nih-gov/www.nlm.nih.gov/oet/ed/pmc/preprints/01-300.html
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<h2>1. What Is a Preprint?
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<h3>Other Differences Between Preprints and Published Articles</h3>
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<p>In addition to peer review and the resulting changes to the article from review feedback, there are several other differences between preprints and published articles.</p>
<h4>Assigned Digital Object Identifier (DOI)</h4>
<p>Think of a DOI as a home address. There will be a different address for the preprint and the published article. If a preprint eventually becomes a published article, the preprint record may also include the Article DOI so researchers can find the final scholarly work. Notice the DOI address in the preprint screenshot. In the published article, the DOI will be different.</p>
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Screenshot of Preprint DOI from bioRxiv
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<em><small>(Image Source: <a href="https://www.biorxiv.org/content/10.1101/2021.07.07.449660v1" title="https://www.biorxiv.org/content/10.1101/2021.07.07.449660v1" target="_blank" id="anch_44">https://www.biorxiv.org/content/10.1101/2021.07.07.449660v1</a>)</small></em>
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<h4>Associated Journal</h4>
<p>Most scholarly articles will be published through specific research journals, whereas preprints can be posted prior to journal submission. As a result, citations to preprints generally carry the name of the preprint server or repository, in lieu of a journal.</p>
<h4>Access</h4>
<p>While most preprint servers and indices are open access, journals may have different access policies, including open access and paid subscriptions. Preprint servers may preserve all preprints so that you can access them even when the final article is published. To learn more about preprint server preservation policies, please refer to <a href="https://asapbio.org/preprint-servers" title="https://asapbio.org/preprint-servers" target="_blank">ASAPBios preprint server policy directory</a>.</p>
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<h4><i class="fas fa-user-edit"></i> Exercises</h4>
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<p>Check your knowledge from the <strong>1. What Is a Preprint?</strong> section by answering the following questions:</p>
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<li><strong>True or False? In general, preprints are peer reviewed at the time of posting.</strong></li>
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<p><strong>False.</strong> In general, preprints are not peer reviewed.
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a) To quickly share new research results with your peers.
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b) To solicit feedback on new ideas before finalizing a paper.
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c) To bypass peer review.
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<p>The answers are <strong>a) To quickly share new research results with your peers</strong> and <strong>b) To solicit feedback on new ideas before finalizing a paper</strong>.</p>
<p>c) To bypass peer review is incorrect because a preprint does not replace the peer review process.
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<li><strong>Click the links below to review the article information as a preprint and a published article:</strong></li>
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<br>
<blockquote class="blockquote ml-5">
<div style="padding-left: 4em; text-indent: -4em;">
<p class="m-b-0">Arunachalam PS, Walls AC, et al. Adjuvanting a subunit COVID-19 vaccine to induce protective immunity. <em>Nature</em>. 2021 Apr 19. doi: 10.1038/s41586-021-03530-2. Epub ahead of print. PMID: 33873199.</p>
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<ul>
<li>Preprint (bioRxiv): <a href="https://doi.org/10.1101/2021.02.10.430696" title="https://doi.org/10.1101/2021.02.10.430696" target="_blank">https://doi.org/10.1101/2021.02.10.430696</a> (PubMed record <a href="https://pubmed.ncbi.nlm.nih.gov/33594366/" title="https://pubmed.ncbi.nlm.nih.gov/33594366/" target="_blank">33594366</a>)</li>
<li>Published Article (<em>Nature</em>): <a href="https://www.nature.com/articles/s41586-021-03530-2" title="https://www.nature.com/articles/s41586-021-03530-2" target="_blank">https://www.nature.com/articles/s41586-021-03530-2</a> (PubMed record <a href="https://pubmed.ncbi.nlm.nih.gov/33873199/" title="https://pubmed.ncbi.nlm.nih.gov/33873199/" target="_blank">33873199</a>)</li>
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<p><strong>What differences do you notice (select all that apply)?</strong></p>
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a) The preprint and the published article have distinct DOIs.
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b) The preprint includes a &quot;warning&quot; message that it is a preprint and not certified by peer review.
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c) The published article has a shorter title.
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d) There are a number of edits to the text, including revisions to the abstract.
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<p>All of the choices (a through d) are correct.
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