nih-gov/www.nlm.nih.gov/hmd/conjoined/separation.html
2025-02-26 13:17:41 -05:00

431 lines
28 KiB
HTML
Raw Permalink Blame History

This file contains ambiguous Unicode characters

This file contains Unicode characters that might be confused with other characters. If you think that this is intentional, you can safely ignore this warning. Use the Escape button to reveal them.

<!doctype html>
<html lang="en">
<head>
<meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
<meta http-equiv="X-UA-Compatible" content="IE=edge" />
<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
<meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"/>
<link rel="preconnect" href="https://fonts.googleapis.com">
<link rel="preconnect" href="https://fonts.gstatic.com" crossorigin>
<link href="https://fonts.googleapis.com/css2?family=Roboto:wght@100;300;400;500;700&display=swap" rel="stylesheet">
<link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.0.10/css/all.css" integrity="sha384-+d0P83n9kaQMCwj8F4RJB66tzIwOKmrdb46+porD/OvrJ+37WqIM7UoBtwHO6Nlg" crossorigin="anonymous">
<link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" title="The Dublin Core metadata Element Set" />
<link rel="stylesheet" href="/home_assets/uswds/css/styles.css">
<title>From 'Monsters' to Modern Medical Miracles - Separation Surgeries (20th century-present)</title>
<link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" title="The Dublin Core metadata Element Set" />
<meta name="DC.Title" content="From Monsters to Modern Medical Miracles - Separation Surgeries (20th century-present)" />
<meta name="DC.Publisher" content="U.S. National Library of Medicine" />
<meta name="DC.Date.Issued" content="2006-08-04" />
<meta name="DC.Date.Modified" content="2024-03-11" />
<meta name="NLMDC.Date.LastReviewed" content="2024-03-11" />
<meta name="NLM.Contact.Email" content="hmdweb@nlm.nih.gov" />
<meta name="DC.Type" content="Exhibitions" />
<meta name="NLM.Permanence.Level" content="Permanent: Stable Content" />
<meta name="DC.Rights" content="Public Domain" />
<meta name="DC.Language" content="eng" />
<link href="conjoined.css" rel="stylesheet" type="text/css" media="all" />
<!-- Google Tag Manager --><script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push(
{'gtm.start': new Date().getTime(),event:'gtm.js'}
);var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-MT6MLL');</script>
<!-- End Google Tag Manager -->
</head>
<body>
<!-- Google Tag Manager -->
<noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-MT6MLL" height="0" width="0" style="display:none;visibility:hidden" title="googletagmanager"></iframe></noscript>
<!-- End Google Tag Manager -->
<!-- TOP NAV -->
<a class="usa-skipnav" href="#main">Skip to main content</a>
<div class="usa-banner site-banner" aria-label="Official government website">
<div class="usa-accordion">
<header class="usa-banner__header">
<div class="usa-banner__inner">
<div class="grid-col-auto"> <img class="usa-banner__header-flag" src="https://assets.nlm.nih.gov/uswds/img/us_flag_small.png" alt="U.S. flag"/> </div>
<div class="grid-col-fill tablet:grid-col-auto">
<p class="usa-banner__header-text"> An official website of the United States government </p>
<p class="usa-banner__header-action" aria-hidden="true"> Heres how you know </p>
</div>
<button class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner"> <span class="usa-banner__button-text">Heres how you know</span> </button>
</div>
</header>
<div class="usa-banner__content usa-accordion__content" id="gov-banner">
<div class="grid-row grid-gap-lg">
<div class="usa-banner__guidance tablet:grid-col-6"> <img class="usa-banner__icon usa-media-block__img" src="https://assets.nlm.nih.gov/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/>
<div class="usa-media-block__body">
<p> <strong> Official websites use .gov </strong> <br />
A <strong>.gov</strong> website belongs to an official government
organization in the United States. </p>
</div>
</div>
<div class="usa-banner__guidance tablet:grid-col-6"> <img class="usa-banner__icon usa-media-block__img" src="https://assets.nlm.nih.gov/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/>
<div class="usa-media-block__body">
<p> <strong> Secure .gov websites use HTTPS </strong> <br />
A <strong>lock</strong> ( <span class="icon-lock">
<svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewBox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-title-default banner-lock-description-default" focusable="false">
<title id="banner-lock-title-default">Lock</title>
<desc id="banner-lock-description-default">A locked padlock</desc>
<path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z"/>
</svg>
</span> ) or <strong>https://</strong> means youve safely connected to the .gov website. Share sensitive information only on official, secure websites. </p>
</div>
</div>
</div>
</div>
</div>
</div>
<!-- HEADER -->
<header id="siteheader" class="usa-header usa-header--basic">
<div class="usa-nav-container tablet:padding-x-4 mobile-lg:padding-x-2 padding-y-1">
<div class="grid-row padding-y-105">
<div class="grid-col-8 desktop:grid-col-4 tablet-lg:grid-col-4 tablet:grid-col-6"> <a href="https://www.nlm.nih.gov/"> <img src="https://assets.nlm.nih.gov/uswds/img/NLM_White.png" alt="NLM logo" class="logo margin-top-1"> </a> </div>
<div class="desktop:grid-col-4 desktop:grid-offset-4 tablet-lg:grid-col-6 tablet-lg:grid-offset-2 tablet:grid-col-6 grid-col-12">
<form class="usa-search desktop:margin-top-2 tablet:margin-top-2 mobile:margin-top-1" role="search" data-gtm-form-interact-id="0" method="get" action="//vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta" target="_self" name="searchForm" id="searchForm2">
<input class="usa-input ui-autocomplete-input" aria-label="Search" type="search" name="query" data-gtm-form-interact-field-id="0" id="search2" autocomplete="off" placeholder="Search NLM" >
<input type="hidden" name="v:project" value="nlm-main-website">
<button class="usa-button border border-top border-bottom border-right border-white" role="button" aria-label="Search" type="submit"> <span class="usa-search__submit-text"> <i class="fas fa-search"></i> </span> </button>
</form>
</div>
</div>
</div>
</header>
<div class="bg-secondary insertCOOP">
<div class="usa-nav-container">
<div class="usa-navbar ">
<button class="usa-menu-btn">Menu</button>
</div>
<nav aria-label="Primary navigation" class="usa-nav">
<button class="usa-nav__close"><img src="https://assets.nlm.nih.gov/uswds/img/close.svg" alt="close"></button>
<ul class="usa-nav__primary usa-accordion insertNav">
<li class="usa-nav__primary-item desktop-lg:margin-x-5 desktop:margin-x-3 tablet:margin-x-0">
<button type="button" class="usa-accordion__button usa-nav__link usa-current" aria-expanded="false" aria-controls="basic-nav-section-one"> <span>Products and Services <i class="fas fa-caret-down margin-left-05"></i> </span> </button>
<ul id="basic-nav-section-one" class="usa-nav__submenu bg-secondary" hidden="">
<li class="usa-nav__submenu-item"> <a href="//eresources.nlm.nih.gov/nlm_eresources/"><span>All Products and Services</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="//clinicaltrials.gov/"><span>ClinicalTrials.gov</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="//collections.nlm.nih.gov/"><span>Digital Collections</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="//catalog.nlm.nih.gov"><span>LocatorPlus Catalog</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="//meshb.nlm.nih.gov/search"><span>Medical Subject Headings (MeSH)</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="//medlineplus.gov/"><span>MedlinePlus</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="//pubmed.ncbi.nlm.nih.gov/"><span>PubMed/MEDLINE</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="//uts.nlm.nih.gov/uts/"><span>Unified Medical Language System (UMLS)</span></a> </li>
</ul>
</li>
<li class="usa-nav__primary-item desktop-lg:margin-x-5 desktop:margin-x-3 tablet:margin-x-0">
<button type="button" class="usa-accordion__button usa-nav__link usa-current" aria-expanded="false" aria-controls="basic-nav-section-two"> <span> Resources for You <i class="fas fa-caret-down margin-left-05"></i></span> </button>
<ul id="basic-nav-section-two" class="usa-nav__submenu bg-secondary" hidden="">
<li class="usa-nav__submenu-item"> <a href="/portals/researchers.html"><span>For Researchers</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/portals/publishers.html "><span>For Publishers</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/portals/librarians.html"><span>For Librarians</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/training.html "><span>For Educators/Trainers </span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/portals/healthcare.html"><span>For Health care Professionals</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/portals/public.html "><span>For the Public</span></a> </li>
