nih-gov/medlineplus.gov/ency/article/001398.htm
2025-02-26 13:17:41 -05:00

294 lines
No EOL
31 KiB
HTML
Raw Blame History

This file contains ambiguous Unicode characters

This file contains Unicode characters that might be confused with other characters. If you think that this is intentional, you can safely ignore this warning. Use the Escape button to reveal them.

<!DOCTYPE html>
<html lang="en" id="article" class="nojs us" data-root="//medlineplus.gov" itemid="https://medlineplus.gov/ency/article/001398.htm" itemtype="http://schema.org/MedicalWebPage" itemscope="">
<head>
<meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"/>
<meta http-equiv="window-target" content="_top"/>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/>
<meta charset="utf-8"/>
<meta property="fb:app_id" content="1042245625821448"/>
<meta name="expires" content="Wed, 05 02 2025"/>
<meta name="ac-dictionary" content="medlineplus-ac-dictionary"/>
<link rel="shortcut icon" href="https://medlineplus.gov/images/favicon.ico" type="image/x-icon"/>
<link rel="apple-touch-icon" href="//medlineplus.gov/images/touch-icon.png"/>
<meta name="viewport" content="width=device-width, initial-scale=1"/>
<link rel="stylesheet" href="https://medlineplus.gov/css/common_new.css?04272023"/>
<!--[if IE 8]> <link rel="stylesheet" href="https://medlineplus.gov/css/ie8/common.css"><![endif]-->
<link rel="stylesheet" href="https://medlineplus.gov/uswds/css/uswds_styles.css"/>
<link rel="stylesheet" href="https://medlineplus.gov/css/ency/ency2.css?07162024"/>
<script type="text/javascript">document.querySelector("html").className = document.querySelector("html").className.replace(/nojs[\s]*/g, '');</script>
<script src="https://medlineplus.gov/uswds/js/uswds-init.min.js" type="text/javascript">
</script>
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&amp;l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-MMVM77');</script>
<link rel="canonical" href="https://medlineplus.gov/ency/article/001398.htm" itemprop="url"/>
<link rel="alternative" hreflang="es" href="https://medlineplus.gov/spanish/ency/article/001398.htm"/>
<link rel="alternative" hreflang="en" href="https://medlineplus.gov/ency/article/001398.htm"/><meta property="og:title" content="Syringomyelia: MedlinePlus Medical Encyclopedia"/><meta property="og:url" content="https://medlineplus.gov/ency/article/001398.htm"/><meta property="twitter:title" content="Syringomyelia: MedlinePlus Medical Encyclopedia"/><meta name="twitter:card" content="summary_large_image"/><meta name="description" content="Syringomyelia is a cyst-like collection of cerebrospinal fluid (CSF) that forms in the spinal cord. Over time, it may damage the spinal cord."/><meta itemprop="description" name="description" content="Syringomyelia is a cyst-like collection of cerebrospinal fluid (CSF) that forms in the spinal cord. Over time, it may damage the spinal cord."/><meta property="og:description" content="Syringomyelia is a cyst-like collection of cerebrospinal fluid (CSF) that forms in the spinal cord. Over time, it may damage the spinal cord."/><meta property="twitter:description" content="Syringomyelia is a cyst-like collection of cerebrospinal fluid (CSF) that forms in the spinal cord. Over time, it may damage the spinal cord."/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_1.jpg"/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_2.jpg"/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_3.jpg"/><meta property="twitter:image" content="https://medlineplus.gov/images/share_ency_1.jpg"/>
<title>Syringomyelia: MedlinePlus Medical Encyclopedia</title>
</head>
<body><link href="http://schema.org/Patient" itemprop="audience"/>
<!-- Google Tag Manager -->
<noscript><iframe title="googletagmanager" src="//www.googletagmanager.com/ns.html?id=GTM-MMVM77" height="0" width="0" style="display:none;visibility:hidden">
</iframe>
</noscript>
<!-- End Google Tag Manager -->
<a name="top" id="top">
</a>
<a class="hide-offscreen" href="#start">Skip navigation</a>
<section class="usa-banner" aria-label="Official website of the United States government">
<div class="usa-accordion">
<header class="usa-banner__header">
<div class="usa-banner__inner">
<div class="grid-col-auto">
<img aria-hidden="true" class="usa-banner__header-flag" src="https://medlineplus.gov/uswds/img/us_flag_small.png" alt=""/>
</div>
<div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true">
<p class="usa-banner__header-text">
An official website of the United States government
</p>
<p class="usa-banner__header-action">Heres how you know</p>
</div>
<button type="button" class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default-default">
<span class="usa-banner__button-text">Heres how you know</span>
</button>
</div>
</header>
<div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default">
<div class="grid-row grid-gap-lg">
<div class="usa-banner__guidance tablet:grid-col-6">
<img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/>
<div class="usa-media-block__body">
<p>
<strong>Official websites use .gov</strong><br/>A
<strong>.gov</strong> website belongs to an official government
organization in the United States.
