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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/nih-research-matters">NIH Research Matters</a></div> <div class="l-region l-region--section-header">
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2010-12-13T00:00:00-05:00" class="date-display-single">December 13, 2010</span></p><div class='syndicate'><h1>Insight into Memory Loss in Alzheimer’s Disease</h1><div class="media-float-right"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2010/20101213-alzheimers.jpg?itok=i1UuGjXd&timestamp=1433965385 1x" media="screen and (min-width: 0)" />
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2010/20101213-alzheimers.jpg?itok=AZu_21nt&timestamp=1433965385" alt="Microscope image showing clusters of red dots scattered among a field of green neurons" title="Microscope image showing clusters of red dots scattered among a field of green neurons" />
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</picture><span class="caption">NMDA receptors (red) in the mouse brain. </span><span class="credit"> MRC Toxicology Unit, Wellcome Images. All rights reserved by Wellcome Images. </span></div>
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</div><p>A protein lost in Alzheimer’s disease may play a key role in memory development, according to a new study in mice. The findings give insight into how brain signals are disrupted by the disease and offer a potential new treatment target.</p>
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<p>Alzheimer's disease leads to permanent losses in memory and other thinking skills, like learning and judgment. While its causes are still unclear, research has shown a strong relationship between the buildup of amyloid-beta proteins in the brain and damage to memory. How these proteins may contribute to memory loss, though, is largely unknown. Recent work has suggested that free-floating amyloids may play more of a role than the well-known amyloid plaques.</p>
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<p>Past studies have reported that both Alzheimer's patients and mice with an Alzheimer's-like condition have lower levels of NMDA receptor activity, which is known to be involved in memory formation. Researchers have also found lower levels of the receptor tyrosine kinase EphB2, which is known to regulate NMDA levels.</p>
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<p>A team of researchers led by Dr. Lennart Mucke from the Gladstone Institute of Neurological Disease in San Francisco decided to test how free-floating amyloids affect the levels of these molecules. They used both normal mice and transgenic mice that make high levels of human amyloid proteins. The transgenic mice have memory and neuron-signaling problems that resemble those in humans with Alzheimer's disease. They also have lower levels of EphB2 than normal mice. The study was supported by several grants from NIH.</p>
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<p>In the November 28, 2010, issue of <em>Nature</em>, the team reported that free-floating amyloids bind to EphB2 and lead it to be broken down by the cell. When the researchers depleted EphB2 in cultured neuron cells from normal mice, they found that the loss of this protein led to less activity from NMDA receptors.</p>
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<p>The team then tested how EphB2 levels affected memory formation in the mice. Depleting EphB2 from normal mice led to decreases in neuron signaling that mimicked those seen in the amyloid transgenic mice. When the scientists expressed high levels of EphB2 in the transgenic mice, they saw improvement in neuron signaling as well as in memory and learning tests.</p>
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<p>These results suggest that Alzheimer's disease might someday be treated by modifying EphB2 levels or preventing its breakdown. "Based on our results, we think that blocking amyloid proteins from binding to EphB2 and enhancing EphB2 levels or function with drugs might be of benefit in Alzheimer's disease," Mucke says.</p>
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<p>Although humans share many characteristics with mice, promising findings in animal models don’t always translate to humans. Nevertheless, this study represents a step forward in understanding how memory loss may occur in Alzheimer's disease, and hints at how that loss might be prevented or treated.</p>
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<p>—Allison Bierly, Ph.D.</p>
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</div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nia.nih.gov/alzheimers" target="_top">Alzheimer’s Disease</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/broader-role-amyloids" target="_top">A Broader Role for Amyloids</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/molecule-dissolves-fibers-found-alzheimers-disease-patients" target="_top">Molecule Dissolves Fibers Found in Alzheimer’s Disease Patients</a></li></ul>
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<h3 class="block__title">About NIH Research Matters</h3>
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<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
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<p><strong>Assistant Editors:</strong> Vicki Contie and Brian Doctrow, Ph.D.</p>
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<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
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<p>ISSN 2375-9593</p>
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