</ul>
</li>
<li class="usa-nav__primary-item desktop-lg:margin-x-5 desktop:margin-x-3 tablet:margin-x-0">
<button type="button" class="usa-accordion__button usa-nav__link usa-current" aria-expanded="false" aria-controls="basic-nav-section-three"> <span>Explore NLM <i class="fas fa-caret-down margin-left-05"></i> </span> </button>
<ul id="basic-nav-section-three" class="usa-nav__submenu bg-secondary" hidden="">
<li class="usa-nav__submenu-item"> <a href="/about/index.html"><span>About the Library</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/about/visitor.html"><span>Visit the Library</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/hmd/index.html"><span>History of Medicine</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/about/org.html"><span>NLM by Organization</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/news/newsandevents.html"><span>News, Events, and Updates</span></a> </li>
</ul>
</li>
<li class="usa-nav__primary-item desktop-lg:margin-x-5 desktop:margin-x-3 tablet:margin-x-0">
<button type="button" class="usa-accordion__button usa-nav__link usa-current" aria-expanded="false" aria-controls="basic-nav-section-four"> <span> Grants and Research <i class="fas fa-caret-down margin-left-05"></i> </span> </button>
<ul id="basic-nav-section-four" class="usa-nav__submenu bg-secondary" hidden="">
<li class="usa-nav__submenu-item"> <a href="/ep/index.html"><span>NLM Extramural Programs</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="/research/index.html"><span>NLM Intramural Research Program</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="https://www.ncbi.nlm.nih.gov/"><span>National Center for Biotechnology Information</span></a> </li>
<li class="usa-nav__submenu-item"> <a href="//lhncbc.nlm.nih.gov/"><span>Lister Hill National Center for Biomedical Communications</span></a> </li>
</ul>
</li>
</ul>
</nav>
</div>
</div>
<!-- End of TOP NAV -->
<!-- DIVISIONAL BANNER -->
<div class="bg-gray-70">
<div class="grid-container">
<div class="grid-row divisional">
<div class="grid-col text-white">
<div class="float-left">
<h4 class="margin-bottom-0">History of Medicine</h4>
</div>
<div class="float-right margin-top-05">
<p>
<a class="text-white" href="/hmd/about/index.html">About</a>
&nbsp;&nbsp;|&nbsp;&nbsp;<a class="text-white" href="/hmd/collections/index.html">Collections</a>
&nbsp;&nbsp;|&nbsp;&nbsp;<a class="text-white" href="/hmd/about/exhibition/index.html">Exhibitions</a>
&nbsp;&nbsp;|&nbsp;&nbsp;<a class="text-white" href="/hmd/research-tools/index.html">Research Tools</a>
&nbsp;&nbsp;|&nbsp;&nbsp;<a class="text-white" href="/hmd/copyright/index.html">Copyright</a>
&nbsp;&nbsp;|&nbsp;&nbsp;<a class="text-white" href="/hmd/get-involved/index.html">Get Involved</a>
&nbsp;&nbsp;|&nbsp;&nbsp;<a class="text-white" href="/hmd/visit/index.html">Visit</a>
&nbsp;&nbsp;|&nbsp;&nbsp;<a class="text-white" href="/hmd/contact/index.html">Contact</a>
</p>
</div>
</div>
</div>
</div>
</div>
<!--END DIVISIONAL BANNER -->
<!-- Breadcrumbs -->
<div class="grid-container">
<nav class="usa-breadcrumb usa-breadcrumb--wrap padding-top-1" aria-label="Breadcrumbs">
<ol class="usa-breadcrumb__list">
<li class="usa-breadcrumb__list-item"> <a href="/index.html" class="usa-breadcrumb__link"><span>Home</span></a> </li>
<li class="usa-breadcrumb__list-item"> <a href="../../hmd/index.html" class="usa-breadcrumb__link"><span>History Home</span></a> </li><li class="usa-breadcrumb__list-item"> <a href="index.html" class="usa-breadcrumb__link"><span>From 'Monsters' to Modern Medical Miracles Home</span></a> </li><li class="usa-breadcrumb__list-item"> <span>Separation Surgeries (20th century-present)</span></li>
</ol>
</nav>
</div>
<!-- End Breadcrumbs -->
<main class="padding-bottom-5" id="main">
<div class="grid-container">
<div id="monsterMain">
<div class="imgCentered">
