309 lines
40 KiB
HTML
309 lines
40 KiB
HTML
|
||
|
||
|
||
|
||
<!DOCTYPE html>
|
||
<html lang="en-US">
|
||
<head>
|
||
<meta name="title" property="og:title" content="Evolutionary Genomics and Biomolecular Structure">
|
||
<meta name="type" property="og:type" content="website">
|
||
<meta name="image" property="og:image" content="https://www.nlm.nih.gov/images/NLMgeneric.jpg">
|
||
<meta name="image:alt" property="og:image:alt" content="National Library of Medicine (NLM)">
|
||
|
||
<meta name="twitter:card" content="summary_large_image">
|
||
<meta name="twitter:site" content="@NLM_NIH">
|
||
<meta name="twitter:title" content="Evolutionary Genomics and Biomolecular Structure">
|
||
<meta name="twitter:image" content="https://www.nlm.nih.gov/images/NLMgeneric.jpg">
|
||
<meta name="twitter:image:alt" content ="National Library of Medicine (NLM)">
|
||
<meta charset="UTF-8">
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0">
|
||
<meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1">
|
||
<link rel="stylesheet" href="/research/css/main.css" media="screen" >
|
||
<link rel="stylesheet" href="/research/css/styles.css" media="screen" >
|
||
<title>NLM Intramural Research - Evolutionary Genomics and Biomolecular Structure</title>
|
||
<link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" title="The Dublin Core metadata Element Set" />
|
||
<meta name="DC.Title" content="NLM Intramural Research - Evolutionary Genomics and Biomolecular Structure" />
|
||
|
||
|
||
<meta name="DC.Publisher" content="U.S. National Library of Medicine" />
|
||
<meta name="DC.Date.Issued" content="2019-12-16" />
|
||
<meta name="DC.Date.Modified" content="2019-12-16" />
|
||
<meta name="NLMDC.Date.LastReviewed" content="2019-12-16" />
|
||
<meta name="NLM.Contact.Email" content="NLMCommunications@nlm.nih.gov" />
|
||
<meta name="DC.Type" content="Product, Program, and Project Descriptions" />
|
||
<meta name="DC.Rights" content="Public Domain" />
|
||
|
||
<!-- Google Tag Manager -->
|
||
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-MT6MLL');</script>
|
||
<!-- End Google Tag Manager -->
|
||
</head>
|
||
<body>
|
||
<!-- Google Tag Manager -->
|
||
<noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-MT6MLL" height="0" width="0" style="display:none;visibility:hidden" title="googletagmanager"></iframe></noscript>
|
||
<!-- End Google Tag Manager -->
|
||
<header class="header">
|
||
<div class="usa-grid">
|
||
<div class="header-container">
|
||
<a href="https://www.nlm.nih.gov/" class="icon_logo" title="National Library of Medicine" aria-label="National Library of Medicine" id="anch_0">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 2039.55 243.26"><defs><style>.cls-1{fill:#fff;}</style></defs><g id="Layer_2" data-name="Layer 2"><g id="Text_outlines" data-name="Text outlines"><path class="cls-1" d="M266.77,67.24V176H248.18v-49.2H199.53V176H180.4V67.24H199v43.19h48.66V67.24ZM161.26,176H142.68V67.24h18.58Zm-37.17,0H104.41L55.76,96.21h-.55V176h-18V67.24H56.85l49.2,79.81h.55V67.24h18V176Zm208.83-54.66L266.77,0H21.87A22.05,22.05,0,0,0,0,22.41V220.85a22.05,22.05,0,0,0,21.87,22.41H266.22Z"></path><path class="cls-1" d="M283.17,242.72l66.69-121.36L283.17,0h16.4c9.29,0,20.23,6.56,24.6,14.76l58.49,106.6L324.17,228c-4.37,8.2-15.31,14.76-24.6,14.76Z"></path><path class="cls-1" d="M428.15,66.88h16.5l40.75,65.75h.25V66.88h14.88v89.25H484L443.4,90.5H443v65.63H428.15Z"></path><path class="cls-1" d="M571.15,141.75a7.54,7.54,0,0,0,.69,3.75,2.9,2.9,0,0,0,2.69,1.13H576a9.16,9.16,0,0,0,2-.25v9.87c-.5.17-1.15.36-1.94.57s-1.61.39-2.44.56a23.93,23.93,0,0,1-2.5.37,20,20,0,0,1-2.12.13,13.68,13.68,0,0,1-7.25-1.75Q558.9,154.38,558,150a25.29,25.29,0,0,1-10.44,6,41.17,41.17,0,0,1-11.94,1.88,29.25,29.25,0,0,1-8.37-1.19,21.77,21.77,0,0,1-7.07-3.5,16.81,16.81,0,0,1-4.87-5.87,18.11,18.11,0,0,1-1.81-8.32,19.18,19.18,0,0,1,2.18-9.75,16.27,16.27,0,0,1,5.75-5.87,25.79,25.79,0,0,1,8-3.06,90.4,90.4,0,0,1,8.94-1.44,73.25,73.25,0,0,1,7.38-1.06,34.66,34.66,0,0,0,6.18-1.07,9.39,9.39,0,0,0,4.25-2.31,6.37,6.37,0,0,0,1.57-4.69,7.28,7.28,0,0,0-1.32-4.5,8.78,8.78,0,0,0-3.25-2.68,14,14,0,0,0-4.31-1.25,34.25,34.25,0,0,0-4.5-.32,17.93,17.93,0,0,0-9.87,2.5,9.74,9.74,0,0,0-4.38,7.75H515.9a21.45,21.45,0,0,1,3-10.37,20.76,20.76,0,0,1,6.69-6.63,27.57,27.57,0,0,1,9.19-3.5,55.13,55.13,0,0,1,10.5-1,44.65,44.65,0,0,1,9.37,1A26.74,26.74,0,0,1,563,94a18,18,0,0,1,5.94,5.82,15.93,15.93,0,0,1,2.25,8.68Zm-14.25-18a17.24,17.24,0,0,1-8,2.57c-3.17.29-6.33.73-9.5,1.31a31.3,31.3,0,0,0-4.37,1.06,13.18,13.18,0,0,0-3.75,1.88,8.22,8.22,0,0,0-2.57,3.12,10.81,10.81,0,0,0-.93,4.69,6,6,0,0,0,1.37,4,10,10,0,0,0,3.31,2.56,15.17,15.17,0,0,0,4.25,1.31,26.44,26.44,0,0,0,4.19.38A23.14,23.14,0,0,0,546,146a16.81,16.81,0,0,0,5.18-2.12,13.72,13.72,0,0,0,4.07-3.81,9.67,9.67,0,0,0,1.62-5.69Z"></path><path