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<span>Adermatoglyphia</span>
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<span class="page-url print-only">URL of this page: https://medlineplus.gov/genetics/condition/adermatoglyphia/</span>
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<h1>Adermatoglyphia</h1>
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<h2>Description</h2>
<section><div class="mp-content"><p>Adermatoglyphia is the absence of ridges on the skin on the pads of the fingers and toes, as well as on the palms of the hands and soles of the feet. The patterns of these ridges (called dermatoglyphs) form whorls, arches, and loops that are the basis for each person's unique fingerprints. Because no two people have the same patterns, fingerprints have long been used as a way to identify individuals. However, people with adermatoglyphia do not have these ridges, and so they cannot be identified by their fingerprints. Adermatoglyphia has been called the "immigration delay disease" because affected individuals have had difficulty entering countries that require fingerprinting for identification.</p><p>In some families, adermatoglyphia occurs without any related signs and symptoms. In others, a lack of dermatoglyphs is associated with other features, typically affecting the skin. These can include small white bumps called milia on the face, blistering of the skin in areas exposed to heat or friction, and a reduced number of sweat glands on the hands and feet. Adermatoglyphia is also a feature of several rare syndromes classified as ectodermal dysplasias, including a condition called <a data-pid="16095" href="https://medlineplus.gov/genetics/condition/naegeli-franceschetti-jadassohn-syndrome-dermatopathia-pigmentosa-reticularis/">Naegeli-Franceschetti-Jadassohn syndrome/dermatopathia pigmentosa reticularis</a> that affects the skin, hair, sweat glands, and teeth.</p></div>
</section>
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<div class="mp-exp exp-full" data-bookmark="frequency">
<h2>Frequency</h2>
<section><div class="mp-content"><p>Adermatoglyphia appears to be a rare condition. Only a few affected families have been identified worldwide.</p></div>
</section>
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<div class="mp-exp exp-full" data-bookmark="causes">
<h2>Causes</h2>
<section><div class="mp-content"><p>Adermatoglyphia is caused by mutations in the <i><a data-pid="19549" href="https://medlineplus.gov/genetics/gene/smarcad1/">SMARCAD1</a></i> gene. This gene provides information for making two versions of the SMARCAD1 protein: a full-length version that is active (expressed) in multiple tissues and a shorter version that is expressed only in the skin. Studies suggest that the full-length SMARCAD1 protein regulates the activity of a wide variety of genes involved in maintaining the stability of cells' genetic information. Little is known about the function of the skin-specific version of the SMARCAD1 protein, but it appears to play a critical role in dermatoglyph formation. Dermatoglyphs develop before birth and remain the same throughout life. The activity of this protein is likely one of several factors that determine each person's unique fingerprint pattern.</p><p>The <i>SMARCAD1</i> gene mutations that cause adermatoglyphia affect only the skin-specific version of the SMARCAD1 protein. These mutations reduce the total amount of this protein available in skin cells. Although it is unclear how these genetic changes cause adermatoglyphia, researchers speculate that a shortage of the skin-specific version of the SMARCAD1 protein impairs signaling pathways needed for normal skin development and function, including the formation of dermatoglyphs.</p></div>
</section>
<section>
<div class="related-genes mp-exp exp-full">
<h3>Learn more about the gene associated with Adermatoglyphia</h3>
<ul class="relatedmp">
<li><a href="https://medlineplus.gov/genetics/gene/smarcad1/">SMARCAD1</a></li>
</ul>
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</section>
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<div class="mp-exp exp-full" data-bookmark="inheritance">
<h2>Inheritance</h2>
<section><div class="mp- mp-content"><p>Adermatoglyphia is inherited in an <a class="image-modal" data-alt="A parent with an autosomal dominant condition passes the altered gene to two affected children. Two other children do not receive the altered gene, and are unaffected." data-caption="" data-credit="U.S. National Library of Medicine" data-filepath="images/PX00009C_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX00009C" data-sourceurl="" data-title="Autosomal dominant inheritance" href="https://medlineplus.gov/images/PX00009C_PRESENTATION.jpeg" id="PX00009C_1" title="Show image">autosomal dominant pattern<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a>, which means one copy of the altered <i><a data-pid="19549" href="https://medlineplus.gov/genetics/gene/smarcad1/">SMARCAD1</a></i> gene in each cell is sufficient to cause the condition. In many cases, an affected person has one parent with the condition.</p></div>
</section>
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<div class="mp-exp exp-full" data-bookmark="synonyms">
<h2>Other Names for This Condition</h2>
<section>
<ul class="bulletlist">
<li>Absence of fingerprints</li> <li>ADERM</li> <li>ADG</li> <li>Immigration delay disease</li>
</ul>
</section>
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<div class="mp-exp exp-full" data-bookmark="resources">
<h2>Additional Information & Resources</h2>
<section>
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<h2>Genetic and Rare Diseases Information Center</h2>
<ul>
<li><a href="https://rarediseases.info.nih.gov/diseases/12550/index" target="TheNewWin">Isolated congenital adermatoglyphia</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
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<section>
<div class="mp-content">
<h2>Catalog of Genes and Diseases from OMIM</h2>
<ul>
<li><a href="https://omim.org/entry/136000" target="TheNewWin">ADERMATOGLYPHIA; ADERM</a></li>
<li><a href="https://omim.org/entry/129200" target="TheNewWin">BASAN SYNDROME</a></li>
</ul>
</div>
</section>
<section>
<div class="mp-content">
<h2>Scientific Articles on PubMed</h2>
<ul>
<li><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%28adermatoglyphia%5BTIAB%5D%29" target="TheNewWin">PubMed</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li>
</ul>
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</section>
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<div class="mp-exp exp-full" data-bookmark="references">
<h2>References</h2>
<section>
<div class="mp-content">
<ul>
<li>Burger B, Fuchs D, Sprecher E, Itin P. The immigration delay disease:
adermatoglyphia-inherited absence of epidermal ridges. J Am Acad Dermatol. 2011
May;64(5):974-80. doi: 10.1016/j.jaad.2009.11.013. Epub 2010 Jul 8. <a href="https://pubmed.ncbi.nlm.nih.gov/20619487" target="TheNewWin">Citation on PubMed</a></li>
<li>Nousbeck J, Burger B, Fuchs-Telem D, Pavlovsky M, Fenig S, Sarig O, Itin P,
Sprecher E. A mutation in a skin-specific isoform of SMARCAD1 causes
autosomal-dominant adermatoglyphia. Am J Hum Genet. 2011 Aug 12;89(2):302-7. doi:
10.1016/j.ajhg.2011.07.004. Epub 2011 Aug 4. <a href="https://pubmed.ncbi.nlm.nih.gov/21820097" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155166/" target="TheNewWin">Free article on PubMed Central</a></li>
<li>Nousbeck J, Sarig O, Magal L, Warshauer E, Burger B, Itin P, Sprecher E.
Mutations in SMARCAD1 cause autosomal dominant adermatoglyphia and perturb the
expression of epidermal differentiation-associated genes. Br J Dermatol. 2014
Dec;171(6):1521-4. doi: 10.1111/bjd.13176. Epub 2014 Oct 26. <a href="https://pubmed.ncbi.nlm.nih.gov/24909267" target="TheNewWin">Citation on PubMed</a></li>
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