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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/research-training">Research & Training</a> » <a href="/research-training/medical-research-initiatives">Medical Research Initiatives</a> » <a href="/research-training/medical-research-initiatives/cures">Cures</a> » <a href="/rmi">RMI</a></div> <div class="l-region l-region--section-header">
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<h2><a href="/rmi">Regenerative Medicine Innovation Project</a></h2> </div>
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<h1>Funded Awards</h1><div class="collapsible collapsible-with-controls">
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<h3 class="collapsible-trigger">FY 2023 Funded Awards</h3>
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<div class="collapsible-content">
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<p>NIH is pleased to announce the research awards funded through the NIH Regenerative Medicine Innovation Project (RMIP) for this year. The awardees funded by the RMIP in FY 2023 include:</p>
|
||
|
||
<p><strong>Late Stage Investigational New Drug (IND) - or Investigational Device Exemption (IDE) Enabling Pre-clinical Studies:</strong></p>
|
||
|
||
<p><strong>University of Miami School of Medicine, Florida</strong><br />
|
||
Joshua M. Hare, M.D. <br />
|
||
Full-scale GMP Production for a Pre-Clinical Systemic Delivered Mesenchymal Stem Cells Derived Extracellular Vesicles For Cardiovascular Disease<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/R3jmxdIDekij8H_8xIHquA/project-details/10721103">1U01HL169362-01</a></p>
|
||
|
||
<p><strong>Clemson University, South Carolina</strong><br />
|
||
Ying Mei, Ph.D.<br />
|
||
Nanowired human isogenic cardiac organoids to treat acute myocardial ischemia/reperfusion injuries<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/rRuQ4XQrw0eLCYpAq1_HeQ/project-details/10721208">1U01HL169361-01 </a> </p>
|
||
|
||
<p><strong>University of Pittsburgh, Pennsylvania</strong><br />
|
||
Hin-Fai Yam, Ph.D.<br />
|
||
Cell Therapy Program with Scale-up cGMP Manufacturing of Human Corneal Stromal Stem Cells<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/eHWHdMmYmEKOnYbdG-3Lcg/project-details/10720562">1U01EY035252-01</a></p>
|
||
|
||
<p><strong>University of Colorado Boulder, Colorado</strong><br />
|
||
Corey P. Neu, Ph.D.<br />
|
||
Development and Translation of Granulated Human-Derived Biomaterials for Integrative Cartilage Repair<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/QD6Kj7jhFkaJmI3QJF236w/project-details/10718170">1U01AR082845-01</a></p>
|
||
|
||
<p><strong>Early Phase Clinical Trials:</strong></p>
|
||
|
||
<p><strong>University of Colorado Denver, Colorado</strong><br />
|
||
Dennis Roop, Ph.D.<br />
|
||
Study of the Safety, Tolerability, and Efficacy of an iPS Cell-based Therapy for Recessive Dystrophic Epidermolysis Bullosa Delivered with a Spray on Skin Device<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/JTWOSm-6QU-o6K8tMpYA7g/project-details/10721324">1UG3AR082887-01</a></p>
|
||
|
||
<p><strong>Medical University of South Carolina, South Carolina</strong><br />
|
||
Hongjun Wang, Ph.D<br />
|
||
Safety and Efficacy of Mesenchymal Stem Cells in the Treatment of Chronic Pancreatitis and Its Associated Pain<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/-5574GrEcUOONwb76YF5HA/project-details/10721284">1UG3DK136705-01</a></p>
|
||
|
||
<p><strong>Clinical Trial Planning Grant:</strong></p>
|
||
|
||
<p><strong>University of Wisconsin Madison, Wisconsin</strong><br />
|
||
Randall J. Kimple, M.D., Ph.D<br />
|
||
Planning a phase I study of minor salivary gland derived autologous MSCs for prevention of long-term radiation induced xerostomia<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/wOgUOhUb8ECrFVrOPNSuqA/project-details/10720234">1R34DE033042-01</a></p>
|
||
|
||
<p> </p>
|
||
</div>
|
||
|
||
<h3 class="collapsible-trigger">FY 2021 Funded Awards</h3>
|
||
|
||
<div class="collapsible-content">
|
||
<p><strong>The awardees funded by the Regenerative Medicine Innovation Project (RMIP) in FY 2021 include:</strong></p>
|
||
|
||
<p><strong>Johns Hopkins University, Maryland</strong><br />
|
||
Luis Andres Garza, M.D., Ph.D.<br />
|
||
Injection of Autologous Volar Fibroblasts to the Stump Site to Allow Pressure Adaptation and Enhanced Prosthetic Use in Amputees<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/EDg540xPfUWkDjn5E_bGWQ/project-details/10276515">1UG3AR079376-01</a></p>
|
||
</div>
|
||
|
||
<h3 class="collapsible-trigger">FY 2020 Funded Awards</h3>
|
||
|
||
<div class="collapsible-content">
|
||
<p><strong>The awardees funded by the Regenerative Medicine Innovation Project (RMIP) in FY 2020 include:</strong></p>
|
||
|
||
<p><strong>Regenerative Research Foundation, New York</strong><br />