class="cls-1" d="M580,91.5h10.75V72.13H605V91.5H617.9v10.63H605v34.5a35.69,35.69,0,0,0,.18,3.87,6.71,6.71,0,0,0,.88,2.75,4.15,4.15,0,0,0,2.06,1.69,10.07,10.07,0,0,0,3.75.56c1,0,2,0,3-.06a14.79,14.79,0,0,0,3-.44v11l-4.62.5a41.2,41.2,0,0,1-4.63.25,31.47,31.47,0,0,1-9.06-1.06,12.08,12.08,0,0,1-5.38-3.12,10.85,10.85,0,0,1-2.62-5.19,38.6,38.6,0,0,1-.81-7.13V102.13H580Z"></path><path class="cls-1" d="M628.52,66.88h14.25v13.5H628.52Zm0,24.62h14.25v64.63H628.52Z"></path><path class="cls-1" d="M687.9,157.88a35.31,35.31,0,0,1-13.81-2.56,29.4,29.4,0,0,1-10.25-7.07,30.09,30.09,0,0,1-6.38-10.75,43.85,43.85,0,0,1,0-27.37,30.09,30.09,0,0,1,6.38-10.75,29.38,29.38,0,0,1,10.25-7.06,38.39,38.39,0,0,1,27.62,0A29.47,29.47,0,0,1,712,99.38a30.24,30.24,0,0,1,6.38,10.75,44,44,0,0,1,0,27.37A30.24,30.24,0,0,1,712,148.25a29.5,29.5,0,0,1-10.25,7.07A35.31,35.31,0,0,1,687.9,157.88Zm0-11.25a16.37,16.37,0,0,0,8.25-2,17.35,17.35,0,0,0,5.75-5.25,23,23,0,0,0,3.31-7.31,32.91,32.91,0,0,0,0-16.57,22.18,22.18,0,0,0-3.31-7.31,17.83,17.83,0,0,0-5.75-5.19,18,18,0,0,0-16.5,0,17.83,17.83,0,0,0-5.75,5.19,22,22,0,0,0-3.31,7.31,32.61,32.61,0,0,0,0,16.57,22.73,22.73,0,0,0,3.31,7.31,17.35,17.35,0,0,0,5.75,5.25A16.37,16.37,0,0,0,687.9,146.63Z"></path><path class="cls-1" d="M732.4,91.5h13.5V101l.25.25a23.83,23.83,0,0,1,8.5-8.43,22.65,22.65,0,0,1,11.62-3.07q10.62,0,16.75,5.5t6.13,16.5v44.38H774.9V115.5q-.25-7.62-3.25-11.06T762.27,101a15.41,15.41,0,0,0-6.5,1.32,14,14,0,0,0-4.87,3.62,17.07,17.07,0,0,0-3.13,5.44,19.38,19.38,0,0,0-1.12,6.62v38.13H732.4Z"></path><path class="cls-1" d="M858.27,141.75a7.54,7.54,0,0,0,.69,3.75,2.9,2.9,0,0,0,2.69,1.13h1.5a9.16,9.16,0,0,0,2-.25v9.87c-.5.17-1.15.36-1.94.57s-1.61.39-2.44.56a23.93,23.93,0,0,1-2.5.37,20,20,0,0,1-2.12.13,13.68,13.68,0,0,1-7.25-1.75q-2.88-1.75-3.75-6.13a25.29,25.29,0,0,1-10.44,6,41.17,41.17,0,0,1-11.94,1.88,29.25,29.25,0,0,1-8.37-1.19,21.87,21.87,0,0,1-7.07-3.5,16.81,16.81,0,0,1-4.87-5.87,18.11,18.11,0,0,1-1.81-8.32,19.29,19.29,0,0,1,2.18-9.75,16.27,16.27,0,0,1,5.75-5.87,25.89,25.89,0,0,1,8-3.06,90.4,90.4,0,0,1,8.94-1.44,73.25,73.25,0,0,1,7.38-1.06,34.66,34.66,0,0,0,6.18-1.07,9.34,9.34,0,0,0,4.25-2.31,6.33,6.33,0,0,0,1.57-4.69,7.28,7.28,0,0,0-1.32-4.5,8.7,8.7,0,0,0-3.25-2.68,14,14,0,0,0-4.31-1.25,34.25,34.25,0,0,0-4.5-.32,17.93,17.93,0,0,0-9.87,2.5,9.74,9.74,0,0,0-4.38,7.75H803a21.45,21.45,0,0,1,3-10.37,20.76,20.76,0,0,1,6.69-6.63,27.57,27.57,0,0,1,9.19-3.5,55.13,55.13,0,0,1,10.5-1,44.65,44.65,0,0,1,9.37,1A26.65,26.65,0,0,1,850.08,94,18,18,0,0,1,856,99.82a15.93,15.93,0,0,1,2.25,8.68Zm-14.25-18a17.24,17.24,0,0,1-8,2.57c-3.17.29-6.33.73-9.5,1.31a31.3,31.3,0,0,0-4.37,1.06,13.18,13.18,0,0,0-3.75,1.88,8.22,8.22,0,0,0-2.57,3.12,10.81,10.81,0,0,0-.93,4.69,6,6,0,0,0,1.37,4,10,10,0,0,0,3.31,2.56,15.27,15.27,0,0,0,4.25,1.31,26.55,26.55,0,0,0,4.19.38,23.14,23.14,0,0,0,5.13-.63,16.81,16.81,0,0,0,5.18-2.12,13.72,13.72,0,0,0,4.07-3.81,9.67,9.67,0,0,0,1.62-5.69Z"></path><path class="cls-1" d="M874,66.88h14.25v89.25H874Z"></path><path class="cls-1" d="M940.52,66.88h15.63v75.75h45.37v13.5h-61Z"></path><path class="cls-1" d="M1010.65,66.88h14.25v13.5h-14.25Zm0,24.62h14.25v64.63h-14.25Z"></path><path class="cls-1" d="M1040.77,66.88H1055v33h.25a19.61,19.61,0,0,1,3.63-4.25,22.61,22.61,0,0,1,4.68-3.19,24.84,24.84,0,0,1,5.38-2,23.77,23.77,0,0,1,5.56-.69,30.88,30.88,0,0,1,13.31,2.69,26.32,26.32,0,0,1,9.44,7.38,32,32,0,0,1,5.63,10.93,46.38,46.38,0,0,1,1.87,13.38,47.08,47.08,0,0,1-1.69,12.62,32.79,32.79,0,0,1-5.12,10.82,25,25,0,0,1-21.06,10.31,50.47,50.47,0,0,1-6.57-.44,24.4,24.4,0,0,1-6.31-1.69,21.45,21.45,0,0,1-5.44-3.25,15.76,15.76,0,0,1-4.06-5.25h-.25v8.88h-13.5Zm49.75,57a32.14,32.14,0,0,0-1.12-8.5,23,23,0,0,0-3.38-7.31,17.46,17.46,0,0,0-5.62-5.13,15.32,15.32,0,0,0-7.75-1.94q-9,0-13.57,6.25t-4.56,16.63a33.14,33.14,0,0,0,1.19,9.06,20.36,20.36,0,0,0,3.56,7.19,17.79,17.79,0,0,0,5.69,4.75,16.19,16.19,0,0,0,7.69,1.75,16,16,0,0,0,8.25-2,17.37,17.37,0,0,0,5.56-5.19,20.85,20.85,0,0,0,3.12-7.25A36.51,36.51,0,0,0,1090.52,123.88Z"></path><path