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</style><div class="row feature-box m-0 mb-3"><div class="col-xl-12"><h5 class="mt-2 mb-0"><i class="fa-regular fa-box-archive"></i> Archived Content</h5><p><small>The National Institute of Mental Health archives materials that are over 4 years old and no longer being updated. The content on this page is provided for historical reference purposes only and may not reflect current knowledge or information.</small></p></div></div></div>
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<h1 class="titleblock__title" id="title">NIH Announces Funding Awards for National Early Psychosis Learning Community</h1>
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<p id="subtitle">NIH-funded research projects aim to improve quality of care and patient outcomes while speeding advances in early psychosis services and science</p>
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<p class="pagestamp_news_wrap">
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<time class="pagestamp_news_time" datetime="2019-09-20">September 20, 2019</time>
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• <span class="pagestamp_news_type">Press Release</span></p>
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<html><body><p>The National Institutes of Health (NIH) awarded six research grants for studies to develop a learning health care system for the treatment of early psychosis. The awards are part of a broad research initiative called <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="0c6e1395-9442-40e1-a22a-20079848c9b0" href="/funding/grant-writing-and-application-process/concept-clearances/2015/early-psychosis-intervention-network-epinet-a-learning-healthcare-system-for-early-serious-mental-illness">Early Psychosis Intervention Network (EPINET)</a>, which aims to develop models for the effective delivery of coordinated specialty care (CSC) services for early psychosis. The grants are administered by the National Institute of Mental Health (NIMH), part of NIH.</p>
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<p>The word <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="088ab204-cd6b-453c-9269-4d0010c4562a" href="/health/topics/schizophrenia/raise/raise-questions-and-answers">psychosis</a> is used to describe conditions that affect the mind, where there has been some loss of contact with reality. About <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="088ab204-cd6b-453c-9269-4d0010c4562a" href="/health/topics/schizophrenia/raise/raise-questions-and-answers">100,000</a> youth and young adults in the United States experience a first episode of psychosis each year. Left untreated, psychotic symptoms can lead to disruptions in school and work, strained family relations, and separation from friends. The longer the symptoms go untreated, the greater the risk of additional problems.</p>
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<p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="088ab204-cd6b-453c-9269-4d0010c4562a" href="/health/topics/schizophrenia/raise/raise-questions-and-answers">CSC</a> is a recovery-oriented treatment program for people with early psychosis (i.e., those in the early stages of a psychotic illness). It promotes shared decision making and uses a team of specialists who work with the client to create a personal treatment plan. Through these EPINET awards, NIMH aims to establish regional scientific hubs each connected to six or more community-based CSC programs that endorse measurement-based early psychosis treatment. A national data coordinating center will support and extend the work of the regional hubs by integrating data obtained from 58 CSC programs across nine states.</p>
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<p>The groundwork for EPINET was laid by NIMH’s <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="2e820adc-8bb6-43bc-98e4-9cf6b12e0db1" href="/health/topics/schizophrenia/raise/recovery-after-an-initial-schizophrenia-episode-raise">Recovery After an Initial Schizophrenia Episode</a> (RAISE) initiative. RAISE demonstrated the superiority of team-based, multi-component CSC treatment compared to usual care for early psychosis and the feasibility of implementing CSC programs in U.S. community settings. Individuals in the RAISE studies who received CSC stayed in treatment longer and experienced greater improvement in their symptoms, interpersonal relationships, quality of life, and involvement in work and school compared with those who received typical care.</p>
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<p>“The RAISE findings have been replicated by other studies, adding momentum to early intervention programs in America,” said Robert K. Heinssen, Ph.D., director of NIMH’s <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="2f9d09b0-12c2-4c1a-90c6-6b9edaa8735e" href="/about/organization/dsir">Division of Services and Intervention Research</a> (DSIR). “EPINET represents the next chapter in a science-to-service story that started with RAISE but is moving toward learning health care that fosters recovery in early serious mental illness.”</p>
|
||
|
||
<p>Today, over 260 early psychosis specialty care programs have been established in 49 states. NIMH is seeking to build on states’ investments by supporting practice-based research that promotes high quality, continuously improving care across all CSC programs.</p>
|
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||
<p>“As the number of early intervention programs expands, it is essential that we learn how to ensure those receiving these services get the best possible care,” said Joshua A. Gordon, M.D., Ph.D., director of NIMH. “Through EPINET, we hope to learn how best to deliver cutting edge care in real-world, community-based settings. This will help us rapidly translate scientific advances into the clinic."</p>
