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<div about="/research-training/advances-colorectal-cancer-research" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-basic-page featured-media-floated view-mode-full node--full node--nih-basic-page--full clearfix">
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<div class='syndicate'><h1>Advances in Colorectal Cancer Research</h1><div class="featured-media"><div class="ds-1col file file-image file-image-jpeg view-mode-featured_media clearfix">
|
||
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||
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||
<picture title="Microscopic image of a several oval-shaped nanoparticles with an honeycomb-like internal structure">
|
||
<!--[if IE 9]><video style="display: none;"><![endif]-->
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||
<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-large-extra/public/research-training/colorectal-cancer-nanotechnology.jpg?itok=517o_dHm&timestamp=1440009702 1x" media="screen and (min-width: 1100px)" />
|
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-large/public/research-training/colorectal-cancer-nanotechnology.jpg?itok=0tN1hMpC&timestamp=1440009702 1x" media="screen and (min-width: 960px)" />
|
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/research-training/colorectal-cancer-nanotechnology.jpg?itok=q9nca5Xf&timestamp=1440009702 1x" media="screen and (min-width: 800px)" />
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium-small/public/research-training/colorectal-cancer-nanotechnology.jpg?itok=LVWRfIK5&timestamp=1440009702 1x" media="screen and (min-width: 600px)" />
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-small/public/research-training/colorectal-cancer-nanotechnology.jpg?itok=bEjIq8rS&timestamp=1440009702 1x" media="screen and (min-width: 480px)" />
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media__breakpoint-tiny_/public/research-training/colorectal-cancer-nanotechnology.jpg?itok=RxseLE8i&timestamp=1440009702 1x" media="screen and (min-width: 0)" />
|
||
<!--[if IE 9]></video><![endif]-->
|
||
<img src="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/research-training/colorectal-cancer-nanotechnology.jpg?itok=q9nca5Xf&timestamp=1440009702" alt="Microscopic image of a several oval-shaped nanoparticles with an honeycomb-like internal structure." title="Microscopic image of a several oval-shaped nanoparticles with an honeycomb-like internal structure" />
|
||
</picture><span class="caption">A nanotechnology-based method is being developed to detect markers predictive of increased colon cancer risk.</span><span class="credit">Winship Cancer Institute</span></div>
|
||
|
||
</div><div><p>For an update on what medical science is doing to find colorectal cancer early and to treat it more effectively, read a <em>Parade</em> article by NIH Director Francis S. Collins, <a href="/sites/default/files/research-training/the-cancer-you-can-beat.pdf"><em>The Cancer You Can Beat</em></a>.</p>
|
||
|
||
<p>Cancers of the colon and rectum, also known as colorectal cancers, are the third most commonly diagnosed cancers among men and women in the United States and the second leading cause of cancer death in this country. In 2010, it is estimated that more than 140,000 Americans will be diagnosed with colorectal cancer and more than 50,000 will die of the disease. Over the past several decades, researchers have learned a lot about colorectal cancer, but much more research is needed to find ways to prevent the disease and to detect it earlier and treat it more effectively should it occur.</p>
|
||
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||
<div class="media-float-left"><div class="media media-element-container media-floated_media"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
|
||
|
||
|
||
<picture title="Illustration of the human colon" class="media-element file-floated-media">
|
||
<!--[if IE 9]><video style="display: none;"><![endif]-->
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/research-training/human-colon-illustration_0.jpg?itok=xdsi6nfG&timestamp=1440009984 1x" media="screen and (min-width: 960px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/research-training/human-colon-illustration_0.jpg?itok=zf5rhw58&timestamp=1440009984 1x" media="screen and (min-width: 800px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/research-training/human-colon-illustration_0.jpg?itok=Gkhy2RIo&timestamp=1440009984 1x" media="screen and (min-width: 600px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/research-training/human-colon-illustration_0.jpg?itok=dEsOI9qJ&timestamp=1440009984 1x" media="screen and (min-width: 480px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/research-training/human-colon-illustration_0.jpg?itok=VtDCV-vc&timestamp=1440009984 1x" media="screen and (min-width: 0)"></source>
|
||
<!--[if IE 9]></video><![endif]-->
|
||