class="cls-1" d="M1116.77,91.5h13.37V104h.25a14.47,14.47,0,0,1,2.44-5.12,23.55,23.55,0,0,1,4.38-4.56,22.05,22.05,0,0,1,5.68-3.32,17.13,17.13,0,0,1,6.38-1.25,31.47,31.47,0,0,1,3.44.13l1.93.25v13.75c-1-.17-2-.31-3.06-.44a26.73,26.73,0,0,0-3.06-.19,16.47,16.47,0,0,0-6.81,1.44,15.76,15.76,0,0,0-5.57,4.25,21,21,0,0,0-3.75,6.94,30.24,30.24,0,0,0-1.37,9.5v30.75h-14.25Z"></path><path class="cls-1" d="M1214.89,141.75a7.54,7.54,0,0,0,.69,3.75,2.9,2.9,0,0,0,2.69,1.13h1.5a9.16,9.16,0,0,0,2-.25v9.87c-.5.17-1.15.36-1.94.57s-1.6.39-2.44.56a23.54,23.54,0,0,1-2.5.37,20,20,0,0,1-2.12.13,13.68,13.68,0,0,1-7.25-1.75q-2.88-1.75-3.75-6.13a25.22,25.22,0,0,1-10.44,6,41.07,41.07,0,0,1-11.94,1.88,29.3,29.3,0,0,1-8.37-1.19,21.71,21.71,0,0,1-7.06-3.5,16.73,16.73,0,0,1-4.88-5.87,18.11,18.11,0,0,1-1.81-8.32,19.18,19.18,0,0,1,2.19-9.75,16.11,16.11,0,0,1,5.75-5.87,25.69,25.69,0,0,1,8-3.06,89.73,89.73,0,0,1,8.93-1.44,73.66,73.66,0,0,1,7.38-1.06,34.94,34.94,0,0,0,6.19-1.07,9.45,9.45,0,0,0,4.25-2.31,6.37,6.37,0,0,0,1.56-4.69,7.34,7.34,0,0,0-1.31-4.5,8.86,8.86,0,0,0-3.25-2.68,14,14,0,0,0-4.32-1.25,34.25,34.25,0,0,0-4.5-.32,17.93,17.93,0,0,0-9.87,2.5,9.76,9.76,0,0,0-4.38,7.75h-14.25a21.45,21.45,0,0,1,3-10.37,20.76,20.76,0,0,1,6.69-6.63,27.57,27.57,0,0,1,9.19-3.5,55.13,55.13,0,0,1,10.5-1,44.65,44.65,0,0,1,9.37,1,26.71,26.71,0,0,1,8.32,3.25,18,18,0,0,1,5.93,5.82,15.93,15.93,0,0,1,2.25,8.68Zm-14.25-18a17.21,17.21,0,0,1-8,2.57q-4.74.44-9.5,1.31a31.3,31.3,0,0,0-4.37,1.06,13.18,13.18,0,0,0-3.75,1.88,8.1,8.1,0,0,0-2.56,3.12,10.66,10.66,0,0,0-.94,4.69,6,6,0,0,0,1.37,4,9.94,9.94,0,0,0,3.32,2.56,15.07,15.07,0,0,0,4.25,1.31,26.33,26.33,0,0,0,4.18.38,23.07,23.07,0,0,0,5.13-.63,17,17,0,0,0,5.19-2.12,13.8,13.8,0,0,0,4.06-3.81,9.67,9.67,0,0,0,1.62-5.69Z"></path><path class="cls-1" d="M1230.27,91.5h13.37V104h.25a14.47,14.47,0,0,1,2.44-5.12,23.55,23.55,0,0,1,4.38-4.56,22.05,22.05,0,0,1,5.68-3.32,17.13,17.13,0,0,1,6.38-1.25,31.6,31.6,0,0,1,3.44.13l1.93.25v13.75c-1-.17-2-.31-3.06-.44a26.73,26.73,0,0,0-3.06-.19,16.47,16.47,0,0,0-6.81,1.44,15.76,15.76,0,0,0-5.57,4.25,21,21,0,0,0-3.75,6.94,30.24,30.24,0,0,0-1.37,9.5v30.75h-14.25Z"></path><path class="cls-1" d="M1267.14,91.5h15.63l16.87,48.25h.25l16.38-48.25h14.87L1306,159.63c-1.17,2.92-2.31,5.71-3.44,8.37a30.11,30.11,0,0,1-4.12,7.07,17.89,17.89,0,0,1-6.07,4.87,20.65,20.65,0,0,1-9.25,1.81,64.81,64.81,0,0,1-9.87-.75V169c1.16.17,2.29.36,3.37.57a18.55,18.55,0,0,0,3.38.31,11.51,11.51,0,0,0,4.12-.63,6.81,6.81,0,0,0,2.69-1.81,11.22,11.22,0,0,0,1.81-2.81,27.6,27.6,0,0,0,1.38-3.75l1.62-5Z"></path><path class="cls-1" d="M1403.52,157.88a35.31,35.31,0,0,1-13.81-2.56,29.4,29.4,0,0,1-10.25-7.07,30.09,30.09,0,0,1-6.38-10.75,43.85,43.85,0,0,1,0-27.37,30.09,30.09,0,0,1,6.38-10.75,29.38,29.38,0,0,1,10.25-7.06,38.39,38.39,0,0,1,27.62,0,29.47,29.47,0,0,1,10.25,7.06,30.24,30.24,0,0,1,6.38,10.75,44,44,0,0,1,0,27.37,30.24,30.24,0,0,1-6.38,10.75,29.5,29.5,0,0,1-10.25,7.07A35.35,35.35,0,0,1,1403.52,157.88Zm0-11.25a16.42,16.42,0,0,0,8.25-2,17.35,17.35,0,0,0,5.75-5.25,23,23,0,0,0,3.31-7.31,32.91,32.91,0,0,0,0-16.57,22.18,22.18,0,0,0-3.31-7.31,17.83,17.83,0,0,0-5.75-5.19,18,18,0,0,0-16.5,0,17.73,17.73,0,0,0-5.75,5.19,22,22,0,0,0-3.31,7.31,32.61,32.61,0,0,0,0,16.57,22.73,22.73,0,0,0,3.31,7.31,17.25,17.25,0,0,0,5.75,5.25A16.37,16.37,0,0,0,1403.52,146.63Z"></path><path class="cls-1" d="M1441.64,91.5h10.63V86.13a27.62,27.62,0,0,1,1.5-9.94,14,14,0,0,1,4-5.87,13.1,13.1,0,0,1,5.68-2.75,31.62,31.62,0,0,1,6.69-.69,41,41,0,0,1,10,.87V78.88a19.9,19.9,0,0,0-2.94-.56,30.26,30.26,0,0,0-3.68-.19,8.73,8.73,0,0,0-4.94,1.37c-1.38.92-2.06,2.71-2.06,5.38V91.5h12.12v10.63h-12.12v54h-14.25v-54h-10.63Z"></path><path class="cls-1" d="M1523.89,66.88h22l24.62,69.87h.25l24-69.87h21.75v89.25h-14.87V87.25h-.25l-24.75,68.88h-12.88L1539,87.25h-.25v68.88h-14.87Z"></path><path class="cls-1" d="M1644.39,127.5a24.75,24.75,0,0,0,1.06,7.25,17.8,17.8,0,0,0,3.19,6.13,15.33,15.33,0,0,0,5.37,4.19,17.77,17.77,0,0,0,7.75,1.56q6.26,0,10.07-2.69a15.89,15.89,0,0,0,5.68-8.06H1691a26.76,26.76,0,0,1-10.5,16.31,28.31,28.31,0,0,1-8.68,4.25,35,35,0,0,1-10.07,1.44,34.18,34.18,0,0,1-13.5-2.5,27.91,27.91,0,0,1-9.93-7,29.73,29.73,0,0,1-6.13-10.75,43.83,43.83,0,0,1-2.06-13.75,38.84,38.84,0,0,1,2.19-13.06,33.28,33.28,0,0,1,6.25-10.88,29.3,29.3,0,0,1,22.81-10.19,29.07,29.07,0,0,1,13.69,3.19,30.14,30.14,0,0,1,10.06,8.44,34.3,34.3,0,0,1,5.81,12.06,37,37,0,0,1,.94,14.06Zm33.25-9.37a23.13,23.13,0,0,0-1.44-6.5,17.34,17.34,0,0,0-3.25-5.44,16.07,16.07,0,0,0-5-3.75,14.86,14.86,0,0,0-6.56-1.44,17,17,0,0,0-6.81,1.32,15.36,15.36,0,0,0-5.25,3.62,18,18,0,0,0-3.5,5.44,18.76,18.76,0,0,0-1.44,6.75Z"></path><path