|
||
|
||
<p>NIMH has awarded over $40 million in funding for EPINET over five years. The grants that have been awarded include:</p>
|
||
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||
<p><strong>EPINET Regional Scientific Hubs</strong></p>
|
||
|
||
<ul>
|
||
<li><a href="https://reporter.nih.gov/project-details/9815936" rel="external">California Collaborative Network to Promote Data Driven Care and Improve Outcomes in Early Psychosis (EPI-CAL) <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a><strong>, </strong>University of California, Davis, Dr. <a href="https://carterlab.ucdavis.edu/people/niendam.php" rel="external noreferrer"> Tara Ann Niendam <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a></li>
|
||
<li><a href="https://reporter.nih.gov/project-details/9817331" rel="external">Early-phase Schizophrenia: Practice-based Research to Improve Treatment Outcomes (ESPRITO) <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a><strong>, </strong>Feinstein Institute for Medical Research, New York City, Drs. <a href="https://feinstein.northwell.edu/institutes-researchers/our-researchers/john-m-kane-md" rel="external noreferrer">John Kane <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a> and <a href="https://feinstein.northwell.edu/institutes-researchers/our-researchers/delbert-g-robinson-md" rel="external noreferrer">Delbert Robinson <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a></li>
|
||
<li><a href="https://reporter.nih.gov/project-details/10001157" rel="external">Laboratory for Early Psychosis Research (LEAP)-Supplement <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a><strong>, </strong>McLean Hospital, Belmont, Massachusetts, Drs. <a href="https://www.mcleanhospital.org/biography/dost-ongur" rel="external noreferrer">Dost Ongur <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>, <a href="https://www.hsph.harvard.edu/miguel-hernan/" rel="external noreferrer">Miguel Hernan <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>, and <a href="https://hcp.hms.harvard.edu/people/john-hsu" rel="external noreferrer">John Hsu <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a></li>
|
||
<li><a href="https://reporter.nih.gov/project-details/9817350" rel="external">OnTrackNY’s Learning Healthcare System <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a><strong>, </strong>New York State Psychiatric Institute, New York City, Drs. <a href="https://www.columbiapsychiatry.org/profile/lisa-b-dixon-md" rel="external noreferrer">Lisa Dixon <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a> and <a href="https://www.columbiapsychiatry.org/profile/jennifer-humensky-phd" rel="external noreferrer">Jennifer Humensky <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a></li>
|
||
<li><a href="https://reporter.nih.gov/project-details/9816739" rel="external">Targeting Cognition and Motivation in Coordinated Specialty Care for Early Psychosis <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a><strong>, </strong>University of Minnesota, Minneapolis, Drs. <a href="https://med.umn.edu/bio/psychiatry/sophia-vinogradov" rel="external noreferrer">Sophia Vinogradov <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a> and <a href="https://med.umn.edu/bio/piper-meyer-kalos" rel="external noreferrer">Piper Meyer-Kalos <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a></li>
|
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</ul>
|
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|
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<p><a href="https://reporter.nih.gov/project-details/9816841" rel="external"><strong>EPINET National Data Coordinating Center</strong> <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a></p>
|
||
|
||
<ul>
|
||
<li>Westat, Rockville, Maryland, Dr. <a href="https://www.westat.com/team/abram" rel="external noreferrer">Abram Rosenblatt <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a></li>
|
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</ul>
|
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<p>Each regional hub will have one or more studies focused on reducing delays in accessing care, improving cognitive functioning, preventing suicide, increasing treatment adherence, and sustaining clinical gains over time. Each CSC program participating in EPINET will use standard clinical measures and uniform data collection and analysis methods to facilitate learning about the most effective ways to deliver early psychosis treatment. The EPINET National Data Coordinating Center will enable large-scale, practice-based research using data shared by the regional hubs to improve early identification, diagnosis, clinical assessment, intervention effectiveness, and health outcomes in clinics offering evidence-based care to persons in the early stages of psychotic illness.</p>
|
||
|
||
<h2>Grants</h2>
|
||
|
||
<p><a href="https://reporter.nih.gov/project-details/9815936" rel="external">MH120555-01 <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>; <a href="https://reporter.nih.gov/project-details/9817331" rel="external">MH120594-01 <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>; <a href="https://reporter.nih.gov/project-details/10001157" rel="external">MH115846-01A1S1 <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>; <a href="https://reporter.nih.gov/project-details/9817350" rel="external">MH120597-01 <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>; <a href="https://reporter.nih.gov/project-details/9816739" rel="external">MH120589-01 <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>; <a href="https://reporter.nih.gov/project-details/9816841" rel="external">MH120591-01 <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a></p>
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