</p>
</div>
</div>
<div class="usa-banner__guidance tablet:grid-col-6">
<img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/>
<div class="usa-media-block__body">
<p>
<strong>Secure .gov websites use HTTPS</strong><br/>A
<strong>lock</strong> (
<span class="icon-lock"><svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewBox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-description-default" focusable="false">
<title id="banner-lock-title-default">Lock</title>
<desc id="banner-lock-description-default">Locked padlock icon</desc>
<path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z">
</path>
</svg> </span>) or <strong>https://</strong> means youve safely connected to
the .gov website. Share sensitive information only on official,
secure websites.
</p>
</div>
</div>
</div>
</div>
</div>
</section>
<div id="mplus-wrap">
<header>
<div id="mplus-header">
<!-- Orgs
================================================== -->
<div id="mplus-orgs">
<a title="National Institutes of Health" target="_blank" class="nih-org" href="//www.nih.gov/">
<img alt="National Institutes of Health" src="https://medlineplus.gov/images/nihlogo.png" class="nihlogo"/>
</a><a target="_blank" href="https://www.nlm.nih.gov/"> National Library of Medicine </a>
</div>
<!-- Logo
================================================== -->
<div id="mplus-logo" class="years-25">
<a href="https://medlineplus.gov">
<img src="https://medlineplus.gov/images/m_logo_25.png" title="MedlinePlus Trusted Health Information for You" alt="MedlinePlus Trusted Health Information for You"/>
</a>
</div>
<!-- Nav Menu
================================================== -->
<div id="mplus-nav">
<div class="sm-live-area hide-offscreen" aria-live="polite">The navigation menu has been collapsed.</div>
<!-- Menu Button-->
<button type="submit" aria-controls="mplus-menu-list" role="button" title="Menu" class="navmenu-btn" id="sm-menu-btn" aria-pressed="false" tabindex="0">Menu<span class="icon icon-nav-menu">
</span></button><ul class="nav-list" id="mplus-menu-list">
<li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li>
<li><a href="https://medlineplus.gov/druginformation.html">Drugs &amp; Supplements</a></li>
<li><a href="https://medlineplus.gov/genetics/">Genetics</a></li>
<li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li>
<li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li>
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
</ul><button type="submit" aria-controls="mplus-search" role="button" title="Search" class="navmenu-btn" id="sm-search-btn" aria-pressed="false" tabindex="0"><span class="hide-offscreen">Show </span>Search<span class="icon icon-nav-search">
</span></button>
<div class="top-1">
<!-- Search
================================================== -->
<form target="_self" title="Search MedlinePlus" action="//vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta" method="get" id="mplus-search">
<input type="hidden" value="medlineplus" name="v:project"/>
<input type="hidden" value="medlineplus-bundle" name="v:sources"/>
<div class="form-box text-combo">
<div class="form-area"><label for="searchtext_primary" class="hide-offscreen">Search MedlinePlus</label>
<span role="status" aria-live="polite" class="ui-helper-hidden-accessible">
</span><input type="text" aria-haspopup="true" aria-autocomplete="list" role="textbox" autocomplete="off" name="query" size="40" maxlength="400" title="Site Search input" alt="Site Search input" placeholder="Search MedlinePlus" class="form-text ui-autocomplete-input" id="searchtext_primary"/>
</div>
<div class="button-area">
<button type="submit" alt="Search MedlinePlus" title="Search MedlinePlus" class="form-btn">GO</button>
</div>
</div>
</form>
<!-- Secondary Nav
================================================== -->
<div class="secondarynav">
<ul class="nav-list">
<li><a href="https://medlineplus.gov/about/"><span>About MedlinePlus</span></a></li>
<li><a href="https://medlineplus.gov/whatsnew/"><span>What's New</span></a></li>
<li><a href="https://medlineplus.gov/sitemap.html"><span>Site Map</span></a></li>
<li><a target="_blank" href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&amp;category=medlineplus&amp;from=//medlineplus.gov/ency/article/001398.htm"><span>Customer Support</span></a></li>
</ul>
</div>
</div>
<!-- Nav Bar
================================================== -->
<div id="mplus-nav-bar">
<ul class="nav-list">
<li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li><li><a href="https://medlineplus.gov/druginformation.html">Drugs &amp; Supplements</a></li><li><a href="https://medlineplus.gov/genetics/">Genetics</a></li><li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li><li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li>