class="cls-1" d="M1763.64,156.13h-13.5v-8.75h-.25a16.91,16.91,0,0,1-8.38,8.06,28.26,28.26,0,0,1-11.62,2.44,30.85,30.85,0,0,1-13.31-2.69,26.5,26.5,0,0,1-9.44-7.31,31.27,31.27,0,0,1-5.63-10.94,47.38,47.38,0,0,1-1.87-13.56,43.46,43.46,0,0,1,2.37-15.13,30.33,30.33,0,0,1,6.32-10.5,24.42,24.42,0,0,1,9-6.06,28.64,28.64,0,0,1,10.31-1.94,34,34,0,0,1,6.12.57,26.68,26.68,0,0,1,6,1.81,23.69,23.69,0,0,1,5.32,3.19,17.84,17.84,0,0,1,4.06,4.56h.25v-33h14.25Zm-49.75-31.63a31.5,31.5,0,0,0,1.06,8.13,22.18,22.18,0,0,0,3.25,7.12,15.81,15.81,0,0,0,13.56,6.88,16,16,0,0,0,8.19-2,17,17,0,0,0,5.63-5.25,24,24,0,0,0,3.25-7.31,33.12,33.12,0,0,0,1.06-8.32q0-10.74-4.81-16.75a15.87,15.87,0,0,0-13.07-6,16.06,16.06,0,0,0-8.43,2.07,17.32,17.32,0,0,0-5.63,5.37,22.21,22.21,0,0,0-3.12,7.5A38.85,38.85,0,0,0,1713.89,124.5Z"></path><path class="cls-1" d="M1779.51,66.88h14.25v13.5h-14.25Zm0,24.62h14.25v64.63h-14.25Z"></path><path class="cls-1" d="M1852.89,113.13q-.89-6-4.82-9.06a15.68,15.68,0,0,0-9.93-3.07,20.65,20.65,0,0,0-5.88.94,14.1,14.1,0,0,0-5.75,3.5,19.58,19.58,0,0,0-4.37,7.13,33.82,33.82,0,0,0-1.75,11.93,35.16,35.16,0,0,0,.93,8,22.05,22.05,0,0,0,3,7.13,16.3,16.3,0,0,0,5.32,5.06,15,15,0,0,0,7.87,1.94,14.29,14.29,0,0,0,10.31-3.88q4.07-3.87,5.07-10.87h14.25q-2,12.63-9.57,19.31t-20.06,6.69a33.22,33.22,0,0,1-13.44-2.56,28.55,28.55,0,0,1-9.81-7,29.59,29.59,0,0,1-6.06-10.57,41.12,41.12,0,0,1-2.06-13.25,45,45,0,0,1,2-13.62,31.05,31.05,0,0,1,6-11.06,28.11,28.11,0,0,1,9.93-7.38A33.59,33.59,0,0,1,1838,89.75a39.31,39.31,0,0,1,10.69,1.44,28.42,28.42,0,0,1,9,4.31,23.17,23.17,0,0,1,6.44,7.25,25.06,25.06,0,0,1,3,10.38Z"></path><path class="cls-1" d="M1879.14,66.88h14.25v13.5h-14.25Zm0,24.62h14.25v64.63h-14.25Z"></path><path class="cls-1" d="M1908.89,91.5h13.5V101l.25.25a23.83,23.83,0,0,1,8.5-8.43,22.65,22.65,0,0,1,11.62-3.07q10.62,0,16.75,5.5t6.13,16.5v44.38h-14.25V115.5q-.26-7.62-3.25-11.06t-9.38-3.44a15.41,15.41,0,0,0-6.5,1.32,14,14,0,0,0-4.87,3.62,17.07,17.07,0,0,0-3.13,5.44,19.38,19.38,0,0,0-1.12,6.62v38.13h-14.25Z"></path><path class="cls-1" d="M1991.76,127.5a24.75,24.75,0,0,0,1.06,7.25,17.8,17.8,0,0,0,3.19,6.13,15.37,15.37,0,0,0,5.38,4.19,17.74,17.74,0,0,0,7.75,1.56q6.24,0,10.06-2.69a15.9,15.9,0,0,0,5.69-8.06h13.5a26.88,26.88,0,0,1-10.5,16.31,28.36,28.36,0,0,1-8.69,4.25,34.91,34.91,0,0,1-10.06,1.44,34.11,34.11,0,0,1-13.5-2.5,27.94,27.94,0,0,1-9.94-7,29.73,29.73,0,0,1-6.13-10.75,43.83,43.83,0,0,1-2.06-13.75,38.84,38.84,0,0,1,2.19-13.06A33.46,33.46,0,0,1,1986,99.94a29.3,29.3,0,0,1,22.81-10.19,29,29,0,0,1,13.69,3.19,30.14,30.14,0,0,1,10.06,8.44,34.13,34.13,0,0,1,5.81,12.06,37,37,0,0,1,.94,14.06Zm33.25-9.37a23.13,23.13,0,0,0-1.44-6.5,17.34,17.34,0,0,0-3.25-5.44,16.07,16.07,0,0,0-5-3.75,14.83,14.83,0,0,0-6.56-1.44,17,17,0,0,0-6.81,1.32,15.55,15.55,0,0,0-5.25,3.62,18,18,0,0,0-3.5,5.44,18.76,18.76,0,0,0-1.44,6.75Z"></path></g></g></svg>
|
||
<!-- <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" viewBox="0 0 216.34 45">
|
||
<defs>
|
||
<style>
|
||
.cls-1 {
|
||
fill: none;
|
||
}
|
||
.cls-2 {
|
||
clip-path: url(#clip-path);
|
||
}
|
||
.cls-3 {
|
||
fill: #fff;
|
||
}
|
||
</style>
|
||
<clipPath id="clip-path">
|
||
<rect class="cls-1" width="215.59" height="45"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
<title>NLM Logo</title>
|
||
<g id="Layer_1" data-name="Layer 1">
|
||
<g class="cls-2">
|
||
<path class="cls-3" d="M39.36,16.25V28.86H37.21v-5.7H31.57v5.7H29.35V16.25H31.5v5h5.64v-5ZM27.13,28.86H25V16.25h2.15Zm-4.31,0H20.54L14.9,19.61h-.06v9.25H12.75V16.25H15l5.7,9.25h.06V16.25h2.09V28.86ZM47,22.52,39.36,8.46H11a2.56,2.56,0,0,0-2.53,2.6v23A2.55,2.55,0,0,0,11,36.65H39.3Z"></path>
|
||
<path class="cls-3" d="M41.26,36.59,49,22.52,41.26,8.46h1.9A3.52,3.52,0,0,1,46,10.17l6.78,12.35L46,34.88a3.52,3.52,0,0,1-2.85,1.71Z"></path>
|
||
<path class="cls-3" d="M57.86,18.54h1.53l3.78,6.1h0v-6.1h1.38v8.28H63l-3.77-6.09h0v6.09H57.86Z"></path>
|
||