<img src="images/conjoined.png" alt="Banner containing six icons that link to the individual pages of the website. From left to right: 1. Image of three embryos, that links to the Embryology page. 2. Image of conjoined twins from a 15th century book, that links to the Age of Superstition page. 3. Image of Millie-Christine McCoy, that links to the Marvels on Exhibit page. 4. Image of Clara and Alta Rodriguez, that links to the Separation Surgeries page. 5. Image of a fine engraving of two sets of conjoined twins, that links to the Gallery of Images page. 6. Image of a title page, that links to the bibliography page. Below the banner, to the left of the links to each page is a large eighteenth century woodcut illustration of female twins joined at the back." title="From 'Monsters' to Modern Medical Miracles: selected moments in the history of conjoined twins from medieval to modern times." usemap="#Map2" />
<map name="Map2" id="Map2">
<area shape="rect" coords="0,0,960,107" href="index.html" alt="From 'Monsters' to Modern Medical Miracles: selected moments in the history of conjoined twins from medieval to modern times." title="From 'Monsters' to Modern Medical Miracles: selected moments in the history of conjoined twins from medieval to modern times home" />
<area shape="rect" coords="66,108,203,216" href="embryology.html" alt="Embryology and Classification of Conjoined Twins" title="Click here to go to the Embryology and Classification of Conjoined Twins page" />
<area shape="rect" coords="210,108,339,216" href="age.html" alt="Age of Superstition" title="Click here to go to the Age of Superstition (15th-18th Centuries) page" />
<area shape="rect" coords="349,108,483,216" href="marvels.html" alt="Marvels on Exhibit" title="Click here to go to the Marvels on Exhibit (19th Century) page" />
<area shape="rect" coords="493,108,615,216" href="separation.html" alt="Separation Surgeries" title="Click here to go to the Separation Surgeries (20th Century) page" />
<area shape="rect" coords="625,108,764,216" href="gallery.html" alt="Gallery of Images" title="Click here to go to the Gallery of Images page." />
<area shape="rect" coords="773,108,898,216" href="bibliography.html" alt="Bibliography" title="Click here to go to the Bibliography page." />
</map>
</div>
<hr />
<h2>Separation Surgeries (20th century)</h2>
<h3>Brief overview of attempts and successes</h3>
<p>Historically, the separation of conjoined twins was frowned upon. Even if the physicians thought it might be anatomically possible, the twins' relations, who often had a vested financial interest in keeping the twins together, usually dismissed the idea. In fact surgical separation was only seriously considered if one of the twins acquired an incurable disease. For example, both Eng and Millie were advised to seriously consider separation when Chang and Christine became gravely ill with pneumonia and tuberculosis, respectively; both refused.</p>
<p>Early surgeries were usually only performed on xiphopagus twins, which were joined by only a band of skin and tissue. The earliest recorded successful case occurred in 1690, when two sisters were separated by means of having a ligature around the band tightened daily until at last the final bit of skin was separated by a knife.</p>
<p>Surgeries on other types of twins, with more shared tissues or organs, frequently resulted in the survival of only one twin. Such was the case of Maria-Rosalina, thoracopagus twins who were separated in May 1900 by Eduoard Chapot-Pr&#233;vost. Maria died eight days after separation, but Rosalina survived.</p>
<p>By the 1950s advancing medical knowledge and technology enabled both conjoined twins of many different types to survive separation. Dr. Maitland Baldwin performed one of the first successful operations to separate craniopagus twins, on Dec. 11, 1956, at the National Institutes of Health. On Oct. 5, 1957, at The Children's Hospital of Philadelphia, Dr. C. Everett Koop performed one of the first successful operations to separate pygopagus twins. Nearly twenty years later Koop also lead a team at Children's Hospital that successfully separated ischiopagus twins, Clara and Alta Rodriguez, who are profiled below.</p>
<h3>Clara-Alta Rodriguez</h3>
<div class="imgLeft"><a href="images/sep_6B.jpg" target="_blank"><img src="images/sep_6.jpg" alt="Photograph of newborn ischiopagus twin girls, Clara-Alta Rodriguez, being held by a nurse shortly after their birth." title="Photograph of newborn twins, Clara- Alta Rodriguez, 1973. Courtesy C. Everett Koop (NLM UI 100961905)." /></a>
</div>
