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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/news-releases">News Releases</a></div> <div class="l-region l-region--section-header">
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<div about="/news-events/news-releases/nih-researchers-rescue-photoreceptors-prevent-blindness-animal-models-retinal-degeneration" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-news-release news-release featured-media-floated view-mode-full node--full node--nih-news-release--full clearfix">
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<p class="publishdate"><span class="tag-term">News Release</span></p><p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2019-01-16T14:00:00-05:00" class="date-display-single">Wednesday, January 16, 2019</span></p><h1>NIH researchers rescue photoreceptors, prevent blindness in animal models of retinal degeneration</h1><p class="subtitle">
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Findings set stage for first clinical trial of stem cell-based therapeutic approach for AMD.</p><div class="featured-media"><div class="ds-1col file file-image file-image-jpeg view-mode-featured_media clearfix">
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<picture title="Image of a blood cell turning into an induced pluripotent stem cell and then an RPE cell">
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<!--[if IE 9]><video style="display: none;"><![endif]-->
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-large-extra/public/news-events/news-releases/2019/20190116-nei-how-ispc-works_0.JPG?itok=gXzwv1np&timestamp=1547571451 1x" media="screen and (min-width: 1100px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-large/public/news-events/news-releases/2019/20190116-nei-how-ispc-works_0.JPG?itok=PEij2fD0&timestamp=1547571451 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/news-events/news-releases/2019/20190116-nei-how-ispc-works_0.JPG?itok=BOcLQcdS&timestamp=1547571451 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium-small/public/news-events/news-releases/2019/20190116-nei-how-ispc-works_0.JPG?itok=-ISUKVky&timestamp=1547571451 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-small/public/news-events/news-releases/2019/20190116-nei-how-ispc-works_0.JPG?itok=5QDWm8P_&timestamp=1547571451 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media__breakpoint-tiny_/public/news-events/news-releases/2019/20190116-nei-how-ispc-works_0.JPG?itok=D2YL5r1s&timestamp=1547571451 1x" media="screen and (min-width: 0)" />
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<!--[if IE 9]></video><![endif]-->
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<img src="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/news-events/news-releases/2019/20190116-nei-how-ispc-works_0.JPG?itok=BOcLQcdS&timestamp=1547571451" alt="Image of a blood cell turning into an induced pluripotent stem cell and then an RPE cell" title="Image of a blood cell turning into an induced pluripotent stem cell and then an RPE cell" />
|
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</picture><span class="caption">The researchers will take a patient’s own blood cells, and in a lab, convert them into iPS cells capable of becoming any type of cell in the body. The iPS cells are then programmed to become retinal pigment epithelial cells, the type of cell that dies early in the geographic atrophy form of AMD. </span><span class="credit">NEI</span></div>
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||
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</div><p>Using a novel patient-specific stem cell-based therapy, researchers at the National Eye Institute (NEI) prevented blindness in animal models of geographic atrophy, the advanced "dry" form of age-related macular degeneration (AMD), which is a leading cause of vision loss among people age 65 and older. The protocols established by the animal study, published January 16 in Science Translational Medicine (STM), set the stage for a first-in-human clinical trial testing the therapy in people with geographic atrophy, for which there is currently no treatment.</p>
|
||
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||
<p>"If the clinical trial moves forward, it would be the first ever to test a stem cell-based therapy derived from induced pluripotent stem cells (iPSC) for treating a disease," said Kapil Bharti, Ph.D., a Stadtman Investigator and head of the NEI Unit on Ocular and Stem Cell Translational Research. Bharti was the lead investigator for the animal-model study published in STM. The NEI is part of the National Institutes of Health.</p>
|
||
|
||
<p>The therapy involves taking a patient’s blood cells and, in a lab, converting them into iPS cells, which can become any type of cell in the body. The iPS cells are programmed to become retinal pigment epithelial cells, the type of cell that dies early in the geographic atrophy stage of macular degeneration. RPE cells nurture photoreceptors, the light-sensing cells in the retina. In geographic atrophy, once RPE cells die, photoreceptors eventually also die, resulting in blindness. The therapy is an attempt to shore up the health of remaining photoreceptors by replacing dying RPE with iPSC-derived RPE.</p>