<path class="cls-3" d="M71.12,25.48a.73.73,0,0,0,.06.35.28.28,0,0,0,.25.11h.14l.19,0v.92l-.18.05-.23.05-.23,0h-.2a1.26,1.26,0,0,1-.67-.16.83.83,0,0,1-.35-.57,2.39,2.39,0,0,1-1,.56,4,4,0,0,1-1.1.17,2.88,2.88,0,0,1-.78-.11,2,2,0,0,1-.65-.32,1.76,1.76,0,0,1-.46-.55,2,2,0,0,1,0-1.67,1.4,1.4,0,0,1,.53-.55,2.27,2.27,0,0,1,.74-.28,8,8,0,0,1,.83-.14,5.94,5.94,0,0,1,.69-.09,4.19,4.19,0,0,0,.57-.1.82.82,0,0,0,.39-.22.56.56,0,0,0,.15-.43.7.7,0,0,0-.12-.42.81.81,0,0,0-.3-.25,1.08,1.08,0,0,0-.4-.11l-.42,0a1.63,1.63,0,0,0-.92.23.88.88,0,0,0-.4.72H66a1.82,1.82,0,0,1,.89-1.58,2.68,2.68,0,0,1,.86-.32,4.43,4.43,0,0,1,1-.1,3.69,3.69,0,0,1,.87.1,2.38,2.38,0,0,1,.77.3,1.67,1.67,0,0,1,.55.54,1.44,1.44,0,0,1,.21.8ZM69.8,23.82a1.54,1.54,0,0,1-.74.23,8.48,8.48,0,0,0-.88.13,2.71,2.71,0,0,0-.41.09,1.28,1.28,0,0,0-.35.18.76.76,0,0,0-.24.29,1.1,1.1,0,0,0-.08.43.52.52,0,0,0,.13.37.89.89,0,0,0,.3.24,1.25,1.25,0,0,0,.4.12,1.82,1.82,0,0,0,.38,0,2.1,2.1,0,0,0,.48-.06,1.68,1.68,0,0,0,.48-.2,1.27,1.27,0,0,0,.38-.35.9.9,0,0,0,.15-.53Z"></path>
|
||
<path class="cls-3" d="M71.94,20.83h1V19h1.32v1.8h1.19v1H74.26V25a3.53,3.53,0,0,0,0,.36.61.61,0,0,0,.08.25.38.38,0,0,0,.19.16.86.86,0,0,0,.35,0h.28l.27,0v1l-.42,0a3.4,3.4,0,0,1-1.27-.07,1.2,1.2,0,0,1-.5-.29A1,1,0,0,1,73,26a3.31,3.31,0,0,1-.08-.66V21.81h-1Z"></path>
|
||
<path class="cls-3" d="M76.44,18.54h1.32v1.25H76.44Zm0,2.29h1.32v6H76.44Z"></path>
|
||
<path class="cls-3" d="M82,27a3.21,3.21,0,0,1-1.28-.24,2.72,2.72,0,0,1-1-.65,3,3,0,0,1-.59-1,4.13,4.13,0,0,1,0-2.54,3,3,0,0,1,.59-1,2.74,2.74,0,0,1,1-.66A3.21,3.21,0,0,1,82,20.66a3.28,3.28,0,0,1,1.28.24,2.73,2.73,0,0,1,1.54,1.65,4.13,4.13,0,0,1,0,2.54,2.85,2.85,0,0,1-.59,1,2.77,2.77,0,0,1-1,.65A3.28,3.28,0,0,1,82,27Zm0-1a1.45,1.45,0,0,0,.76-.19,1.39,1.39,0,0,0,.53-.49,2,2,0,0,0,.31-.67,2.86,2.86,0,0,0,.1-.77,2.91,2.91,0,0,0-.1-.77,2,2,0,0,0-.31-.68,1.64,1.64,0,0,0-.53-.48,1.72,1.72,0,0,0-1.53,0,1.75,1.75,0,0,0-.53.48,2.22,2.22,0,0,0-.31.68,2.91,2.91,0,0,0-.1.77,2.86,2.86,0,0,0,.1.77,2.16,2.16,0,0,0,.31.67,1.52,1.52,0,0,0,1.3.68Z"></path>
|
||
<path class="cls-3" d="M86.07,20.83h1.25v.88l0,0a2.19,2.19,0,0,1,.79-.78,2.07,2.07,0,0,1,1.07-.29,2.26,2.26,0,0,1,1.56.51,1.94,1.94,0,0,1,.56,1.53v4.12H90V23.05a1.6,1.6,0,0,0-.3-1,1.09,1.09,0,0,0-.87-.31,1.46,1.46,0,0,0-.6.12,1.25,1.25,0,0,0-.45.33,1.61,1.61,0,0,0-.29.51,1.78,1.78,0,0,0-.11.61v3.54H86.07Z"></path>
|
||
<path class="cls-3" d="M97.74,25.48a.71.71,0,0,0,.07.35.26.26,0,0,0,.25.11h.14l.18,0v.92l-.18.05-.22.05-.24,0h-.19a1.29,1.29,0,0,1-.68-.16.82.82,0,0,1-.34-.57,2.53,2.53,0,0,1-1,.56,4,4,0,0,1-1.11.17,2.76,2.76,0,0,1-.77-.11,2,2,0,0,1-.66-.32,1.6,1.6,0,0,1-.45-.55,1.71,1.71,0,0,1-.17-.77,1.82,1.82,0,0,1,.2-.9,1.5,1.5,0,0,1,.54-.55,2.19,2.19,0,0,1,.74-.28,7.56,7.56,0,0,1,.83-.14,5.78,5.78,0,0,1,.68-.09,4.09,4.09,0,0,0,.58-.1.93.93,0,0,0,.39-.22.56.56,0,0,0,.14-.43.7.7,0,0,0-.12-.42.81.81,0,0,0-.3-.25,1,1,0,0,0-.4-.11l-.42,0a1.6,1.6,0,0,0-.91.23.89.89,0,0,0-.41.72H92.62a2,2,0,0,1,.28-1,1.9,1.9,0,0,1,.62-.61,2.54,2.54,0,0,1,.85-.32,4.5,4.5,0,0,1,1-.1,3.57,3.57,0,0,1,.87.1,2.44,2.44,0,0,1,.78.3,1.77,1.77,0,0,1,.55.54,1.53,1.53,0,0,1,.2.8Zm-1.32-1.66a1.54,1.54,0,0,1-.74.23,8.89,8.89,0,0,0-.88.13,3,3,0,0,0-.41.09,1.22,1.22,0,0,0-.34.18.76.76,0,0,0-.24.29.94.94,0,0,0-.09.43.52.52,0,0,0,.13.37.92.92,0,0,0,.31.24,1.27,1.27,0,0,0,.39.12,1.84,1.84,0,0,0,.39,0,2,2,0,0,0,.47-.06,1.87,1.87,0,0,0,.49-.2,1.24,1.24,0,0,0,.37-.35.9.9,0,0,0,.15-.53Z"></path>
|
||
<path class="cls-3" d="M99.2,18.54h1.33v8.28H99.2Z"></path>
|
||
<path class="cls-3" d="M105.37,18.54h1.45v7H111v1.25h-5.66Z"></path>
|
||
<path class="cls-3" d="M111.87,18.54h1.33v1.25h-1.33Zm0,2.29h1.33v6h-1.33Z"></path>
|
||
<path class="cls-3" d="M114.67,18.54H116V21.6h0a1.8,1.8,0,0,1,.34-.39,1.84,1.84,0,0,1,.43-.3,2.3,2.3,0,0,1,.5-.18,1.86,1.86,0,0,1,.52-.07,2.93,2.93,0,0,1,1.23.25,2.6,2.6,0,0,1,.88.69,3,3,0,0,1,.52,1,4.53,4.53,0,0,1,.17,1.24,4.58,4.58,0,0,1-.15,1.17,3.2,3.2,0,0,1-.48,1,2.29,2.29,0,0,1-.81.7A2.4,2.4,0,0,1,118,27a4.17,4.17,0,0,1-.61,0,2.34,2.34,0,0,1-.59-.16,1.71,1.71,0,0,1-.5-.3,1.37,1.37,0,0,1-.38-.49h0v.83h-1.25Zm4.61,5.29a3,3,0,0,0-.1-.79,2.13,2.13,0,0,0-.32-.68,1.56,1.56,0,0,0-.52-.47,1.6,1.6,0,0,0-2,.4,2.49,2.49,0,0,0-.43,1.54,3.22,3.22,0,0,0,.11.84,2,2,0,0,0,.33.66,1.58,1.58,0,0,0,.53.44,1.46,1.46,0,0,0,.71.17,1.44,1.44,0,0,0,.77-.19,1.47,1.47,0,0,0,.51-.48,1.75,1.75,0,0,0,.29-.67A3.31,3.31,0,0,0,119.28,23.83Z"></path>
|
||
<path class="cls-3" d="M121.71,20.83H123V22h0a1.34,1.34,0,0,1,.22-.47,2,2,0,0,1,.41-.42,2,2,0,0,1,.53-.31,1.52,1.52,0,0,1,.59-.12h.32l.18,0V22l-.29,0-.28,0a1.46,1.46,0,0,0-.63.14,1.52,1.52,0,0,0-.52.39,2,2,0,0,0-.35.65A2.88,2.88,0,0,0,123,24v2.85h-1.33Z"></path>
|
||
