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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2019-02-05T00:00:00-05:00" class="date-display-single">February 5, 2019</span></p><div class='syndicate'><h1>Ebola antibody treatment tested in people</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
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<ul>
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<li>A treatment for Ebola developed from a survivor’s protective antibody was found safe in a study of healthy volunteers at the NIH Clinical Center.</li>
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<li>The treatment is now being studied in the current Ebola outbreak in the Democratic Republic of the Congo.</li>
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</ul></div><div class="media-float-right"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
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<picture title="Ebola Virus Experimental Treatment">
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<!--[if IE 9]><video style="display: none;"><![endif]-->
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/research-matters/2019/20190205-ebola.jpg?itok=mEHvJFvB&timestamp=1549379451 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2019/20190205-ebola.jpg?itok=re2ft-Dr&timestamp=1549379451 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2019/20190205-ebola.jpg?itok=XdUbPnkX&timestamp=1549379451 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2019/20190205-ebola.jpg?itok=poISMB9g&timestamp=1549379451 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2019/20190205-ebola.jpg?itok=sLIfK284&timestamp=1549379451 1x" media="screen and (min-width: 0)" />
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2019/20190205-ebola.jpg?itok=re2ft-Dr&timestamp=1549379451" alt="Ebola Virus Experimental Treatment." title="Ebola Virus Experimental Treatment" />
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</picture><span class="caption">A healthy volunteer receives an infusion of mAb114—an experimental treatment for Ebola virus disease—at the NIH Clinical Center.</span><span class="credit">NIAID</span></div>
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</div><p>The Ebola virus causes severe illness and is often fatal. Early symptoms include fever, headache, body aches, weakness, stomach pain, and lack of appetite. Later, it can cause vomiting, diarrhea, and severe bleeding. No treatments have been approved yet, but supportive care can improve survival.</p>
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||
<p>Ebola outbreaks in Africa are challenging settings to deliver treatments, but researchers have made progress evaluating potential therapies. ZMapp, which is a combination of three proteins called monoclonal antibodies that were made in the lab, seems to help protect against death. ZMapp was tested during an outbreak from 2014-2016, but not enough people could be treated during the outbreak to establish whether ZMapp is more effective than supportive care.</p>
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<p>Dr. Nancy J. Sullivan and colleagues at NIH’s National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center developed a similar monoclonal antibody called mAb114 that was derived from the blood of an Ebola survivor. It can bind to the virus and prevent it from entering cells. Unlike ZMapp and other treatments undergoing testing, mAb114 is a single antibody rather than a combination. Also, one infusion, rather than several over multiple days, protected Ebola-infected rhesus monkeys from death. In addition, the freeze-dried form of mAb114 is easier than previous treatments to store.</p>
|
||
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||
<p>After mAb114 showed effectiveness in monkeys, a team led by Dr. Julie E. Ledgerwood, head of the clinical trials program at the Vaccine Research Center, set out to evaluate whether mAb114 is safe to use in people. Eighteen healthy adults received mAb114 at the NIH Clinical Center. Results appeared in the <em>Lancet</em> on January 24, 2019.</p>
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||
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||
<p>After monitoring for side effects for 6 months, the researchers found that mAb114 was safe and well tolerated. The volunteers did not report any serious side effects. Mild reactions included headache (in four people), chills (in two), nausea (in two), and joint pain (in two). In addition, none of the volunteers developed an immune reaction against mAb114.</p>
|
||
|
||
<p>In November 2018, researchers in the Democratic Republic of the Congo began to compare several test treatments, including mAb114 and ZMapp. The projected end date for testing is 2023.</p>
|
||
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||
<p>“Combatting Ebola requires a comprehensive response that draws on the strengths of all areas of public health,” says NIAID Director Dr. Anthony S. Fauci. “Through scientifically and ethically sound clinical trials, we hope to efficiently and definitively establish the safety and efficacy of these investigational Ebola treatments, offering new ways to save lives.”</p></div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/antibodies-ebola-survivor-could-lead-treatments-vaccines" target="_top">Antibodies from Ebola Survivor Could Lead to Treatments and Vaccines</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/antibody-cures-animals-ebola-related-viruses" target="_top">Antibody Cures Animals of Ebola-Related Viruses</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/experimental-ebola-antibody-protects-monkeys" target="_top">Experimental Ebola Antibody Protects Monkeys</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/progress-two-ebola-vaccines" target="_top">Progress on Two Ebola Vaccines</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/ebola-vaccine-candidate-promising-early-study" target="_top">Ebola Vaccine Candidate Promising in Early Study</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/lipid-nanoparticle-therapeutic-treats-ebola-monkeys" target="_top">Lipid Nanoparticle Therapeutic Treats Ebola in Monkeys</a></li><li><a href="https://www.niaid.nih.gov/diseases-conditions/ebola-marburg" target="_top">Ebola & Marburg</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/30686586">Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study</a>. Gaudinski MR, Coates EE, Novik L, Widge A, Houser KV, Burch E, Holman LA, Gordon IJ, Chen GL, Carter C, Nason M, Sitar S, Yamshchikov G, Berkowitz N, Andrews C, Vazquez S, Laurencot C, Misasi J, Arnold F, Carlton K, Lawlor H, Gall J, Bailer RT, McDermott A, Capparelli E, Koup RA, Mascola JR, Graham BS, Sullivan NJ, Ledgerwood JE; VRC 608 Study team. <em>Lancet.</em> 2019 Jan 24. pii: S0140-6736(19)30036-4. doi: 10.1016/S0140-6736(19)30036-4. [Epub ahead of print]. PMID: 30686586.</p><p class="footnote"><strong class="label-inline">Funding: </strong>NIH’s National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center and the Defense Advanced Research Projects Agency.</p>
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<div about="/block/research-matters---popular-stori" class="ds-1col entity entity-bean bean-research-matters-block view-mode-default clearfix">
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-can-we-slow-aging">Research in Context: Can we slow aging?</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/brain-changes-observed-during-pregnancy">Brain changes observed during pregnancy</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-detecting-cancer">Research in Context: Detecting cancer</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/risk-future-burden-dementia-united-states">Risk and future burden of dementia in the United States </a></p>
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||
|
||
<p><a href="https://www.nih.gov/news-events/nih-research-matters/complete-wiring-map-adult-fruit-fly-brain">Complete wiring map of an adult fruit fly brain</a></p>
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<h3 class="block__title">About NIH Research Matters</h3>
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<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
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<p><strong>Assistant Editors:</strong> Vicki Contie and Brian Doctrow, Ph.D.</p>
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<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
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<p>ISSN 2375-9593</p>
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