1114 lines
42 KiB
Text
1114 lines
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<p>Researchers looked at <em>All of Us</em> and another database to learn more about medicine safety. They found five pairs of medicines that were linked to major health problems when taken at the same time. Large health datasets could give researchers a new way to study which medicines are safe to take together.</p>
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<p>A study linked 27 health conditions, including obesity, substance use disorders, and breathing problems, to the risk of severe COVID-19 in people of European ancestry. This study involved data from DNA and health records from more than half a million participants from three databases, including <em>All of Us</em>. </p>
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<p>Polygenic risk scores are a measure of how likely you are to get a particular health condition—your risk—based on changes in many genes in your DNA. However, these scores are often most accurate for people of European ancestry, because past research left out many other groups. Researchers adjusted polygenic risk scores for 10 common conditions using the diverse genetic data in <em>All of Us</em> so that the scores are accurate for people from a variety of backgrounds.</p>
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<p>A study of <em>All of Us</em> survey data confirmed that feelings of depression increased during the COVID-19 pandemic, particularly among participants who experienced discrimination. Having a high level of resilience lessened the effect of discrimination on mental health in some racial and ethnic groups.</p>
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<p>The long-term health of teens and young adults who have had cancer has not been well studied. A look at <em>All of Us</em> data showed that young cancer survivors were more likely to have certain brain- and nerve-related conditions than participants who never had cancer. This age group may need unique treatment and management plans.</p>
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<p>People of African ancestry can be more likely to develop kidney disease if they have certain genetic variants. Researchers studied genetic data from three different databases, including the <em>All of Us</em> Research Program. They found another variant that protected people with the high-risk variants from developing kidney disease. This finding could help find new treatments for kidney disease.</p>
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