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</div><div><span>Neonatal hypothyroidism</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Neonatal hypothyroidism</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Neonatal hypothyroidism is decreased thyroid hormone production in a newborn. In very rare cases, no thyroid hormone is produced. The condition is also called congenital hypothyroidism. Congenital means present from birth.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>The thyroid gland is an important organ of the <a test="test" href="./002351.htm">endocrine system</a>. It is located at the front of the neck, just above where the collarbones meet. The thyroid makes hormones that control the way every cell in the body uses energy. This process is called <a test="test" href="./002257.htm">metabolism</a>.</p><p>Hypothyroidism in the newborn may be caused by:</p><ul><li>A missing or poorly developed thyroid gland</li><li>A pituitary gland that does not stimulate the thyroid gland</li><li>Thyroid hormones that are poorly formed or do not work</li><li>Medicines the mother took during pregnancy</li><li>Lack of iodine in the mother's diet during pregnancy</li><li><a test="test" href="./002223.htm">Antibodies</a> made by the mother's body that block the baby's thyroid function</li></ul><p>A thyroid gland that is not fully developed is the most common defect. Girls are affected twice as often as boys.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Most affected infants have few or no symptoms. This is because their thyroid hormone level is only slightly low. Infants with severe hypothyroidism often have a unique appearance, including:</p><ul><li>
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Dull look
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</li><li>Puffy face</li><li>Thick tongue that sticks out</li></ul><p>This appearance often develops as the disease gets worse.</p><p>The child may also have:</p><ul><li>Poor feeding, choking episodes</li><li>Constipation</li><li>Dry, brittle hair</li><li>Hoarse cry</li><li><a test="test" href="./001559.htm">Jaundice</a> (skin and whites of the eyes look yellow)</li><li>Lack of muscle tone (<a test="test" href="./003298.htm">floppy</a> infant)</li><li>Low hairline</li><li>Short height</li><li>Sleepiness</li><li>Sluggishness</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>A physical exam of the infant may show:</p><ul><li>Decreased muscle tone</li><li>Slow growth</li><li>Hoarse-sounding cry or voice</li><li>Short arms and legs</li><li>Very large soft spots on the skull (fontanelles)</li><li>Wide hands with short fingers</li><li><a test="test" href="./003307.htm">Widely separated skull bones</a></li></ul><p>Blood tests are done to check thyroid function. Other tests may include:</p><ul><li><a test="test" href="./003776.htm">Thyroid ultrasound scan</a></li><li>
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X-ray of the <a test="test" href="./002249.htm">long bones</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Early diagnosis is very important. Most of the effects of hypothyroidism are easy to reverse. For this reason, most US states require that all newborns be screened for hypothyroidism.</p><p>Thyroxine is usually given to treat hypothyroidism. Once the child starts taking this medicine, blood tests are regularly done to make sure thyroid hormone levels are in a normal range.</p><p>Referral to a pediatric endocrinologist is recommended for care.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Getting diagnosed early usually leads to a good outcome. Newborns diagnosed and treated in the first month or so usually have normal intelligence.</p><p>Untreated mild hypothyroidism can lead to severe <a test="test" href="./001523.htm">intellectual disability</a> and growth problems. The nervous system goes through important development during the first few months after birth. Lack of thyroid hormones can cause damage that cannot be reversed.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Contact your health care provider if:</p><ul><li><div>You feel your infant shows signs or symptoms of hypothyroidism</div></li><li><div>You are pregnant and have been exposed to antithyroid medicines or procedures</div></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>If a pregnant woman takes radioactive iodine for thyroid cancer, the thyroid gland may be destroyed in the developing fetus. Infants whose mothers have taken such medicines should be observed carefully after birth for signs of hypothyroidism. Also, pregnant women should not avoid iodine-supplemented salt.</p><p>Most states require a routine <a test="test" href="./007257.htm">screening test</a> to check all newborns for hypothyroidism. If your state does not have this requirement, ask your provider if your newborn should be screened.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Cretinism; Congenital hypothyroidism</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Chuang J, Gutmark-Little I. Thyroid disorders in the neonate. In: Martin RJ, Fanaroff AA, Walsh MC, eds. <em>Fanaroff and Martin's Neonatal-Perinatal Medicine</em>. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 88.</p><p>Wassner AJ, Smith JR. Hypothyroidism. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. <em>Nelson Textbook of Pediatrics</em>. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 581.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 4/28/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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