<path class="cls-3" d="M130.81,25.48a.61.61,0,0,0,.07.35.26.26,0,0,0,.25.11h.14l.18,0v.92l-.18.05-.22.05-.24,0h-.19a1.29,1.29,0,0,1-.68-.16.82.82,0,0,1-.34-.57,2.53,2.53,0,0,1-1,.56,4,4,0,0,1-1.11.17,2.76,2.76,0,0,1-.77-.11,2,2,0,0,1-.66-.32,1.6,1.6,0,0,1-.45-.55,1.71,1.71,0,0,1-.17-.77,1.82,1.82,0,0,1,.2-.9,1.5,1.5,0,0,1,.54-.55,2.19,2.19,0,0,1,.74-.28,7.56,7.56,0,0,1,.83-.14,5.78,5.78,0,0,1,.68-.09,3.7,3.7,0,0,0,.57-.1.91.91,0,0,0,.4-.22.6.6,0,0,0,.14-.43.7.7,0,0,0-.12-.42.81.81,0,0,0-.3-.25,1,1,0,0,0-.4-.11l-.42,0a1.6,1.6,0,0,0-.91.23.89.89,0,0,0-.41.72h-1.32a2,2,0,0,1,.28-1,1.9,1.9,0,0,1,.62-.61,2.54,2.54,0,0,1,.85-.32,4.5,4.5,0,0,1,1-.1,3.57,3.57,0,0,1,.87.1,2.29,2.29,0,0,1,.77.3,1.58,1.58,0,0,1,.55.54,1.44,1.44,0,0,1,.21.8Zm-1.32-1.66a1.54,1.54,0,0,1-.74.23,8.89,8.89,0,0,0-.88.13,2.71,2.71,0,0,0-.41.09,1.22,1.22,0,0,0-.34.18.76.76,0,0,0-.24.29.94.94,0,0,0-.09.43.52.52,0,0,0,.13.37.92.92,0,0,0,.31.24,1.27,1.27,0,0,0,.39.12,1.84,1.84,0,0,0,.39,0,2,2,0,0,0,.47-.06,1.68,1.68,0,0,0,.48-.2,1.16,1.16,0,0,0,.38-.35.9.9,0,0,0,.15-.53Z"></path>
|
||
<path class="cls-3" d="M132.24,20.83h1.24V22h0a1.37,1.37,0,0,1,.23-.47,2,2,0,0,1,.4-.42,2.17,2.17,0,0,1,.53-.31,1.52,1.52,0,0,1,.59-.12h.32l.18,0V22l-.28,0-.29,0a1.52,1.52,0,0,0-.63.14,1.39,1.39,0,0,0-.51.39,1.84,1.84,0,0,0-.35.65,2.59,2.59,0,0,0-.13.88v2.85h-1.32Z"></path>
|
||
<path class="cls-3" d="M135.66,20.83h1.45l1.56,4.47h0l1.51-4.47h1.38l-2.33,6.31c-.11.27-.21.53-.32.78a2.58,2.58,0,0,1-.38.65A1.8,1.8,0,0,1,138,29a1.94,1.94,0,0,1-.86.16,5.49,5.49,0,0,1-.91-.07V28l.31,0a1.55,1.55,0,0,0,.31,0,1,1,0,0,0,.38-.06.49.49,0,0,0,.25-.16.9.9,0,0,0,.17-.26,2.34,2.34,0,0,0,.13-.35l.15-.47Z"></path>
|
||
<path class="cls-3" d="M148.3,27a3.25,3.25,0,0,1-1.28-.24,2.77,2.77,0,0,1-1-.65,2.85,2.85,0,0,1-.59-1,4.13,4.13,0,0,1,0-2.54A2.73,2.73,0,0,1,147,20.9a3.25,3.25,0,0,1,1.28-.24,3.3,3.3,0,0,1,1.29.24,2.79,2.79,0,0,1,.95.66,3,3,0,0,1,.59,1,4.13,4.13,0,0,1,0,2.54,3,3,0,0,1-.59,1,2.77,2.77,0,0,1-.95.65A3.3,3.3,0,0,1,148.3,27Zm0-1a1.52,1.52,0,0,0,1.3-.68,2.16,2.16,0,0,0,.31-.67,2.86,2.86,0,0,0,.1-.77,2.91,2.91,0,0,0-.1-.77,2.22,2.22,0,0,0-.31-.68,1.75,1.75,0,0,0-.53-.48,1.72,1.72,0,0,0-1.53,0,1.75,1.75,0,0,0-.53.48,2,2,0,0,0-.31.68,2.91,2.91,0,0,0-.1.77,2.86,2.86,0,0,0,.1.77,2,2,0,0,0,.31.67,1.52,1.52,0,0,0,1.29.68Z"></path>
|
||
<path class="cls-3" d="M151.84,20.83h1v-.5a2.58,2.58,0,0,1,.14-.92,1.44,1.44,0,0,1,.37-.55,1.23,1.23,0,0,1,.53-.25,2.56,2.56,0,0,1,.62-.07,4,4,0,0,1,.93.08v1l-.27,0h-.34a.83.83,0,0,0-.46.12.56.56,0,0,0-.19.5v.62h1.12v1h-1.12v5h-1.33v-5h-1Z"></path>
|
||
<path class="cls-3" d="M159.47,18.54h2L163.79,25h0L166,18.54h2v8.28h-1.38V20.43h0l-2.29,6.39h-1.2l-2.29-6.39h0v6.39h-1.38Z"></path>
|
||
<path class="cls-3" d="M170.64,24.16a2.2,2.2,0,0,0,.1.68,1.57,1.57,0,0,0,.29.56,1.36,1.36,0,0,0,.5.39,1.83,1.83,0,0,0,1.65-.1,1.45,1.45,0,0,0,.53-.75H175a2.58,2.58,0,0,1-.36.87,2.48,2.48,0,0,1-.61.64,2.56,2.56,0,0,1-.81.4,3.12,3.12,0,0,1-.93.13,3.24,3.24,0,0,1-1.25-.23,2.65,2.65,0,0,1-.92-.65,2.81,2.81,0,0,1-.57-1,3.94,3.94,0,0,1-.19-1.27,3.7,3.7,0,0,1,.2-1.21,3.14,3.14,0,0,1,.58-1,2.74,2.74,0,0,1,2.12-.95,2.67,2.67,0,0,1,1.27.3,2.94,2.94,0,0,1,.93.78,3.15,3.15,0,0,1,.54,1.12,3.34,3.34,0,0,1,.08,1.3Zm3.08-.87a2.08,2.08,0,0,0-.13-.6,1.48,1.48,0,0,0-.3-.5,1.38,1.38,0,0,0-.47-.35,1.32,1.32,0,0,0-.6-.13,1.62,1.62,0,0,0-.64.12,1.47,1.47,0,0,0-.48.33,1.72,1.72,0,0,0-.33.51,1.8,1.8,0,0,0-.13.62Z"></path>
|
||
<path class="cls-3" d="M181.7,26.82h-1.25V26h0a1.54,1.54,0,0,1-.77.74,2.65,2.65,0,0,1-1.08.23,2.86,2.86,0,0,1-1.24-.25,2.44,2.44,0,0,1-.87-.68,2.77,2.77,0,0,1-.52-1,4.26,4.26,0,0,1-.18-1.26,4.16,4.16,0,0,1,.22-1.4,2.94,2.94,0,0,1,.59-1,2.3,2.3,0,0,1,.83-.56,2.72,2.72,0,0,1,1-.18,2.83,2.83,0,0,1,.57.06,2.49,2.49,0,0,1,.55.16,2.29,2.29,0,0,1,.5.3,1.64,1.64,0,0,1,.37.42h0V18.54h1.32Zm-4.62-2.93a3.22,3.22,0,0,0,.1.75,2.22,2.22,0,0,0,.3.66,1.53,1.53,0,0,0,.52.46,1.47,1.47,0,0,0,.74.18,1.41,1.41,0,0,0,.76-.19,1.44,1.44,0,0,0,.52-.49,1.94,1.94,0,0,0,.3-.67,2.86,2.86,0,0,0,.1-.77,2.47,2.47,0,0,0-.44-1.56,1.47,1.47,0,0,0-1.21-.55,1.52,1.52,0,0,0-.79.19,1.55,1.55,0,0,0-.52.5,2.14,2.14,0,0,0-.29.69A3.5,3.5,0,0,0,177.08,23.89Z"></path>
|
||
<path class="cls-3" d="M183.17,18.54h1.32v1.25h-1.32Zm0,2.29h1.32v6h-1.32Z"></path>
|
||
<path class="cls-3" d="M190,22.83a1.23,1.23,0,0,0-.44-.84,1.46,1.46,0,0,0-.92-.28,2.22,2.22,0,0,0-.55.08,1.31,1.31,0,0,0-.53.33,1.91,1.91,0,0,0-.41.66,3.1,3.1,0,0,0-.16,1.11,3.18,3.18,0,0,0,.09.74,2.15,2.15,0,0,0,.28.66,1.47,1.47,0,0,0,.49.47,1.39,1.39,0,0,0,.73.18,1.32,1.32,0,0,0,.95-.36,1.63,1.63,0,0,0,.47-1h1.33a2.91,2.91,0,0,1-.89,1.79,2.73,2.73,0,0,1-1.86.62,3.06,3.06,0,0,1-1.25-.24,2.61,2.61,0,0,1-.91-.65,2.7,2.7,0,0,1-.56-1,3.67,3.67,0,0,1-.19-1.22,4.38,4.38,0,0,1,.18-1.27,3,3,0,0,1,.56-1,2.65,2.65,0,0,1,.92-.69,3.22,3.22,0,0,1,1.29-.25,3.66,3.66,0,0,1,1,.14,2.56,2.56,0,0,1,.83.4,2.16,2.16,0,0,1,.6.67,2.51,2.51,0,0,1,.28,1Z"></path>
