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</noscript></div><div class="main"><div id="ency_summary"><p>Beriberi is a disease in which the body does not have enough <a test="test" href="./002401.htm">thiamine</a> (vitamin B1).</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>There are two major types of beriberi:</p><ul><li>Wet beriberi: Affects the cardiovascular system.</li><li>Dry beriberi and <a test="test" href="./000771.htm">Wernicke-Korsakoff syndrome</a>: Affects the nervous system.</li></ul><p>Beriberi is rare in the United States. This is because many foods are now vitamin enriched. If you eat a normal, healthy diet, you should get enough thiamine. Today, beriberi occurs mostly in people who drink too much alcohol. Drinking heavily can lead to poor nutrition. Excess alcohol makes it harder for the body to absorb and store vitamin B1.</p><p>In rare cases, beriberi can be genetic. This condition is passed down through families. People with this condition lose the ability to absorb thiamine from foods. This can happen slowly over time. The symptoms occur when the person is an adult. However, this diagnosis is often missed. This is because health care providers may not consider beriberi in nonalcoholics.</p><p>Beriberi can occur in infants when they are:</p><ul><li>Breastfed and the mother's body is lacking in thiamine</li><li>Fed unusual <a test="test" href="./002447.htm">formulas</a> that don't have enough thiamine</li></ul><p>Some medical treatments that can raise your risk of beriberi are:</p><ul><li>Getting <a test="test" href="../patientinstructions/000707.htm">dialysis</a></li><li>Taking high doses of diuretics (water pills)</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms of dry beriberi include:</p><ul><li>Difficulty walking</li><li><a test="test" href="./003206.htm">Loss of feeling (sensation)</a> in hands and feet</li><li>Loss of muscle function or paralysis of the lower legs</li><li>Mental <a test="test" href="./003205.htm">confusion</a></li><li>Pain</li><li>Speech difficulties</li><li>Strange eye movements (nystagmus)</li><li>Tingling</li><li>Vomiting</li></ul><p>Symptoms of wet beriberi include:</p><ul><li>Awakening at night short of breath</li><li>Increased heart rate</li><li><a test="test" href="./003075.htm">Shortness of breath</a> with activity</li><li>Swelling of the lower legs</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>A physical examination may show signs of <a test="test" href="./000158.htm">congestive heart failure</a>, including:</p><ul><li>Difficulty breathing, with neck veins that stick out</li><li>Enlarged heart</li><li>Fluid in the lungs</li><li>Rapid heartbeat</li><li><a test="test" href="./003104.htm">Swelling in both lower legs</a></li></ul><p>A person with late-stage beriberi may be confused or have memory loss and delusions. The person may be less able to sense vibrations.</p><p>A neurological exam may show signs of:</p><ul><li>Changes in walking</li><li>Coordination problems</li><li>Decreased reflexes</li><li>Drooping of the eyelids</li></ul><p>The following tests may be done:</p><ul><li>Blood tests to measure the amount of thiamine in the blood</li><li>Urine tests to see if thiamine is passing through the urine</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>The goal of treatment is to replace the thiamine your body is lacking. This is done with thiamine supplements. Thiamine supplements are given through a shot (injection) or taken by mouth.</p><p>Your provider may also suggest other types of vitamins.</p><p>Blood tests may be repeated after the treatment is started. These tests will show how well you are responding to the medicine.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Untreated, beriberi can be fatal. With treatment, symptoms usually improve quickly.</p><p>Heart damage is usually reversible. A full recovery is expected in these cases. However, if acute heart failure has already occurred, the outlook is poor.</p><p>Nervous system damage is also reversible, if caught early. If it is not caught early, some symptoms (such as memory loss or confusion) may remain, even with treatment.</p><p>If a person with Wernicke encephalopathy receives thiamine replacement, language problems, unusual eye movements, and walking difficulties may go away. However, Korsakoff syndrome (or Korsakoff psychosis) may develop as Wernicke symptoms go away.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Complications may include:</p><ul><li>Coma</li><li>Congestive heart failure</li><li>Death</li><li><a test="test" href="./001553.htm">Psychosis</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Beriberi is extremely rare in the United States. However, contact your provider if:</p><ul><li>You feel your family's diet is inadequate or poorly balanced</li><li>You or your children have any symptoms of beriberi</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Eating a proper diet that is rich in vitamins will prevent beriberi. Nursing mothers should make sure that their diet contains all vitamins. If your infant is not breastfed, make sure that the infant formula contains thiamine.</p><p>If you drink heavily, try to cut down or quit. Also, take B vitamins to help your body get enough thiamine.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Thiamine deficiency; Vitamin B1 deficiency</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Koppel BS, Weimer LH, Daras M. Nutritional and alcohol-related neurologic disorders. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 384.</p><p>Sachdev HPS, Shah D. Vitamin B complex deficiency and excess. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. <em>Nelson Textbook of Pediatrics</em>. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 67.</p><p>So YT. Deficiency diseases of the nervous system. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. <em>Bradley and Daroff's Neurology in Clinical Practice</em>. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 85.</p></div></div></section>
<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 7/23/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Linda J. Vorvick, MD, Clinical Professor, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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