<img class="media-element file-floated-media" src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/research-training/human-colon-illustration_0.jpg?itok=zf5rhw58&timestamp=1440009984" alt="Illustration of the human colon." title="Illustration of the human colon" />
|
||
</picture><span class="caption">Anatomy of the lower digestive system, showing the colon, rectum, and other organs.</span><span class="credit">NCI, NIH</span></div>
|
||
|
||
</div></div>
|
||
|
||
<p>At the National Institutes of Health (NIH), the research effort on colorectal cancer is led by the National Cancer Institute (NCI). A vast network of NCI-supported scientists, located on the NIH campus in Bethesda, Md., and at research centers across the nation and around the world, are exploring new ways to prevent, detect, and treat colorectal cancer. Many other NIH institutes and centers, including the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of General Medical Sciences (NIGMS), and the National Human Genome Research Institute (NHGRI), also support colorectal cancer-related research.</p>
|
||
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||
<div class="media-float-right"><div class="media media-element-container media-floated_media"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
|
||
|
||
|
||
<picture title="Illustration of colorectal cancer stages" class="media-element file-floated-media">
|
||
<!--[if IE 9]><video style="display: none;"><![endif]-->
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/research-training/colon-cancer-stages-illustration_0.jpg?itok=0P3G0bls&timestamp=1440009999 1x" media="screen and (min-width: 960px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/research-training/colon-cancer-stages-illustration_0.jpg?itok=A8WK0qQ_&timestamp=1440009999 1x" media="screen and (min-width: 800px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/research-training/colon-cancer-stages-illustration_0.jpg?itok=HmIz_uAU&timestamp=1440009999 1x" media="screen and (min-width: 600px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/research-training/colon-cancer-stages-illustration_0.jpg?itok=KXIabfpD&timestamp=1440009999 1x" media="screen and (min-width: 480px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/research-training/colon-cancer-stages-illustration_0.jpg?itok=TW-l3A-9&timestamp=1440009999 1x" media="screen and (min-width: 0)"></source>
|
||
<!--[if IE 9]></video><![endif]-->
|
||
<img class="media-element file-floated-media" src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/research-training/colon-cancer-stages-illustration_0.jpg?itok=A8WK0qQ_&timestamp=1440009999" alt="Illustration of colorectal cancer stages." title="Illustration of colorectal cancer stages" />
|
||
</picture><span class="caption">Stages of colorectal cancer.</span><span class="credit">NCI, NIH</span></div>
|
||
|
||
</div></div>
|
||
|
||
<p>Both basic and clinical research scientists are utilizing the latest advances in technology in the effort to reduce the burden and toll of colorectal cancer. In the area of cancer screening and early detection, advances in computer-aided imaging, nanotechnology, and methods of molecular analysis promise to enhance our ability to identify abnormal growths in colorectal tissue that either are or could become cancerous. Meanwhile, other researchers are investigating ways to ensure that people adhere to current colorectal cancer screening recommendations.</p>
|
||
|
||
<div class="media-float-left"><div class="media media-element-container media-floated_media"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
|
||
|
||
|
||
<picture title="Illustration of colon polyps" class="media-element file-floated-media">
|
||
<!--[if IE 9]><video style="display: none;"><![endif]-->
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/research-training/colon-polyps-illustration.jpg?itok=R8EVv73u&timestamp=1440010053 1x" media="screen and (min-width: 960px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/research-training/colon-polyps-illustration.jpg?itok=LRocBfvI&timestamp=1440010053 1x" media="screen and (min-width: 800px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/research-training/colon-polyps-illustration.jpg?itok=Ju9J_jH0&timestamp=1440010053 1x" media="screen and (min-width: 600px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/research-training/colon-polyps-illustration.jpg?itok=vZgY-oTJ&timestamp=1440010053 1x" media="screen and (min-width: 480px)"></source>
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/research-training/colon-polyps-illustration.jpg?itok=-kJnZkFu&timestamp=1440010053 1x" media="screen and (min-width: 0)"></source>
|
||
<!--[if IE 9]></video><![endif]-->
|
||
<img class="media-element file-floated-media" src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/research-training/colon-polyps-illustration.jpg?itok=LRocBfvI&timestamp=1440010053" alt="Illustration of colon polyps." title="Illustration of colon polyps" />
|
||
</picture><span class="caption">Colon polyps.</span><span class="credit">NCI, NIH</span></div>
|
||
|
||
</div></div>
|
||
|
||
