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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2017-10-31T00:00:00-04:00" class="date-display-single">October 31, 2017</span></p><div class='syndicate'><h1>Hydrogel-grown tissues speed wound healing in mouse colon</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
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<ul>
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<li>Researchers designed an injectable hydrogel that grew intestine-like tissues and accelerated wound healing in the intestines of mice.</li>
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<li>These findings suggest new treatments to explore for intestinal injuries caused by diseases such as inflammatory bowel disease.</li>
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</ul></div><div class="media-float-right"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
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<picture title="Human intestinal organoids in mouse intestine">
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<!--[if IE 9]><video style="display: none;"><![endif]-->
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/research-matters/2017/20171031-wound-healing.jpg?itok=avCN_x8-&timestamp=1509397395 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2017/20171031-wound-healing.jpg?itok=BLZJLEEo&timestamp=1509397395 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2017/20171031-wound-healing.jpg?itok=ZOxBIIYE&timestamp=1509397395 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2017/20171031-wound-healing.jpg?itok=nwMnUaed&timestamp=1509397395 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2017/20171031-wound-healing.jpg?itok=VMcnAf7C&timestamp=1509397395 1x" media="screen and (min-width: 0)" />
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<!--[if IE 9]></video><![endif]-->
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2017/20171031-wound-healing.jpg?itok=BLZJLEEo&timestamp=1509397395" alt="Human intestinal organoids in mouse intestine" title="Human intestinal organoids in mouse intestine" />
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||
</picture><span class="caption">After transplantation into an animal, human intestinal organoids differentiate into mature intestinal tissue with specialized cell types, such as enteroendocrine cells (red). </span><span class="credit">Miguel Quirós, University of Michigan</span></div>
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||
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||
</div><p>Engineered organ-like structures, called organoids, have the potential to repair or replace tissue that is damaged or diseased. Organoids are grown by bringing together stem cells, scaffolds made of biomaterials, and biologically active molecules. With the right mixture, these can combine to assemble functional tissues.</p>
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||
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<p>To engineer specific tissues, scaffolds must contain the proper combination of proteins, stem cells, and growth factors. Scaffold materials must also be carefully formulated to minimize potential toxic effects.</p>
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||
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||
<p>Matrigel is a commonly used scaffold that is derived from animal cells. This gel presents clinical challenges, though, because it could potentially transfer animal diseases. Hydrogels are a synthetically made, flexible material that can also serve as a scaffold and may be safer for clinical use.</p>
|
||
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||
<p>A research team led by Dr. Andrés J. García at Georgia Institute of Technology and Drs. Asma Nusrat and Jason Spence at the University of Michigan compared hydrogel-grown versus Matrigel-grown intestine-like organoids in mice. The study was funded in part by NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and other NIH components. Results were published online on October 23, 2017 in <em>Nature Cell Biology</em>.</p>
|
||
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||
<p>The team first created hydrogels using different chemical formulations of polymers to see which supported the growth of human intestinal organoids in the lab. They then compared the hydrogel that best supported organoid growth with Matrigel. Organoid growth and proliferation were similar between the two scaffolds.</p>
|
||
|
||
<p>Hydrogel-grown and Matrigel-grown human intestinal organoids were then implanted into the kidneys of mice. Both developed, or differentiated, into tissue that resembled mature human intestine after twelve weeks.</p>
|
||
|
||
<p>The hydrogel was formulated as a solution that could be injected before solidifying. This allowed the gel to be delivered using an endoscope, a flexible tube and camera that can be inserted into the intestine. The researchers injected the hydrogel into wounded colons of mice. The gel engrafted to the intestine, where intestine-like tissue developed and helped heal the wound.</p>
|
||
|
||
<p>“In this work, we demonstrated that the hydrogels facilitate the transplantation of [human intestinal organoids] into an injured intestine, suggesting that this technique has significant implications for treating intestinal injuries caused by diseases such as inflammatory bowel disease,” Nusrat explains.</p>
|
||
|
||
<p>“This work provides a proof of principle for using stem cell-derived human intestinal organoids in a therapeutic setting.” García says.</p>
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<p>—Tianna Hicklin, Ph.D.</p></div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/stem-cells-grown-scaffold-mimic-hip-joint-cartilage" target="_top">Stem Cells Grown on Scaffold Mimic Hip Joint Cartilage</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/stem-cells-coaxed-create-working-blood-vessels" target="_top">Stem Cells Coaxed To Create Working Blood Vessels</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/liver-stem-cells-discovered-mice" target="_top">Liver Stem Cells Discovered in Mice</a></li><li><a href="https://newsinhealth.nih.gov/2015/02/fixing-flawed-body-parts" target="_top">Fixing Flawed Body Parts</a></li><li><a href="https://newsinhealth.nih.gov/2015/03/better-check-your-bowels" target="_top">Better Check Your Bowels</a></li><li><a href="https://newsinhealth.nih.gov/2012/02/grumbling-guts" target="_top">Grumbling Guts? </a></li><li><a href="https://www.niddk.nih.gov/health-information/digestive-diseases/irritable-bowel-syndrome/definition-facts" target="_top">Irritable Bowel Syndrome </a></li><li><a href="https://www.nibib.nih.gov/science-education/science-topics/tissue-engineering-and-regenerative-medicine" target="_top">Tissue Engineering and Regenerative Medicine</a></li><li><a href="https://stemcells.nih.gov/info/basics.htm" target="_top">Stem Cell Basics</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/29058719">Synthetic hydrogels for human intestinal organoid generation and colonic wound repair.</a> Cruz-Acuña R, Quirós M, Farkas AE, Dedhia PH, Huang S, Siuda D, García-Hernández V, Miller AJ, Spence JR, Nusrat A, García AJ. <em>Nat Cell Biol</em>. 2017 Oct 23. doi: 10.1038/ncb3632. [Epub ahead of print] PMID: 29058719.</p><p class="footnote"><strong class="label-inline">Funding: </strong>NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), and National Center for Advancing Translational Sciences (NCATS); Regenerative Engineering and Medicine Research Center between Emory University, Georgia Tech, and the University of Georgia; National Science Foundation; Alfred P. Sloan Foundation; Crohn’s and Colitis Foundation of America; and the János Bolyai Research Fellowship.</p>
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NIH Research Matters<br />
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Bldg. 31, Rm. 5B52, MSC 2094<br />
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Bethesda, MD 20892-2094</p></div>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-can-we-slow-aging">Research in Context: Can we slow aging?</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/brain-changes-observed-during-pregnancy">Brain changes observed during pregnancy</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-detecting-cancer">Research in Context: Detecting cancer</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/risk-future-burden-dementia-united-states">Risk and future burden of dementia in the United States </a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/complete-wiring-map-adult-fruit-fly-brain">Complete wiring map of an adult fruit fly brain</a></p>
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<h3 class="block__title">About NIH Research Matters</h3>
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<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
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<p><strong>Assistant Editors:</strong> Vicki Contie and Brian Doctrow, Ph.D.</p>
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<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
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