|
||
<path class="cls-3" d="M192.41,18.54h1.32v1.25h-1.32Zm0,2.29h1.32v6h-1.32Z"></path>
|
||
<path class="cls-3" d="M195.17,20.83h1.25v.88l0,0a2.27,2.27,0,0,1,.79-.78,2.08,2.08,0,0,1,1.08-.29,2.25,2.25,0,0,1,1.55.51,2,2,0,0,1,.57,1.53v4.12h-1.32V23.05a1.73,1.73,0,0,0-.3-1,1.11,1.11,0,0,0-.87-.31,1.48,1.48,0,0,0-.61.12,1.45,1.45,0,0,0-.45.33,1.83,1.83,0,0,0-.29.51,1.77,1.77,0,0,0-.1.61v3.54h-1.32Z"></path>
|
||
<path class="cls-3" d="M202.85,24.16a2.2,2.2,0,0,0,.1.68,1.59,1.59,0,0,0,.3.56,1.25,1.25,0,0,0,.49.39,1.59,1.59,0,0,0,.72.15,1.66,1.66,0,0,0,.94-.25,1.49,1.49,0,0,0,.52-.75h1.25a2.38,2.38,0,0,1-.35.87,2.52,2.52,0,0,1-.62.64,2.61,2.61,0,0,1-.8.4,3.49,3.49,0,0,1-2.19-.1,2.65,2.65,0,0,1-.92-.65,2.81,2.81,0,0,1-.57-1,3.94,3.94,0,0,1-.19-1.27,3.7,3.7,0,0,1,.2-1.21,3.14,3.14,0,0,1,.58-1,2.74,2.74,0,0,1,2.12-.95,2.67,2.67,0,0,1,1.27.3,2.94,2.94,0,0,1,.93.78,3.15,3.15,0,0,1,.54,1.12,3.55,3.55,0,0,1,.09,1.3Zm3.08-.87a2.08,2.08,0,0,0-.13-.6,1.48,1.48,0,0,0-.3-.5,1.44,1.44,0,0,0-.46-.35,1.39,1.39,0,0,0-.61-.13,1.61,1.61,0,0,0-.63.12,1.41,1.41,0,0,0-.49.33,1.94,1.94,0,0,0-.33.51,1.8,1.8,0,0,0-.13.62Z"></path>
|
||
</g>
|
||
</g>
|
||
</svg>-->
|
||
</a>
|
||
</div>
|
||
</div>
|
||
<a class="usa-skipnav" href="https://www.nlm.nih.gov/research/index.html#main-content" id="anch_1">Skip to main content</a>
|
||
<div class="nav usa-header usa-header--basic">
|
||
<div class="usa-nav-container nav-container">
|
||
<div class="usa-navbar">
|
||
<button class="usa-menu-btn"><svg version="1.2" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" overflow="visible" preserveAspectRatio="none" viewBox="0 0 24 24" width="32" height="32"><g><path xmlns:default="http://www.w3.org/2000/svg" d="M3 18h18v-2H3v2zm0-5h18v-2H3v2zm0-7v2h18V6H3z" style="fill: rgb(50, 98, 149);" vector-effect="non-scaling-stroke"></path></g></svg></button>
|
||
</div>
|
||
<nav aria-label="Primary navigation" class="usa-nav">
|
||
<button class="usa-nav-close"><img src="/research/assets/close.svg" alt="close"></button>
|
||
<ul class="usa-nav-primary usa-accordion">
|
||
<li class="usa-nav-primary-item"> <a class="usa-nav-link" href="/research/" title="DIR Home" aria-label="DIR Home"><span>DIR Home</span></a> </li>
|
||
<li class="usa-nav-primary-item"> <a class="usa-nav-link" href="/research/researchstaff/staff-index.html" title="Principal Investigators" aria-label="Principal Investigators" ><span>Principal Investigators</span></a> </li>
|
||
<li class="usa-nav-primary-item"> <a class="usa-nav-link" href="/research/training.html" title="Training Program" aria-label="Training Program">Training Program</a> </li>
|
||
<li class="usa-nav-primary-item"> <a class="usa-nav-link" href="https://www.ncbi.nlm.nih.gov/CBBresearch/Seminar/" title="Seminars" aria-label="Seminars" target="_blank">Seminars</a> </li>
|
||
<li class="usa-nav-primary-item"> <a class="usa-nav-link" href="/research/board-of-scientific-counselors.html" title="Board of Scientific Counselors (BSC)" aria-label="Board of Scientific Counselors (BSC)">ADVISORS</a> </li>
|
||
<li class="usa-nav-primary-item"> <a class="usa-nav-link" href="/research/lectures.html" title="Lectures" aria-label="Lectures">Lectures</a> </li>
|
||
</ul>
|
||
</nav>
|
||
</div>
|
||
</div>
|
||
<div class="usa-overlay"></div>
|
||
<div class="hero">
|
||
<div class="stretch-container">
|
||
<img alt="image-description" src="/research/img/nlm-lhc-front-1200-w-blue-ad-5249-jpg.jpg">
|
||
</div>
|
||
<div class="hero-text-content">
|
||
<h1 class="forstaffpages" style="opacity: 1;">Evolutionary Genomics and Biomolecular Structure</h1>
|
||
</div>
|
||
</div>
|
||
</header>
|
||
<main id="main-content">
|
||
<section class="usa-section">
|
||
<div class="usa-grid">
|
||
<div class="focus-area-row intro-text">
|
||
NLM’s evolutionary genomics and biomolecular structure research focuses on developing and employing advanced computational methods. These methods compare genomes of all life forms, with the goal of understanding their function and evolution. This area of research includes the comprehensive study of the evolution of viruses and host-parasite coevolution, including the genomic evolution of cancers and development of theoretical models of genome evolution.