<p>In the area of cancer treatment, advances in DNA sequencing and genomic profiling methods should enable the identification of the specific molecular defects in a person’s cancer cells and permit the development of therapies that target or take advantage of those defects. This genetic knowledge might also be exploited to help identify people who have an increased risk of colorectal cancer and to develop effective interventions to prevent the disease.</p>
|
||
|
||
|
||
<h2>Additional information about colorectal cancer</h2>
|
||
|
||
<ul class="spaced">
|
||
<li><a href="http://www.cancer.gov/types/colorectal">Visit NCI’s colon and rectal cancer home page</a> (also <a href="http://www.cancer.gov/espanol/tipos/colorrectal">En Español</a>)</li>
|
||
<li>Call NCI’s Cancer Information Service at 1-800-4-CANCER (1-800-422-6237)</li>
|
||
<li><a href="http://www.cancer.gov/publications">Order NCI publications online</a></li>
|
||
</ul></div></div>
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|
||
</div>
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<div class="lastupdated">
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<p>This page last reviewed on August 20, 2015</p> </div> </div>
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<div id="block-bean-advances-in-colorectal-cancer-re" class="block block--bean box block--bean-advances-in-colorectal-cancer-re" id="block-bean-advances-in-colorectal-cancer-re" class="block block--bean box block--bean-advances-in-colorectal-cancer-re">
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<h3 class="block__title">Learn more about research in these areas:</h3>
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<div class="content" class="block__content">
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<div class="teaser-list teaser-list-no-titles">
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<div class="teaser teaser-clickable">
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-19991" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/research-training/virtual-colonoscopy-square.jpg">virtual-colonoscopy-square.jpg</a></h2>
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<div class="content">
|
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<img height="150" width="150" alt="Computer generated image of a colon polyp." title="Computer generated image of a colon polyp" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/research-training/virtual-colonoscopy-square.jpg?itok=LlIditUK" /> </div>
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|
||
|
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</div>
|
||
</div></div>
|
||
|
||
<p class="teaser-description"><a href="/research-training/detecting-abnormal-growths-colorectal-tissue">Detecting Abnormal Growths in Colorectal Tissue</a></p>
|
||
</div>
|
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<div class="teaser teaser-clickable">
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-19976" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/research-training/gold-colored-nanoparticles.jpg">gold-colored-nanoparticles.jpg</a></h2>
|
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|
||
<div class="content">
|
||
<img height="150" width="150" alt="Microscopic image of gold-colored nanoparticles." title="Microscopic image of gold-colored nanoparticles" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/research-training/gold-colored-nanoparticles.jpg?itok=zCTcdvi5" /> </div>
|
||
|
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|
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</div>
|
||
</div></div>
|
||
|
||
<p class="teaser-description"><a href="/research-training/nanotechnology-improve-early-detection-treatment-colorectal-cancer">Nanotechnology to Improve Early Detection and Treatment of Colorectal Cancer</a></p>
|
||
</div>
|
||
|
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<div class="teaser teaser-clickable">
|
||
<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-20001" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/research-training/scientist-preparing-dna-analysis.jpg">scientist-preparing-dna-for-analysis.jpg</a></h2>
|
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|
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<div class="content">
|
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<img height="150" width="150" alt="A scientist preparing DNA for analysis." title="A scientist preparing DNA for analysis" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/research-training/scientist-preparing-dna-for-analysis_0.jpg?itok=eVeJAId2" /> </div>
|
||
|
||
|
||
</div>
|
||
</div></div>
|
||
|
||
<p class="teaser-description"><a href="/research-training/genomic-profiling-help-prevent-treat-colorectal-cancer">Genomic Profiling to Help Prevent and Treat Colorectal Cancer</a></p>
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||
</div>
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<div class="teaser teaser-clickable">
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-20066" class="file file-image file-image-jpeg">
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