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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Primary lymphoma of the brain</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Primary lymphoma of the brain is cancer of white blood cells that starts in the brain.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>The cause of primary brain lymphoma is not known. </p><p>People with a weakened immune system are at high risk for primary lymphoma of the brain. Common causes of a weakened immune system include HIV/AIDS and having had an organ transplant (especially heart transplant).</p><p>Primary lymphoma of the brain may be linked to <a test="test" href="./003513.htm">Epstein-Barr virus</a> (EBV), especially in people with <a test="test" href="./000594.htm">HIV/AIDS</a>. EBV is the virus that causes <a test="test" href="./000591.htm">mononucleosis</a>.</p><p>Primary brain lymphoma is more common in people ages 45 to 70. The rate of primary brain lymphoma is rising. Almost 1,500 new patients are diagnosed with primary brain lymphoma every year in the United States.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms of primary brain lymphoma may include any of the following:</p><ul><li>Changes in speech or vision</li><li>Confusion or <a test="test" href="./003258.htm">hallucinations</a></li><li><a test="test" href="./003200.htm">Seizures</a></li><li><a test="test" href="./003024.htm">Headaches</a>, nausea, or vomiting</li><li>Leaning to one side when walking</li><li>Weakness in hands or loss of coordination</li><li><a test="test" href="./003206.htm">Numbness</a> to hot, cold, and pain</li><li>Personality changes</li><li>Weight loss </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>The following tests may be done to help diagnose a primary lymphoma of the brain:</p><ul><li><a test="test" href="./003416.htm">Biopsy</a> of the brain tumor</li><li><a test="test" href="./003786.htm">Head CT scan</a>, PET scan or <a test="test" href="./003791.htm">MRI</a></li><li><a test="test" href="./003428.htm">Spinal tap</a> (lumbar puncture)</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>The main treatment is with <a test="test" href="./002324.htm">chemotherapy</a> and certain monoclonal antibodies, which are a type of lab-made protein to treat many diseases, including cancer.</p><p>Younger people may receive high-dose chemotherapy, possibly followed by an <a test="test" href="./003009.htm">autologous stem cell transplant</a>.</p><p><a test="test" href="./001918.htm">Radiation therapy</a> of the whole brain may be done after chemotherapy, but is often avoided due to potential neurologic complications.</p><p>Boosting the immune system, such as in those with HIV/AIDS or a history of organ transplant, may also be tried.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Without treatment, people with primary brain lymphoma survive for less than 6 months. When treated with chemotherapy, half of the patients will be in remission 10 years after being diagnosed. Survival may improve with autologous stem cell transplant.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Possible complications include:</p><ul><li>Chemotherapy side effects, including low blood counts</li><li>Radiation side effects, including confusion, headaches, nervous system (neurologic) problems, and tissue death</li><li>Return (recurrence) of the lymphoma</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Brain lymphoma; Cerebral lymphoma; Primary lymphoma of the central nervous system; PCNSL; Lymphoma - B-cell lymphoma, brain</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/1074t.jpg" alt="Brain" title="Brain" class="side-img"/><a href="../imagepages/1074.htm">Brain</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/19238t.jpg" alt="MRI of the brain" title="MRI of the brain" class="side-img"/><a href="../imagepages/19238.htm">MRI of the brain</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>National Cancer Institute website. Primary CNS lymphoma treatment (PDQ) - health professional version. <a href="https://www.cancer.gov/types/lymphoma/hp/primary-cns-lymphoma-treatment-pdq" target="_blank">www.cancer.gov/types/lymphoma/hp/primary-cns-lymphoma-treatment-pdq</a>. Updated December 2, 2022. Accessed May 13, 2024.</p><p>National Comprehensive Cancer Network website. NCCN clinical practice guidelines in oncology (NCCN guidelines): central nervous system cancers. Version 1.2023. <a href="https://www.nccn.org/professionals/physician_gls/pdf/cns.pdf" target="_blank">www.nccn.org/professionals/physician_gls/pdf/cns.pdf</a>. Updated May 31, 2024. Accessed June 18, 2024.</p><p>Roque A, Hochberg FH, Baehring JM. Primary nervous system tumors in adults. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. <em>Bradley and Daroff's Neurology in Clinical Practice</em>. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 74.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 3/31/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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