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</div><div><span>Klippel-Trenaunay syndrome</span></div></div>
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</a><h1 class="with-also" itemprop="name">Klippel-Trenaunay syndrome</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Klippel-Trenaunay syndrome (KTS) is a rare condition that is typically present at birth. The syndrome often involves port wine stains, excess growth of bones and soft tissue, and varicose veins.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>KTS is caused by a genetic variation that occurs during fetal development. Why this occurs is unknown.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms of KTS include:</p><ul><li>Many <a test="test" href="./001475.htm">port wine stains</a> or other blood vessel problems, including dark spots on the skin</li><li><a test="test" href="./001109.htm">Varicose veins</a> (may be seen in early infancy, but are more likely to be seen later in childhood or adolescence)</li><li>Unstable gait due to limb-length difference (involved limb is longer)</li><li>Bone, vein, or nerve pain </li></ul><p>Other possible symptoms:</p><ul><li>Bleeding from the rectum</li><li>Blood in the urine </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>People with this condition may have excessive growth of bones and soft tissue. This occurs most commonly in the legs, but it also may affect the arms, face, head, or internal organs.</p><p>Various imaging techniques can be used to find out any change in body structures due to this condition. These also help in deciding the plan of treatment. These may include:</p><ul><li><a test="test" href="./007269.htm">MRA</a></li><li>
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Endoscopic thermal ablation therapy</li><li>X-rays</li><li><a test="test" href="./003330.htm">CT scans</a> or CT venography</li><li><a test="test" href="./003335.htm">MRI</a></li><li><a test="test" href="./003433.htm">Color duplex ultrasonography</a></li></ul><p>
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Rarely would an <a test="test" href="./003336.htm">ultrasound</a> during pregnancy help detect the condition.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>More information and support for people with KTS and their families can be found at:</p><ul><li>The Klippel-Trenaunay Syndrome Support Group -- <a class="extln" target="_blank" href="https://k-t.org">k-t.org</a></li><li>Vascular Birthmarks Foundation -- <a class="extln" target="_blank" href="https://birthmark.org">birthmark.org</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Most people with KTS do well, although the condition may affect their appearance.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Klippel-Trenaunay-Weber syndrome; KTS; Angio-osteohypertrophy; Hemangiectasia hypertrophicans; Nevus verucosus hypertrophicans; Capillary-lymphatico-venous malformation (CLVM)</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Greene AK, Mulliken JB. Vascular anomalies. In: Losee JE, Hopper RA, eds. <em>Plastic Surgery: Volume 3: Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery</em>. 5th ed. Philadelphia, PA: Elsevier; 2024:chap 31.</p><p>K-T Support Group website. Clinical practice guidelines for Klippel-Trenaunay syndrome (KTS). <a href="https://k-t.org/assets/images/content/BCH-Klippel-Trenaunay-Syndrome-Management-Guidelines-1-6-2016.pdf" target="_blank">k-t.org/assets/images/content/BCH-Klippel-Trenaunay-Syndrome-Management-Guidelines-1-6-2016.pdf</a>. Updated January 6, 2016. Accessed April 18, 2024.</p><p>Longman RE. Klippel-Trenaunay-Weber syndrome. In: Copel JA, D'Alton ME, Feltovich H, et al, eds. <em>Obstetric Imaging: Fetal Diagnosis and Care</em>. 2nd ed. Philadelphia, PA: Elsevier; 2018:chap 131.</p><p>McCormick AA, Grundwaldt LJ. Vascular anomalies. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. <em>Zitelli and Davis' Atlas of Pediatric Physical Diagnosis</em>. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 10.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 12/31/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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