|
||
Jeffrey H. Stern, M.D., Ph.D.<br />
|
||
Phase 1/2a Clinical Trial of RPESC-Derived RPE Transplantation As Therapy For Non-Exudative Age-Related Macular Degeneration<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=10044560&icde=52218924&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=">1UG3EY031810-01</a></p>
|
||
|
||
<p><strong>University of Illinois at Chicago, Illinois</strong><br />
|
||
Ali R. Djalilian, M.D.<br />
|
||
Phase I Study Of Mesenchymal Stromal Cell Secretome For Promoting Corneal Regeneration<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=10044927&icde=52219054&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=">1UG3EY031809-01</a></p>
|
||
|
||
<p><strong>Steadman Philippon Research Institute, Colorado</strong><br />
|
||
Johnny Huard, Ph.D.<br />
|
||
The Use Of Senolytic And Anti-Fibrotic Agents To Improve The Beneficial Effect Of Bone Marrow Stem Cells For Osteoarthritis<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=10044832&icde=52219089&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=">1UG3AR077748-01</a></p>
|
||
</div>
|
||
|
||
<h3 class="collapsible-trigger">FY 2019 Funded Awards</h3>
|
||
|
||
<div class="collapsible-content">
|
||
<p>NIH is pleased to announce the research awards funded through the NIH Regenerative Medicine Innovation Project (RMIP) for this year. The awardees funded by the RMIP in FY 2019 include:</p>
|
||
|
||
<p><strong>Late Stage Investigational New Drug (IND) - or Investigational Device Exemption (IDE) Enabling Pre-clinical Studies:</strong></p>
|
||
|
||
<p><strong>Boston University Medical Campus, Massachusetts</strong><br />
|
||
Darrell N. Kotton, M.D.<br />
|
||
Generation of Functional Lung Stem Cells from Human IPSCS<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9811053&icde=45721182&ddparam=&ddvalue=&ddsub=&cr=3&csb=default&cs=ASC&pball=">1U01HL148692-01</a></p>
|
||
|
||
<p><strong>Columbia University, New York</strong><br />
|
||
Stephen H. Tsang, M.D., Ph.D.<br />
|
||
Precision genome surgery in autologous stem cell transplant<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9811117&icde=45961196&ddparam=&ddvalue=&ddsub=&cr=7&csb=default&cs=ASC&pball=">1U01EY030580-01 </a> </p>
|
||
|
||
<p><strong>Mayo Clinic Rochester, Minnesota</strong><br />
|
||
lan D. Marmorstein, Ph.D.<br />
|
||
Preclinical testing of iPSC derived retinal pigment epithelium to treat macular degeneration<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9809069&icde=45961196&ddparam=&ddvalue=&ddsub=&cr=4&csb=default&cs=ASC&pball=">1U01EY030547-01</a></p>
|
||
|
||
<p><strong>Neural Stem Cell Institute, New York</strong><br />
|
||
Jeffrey H. Stern, M.D., Ph.D.<br />
|
||
Transplantation of Adult, Tissue-Specific RPE Stem Cells as Therapy for Non-exudative Age-Related Macular Degeneration AMD<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9811094&icde=45961196&ddparam=&ddvalue=&ddsub=&cr=6&csb=default&cs=ASC&pball=">1U01EY030581-01</a></p>
|
||
|
||
<p><strong>University of Colorado Denver, Colorado</strong><br />
|
||
Dennis Roop, Ph.D.<br />
|
||
Exploring Alternative iPS Cell Therapies for Recessive Dystrophic Epidermolysis Bullosa<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9811321&icde=45961196&ddparam=&ddvalue=&ddsub=&cr=5&csb=default&cs=ASC&pball=">1U01AR075932-01</a></p>
|
||
|
||
<p><strong>University of Wisconsin-Madison, Wisconsin</strong><br />
|
||
Timothy J. Kamp, M.D., Ph.D<br />
|
||
Committed Cardiac Progenitors to Remuscularize the Failing Ischemic Heart<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9811091&icde=45721182&ddparam=&ddvalue=&ddsub=&cr=2&csb=default&cs=ASC&pball=">1U01HL148690-01</a></p>
|
||
|
||
<p><strong>Wake Forest University, North Carolina</strong><br />
|
||
Graca Duarte Almeida-Porada, M.D., Ph.D<br />
|
||
CGMP Manufacture of FVIII-Expressing Placental Cells for Hemophilia A<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9811291&icde=45721182&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=">1U01HL148681-01</a></p>
|
||
|
||
<p><strong>Early Phase Clinical Trial:</strong></p>
|
||
|
||
<p><strong>The Research Institute at Nationwide Children's Hospital, Ohio</strong><br />
|
||
Christopher K. Breuer, M.D.<br />
|
||
A Study Evaluating the Safety and Efficacy of Second-Generation Tissue Engineered Vascular Grafts (TEVG2)<br />
|
||
GRANT Number: <a href="https://reporter.nih.gov/search/1V4QxqEgKUmG1YggXu9WGg/project-details/9811036">1-UG3-HL-148693-01</a></p>
|
||
</div>
|
||
|
||
<h3 class="collapsible-trigger">FY 2017 Funded Awards</h3>
|
||
|
||
<div class="collapsible-content">
|
||