</ul>
</div>
<a title="Español" id="mplus-lang-toggle" href="../../spanish/ency/article/001398.htm">Español</a>
</div>
</div>
</header>
<!-- Content
================================================== -->
<div id="mplus-content">
<!-- Breadrcumbs -->
<div id="breadcrumbs"><div itemtype="http://schema.org/BreadcrumbList" itemscope="" itemprop="breadcrumb"><span class="hide-offscreen">You Are Here:</span>
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
<a href="https://medlineplus.gov" itemprop="item"><span itemprop="name">Home</span></a>
&rarr;
<meta itemprop="position" content="1"/>
</div>
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
<a href="https://medlineplus.gov/encyclopedia.html" itemprop="item"><span itemprop="name">Medical Encyclopedia</span></a>
&rarr;
<meta itemprop="position" content="2"/>
</div>
</div><div><span>Syringomyelia</span></div></div>
<span class="page-url print-only">URL of this page: //medlineplus.gov/ency/article/001398.htm
</span>
<!-- Article -->
<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
</a><h1 class="with-also" itemprop="name">Syringomyelia</h1>
</div><div class="page-actions">
</div>
<noscript>
<span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span>
</noscript></div><div class="main"><div id="ency_summary"><p>Syringomyelia is a cyst-like collection of cerebrospinal fluid (CSF) that forms in the spinal cord. Over time, it may damage the spinal cord.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-1"><p>The fluid-filled cyst is called a syrinx. The spinal fluid buildup may be caused by: </p><ul><li>Birth defects (especially Chiari malformation, in which part of the brain pushes down onto the spinal cord at the base of the skull)</li><li><a test="test" href="./001066.htm">Spinal cord trauma</a></li><li>Tumors of the spinal cord </li></ul><p>The fluid-filled cyst usually begins in the neck area. It expands slowly, putting pressure on the spinal cord and slowly causing damage.</p><p>Onset of syringomyelia is usually between 25 to 40 years old. Males are more affected than females.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-2"><p>If the condition is due to birth defects, there may be no symptoms until age 30 to 40 years. Symptoms of syringomyelia usually appear slowly and worsen over many years. In the case of trauma, the onset of symptoms may be as early as 2 to 3 months of age. If there are symptoms, they may include:</p><ul><li><a test="test" href="./003024.htm">Headache</a></li><li><a test="test" href="./001241.htm">Scoliosis</a> (in children)</li><li>Loss of muscle mass (<a test="test" href="./003188.htm">wasting</a>, atrophy), often in the arms and hands</li><li>Loss of reflexes in upper limbs</li><li>Increased reflexes in lower limbs</li><li>Spasms or tightness in the leg or hand and arm muscles</li><li><a test="test" href="./003190.htm">Muscle function loss</a>, loss of ability to use arms or legs</li><li><a test="test" href="./003206.htm">Numbness</a> that decreases the feeling of pain or temperature; lowers the ability to feel when the skin is being touched; occurs in the neck, shoulders, upper arms, and trunk in a cape-like pattern; and slowly gets worse over time</li><li>Pain down the arms, neck, or into the middle back or legs</li><li><a test="test" href="./003174.htm">Weakness</a> (decreased muscle strength) in the arms or legs</li><li>Painless burn or injury of the hand</li><li>Difficulty walking or toe walking in children</li><li>Uncontrollable movements of the eyes (<a test="test" href="./003037.htm">nystagmus</a>)</li><li>Condition that affects the nerves to the eye and face (<a test="test" href="./000708.htm">Horner syndrome</a>)</li><li>Trouble controlling the bowel or bladder</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-3"><p>Your health care provider will perform a physical exam and ask about the symptoms, focusing on the nervous system. Tests that may be done include:</p><ul><li><a test="test" href="./003791.htm">MRI of the head</a> and spine</li><li><a test="test" href="./003787.htm">Spinal CT</a> scan with myelogram (may be done when an MRI is not possible)</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-4"><p>There is no known effective treatment for syringomyelia. The goals of treatment are to stop the spinal cord damage from getting worse and to improve function.</p><p>Medicines and devices can help with pain.