|
||
</div>
|
||
|
||
<div class="member-container">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<article class="focus-area-row">
|
||
<div class="image-wrapper"><a href="/research/researchstaff/KooninEugene.html"><img src="/research/img/KooninEugene.jpg" alt="Image of Eugene Koonin, PhD" /></a>
|
||
|
||
<h3><a href="/research/researchstaff/KooninEugene.html">Eugene Koonin, PhD</a></h3>
|
||
Distinguished Investigator, Computational Biology Branch</div>
|
||
<div class="detail-wrapper"> <h4>Eugene Koonin, PhD</h4>
|
||
<ul>
|
||
<li>Discovering new types of CRISPR-Cas systems</li>
|
||
<li>Discovering new families of viruses</li>
|
||
<li>Developing a general theory of microbial evolution</li>
|
||
<li>Classifying human cancers by analyzing tumor-mutation networks</li>
|
||
<li>Expanding metagenomic analyses to discover novel antibiotics, resistance mechanisms, and new mechanisms of microbial immunity</li>
|
||
<li>Increasing the focus on cancer genomics and evolution</li>
|
||
</ul>
|
||
</div>
|
||
</article>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<article class="focus-area-row">
|
||
<div class="image-wrapper"><a href="/research/researchstaff/JiangXiaofang.html"><img src="/research/img/JiangXiaofang.jpg" alt="Image of Xiaofang Jiang, PhD " /></a>
|
||
|
||
<h3><a href="/research/researchstaff/JiangXiaofang.html">Xiaofang Jiang, PhD </a></h3>
|
||
Tenure Track Investigator, NLM DIR</div>
|
||
<div class="detail-wrapper"> <h4>Xiaofang Jiang, PhD </h4>
|
||
<ul>
|
||
<li>Discovering and characterizing novel microbiome enzymes with implications for human health and physiology, exemplified by bilirubin reductase</li>
|
||
<li>Discovering new types of microbial enzymes involved in glycan synthesis and degradation</li>
|
||
<li>Exploring the binding specificity and functional consequences of protein-glycan interactions</li>
|
||
</ul>
|
||
</div>
|
||
</article>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<article class="focus-area-row">
|
||
<div class="image-wrapper"><a href="/research/researchstaff/IyerAravind.html"><img src="/research/img/IyerAravind.jpg" alt="Image of Aravind Iyer, PhD" /></a>
|
||
|
||
<h3><a href="/research/researchstaff/IyerAravind.html">Aravind Iyer, PhD</a></h3>
|
||
Senior Investigator, Computational Biology Branch</div>
|
||
<div class="detail-wrapper"> <h4>Aravind Iyer, PhD</h4>
|
||
<ul>
|
||
<li>Discovering protein domains and systems involved in nucleic acid repair and protein/nucleic acid modifications</li>
|
||
<li>Discovering novel effectors systems deployed in biological conflicts and discovering components of eukaryotic and prokaryotic immunity</li>
|
||
<li>Exploring the unknown biochemical space of proteins</li>
|
||
<li>Developing a unified molecular evolutionary theory for biological conflicts</li>
|
||
</ul>
|
||
</div>
|
||
</article>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<article class="focus-area-row">
|
||
<div class="image-wrapper"><a href="/research/researchstaff/PorterLauren.html"><img src="https://www.nlm.nih.gov/research/img/laurenporter.jpg" alt="Image of Lauren Porter, PhD" /></a>
|
||
|
||
<h3><a href="/research/researchstaff/PorterLauren.html">Lauren Porter, PhD</a></h3>
|
||
Stadtman Tenure Track Investigator, NLM DIR</div>
|
||
<div class="detail-wrapper"> <h4>Lauren Porter, PhD</h4>
|
||
<ul>
|
||
<li>Discovering new fold-switching proteins</li>
|
||
<li>Developing computational modeling of fold-switching proteins</li>
|
||
<li>Validating experimental characterizations of the structures, mechanisms, and functions of fold-switching proteins</li>
|
||
</ul>
|
||
</div>
|
||
</article>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</section>
|
||
</main>
|
||
<footer class="footer">
|
||
|
||
<div class="usa-grid">
|
||
<div class="footer-container">
|
||
<div class="footer-col">
|
||
<p style="margin-bottom:0;"><a href="https://www.nlm.nih.gov/socialmedia/index.html?_gl=1*11jclvw*_ga*MTU4OTg0NTg2LjE2OTgxNzQzMzg.*_ga_7147EPK006*MTY5ODQwODc4Mi44LjEuMTY5ODQxMjM1MC4wLjAuMA..*_ga_P1FPTH9PL4*MTY5ODQwODc4Mi45LjEuMTY5ODQxMjM1MC4wLjAuMA.." id="anch_22">Connect with NLM</a></p>
|
||
<ul class="social_media">
|
||
<li><a href=https://www.facebook.com/nationallibraryofmedicine><img class="bg-secondary" src=https://www.nlm.nih.gov/images/facebook.svg alt="Facebook"></a></li>
|
||
<li><a title="External link: please review our privacy policy." href=https://www.linkedin.com/company/national-library-of-medicine-nlm/><img class="bg-secondary" src="//www.nlm.nih.gov/images/linkedin.svg" alt="LinkedIn"></a></li>
|
||
<li><a title="External link: please review our privacy policy." href=https://twitter.com/NLM_NIH><img src="//www.nlm.nih.gov/images/twitter.svg" class="img-fluid bg-secondary" alt="Twitter"></a></li>
|
||
<li><a title="External link: please review our privacy policy." href=https://www.youtube.com/user/NLMNIH><img src="//www.nlm.nih.gov/images/youtube.svg" class="bg-secondary" alt="You Tube"></a></li>
|
||
<li><a title="External link: please review our privacy policy." href="//public.govdelivery.com/accounts/USNLMOCPL/subscriber/new?preferences=true"><img src="//www.nlm.nih.gov/images/mail.svg" class=" bg-secondary" alt="Government Delivery"></a></li>
|
||
</ul>
|
||
|
||
</div>
|
||
<div class="footer-col">
|
||
<p><a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" target="_blank" id="anch_26" title="External link: please review our privacy policy.">
|
||
National Library of Medicine<br>
|
||
8600 Rockville Pike<br>
|
||
Bethesda, MD 20894
|
||
</a></p>
|
||
</div>
|
||
<div class="footer-col centered-lg">
|
||
<p><a href="https://www.nlm.nih.gov/web_policies.html" target="_blank" id="anch_27">Web Policies</a><br>
|
||
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" target="_blank" id="anch_28">FOIA</a><br>
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank" id="anch_29">HHS Vulnerability Policy</a></p>
|
||
</div>
|
||
<div class="footer-col centered-lg">
|
||
<p><a href="//support.nlm.nih.gov?from=https://teamsite.nlm.nih.gov:81/iw-mount/default/main/nlm/WORKAREA/common/htdocs/research/index_alla.html" target="_blank" class="supportLink" id="anch_30">NLM Support Center</a><br>
|
||
<a href="https://www.nlm.nih.gov/accessibility.html" target="_blank" id="anch_31">Accessibility</a><br>
|
||
<a href="https://www.nlm.nih.gov/careers/" target="_blank" id="anch_32">Careers</a></p>
|
||
</div>
|
||
</div>
|
||
<div class="footer-lower-text"><p>
|
||
<a href="https://www.nlm.nih.gov/" target="_blank" id="anch_33">NLM</a> |
|
||
<a href="https://www.nih.gov/" target="_blank" id="anch_34">NIH</a> |
|
||
<a href="https://www.hhs.gov/" target="_blank" id="anch_35">HHS</a> |
|
||
<a href="https://www.usa.gov/" target="_blank" id="anch_36">USA.gov</a></p>
|
||
</div>
|
||
</div>
|
||
|
||
</footer>
|
||
<script src="//assets.nlm.nih.gov/jquery/jquery-latest.min.js"></script>
|
||
<script src="/research/js/headerFooter.js"></script>
|
||
<script src="/research/js/supportLink.js"></script>
|
||
<script src="/research/uswds/js/uswds.min.js"></script>
|
||
<script src="/core/nlm-notifyExternal/1.0/nlm-notifyExternal.min.js"></script>
|
||
|
||
</body>
|
||
</html>
|
||
|
||
|
||
|