<p>Clara and Altagracia (Alta) Rodriguez were born in San Jos&#233; de Ochoa, Dominican Republic, on August 12, 1973. They were ischiopagus twins, joined together at the lower trunk and pelvis. Their gastrointestinal urinary and reproductive systems were partially united. Clara was the dominant twin of the two; Alta was clearly much weaker.</p>
<br class="clearboth" />
<div class="imgLeft"><a href="images/sep_3B.jpg" target="_blank"><img src="images/sep_3.jpg" alt="Dr. C. Everett Koop stands at a whiteboard, on which he has laid out the details of the surgery for separating the Rodriguez twins." title="Photograph of Chief of Pediatric Surgery C. Everett Koop explaining the details of the surgery to separate the Rodriquez twins, 1974. Courtesy C. Everett Koop (NLM UI 100961905)." /></a>
</div>
<div class="imgRight"><a href="images/sep_4B.jpg" target="_blank"><img src="images/sep_4.jpg" alt="Close-up of Dr. Koops whiteboard notes detailing the surgery that will separate the Rodriguez twins. In addition to a rough diagram showing the shared genitor-urinary area, the notes include the equipment needed for anesthesia and the surgeries; the known surgeries to be performed (cytoscopy, vaginoscopy); the surgical decisions that will need to be made regarding the bladders, rectum, and perineum; and a list of the staff assigned to each twin." title="Photograph of Dr. Koops notes detailing the surgery that will separate the Rodriguez twins. Courtesy C. Everett Koop (NLM UI 100961905)." /></a>
</div>
<p>Thanks to the efforts of relatives and church groups in the United States, the one year old twins were brought to The Children's Hospital of Philadelphia to be separated in September 1974. Chief of Pediatric Surgery Dr. C. Everett Koop, who had successfully performed a similar surgery 18 years earlier, said that if they remained conjoined the girls would never be able to sit up at the same time.</p>
<br class="clearboth" />
<div class="imgLeft"><a href="images/sep_1B.jpg" target="_blank"><img src="images/sep_1.jpg" alt="Photograph of Dr. C. Everett Koop standing over a hospital bed in post-operative recovery, where the separated Rodriguez twins lay, side-by-side, draped in hospital blankets. Clara, on the left, is awake; Alta, on the right, is sleeping." title="Photograph of Dr. C. Everett Koop standing over the separated Rodriguez twins in post-operative recovery. Courtesy The Childrens Hospital of Philadelphia (NLM UI 100961905)." /></a>
</div>
<div class="imgRight"><a href="images/sepB.jpg" target="_blank"><img src="images/sep.jpg" alt="Photograph of the recently separated Rodriguez twins laying side-by-side on a hospital bed. Clara, on the left, is draped in a hospital blanket; her eyes are open; she is looking at her sister and holding her sisters IV. Alta, on the right, is in a hospital gown; her eyes are closed, and her head is in a plastic chamber. Courtesy The Childrens Hospital of Philadelphia (NLM UI 100961905)." title="Photograph of the recently separated Rodriguez twins in post-operative recovery. Courtesy The Childrens Hospital of Philadelphia (NLM UI 100961905)." /></a>
</div>
<p>Koop led a team of 26 doctors and nurses in the eight hour separation surgery. Post-operatively, the girls remained in the intensive care unit for eighty-two days. Additional surgery was also required to shape the girls' pelvic bones so that they would be able to walk.</p>
<br class="clearboth" />
<div class="imgLeft"><a href="images/sep_2B.jpg" target="_blank"><img src="images/sep_2.jpg" alt="Dr. C. Everett Koop stands in a hospital room holding the separated Clara and Alta Rodriguez in each arm, prior to their discharge from the hospital. Both twins are wearing dresses and have bows in their hair." title="Photograph of Dr. C. Everett Koop holding the Rodriguez twins prior to their discharge from the hospital, 1975. Courtesy The Childrens Hospital of Philadelphia (NLM UI 100961905)." /></a>
</div>
<div class="imgRight"><a href="images/sep_5B.jpg" target="_blank"><img src="images/sep_5.jpg" alt="Clara and Alta Rodriguez stand side-by-side, holding onto a white table on the patio at their home in the Dominican Republic. Courtesy C. Everett Koop (NLM UI 100961905)." title="Photograph of Clara and Alta Rodriguez taken after their return home to the Dominican Republic, 1975? Courtesy C. Everett Koop (NLM UI 100961905)." /></a>
</div>
