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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2014-07-14T00:00:00-04:00" class="date-display-single">July 14, 2014</span></p><div class='syndicate'><h1>Protein Critical to Cilia Development</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
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<li>Researchers gained insights into a key protein involved in forming cilia—hair-like extensions found on cells throughout the body.</li>
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<li>The finding adds to our knowledge about ciliopathies, a class of genetic disorders that arise from defects in the structure or function of cilia.</li>
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2014/20140714-cilia-lowres.jpg?itok=0YC1dDQ8&timestamp=1431438097 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2014/20140714-cilia-lowres.jpg?itok=Mq434xFB&timestamp=1431438097 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2014/20140714-cilia-lowres.jpg?itok=R5BQbYo1&timestamp=1431438097 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2014/20140714-cilia-lowres.jpg?itok=1acf7_iA&timestamp=1431438097 1x" media="screen and (min-width: 0)" />
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2014/20140714-cilia-lowres.jpg?itok=0YC1dDQ8&timestamp=1431438097" alt="Cilia in liver cells." title="Cilia in liver cells" />
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</picture><span class="caption">Liver cells from wild-type embryos (left) and embryos lacking Cc2d2a (right) show cilia in green (arrowheads point to examples). Cilia were underdeveloped or absent in embryos without Cc2d2a.</span><span class="credit">Image by the researchers, courtesy of Nature Communications</span></div>
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</div><p>Some single-celled creatures have structures called motile cilia that beat rhythmically to allow the cells to move. Motile cilia are also found in larger organisms, including people. For example, motile cilia are on cells that line the trachea, where their coordinated wave-like motions carry mucus—along with the inhaled dust, bacteria, and other small particles it contains—toward the mouth to be coughed or sneezed out of the body.</p>
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<p>Cilia that aren’t involved in movement are called primary cilia. These cilia are responsible for cell communication. They also play a key role in the receptor cells of sensory systems. For example, they’re essential for odor detection in the nose and light reception in the eye.</p>
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<p>Defects in genes that are involved in cilia development or function can cause complicated syndromes, called ciliopathies, that involve multiple organs and tissues. Bardet-Biedl and Joubert syndromes are ciliopathies with many symptoms that may include deafness, kidney disease, and retina degeneration. Meckel syndrome is a ciliopathy so dangerous that babies with the genetic defect rarely make it to term.</p>
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<p>Researchers have identified several genes that are essential to form and maintain cilia. One important gene involved in ciliopathies is <em>CC2D2A</em>. The <em>CC2D2A </em>protein was thought to be a structural protein needed for cilia growth, but its precise functions have been unclear. The protein is part of a complex structure called the basal body, from which cilia grow.</p>
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<p>To investigate CC2D2A function, a team led by Drs. Shobi Veleri and Anand Swaroop at NIH’s National Eye Institute (NEI) developed mice lacking the mouse version of the gene, <em>Cc2d2a</em>. The study appeared online in <em>Nature Communications</em> on June 20, 2014.</p>
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<p>The researchers found that mice without<em> Cc2d2a</em> were unable to develop past the early embryo stage. An examination of tissues in early development revealed few to no cilia. The findings suggest that <em>Cc2d2a </em>plays a critical role early in development. Looking closely at where the cilia should exist, the researchers saw that the supporting structures needed for cilia to grow were either completely missing or abnormal.</p>
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<p>The absence of <em>Cc2d2a</em> affected genes and proteins involved in the development of many mouse tissues, including sonic hedgehog, a key signaling protein. Other experiments showed that CC2D2A is part of structures called subdistal appendages, which help anchor the basal body at the cell membrane to stabilize cilia and allow them to form.</p>
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<p>“This gene appears to play a key role in building structural support for the development of the cilia. Without this support, cilia are prevented from anchoring in the cell,” Swaroop says. “It’s like trying to build a house without a foundation. It’s a big structural defect.” Further study of how these proteins function could yield insights into the impact that cilia defects cause throughout the body.</p>
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</div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="http://www.nih.gov/researchmatters/october2012/10012012smell.htm" target="_top">Gene Therapy Restores Sense of Smell in Mice</a></li><li><a href="http://rarediseases.info.nih.gov/gard/6866/bardet-biedl-syndrome/more-about-this-disease" target="_top">Bardet-Biedl Syndrome</a></li><li><a href="http://www.ninds.nih.gov/disorders/joubert/joubert.htm" target="_top">Joubert Syndrome Information Page</a></li><li><a href="http://rarediseases.info.nih.gov/gard/6802/joubert-syndrome/resources/1" target="_top">Joubert Syndrome</a></li><li><a href="http://rarediseases.info.nih.gov/gard/3436/resources/resources/1" target="_top">Meckel Syndrome</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong>a href="http://www.ncbi.nlm.nih.gov/pubmed/24947469"> Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis. Veleri S, Manjunath SH, Fariss RN, May-Simera H, Brooks M, Foskett TA, Gao C, Longo TA, Liu P, Nagashima K, Rachel RA, Li T, Dong L, Swaroop A. <em>Nat Commun</em>. 2014 Jun 20;5:4207. doi: 10.1038/ncomms5207. PMID: 24947469.</p><p class="footnote"><strong class="label-inline">Funding: </strong>NIH’s National Eye Institute (NEI) and National Cancer Institute (NCI).</p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-can-we-slow-aging">Research in Context: Can we slow aging?</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/brain-changes-observed-during-pregnancy">Brain changes observed during pregnancy</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/risk-future-burden-dementia-united-states">Risk and future burden of dementia in the United States </a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/complete-wiring-map-adult-fruit-fly-brain">Complete wiring map of an adult fruit fly brain</a></p>
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<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
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<p><strong>Assistant Editors:</strong> Vicki Contie and Brian Doctrow, Ph.D.</p>
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<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
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