios/Shutterstock.com" data-filepath="images/PX0001A0_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0001A0" data-sourceurl="" data-title="Wnt signaling pathway" href="https://medlineplus.gov/images/PX0001A0_PRESENTATION.jpeg" id="PX0001A0_1" title="Show image">Wnt signaling pathway<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a>. This pathway promotes the growth and division (proliferation) of cells and is involved in determining the specialized functions a cell will have (differentiation).</p><p>Abnormal proliferation and differentiation of connective tissue cells called fibroblasts are important in the development of Dupuytren contracture. The fascia of people with this disorder has an excess of myofibroblasts, which are a type of fibroblast containing protein strands called myofibrils. Myofibrils normally form the basic unit of muscle fibers, allowing them to contract. The increased number of myofibroblasts in this disorder cause abnormal contraction of the fascia and produce excess amounts of a connective tissue protein called type III collagen. The combination of abnormal contraction and excess type III collagen likely results in the changes in connective tissue that occurs in Dupuytren contracture. However, it is unknown how changes in genes that affect the Wnt signaling pathway are related to these abnormalities and how they contribute to the risk of developing this disorder.</p><p>Other risk factors for developing Dupuytren contracture may include smoking; extreme alcohol use; <a class="image-modal" data-alt="The liver is in the upper abdomen near the stomach, intestines, gallbladder, and pancreas." data-caption="The liver is in the upper abdomen near the stomach, intestines, gallbladder, and pancreas. The liver has four lobes. Two lobes are on the front and two small lobes (not shown) are on the back of the liver." data-credit="© 2009 Terese Winslow LLC for the National Cancer Institute" data-filepath="images/PX0001V1_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0001V1" data-sourceurl="https://visualsonline.cancer.gov/details.cfm?imageid=9077" data-title="Liver" href="https://medlineplus.gov/images/PX0001V1_PRESENTATION.jpeg" id="PX0001V1_2" title="Show image">liver<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> disease; diabetes; high cholesterol; <a class="image-modal" data-alt="The thyroid gland lies at the base of the throat near the trachea. It is shaped like a butterfly, with the right lobe and left lobe connected by a thin piece of tissue called the isthmus. The parathyroid glands are four pea-sized organs found in the neck near the thyroid." data-caption="The thyroid gland lies at the base of the throat near the trachea. It is shaped like a butterfly, with the right lobe and left lobe connected by a thin piece of tissue called the isthmus. The parathyroid glands are four pea-sized organs found in the neck near the thyroid. The thyroid and parathyroid glands make hormones." data-credit="© 2012 Terese Winslow LLC for the National Cancer Institute" data-filepath="images/PX00025V_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX00025V" data-sourceurl="https://visualsonline.cancer.gov/details.cfm?imageid=9268" data-title="Thyroid gland and parathyroid glands" href="https://medlineplus.gov/images/PX00025V_PRESENTATION.jpeg" id="PX00025V_3" title="Show image">thyroid<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> problems; certain medications, such as those used to treat epilepsy (anticonvulsants); and previous injury to the hand.</p></div>
|
||
</section>
|
||
|
||
<section>
|
||
|
||
<div class="related-genes mp-exp exp-full">
|
||
|
||
<h3>Learn more about the genes associated with Dupuytren contracture</h3>
|
||
|
||
<ul class="relatedmp">
|
||
|
||
<li><a href="https://medlineplus.gov/genetics/gene/sfrp4/">SFRP4</a></li>
|
||
|
||
|
||
<li><a href="https://medlineplus.gov/genetics/gene/wnt4/">WNT4</a></li>
|
||
|
||
|
||
</ul>
|
||
|
||
<p><strong>Additional Information from NCBI Gene:</strong></p>
|
||
<ul class="relatedmp">
|
||
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/gene/116328" target="TheNewWin">C8orf34</a></li>
|
||
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/gene/54749" target="TheNewWin">EPDR1</a></li>
|
||
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/gene/340419" target="TheNewWin">RSPO2</a></li>
|
||
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/gene/23213" target="TheNewWin">SULF1</a></li>
|
||
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/gene/7472" target="TheNewWin">WNT2</a></li>
|
||
|
||
