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</div><div><span>17-hydroxycorticosteroids urine test</span></div></div>
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</a><h1 class="with-also" itemprop="name">17-hydroxycorticosteroids urine test</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>The 17-hydroxycorticosteroids (17-OHCS) test measures the level of 17-OHCS in the urine.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>A 24-hour urine sample is needed. You will need to <a test="test" href="./003425.htm">collect your urine over 24 hours</a>. Your health care provider will tell you how to do this. Follow instructions exactly.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Your provider will instruct you, if necessary, to stop medicines that may interfere with the test. These may include:</p><ul><li>Birth control pills that contain estrogen</li><li>Certain antibiotics</li><li>Glucocorticoids</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>The test involves only normal urination. There is no discomfort.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>17-OHCS is a product formed when the liver and other body tissues break down the steroid hormone cortisol.</p><p>This test can help determine if the body is producing too much cortisol. The test may be used to diagnose <a test="test" href="./000410.htm">Cushing syndrome</a>. This is a disorder that occurs when the body has a constant high level of cortisol.</p><p>The urine volume and urine creatinine are often done with 17-OHCS test at the same time. This helps the provider interpret the test.</p><p>This test is not done often now. The free <a test="test" href="./003703.htm">cortisol urine test</a> is a better screening test for Cushing disease.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Normal values:</p><ul><li>Male: 3 to 9 mg/24 hours (8.3 to 25 µmol/24 hours)</li><li>Female: 2 to 8 mg/24 hours (5.5 to 22 µmol/24 hours)</li></ul><p>Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>A higher than normal level of 17-OHCS may indicate:</p><ul><li>A type of <a test="test" href="./000407.htm">Cushing syndrome</a> caused by a tumor in the adrenal gland that produces cortisol</li><li>Depression</li><li>Hydrocortisone therapy</li><li><a test="test" href="./000404.htm">Malnutrition</a></li><li><a test="test" href="./003101.htm">Obesity</a></li><li>Pregnancy</li><li>A hormonal cause of severe <a test="test" href="./000468.htm">high blood pressure</a></li><li>Severe physical or emotional stress</li><li><a test="test" href="./000704.htm">Tumor in the pituitary gland</a> or elsewhere in the body that releases a hormone called adrenocorticotropic hormone (ACTH) </li></ul><p>A lower than normal level of 17-OHCS may indicate:</p><ul><li><a test="test" href="./000378.htm">Adrenal glands are not producing enough of their hormones</a></li><li><a test="test" href="./000343.htm">Pituitary gland is not producing enough of its hormones</a></li><li>Hereditary enzyme deficiency</li><li>Previous surgery to remove the adrenal gland </li><li>An expected result if part of a standard three- day dexamethasone suppression test<br/></li></ul><p>Urinating more than 3 liters a day (polyuria) can make the result of the test high even though cortisol production is normal.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>There are no risks with this test.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>17-OH corticosteroids; 17-OHCS</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Newell-Price JDC, Auchus RJ. The adrenal cortex. In: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. <em>Williams Textbook of Endocrinology. </em>14th ed. Philadelphia, PA: Elsevier; 2020:chap 15.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 5/12/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Sandeep K. Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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