</p><p>Surgery may be needed to relieve pressure in the spinal cord. Physical and occupational therapy may be needed to improve muscle function and help maximize independence.</p><p><a test="test" href="./003019.htm">Ventriculoperitoneal shunting</a> or syringosubarachnoid shunting may be needed. This is a procedure in which a catheter (thin, flexible tube) is inserted to drain the fluid buildup.</p><p>Other treatments are available to manage bowel and bladder problems and spasticity.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-5"><p>Without treatment, the disorder may get worse very slowly. Over time, it may cause severe disability. </p><p>Surgery usually stops the condition from getting worse. Nervous system function will improve in about 30% of the people who have surgery.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-6"><p>Without treatment, the condition may lead to:</p><ul><li>Loss of nervous system function</li><li>Permanent disability </li></ul><p>Possible complications of surgery include:</p><ul><li>Infection</li><li>Other complications of surgery </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-7"><p>Contact your provider if you have symptoms of syringomyelia.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-8"><p>There is no known way to prevent this condition, other than avoiding injuries to the spinal cord. Getting treated right away slows the worsening due to this disorder.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-Alt"><p>Syrinx</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div name="Images" class="section-body" id="section-tnails"><ul class="img-grid group">
<li><img src="//medlineplus.gov/ency/images/ency/tnails/19588t.jpg" alt="Central nervous system" title="Central nervous system" class="side-img"/><a href="../imagepages/19588.htm">Central nervous system</a></li>
</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-Ref"><p>Alobeidi F, Thurnher MM, Jäger HR. Non-tumoural spinal cord lesions. In: Adam A, Dixon AK, Gillard JH, Schaefer-Prokop CM, eds. <em>Grainger &amp; Allison's Diagnostic Radiology</em>. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 50.</p><p>Benglis DM, Jea A, Vanni S, Shah AH, Green BA. Syringomyelia. In: Garfin SR, Eismont FJ, Bell GR, Fischgrund JS, Bono CM, eds. <em>Rothman-Simeone and Herkowitz's The Spine</em>. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 94.</p><p>National Institute of Neurological Disorders and Stroke website. Syringomyelia. <a href="https://www.ninds.nih.gov/health-information/disorders/syringomyelia" target="_blank">www.ninds.nih.gov/health-information/disorders/syringomyelia</a>. Reviewed September 23, 2023. Accessed July 3, 2024.</p><p>Roguski M, Groves ML. Adult syringomyelia. In: Winn HR, ed. <em>Youmans and Winn Neurological Surgery</em>. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 334.</p></div></div></section>
<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 6/13/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div>
<div id="section-version" class="section-body"><p>Updated by: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
</div></div></section><section><div class="section ency-citation"><div class="section-header"><div class="section-title ency-citation"><div id="citation-how-to"><button><span>Learn how to cite this page</span></button></div></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Related MedlinePlus Health Topics</h2></div><div class="section-button"><button type="submit" aria-controls="section-mtp" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div name="Related MedlinePlus Health Topics" class="section-body" id="section-mtp"><ul class="side-nav"><li><a href="https://medlineplus.gov/syringomyelia.html">Syringomyelia</a></li>
</ul></div></div></section></div></div></article>
</div>
<footer>
<div class="provider-box group">
<div class="urac-logo">
<a href="https://accreditnet.urac.org/directory/#/certification/HCP-2/info"><img src="https://medlineplus.gov/images/CertifiedSeal.png"/></a>
<p class="urac-logo-info">Health Content Provider<br>06/01/2025</p>
</div>
<p class="adam-info">
<a href='javascript:urac_open();'>A.D.A.M., Inc. is accredited by URAC</a>, for Health Content Provider (www.urac.org). URAC's <a href='javascript:hwsopen();'>accreditation program</a> is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s <a href='javascript:edpolopen();'>editorial policy, editorial process</a>, and <a href='javascript:ppopen();'>privacy policy</a>. A.D.A.M. is also a founding member of Hi-Ethics. This site complies with the HONcode standard for trustworthy health information: <a href='javascript:honc_open();'>verify here</a>.
