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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/nih-research-matters">NIH Research Matters</a></div> <div class="l-region l-region--section-header">
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2020-10-20T00:00:00-04:00" class="date-display-single">October 20, 2020</span></p><div class='syndicate'><h1>Final report confirms remdesivir benefits for COVID-19</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
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<ul>
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<li>The antiviral remdesivir shortened recovery time for patients hospitalized with COVID-19, based on results from the completed trial.</li>
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<li>Researchers are now testing remdesivir in combination with antibodies and other medications. </li>
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</ul></div><div class="media-float-right"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/research-matters/2020/20201020-covid.jpg?itok=D6Oj5QPb&timestamp=1603197819 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2020/20201020-covid.jpg?itok=EYYGAYzj&timestamp=1603197819 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2020/20201020-covid.jpg?itok=2PcxMDHm&timestamp=1603197819 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2020/20201020-covid.jpg?itok=MyHiF1Om&timestamp=1603197819 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2020/20201020-covid.jpg?itok=H9FYBcfa&timestamp=1603197819 1x" media="screen and (min-width: 0)" />
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2020/20201020-covid.jpg?itok=EYYGAYzj&timestamp=1603197819" alt="Medical team in protective equipment checking on female patient who is lying in a hospital bed wearing a surgical mask over a breathing device" title="Medical team in protective equipment checking on female patient in hospital bed" />
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</picture><span class="caption">Final results of a treatment trail confirmed that remdesivir speeds recovery for hospitalized patients with severe COVID-19. </span><span class="credit">Xavierarnau / E+ via Getty Images</span></div>
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</div><p>Remdesivir is an antiviral medication that targets a range of viruses. It was originally developed over a decade ago to treat hepatitis C and a cold-like virus called respiratory syncytial virus (RSV). Remdesivir wasn’t an effective treatment for either disease. But it showed promise against other viruses.</p>
|
||
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||
<p>Researchers tested remdesivir in clinical trials during the Ebola outbreak. Other investigational medications worked better, but it was shown to be safe for patients. Studies in cells and animals suggested that remdesivir was effective against viruses in the coronavirus family, such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS).</p>
|
||
|
||
<p>Remdesivir works by interrupting production of the virus. Coronaviruses have genomes made up ribonucleic acid (RNA). Remdesivir interferes with one of the key enzymes the virus needs to replicate RNA. This prevents the virus from multiplying.</p>
|
||
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||
<p>Researchers began a randomized, controlled trial of the antiviral in February 2020 to test whether remdesivir could be used to treat SARS-CoV-2, the coronavirus that causes COVID-19. By April, <a href="https://www.nih.gov/news-events/nih-research-matters/early-results-show-benefit-remdesivir-covid-19">early results</a> indicated that remdesivir accelerated recovery for hospitalized patients with severe COVID-19. It became the first drug to receive emergency use authorization from the U.S. Food and Drug Administration (FDA) to treat people hospitalized with COVID-19.</p>
|
||
|
||
<p>Researchers have now completed the trial, known as the Adaptive COVID-19 Treatment Trial (ACTT-1). The study was funded by the National Institute of Allergy and Infectious Diseases (NIAID). The final report appeared in the<em> New England Journal of Medicine</em> on October 8, 2020.</p>
|
||
|
||
<p>Scientists randomly assigned 1,062 hospitalized COVID-19 patients to receive remdesivir or a placebo plus standard treatment. The patients received an intravenous infusion of remdesivir or placebo for up to 10 days.</p>
|
||
|
||
