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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2012-04-30T00:00:00-04:00" class="date-display-single">April 30, 2012</span></p><div class='syndicate'><h1>Compound Points to Potential Autism Therapy</h1><div class="media-float-right"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
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<picture title="A mouse sniffing another in a cage">
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/research-matters/2012/20120430-autism.jpg?itok=IejnuVfI&timestamp=1433258380 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2012/20120430-autism.jpg?itok=0Ozhglxl&timestamp=1433258380 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2012/20120430-autism.jpg?itok=fWLUKXuF&timestamp=1433258380 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2012/20120430-autism.jpg?itok=W1CzCf2m&timestamp=1433258380 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2012/20120430-autism.jpg?itok=lXA3HR2k&timestamp=1433258380 1x" media="screen and (min-width: 0)" />
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<!--[if IE 9]></video><![endif]-->
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2012/20120430-autism.jpg?itok=0Ozhglxl&timestamp=1433258380" alt="A mouse sniffing another in a cage." title="A mouse sniffing another in a cage" />
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</picture><span class="caption">A mouse pays a social visit to a novel animal.</span><span class="credit">Drs. MuYang and Jacqueline Crawley, NIMH Laboratory of Behavioral Neuroscience.</span></div>
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</div><p>An experimental compound reversed certain autism-like behaviors in mice. The finding may lead to a new strategy for treating autism spectrum disorders (ASD).</p>
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<p>ASD includes several related brain disorders with symptoms ranging from mild to severe. People with ASD generally have trouble with social interactions and repetitive behaviors. There's no proven cure, but treating ASD early with specific behavioral interventions can reduce symptoms.</p>
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<p>Past studies have linked the brain's glutamate neurotransmitter system to ASD. Glutamate is used by nerve cells in the brain to communicate. It also plays an important role in wiring up the brain during early development.</p>
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<p>Drugs that target a glutamate receptor called mGluR5 are now in clinical trials for fragile X syndrome, the most common form of inherited intellectual and developmental disabilities. About 30% of patients with fragile X syndrome meet the diagnostic criteria for autism. A research team led by Dr. Jacqueline Crawley of NIH's National Institute of Mental Health (NIMH) reasoned that the mGluR5 receptor might be a potential target for ASD therapies.</p>
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<p>To test their hunch, the scientists examined the effects of an mGluR5 inhibitor in a naturally occurring inbred strain of mice, called BTBR, that displays autism-like behaviors. Like children with ASD, BTBR mice interact and communicate relatively less with each other and engage in repetitive behaviors, such as spending an inordinate amount of time grooming. The mGluR5 inhibitor, called GRN-529, was developed by Pfizer, whose scientists also participated in the study. Results appeared on April 25, 2012, in <em>Science Translational Medicine</em>.</p>
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<p>The researchers found that BTBR mice injected with GRN-529 showed reduced levels of repetitive self-grooming. They also spent more time around—and sniffing nose-to-nose with—a novel mouse. Similar doses of GRN-529 almost completely stopped the repetitive jumping that characterizes another strain of mice called C58/J.</p>
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<p>“Our findings suggest a strategy for developing a single treatment that could target multiple diagnostic symptoms,” Crawley says.</p>
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<p>Genomic studies suggest that many cases of autism are caused by mutations in genes that control the formation and maturation of synapses, the connections between neurons. “Since defects in these connections are not immutably hard-wired,” Crawley says, “the core symptoms of autism may be treatable with medications.”</p>
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</div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="http://www.nimh.nih.gov/health/topics/autism-spectrum-disorders-pervasive-developmental-disorders/index.shtml" target="_top">Autism Spectrum Disorders</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/largest-ever-search-autism-genes-reveals-new-clues" target="_top">Largest-Ever Search for Autism Genes Reveals New Clues</a></li><li><a href="https://www.nichd.nih.gov/health/topics/fragilex/Pages/default.aspx" target="_top">Fragile X Syndrome</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Negative%20Allosteric%20Modulation%20of%20the%20mGluR5%20Receptor%20Reduces%20Repetitive%20Behaviors%20and%20Rescues%20Social%20Deficits%20in%20Mouse%20Models%20of%20Autism">Sci Transl Med.</a> 2012 Apr 25;4(131):131ra51.</p>
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<h3 class="block__title">About NIH Research Matters</h3>
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<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
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<p><strong>Assistant Editors:</strong> Vicki Contie and Brian Doctrow, Ph.D.</p>
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<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
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<p>ISSN 2375-9593</p>
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