</p>
</div>
<p class="adam-info">
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997-2025 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
</p>
<div class="adam-logo">
<a href="https://www.adam.com/about" target="_blank"><img width="49" height="10" alt="About A.D.A.M." src="https://medlineplus.gov/ency/images/ency/ftrAdamlogo.gif"/></a>
</div>
<div id="mplus-footer">
<div class="footer1">
<ul class="secondarynav">
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
<li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li>
<li><a href="https://medlineplus.gov/sitemap.html">Site Map</a></li>
<li><a name="contact" target="_blank" href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&amp;category=medlineplus&amp;from="><span>Customer Support</span></a></li>
</ul>
<ul class="follow-footer">
<li><a href="https://medlineplus.gov/rss.html" class="follow-item">Subscribe to RSS<img src="https://medlineplus.gov/images/feed.png" class="social-media-toolkit-icon" alt="RSS" title="RSS"></a></li>
<li><span class="follow-label">Follow us</span>
<a href="https://twitter.com/medlineplus" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/i_share_twitter.png" class="follow-icon" alt="X" title="X"></a>
<a href="https://facebook.com/Mplus.gov/" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/i_share_fb.png" class="follow-icon" alt="Facebook" title="Facebook"></a>
<a href="https://www.instagram.com/mplusgov/" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/Instagram_Glyph_Gradient_RGB.png" class="follow-icon" alt="Instagram" title="Instagram"></a>
</li>
<li><a href="https://medlineplus.gov/social-media-toolkit/" class="social-media-toolkit-item">Social Media Toolkit<img src="https://medlineplus.gov/images/i_social_media_toolkit.png" class="social-media-toolkit-icon" alt="Social Media Toolkit" title="Social Media Toolkit"></a></li>
</ul>
</div>
<div class="footer2">
<ul>
<li><a href="https://www.nlm.nih.gov/web_policies.html" target="_blank">NLM Web Policies</a></li>
<li><a href="https://medlineplus.gov/about/using/usingcontent/" >Copyright</a></li>
<li><a href="//medlineplus.gov/accessibility.html">Accessibility</a></li>
<li><a href="https://medlineplus.gov/about/using/criteria/">Guidelines for Links</a></li>
<li><a href="//medlineplus.gov/plugins.html">Viewers &amp; Players</a></li>
<li><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank">HHS Vulnerability Disclosure</a></li>
<li><a href="https://medlineplus.gov/medlineplus-connect/">MedlinePlus Connect for EHRs</a></li>
<li><a href="https://medlineplus.gov/about/developers/">For Developers</a></li>
</ul>
<div class="address">
<a href="//www.nlm.nih.gov" target="_blank">National Library of Medicine</a>
<span>8600 Rockville Pike, Bethesda, MD 20894</span>
<a href="//www.hhs.gov" target="_blank">U.S. Department of Health and Human Services</a>
<a href="//www.nih.gov" target="_blank">National Institutes of Health</a>
</div>
<div class="return-top"><a href="#top" title="Return to top"><img class="return-top-icon" alt="Return to top" src="https://medlineplus.gov/images/return-top.png"></a></div>
</div>
</div>
</footer>
</div><!-- End Wrap -->
<script src="https://medlineplus.gov/jslib/jquery-3.6.0.min.js" type="text/javascript">
</script>
<script src="https://medlineplus.gov/jslib/mplus-frontend-controls.js" type="text/javascript">
</script>
<!--[if lte IE 9]>
<script src="https://medlineplus.gov/jslib/jquery.placeholder.js" type="text/javascript"></script>
<![endif]-->
<script src="https://medlineplus.gov/jslib/mplus-share.js?id=1112022" type="text/javascript">
</script>
<script src="https://medlineplus.gov/jslib/control.js" type="text/javascript">
</script>
<script src="https://medlineplus.gov/uswds/js/uswds.min.js" type="text/javascript">
</script>
<script src="https://medlineplus.gov/jslib/ency/ency.js" type="text/javascript">
</script>
</body>
</html>