<p>The twins returned home in 1975, where Dominican President Joaquin Balaguer awarded Dr. Koop with a medal for the surgery. Mrs. Rodriguez was honored with a presidential decree which allowed her to travel to Puerto Rico to obtain baby supplies and medicine not available in her own country and to bring them back duty-free. Sadly, one year after the separation of the two sisters Alta choked on a bean. Clara survived to maturity and gave birth to a healthy baby boy in 1994.</p>
<br class="clearboth" />
<p><em><strong>Note:</strong> All images displayed on this page may be found in the C. Everett Koop Papers at the National Library of Medicine and are the courtesy of Dr. Koop. Images of the separated twins taken at the hospital are posted to the website by permission of The Children's Hospital of Philadelphia. Every effort was made to secure the permissions to post the other images, but the current copyright owner either could not be identified or could not be contacted. If you have information regarding the copyright owner, please contact us at <a class="paratureLink" href="//support.nlm.nih.gov?folderID=150&from=" target="_blank">NLM Customer Support</a>.</em></p>
</div>
<div class="clearfix"></div>
<p class=”margin-top-5”><small>Last Reviewed: March 11, 2024</small></p>
</div>
</main>
<!-- FOOTER -->
<footer class="usa-footer__primary-section padding-top-5 padding-bottom-3 insertfooter">
<div class="grid-container">
<div class="grid-row">
<div class="desktop:grid-col-3 grid-col-6"> <a href="https://www.nlm.nih.gov/socialmedia/index.html">
<p class="text-white margin-bottom-1">Connect with NLM</p>
</a>
<ul class="social_media add-list-reset">
<li class="margin-right-05"><a href="https://www.facebook.com/nationallibraryofmedicine"><img class="bg-secondary" src="https://www.nlm.nih.gov/images/facebook.svg" alt="Facebook"></a></li>
<li class="margin-right-05"><a title="External link: please review our privacy policy." href="https://www.linkedin.com/company/national-library-of-medicine-nlm/"><img class="bg-secondary" src="//www.nlm.nih.gov/images/linkedin.svg" alt="LinkedIn"></a></li>
<li class="margin-right-05"><a title="External link: please review our privacy policy." href="https://twitter.com/NLM_NIH"><img src="https://www.nlm.nih.gov/images/twitter.svg" class="padding-1 bg-secondary" alt="Twitter"></a></li>
<li class="margin-right-05"><a title="External link: please review our privacy policy." href="https://www.youtube.com/user/NLMNIH"><img src="//www.nlm.nih.gov/images/youtube.svg" class="bg-secondary" alt="You Tube"></a></li>
<li class="margin-right-05"><a title="External link: please review our privacy policy." href="https://public.govdelivery.com/accounts/USNLMOCPL/subscriber/new?preferences=true"><img src="//www.nlm.nih.gov/images/mail.svg" class=" bg-secondary" alt="Government Delivery"></a></li>
</ul>
</div>
<div class="desktop:grid-col-3 grid-col-6">
<p class="address_footer text-white"> National Library of Medicine <br>
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white"> 8600 Rockville Pike <br>
Bethesda, MD 20894 </a></p>
</div>
<div class="desktop:grid-col-3 grid-col-6">
<p><a href="/web_policies.html" class="text-white"> Web Policies </a><br>
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white"> FOIA </a><br>
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white">HHS Vulnerability Disclosure</a> </p>
</div>
<div class="desktop:grid-col-3 grid-col-6">
<p><a class="supportLink text-white" href="//support.nlm.nih.gov?from="> NLM Support Center </a> <br>
<a href="/accessibility.html" class="text-white"> Accessibility </a><br>
<a href="/careers/careers.html" class="text-white"> Careers </a></p>
</div>
</div>
<div class="grid-row">
<div class="grid-col-12">
<p class="text-center text-white"> <a class="text-white" href="//www.nlm.nih.gov/">NLM</a> | <a class="text-white" href="https://www.nih.gov/">NIH</a> | <a class="text-white" href="https://www.hhs.gov/">HHS</a> | <a class="text-white" href="https://www.usa.gov/">USA.gov</a></p>
</div>
</div>
</div>
</footer>
<script src="//assets.nlm.nih.gov/uswds/js/uswds.min.js"></script>
<script src="//assets.nlm.nih.gov/jquery/jquery-latest.min.js"></script>
<script src="//assets.nlm.nih.gov/jquery/jquery-migrate-latest.min.js"></script>
<script src="/scripts/nlm_autocomplete.js"></script>
<script src="/scripts/nlm_uswds.js"></script>
</body>
</html>