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/news-releases/2019/20190116-nei-rpe-sem-on-scaffold.jpg?itok=IHxHPO0E&timestamp=1547572550 1x" media="screen and (min-width: 960px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/news-releases/2019/20190116-nei-rpe-sem-on-scaffold.jpg?itok=mUUN2hJx&timestamp=1547572550 1x" media="screen and (min-width: 800px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/news-releases/2019/20190116-nei-rpe-sem-on-scaffold.jpg?itok=g5C8mYx-&timestamp=1547572550 1x" media="screen and (min-width: 600px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/news-releases/2019/20190116-nei-rpe-sem-on-scaffold.jpg?itok=__plJCzB&timestamp=1547572550 1x" media="screen and (min-width: 480px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/news-releases/2019/20190116-nei-rpe-sem-on-scaffold.jpg?itok=ci4HRHOw&timestamp=1547572550 1x" media="screen and (min-width: 0)"></source>
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<!--[if IE 9]></video><![endif]-->
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<img class="media-element" src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/news-releases/2019/20190116-nei-rpe-sem-on-scaffold.jpg?itok=mUUN2hJx&timestamp=1547572550" alt="Microscopic image of polarized RPE monolayer on a biodegradable scaffold" title="Microscopic image of polarized RPE monolayer on a biodegradable scaffold" />
|
||
</picture><span class="caption">A scanning electron micrograph image shows a polarized RPE monolayer on a biodegradable scaffold. The image is colored to highlight the scaffold in blue, three RPE cells (brown), and the apical process of cells in RPE monolayer are light green.</span><span class="credit">NEI</span></div>
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</div></div>
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<p>Before they are transplanted, the iPSC-derived RPE are grown in tiny sheets one cell thick, replicating their natural structure within the eye. This monolayer of iPSC-derived RPE is grown on a biodegradable scaffold designed to promote the integration of the cells within the retina. A specially designed surgical tool was built for the task of inserting the patch of cells between the RPE and the photoreceptors.</p>
|
||
|
||
<p>In the STM paper, Bharti describes testing the approach in rat and pig models. Ten weeks after the human iPSC-derived RPE patches were implanted in the animals’ retinas, imaging studies confirmed that the lab-made cells had integrated within the animal retina.</p>
|
||
|
||
<p>The investigators report the transplanted cells functioned properly. Immunostaining confirmed that the iPSC-derived RPE expressed the gene RPE65, suggesting the lab-made cells had reached a crucial stage of maturity necessary to maintain photoreceptor health. RPE65 is necessary for the regeneration of visual pigment within the photoreceptors and is an essential component for vision.</p>
|
||
|
||
<p>Further tests showed that the transplanted RPE cells were pruning photoreceptors via phagocytosis, another RPE function that helps keep photoreceptors healthy. In addition, electrical responses recorded from photoreceptors rescued by RPE patches were normal; whereas photoreceptors treated with a control empty scaffold had died.</p>
|
||
|
||
<p>The animal studies inform the processes for conducting a first-in-human clinical trial testing the treatment. Key to that workflow are good manufacturing practice (GMP) protocols, which were established to ensure that the iPSC-derived RPE were a safe and efficacious, clinical-grade product. GMP protocols are also crucial for making the therapy reproducible, a requirement for scaling up production and Food and Drug Administration approval.</p>
|
||
|
||
<p>"Adhering to the protocols helps ensure that the transplanted cells function reliably, and that unintended consequences are minimized," Bharti said.</p>
|
||
|
||
<p>A key concern with any stem cell therapy is its oncogenic potential: the ability for cells to multiply uncontrollably and form tumors. The researchers genetically analyzed the iPSC-derived RPE cells and found no genetic mutations linked to tumor growth.</p>
|
||
|
||
<p>"The protocol also minimizes the chance of rejection by developing the iPSC-RPE with an individual’s autologous (own) blood cells," Bharti said.</p>
|
||
|
||
<p>The planning of a Phase I clinical trial testing the safety of the iPSC-based therapy for geographic atrophy is underway and will be initiated after U.S. Food and Drug Administration approval.</p>
|
||
|
||
<p>The preclinical study was funded by the NEI Intramural Research Program and by an NIH Common Fund Therapeutic Challenge Award.</p>
|
||
|
||
<p>NEI leads the federal government’s research on the visual system and eye diseases. NEI supports basic and clinical science programs to develop sight-saving treatments and address special needs of people with vision loss. For more information, visit <a href="https://www.nei.nih.gov">https://www.nei.nih.gov</a>.</p><p><strong>About the National Institutes of Health (NIH):</strong>
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NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <a href="/">www.nih.gov</a>.</p>
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<p class="slogan"><em>NIH…Turning Discovery Into Health<sup>®</sup></em></p><div about="/field-collection/field-additional-info/33046" class="ds-1col entity entity-field-collection-item field-collection-item-field-additional-info view-mode-full clearfix">
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<h3>Reference</h3><p>Sharma R, Khristov V, Rising A, Jha BS, Dejene R, Hotaling N, Li Y, Stoddard J, Stankewicz C, Wan Q, Zhang C, Campos MM, Miyagishima KJ, McGaughey D, Vilasmil R, Mattapallil M, Stanzel B, Qian H, Wong W, Chase L, Charles S, McGill T, Miller S, Maminishikis A, Amaral J, Bharti K, “Patient-specific clinical-grade iPS cell-derived retinal pigment epithelium patch rescues retinal degeneration in rodent and pig eyes.” January 16, 2019 <em>Science Translational Medicine</em>.</p></div>
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