<p>The final results showed that the antiviral treatment was beneficial, consistent with the preliminary findings. Patients who received remdesivir were quicker to recover, which was defined as being medically stable enough to be discharged from the hospital. The median recovery time was 10 days with remdesivir compared to 15 days for the placebo group. Patients given remdesivir were more likely to have improved by day 15.</p>
|
||
|
||
<p>Remdesivir also improved mortality rates for those receiving supplemental oxygen (4% with remdesivir versus 13% with placebo at day 29 of treatment). All-cause mortality among all patients was 11% with remdesivir and 15% with placebo at day 29, but this difference between the treatment groups was not large enough to rule out chance. The preliminary findings hadn’t shown an effect on mortality.</p>
|
||
|
||
<p>The study also suggested that remdesivir treatment may prevent patients from progressing to more severe respiratory disease. Those treated with remdesivir were less likely to need high levels of respiratory support. Remdesivir appeared to most benefit patients who were receiving supplemental oxygen.</p>
|
||
|
||
<p>“Our findings show that remdesivir is a beneficial treatment for patients with COVID-19,” says study author Dr. John Beigel of NIAID. “It may also help to conserve scarce health care resources, such as ventilators, during this pandemic.”</p>
|
||
|
||
<p>The findings show that remdesivir alone isn’t a sufficient treatment for all patients but does provide some benefit. Studies are underway to evaluate remdesivir in combination with other therapies. </p>
|
||
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||
<p>—by Erin Bryant</p>
|
||
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||
<p><em>*Editor's Note: This story was modified soon after publication to clarify the mortality rate results.</em></p></div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/early-results-show-benefit-remdesivir-covid-19" target="_top">Early Results Show Benefit of Remdesivir for COVID-19</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/sars-cov-2-may-use-key-carbohydrate-infect-cells" target="_top">SARS-CoV-2 May Use Key Carbohydrate to Infect Cells</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/computer-designed-proteins-may-protect-against-coronavirus" target="_top">Computer-designed Proteins May Protect Against Coronavirus</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/immune-cells-common-cold-may-recognize-sars-cov-2" target="_top">Immune Cells for Common Cold May Recognize SARS-CoV-2</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/potent-neutralizing-antibodies-target-new-regions-coronavirus-spike" target="_top">Potent Neutralizing Antibodies Target New Regions of Coronavirus Spike</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/experimental-coronavirus-vaccine-safe-produces-immune-response" target="_top">Experimental Coronavirus Vaccine is Safe and Produces Immune Response</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/potent-antibodies-found-people-recovered-covid-19" target="_top">Potent Antibodies Found in People Recovered from COVID-19</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/unique-genomic-features-fatal-coronaviruses" target="_top">Unique Genomic Features of Fatal Coronaviruses</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/cancer-drug-may-reduce-symptoms-severe-covid-19" target="_top">Cancer Drug May Reduce Symptoms of Severe COVID-19</a></li><li><a href="https://www.nih.gov/coronavirus" target="_top">Coronavirus (COVID-19)</a></li><li><a href="https://www.coronaviruspreventionnetwork.org/" target="_top">Coronavirus Prevention Network</a></li><li><a href="https://www.coronavirus.gov/" target="_top">Coronavirus (COVID-19) (CDC)</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/32445440/">Remdesivir for the Treatment of Covid-19 - Final Report.</a> Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, Finberg RW, Dierberg K, Tapson V, Hsieh L, Patterson TF, Paredes R, Sweeney DA, Short WR, Touloumi G, Lye DC, Ohmagari N, Oh MD, Ruiz-Palacios GM, Benfield T, Fätkenheuer G, Kortepeter MG, Atmar RL, Creech CB, Lundgren J, Babiker AG, Pett S, Neaton JD, Burgess TH, Bonnett T, Green M, Makowski M, Osinusi A, Nayak S, Lane HC; ACTT-1 Study Group Members. <em>N Engl J Med.</em> 2020 Oct 8:NEJMoa2007764. doi: 10.1056/NEJMoa2007764. Online ahead of print. PMID: 32445440.</p><p class="footnote"><strong class="label-inline">Funding: </strong>NIH’s National Institute of Allergy and Infectious Diseases (NIAID) and National Cancer Institute (NCI); Department of Defense; governments of Denmark, Japan, Mexico, and Singapore; Seoul National University Hospital; United Kingdom Medical Research Council.</p>
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