<li><a href="https://www.ncbi.nlm.nih.gov/gene/7477" target="TheNewWin">WNT7B</a></li>
|
||
|
||
</ul>
|
||
|
||
</div>
|
||
|
||
</section>
|
||
|
||
</div>
|
||
<div class="mp-exp exp-full" data-bookmark="inheritance">
|
||
<h2>Inheritance</h2>
|
||
|
||
<section><div class="mp- mp-content"><p>Dupuytren contracture is usually passed down through generations in families and is the most common inherited disorder of connective tissue. The inheritance pattern is often unclear. Some people who inherit gene changes associated with Dupuytren contracture never develop the condition.</p><p>In some cases, Dupuytren contracture is not inherited and occurs in people with no history of the condition in their family. These sporadic cases tend to begin later and be less severe than familial cases.</p></div>
|
||
</section>
|
||
|
||
</div>
|
||
<div class="mp-exp exp-full" data-bookmark="synonyms">
|
||
<h2>Other Names for This Condition</h2>
|
||
|
||
<section>
|
||
<ul class="bulletlist">
|
||
<li>Contraction of palmar fascia</li> <li>Dupuytren disease</li> <li>Dupuytren's contracture</li> <li>Familial palmar fibromatosis</li> <li>Palmar fascial fibromatosis</li> <li>Palmar fibromas</li>
|
||
</ul>
|
||
</section>
|
||
|
||
</div>
|
||
|
||
<div class="mp-exp exp-full" data-bookmark="resources">
|
||
<h2>Additional Information & Resources</h2>
|
||
|
||
<section>
|
||
<div class="mp-content">
|
||
|
||
<h2>Patient Support and Advocacy Resources</h2>
|
||
<ul>
|
||
|
||
<li><a href="https://rarediseases.org/" target="TheNewWin">National Organization for Rare Disorders (NORD)</a></li>
|
||
|
||
</ul>
|
||
|
||
</div>
|
||
</section>
|
||
|
||
<section>
|
||
<div class="mp-content">
|
||
|
||
<h2>Clinical Trials</h2>
|
||
<ul>
|
||
|
||
<li><a href="https://clinicaltrials.gov/search?cond=%22Dupuytren contracture%22" target="TheNewWin">ClinicalTrials.gov</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
|
||
|
||
</ul>
|
||
|
||
</div>
|
||
</section>
|
||
|
||
<section>
|
||
<div class="mp-content">
|
||
|
||
<h2>Catalog of Genes and Diseases from OMIM</h2>
|
||
<ul>
|
||
|
||
<li><a href="https://omim.org/entry/126900" target="TheNewWin">DUPUYTREN CONTRACTURE</a></li>
|
||
|
||
</ul>
|
||
|
||
</div>
|
||
</section>
|
||
|
||
<section>
|
||
<div class="mp-content">
|
||
|
||
<h2>Scientific Articles on PubMed</h2>
|
||
<ul>
|
||
|
||
<li><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%28Dupuytren+Contracture%5BTIAB%5D%29+AND+english%5Bla%5D+AND+human%5Bmh%5D+AND+%22last+1800+days%22%5Bdp%5D" target="TheNewWin">PubMed</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
|
||
|
||
</ul>
|
||
|
||
</div>
|
||
</section>
|
||
|
||
</div>
|
||
|
||
<div class="mp-exp exp-full" data-bookmark="references">
|
||
<h2>References</h2>
|
||
|
||
<section>
|
||
<div class="mp-content">
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||
|
||
<ul>
|
||
|
||
<li>Becker K, Tinschert S, Lienert A, Bleuler PE, Staub F, Meinel A, Rossler J,
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||
Wach W, Hoffmann R, Kuhnel F, Damert HG, Nick HE, Spicher R, Lenze W, Langer M,
|
||
Nurnberg P, Hennies HC. The importance of genetic susceptibility in Dupuytren's
|
||
disease. Clin Genet. 2015 May;87(5):483-7. doi: 10.1111/cge.12410. Epub 2014 May
|
||
15. <a href="https://pubmed.ncbi.nlm.nih.gov/24749973" target="TheNewWin">Citation on PubMed</a></li>
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||
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||
|
||
<li>Black EM, Blazar PE. Dupuytren disease: an evolving understanding of an
|
||
age-old disease. J Am Acad Orthop Surg. 2011 Dec;19(12):746-57. doi:
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||
10.5435/00124635-201112000-00005. <a href="https://pubmed.ncbi.nlm.nih.gov/22134207" target="TheNewWin">Citation on PubMed</a></li>
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||
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||
|
||
<li>Capstick R, Bragg T, Giele H, Furniss D. Sibling recurrence risk in
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||
Dupuytren's disease. J Hand Surg Eur Vol. 2013 May;38(4):424-9. doi:
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||
10.1177/1753193412453359. Epub 2012 Jul 11. <a href="https://pubmed.ncbi.nlm.nih.gov/22791609" target="TheNewWin">Citation on PubMed</a></li>
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||
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||
<li>Debniak T, Zyluk A, Puchalski P, Serrano-Fernandez P. Common variants of the
|
||
EPDR1 gene and the risk of Dupuytren's disease. Handchir Mikrochir Plast Chir.