<p>In September 2017, eight research proposals involving adult stem cells were selected for funding through the RMIP. These projects cover a broad spectrum of science and new technologies, and have the potential to advance understanding and treatment of common diseases – including diabetes, anemia, corneal and other eye diseases, and chronic skin ulcers -- as well as rare diseases, including idiopathic pulmonary fibrosis, inherited skin diseases, and sickle cell disease.</p>
|
||
|
||
<p>Several awards explored the use of adult stem cells to make specialized cells and tissues that could help reduce the need for whole organ transplants or otherwise restore normal function. Others aimed to develop reliable methods of generating red blood cells and platelets in the lab to improve the safety and supply of blood available for transfusion.</p>
|
||
|
||
<p><strong>The awardees funded by the Regenerative Medicine Innovation Project in FY 2017 include:</strong></p>
|
||
|
||
<p><strong>Albert Einstein College of Medicine, New York</strong><br />
|
||
Eric E. Bouhassira, Ph.D.<br />
|
||
Optimization of Reagent Red Blood Cell Production<br />
|
||
GRANT Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9513857&icde=36197415">5-R01-H-130764-04</a></p>
|
||
|
||
<p><strong>Boston Children’s Hospital, Massachusetts </strong><br />
|
||
Markus H. Frank, M.D.<br />
|
||
ABCB5-Positive Stem Cells for Limbal Stem Cell Deficiency (LSCD) Therapy<br />
|
||
Grant Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9516675&icde=36197722">3-R01-EY-025794-02</a></p>
|
||
|
||
<p><strong>Children’s Hospital of Philadelphia, Pennsylvania </strong><br />
|
||
Mortimer Poncz, M.D.<br />
|
||
Optimization of Ex Vivo- and In Vivo-Generated Platelets<br />
|
||
Grant Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9515429&icde=36195970">5-R01-HL-130698-03</a></p>
|
||
|
||
<p><strong>Columbia University Health Sciences, New York</strong><br />
|
||
Hans-Willem E. Snoeck, M.D., Ph.D.<br />
|
||
Modeling, pathogenesis and treatment of idiopathic pulmonary fibrosis<br />
|
||
Grant Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9516638&icde=36196926">5-U01-HL-134760-02</a></p>
|
||
|
||
<p><strong>Harvard University, Cambridge, Massachusetts</strong><br />
|
||
Douglas A Melton, Ph.D.<br />
|
||
Production of Clinical-Grade Diabetes Patient-Specific Induced Pluripotent Stem Cell Lines Intended for Autologous Beta Cell Replacement Therapy<br />
|
||
Grant Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9516419&icde=36195274">3-UC4-DK-104165-01</a></p>
|
||
|
||
<p><strong>Maine Medical Center, Maine </strong><br />
|
||
Leif Oxburgh, D.V.M., Ph.D.<br />
|
||
Engineering Erythropoietin-Producing Cells<br />
|
||
Grant Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9516535&icde=36196122">3-R24-DK-106743-03</a></p>
|
||
|
||
<p><strong>University of Colorado Denver, Colorado</strong><br />
|
||
Dennis Roop, Ph.D.<br />
|
||
Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases<br />
|
||
Grant Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9516699&icde=36194767">3-R01-AR-059947-05</a></p>
|
||
|
||
<p><strong>Yale University, Connecticut</strong><br />
|
||
Mark W. Saltzman, Ph.D.<br />
|
||
Optimizing Therapeutic Revascularization by Endothelial Cell Transplantation<br />
|
||
Grant Number: <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9516109&icde=36196309">5-R01-HL-085416-12</a></p>
|
||
|
||
<h4><strong>2017 Regenerative Medicine Innovation Workshop</strong></h4>
|
||
|
||
<p>This workshop, hosted in December 2017 by NIH and FDA, brought together key stakeholders to explore the state of regenerative medicine clinical research involving adult stem cells with a focus on approaches to the development of safe and effective products. <a href="https://www.youtube.com/playlist?list=PL_ntiNjc6GvlOyKQ_j6RTWgahqzmt6nj3" target="_blank">Video recordings (link is external)</a> from each session are available. The deliberations were instrumental in helping to identify some of the major needs, opportunities, and challenges in the regenerative medicine field.</p>
|
||
|
||
<p>Participants identified a number of critical challenges in RM, including:</p>
|
||
|
||
<ul class="spaced">
|
||
<li>Limited understanding of the identity and nature of stem cell products used in clinical applications;</li>
|
||
<li>The need for effective methods for tracking and monitoring stem cell products <em>in vivo</em>; the need for regulatory “coaching” support to enable submission of well-supported IND/IDE applications;</li>
|
||
<li>Difficulties in obtaining assistance with preparation of current Good Manufacturing Practice (cGMP)-compliant stem cell products;</li>
|
||
<li>The need for improved data sharing; and</li>
|
||
<li>The importance of forging key RM partnerships and collaborations.</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="lastupdated">
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<p>This page last reviewed on September 10, 2024</p> </div> </div>
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