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</div><div><span>Biliary atresia</span></div></div>
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</noscript></div><div class="main"><div id="ency_summary"><p>Biliary atresia is a blockage in the tubes (ducts) that carry a liquid called bile from the liver to the gallbladder.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Biliary atresia occurs when the bile ducts inside or outside the liver are abnormally narrow, blocked, or absent. The bile ducts carry a digestive fluid from liver to small bowel to break down fats and filter out waste from the body.</p><p>The cause of the disease is not clear. It may be due to:</p><ul><li>Viral infection after birth</li><li>Exposure to toxic substances</li><li>Multiple genetic factors</li><li>Perinatal injury</li><li>Some medicines such as carbamazepine</li></ul><p>It more commonly affects people of East Asian and African-American descent.</p><p>The bile ducts help remove waste from the liver and carry salts that help the small intestine break down (digest) fat.</p><p>In babies with biliary atresia, bile flow from the liver to the gallbladder is blocked. This can lead to liver damage and cirrhosis of the liver, which can be deadly.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms usually start to occur between 2 to 8 weeks. Jaundice (a yellow color to the skin and mucus membranes) develops slowly 2 to 3 weeks after birth. The infant may gain weight normally for the first month. After that point, the baby will lose weight and become irritable, and will have worsening jaundice.</p><p>Other symptoms may include:</p><ul><li><a test="test" href="./003139.htm">Dark urine</a></li><li><a test="test" href="./003123.htm">Swollen belly</a></li><li><a test="test" href="./003132.htm">Foul-smelling</a> and <a test="test" href="./003128.htm">floating stools</a></li><li><a test="test" href="./003129.htm">Pale or clay-colored stools</a></li><li><a test="test" href="./003021.htm">Slow growth</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Your health care provider will take medical history of your child and do a physical exam to check for enlarged liver.</p><p>Tests to diagnose biliary atresia include:</p><ul><li><a test="test" href="./003815.htm">Abdominal x-ray</a> to check for enlarged liver and spleen</li><li><a test="test" href="./003777.htm">Abdominal ultrasound</a> to check internal organs</li><li>Blood tests to check total and direct bilirubin levels</li><li>Hepatobiliary scintigraphy or HIDA scan to check whether the bile ducts and gallbladder are working properly</li><li><a test="test" href="./003895.htm">Liver biopsy</a> to check the severity of cirrhosis or to rule out other causes of jaundice</li><li>X-ray of the bile ducts (cholangiogram) to check if the bile ducts are opened or closed</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>An operation called the Kasai procedure is done to connect the liver to the small intestine. The abnormal ducts are bypassed. The surgery is more successful if done before the baby is 8 weeks old.</p><p>Liver transplant may still be needed before 20 years of age in most of the cases.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Early surgery will improve the survival of more than one third of babies with this condition. The long-term benefit of a liver transplant is not yet known, but it is expected to improve survival.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Complications may include:</p><ul><li>Infection</li><li>Irreversible cirrhosis</li><li>Liver failure</li><li>Surgical complications, including failure of the Kasai procedure </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Contact your provider if your child appears jaundiced, or if other symptoms of biliary atresia develop.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Jaundice newborns - biliary atresia; Newborn jaundice - biliary atresia; Extrahepatic ductopenia; Progressive obliterative cholangiopathy</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Patient Instructions</h2></div><div class="section-button"><button type="submit" aria-controls="section-carepnt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Berlin SC. Diagnostic imaging of the neonate. In: Martin RJ, Fanaroff AA, Walsh MC, eds. <em>Fanaroff and Martin's Neonatal-Perinatal Medicine</em>. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 38.</p><p>Cazares J, Ure B, Yamataka A. Biliary atresia. In: Holcomb GW, Murphy JP, St. Peter SD, eds. <em>Holcomb and Ashcraft's Pediatric Surgery</em>. 7th ed. Philadelphia, PA: Elsevier; 2020:chap 43.</p><p>Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC. Cholestasis. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. <em>Nelson Textbook of Pediatrics</em>. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 383.</p><p>O'Hara SM. The pediatric liver and spleen. In: Rumack CM, Levine D, eds. <em>Diagnostic Ultrasound</em>. 6th ed. Philadelphia, PA: Elsevier; 2024:chap 52.</p></div></div></section>
<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 2/17/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Charles I. Schwartz, MD, FAAP, Clinical Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, General Pediatrician at PennCare for Kids, Phoenixville, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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