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||
2013 Oct;45(5):253-7. doi: 10.1055/s-0033-1357119. Epub 2013 Oct 2. <a href="https://pubmed.ncbi.nlm.nih.gov/24089297" target="TheNewWin">Citation on PubMed</a></li>
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||
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||
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||
<li>Dolmans GH, Werker PM, Hennies HC, Furniss D, Festen EA, Franke L, Becker K,
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||
van der Vlies P, Wolffenbuttel BH, Tinschert S, Toliat MR, Nothnagel M, Franke A,
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||
Klopp N, Wichmann HE, Nurnberg P, Giele H, Ophoff RA, Wijmenga C; Dutch Dupuytren
|
||
Study Group; German Dupuytren Study Group; LifeLines Cohort Study; BSSH-GODD
|
||
Consortium. Wnt signaling and Dupuytren's disease. N Engl J Med. 2011 Jul
|
||
28;365(4):307-17. doi: 10.1056/NEJMoa1101029. Epub 2011 Jul 6. <a href="https://pubmed.ncbi.nlm.nih.gov/21732829" target="TheNewWin">Citation on PubMed</a></li>
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||
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||
|
||
<li>Larsen S, Krogsgaard DG, Aagaard Larsen L, Iachina M, Skytthe A, Frederiksen
|
||
H. Genetic and environmental influences in Dupuytren's disease: a study of 30,330
|
||
Danish twin pairs. J Hand Surg Eur Vol. 2015 Feb;40(2):171-6. doi:
|
||
10.1177/1753193414535720. Epub 2014 May 16. <a href="https://pubmed.ncbi.nlm.nih.gov/24835475" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810018/" target="TheNewWin">Free article on PubMed Central</a></li>
|
||
|
||
|
||
<li>Mansur HG, Oliveira ER, Goncalves CB. Epidemiological analysis of patients
|
||
with Dupuytren's disease. Rev Bras Ortop. 2017 Dec 14;53(1):10-14. doi:
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||
10.1016/j.rboe.2017.12.003. eCollection 2018 Jan-Feb. <a href="https://pubmed.ncbi.nlm.nih.gov/29367900" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771785/" target="TheNewWin">Free article on PubMed Central</a></li>
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||
|
||
|
||
<li>McFarlane RM. On the origin and spread of Dupuytren's disease. J Hand Surg Am.
|
||
2002 May;27(3):385-90. doi: 10.1053/jhsu.2002.32334. <a href="https://pubmed.ncbi.nlm.nih.gov/12015711" target="TheNewWin">Citation on PubMed</a></li>
|
||
|
||
|
||
<li>Michou L, Lermusiaux JL, Teyssedou JP, Bardin T, Beaudreuil J, Petit-Teixeira
|
||
E. Genetics of Dupuytren's disease. Joint Bone Spine. 2012 Jan;79(1):7-12. doi:
|
||
10.1016/j.jbspin.2011.05.027. Epub 2011 Jul 30. <a href="https://pubmed.ncbi.nlm.nih.gov/21803632" target="TheNewWin">Citation on PubMed</a></li>
|
||
|
||
|
||
<li>Rodrigues JN, Becker GW, Ball C, Zhang W, Giele H, Hobby J, Pratt AL, Davis T.
|
||
Surgery for Dupuytren's contracture of the fingers. Cochrane Database Syst Rev.
|
||
2015 Dec 9;2015(12):CD010143. doi: 10.1002/14651858.CD010143.pub2. <a href="https://pubmed.ncbi.nlm.nih.gov/26648251" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464957/" target="TheNewWin">Free article on PubMed Central</a></li>
|
||
|
||
|
||
</ul>
|
||
|
||
</div>
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||
</section>
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||
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data-filepath="images/PX0002OQ_PRESENTATION.jpeg"
|
||
data-title="Dupuytren contracture"
|
||
data-caption=""
|
||
data-credit="British Dupuytren's Society"
|
||
data-alt="photo of fifth (pinky) finger in bent position, illustrating Dupuytren contracture"
|
||
data-sourceurl="http://dupuytrens-society.org.uk/">
|
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<li><a href="https://medlineplus.gov/fingerinjuriesanddisorders.html">Finger Injuries and Disorders</a></li>
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<h2>MEDICAL ENCYCLOPEDIA</h2>
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<li><a href="https://medlineplus.gov/ency/article/003185.htm">Contracture deformity</a></li>
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||
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||
<li><a href="https://medlineplus.gov/ency/article/001233.htm">Dupuytrens contracture</a></li>
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||
|
||
<li><a href="https://medlineplus.gov/ency/article/003248.htm">Finger pain</a></li>
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