579 lines
46 KiB
Text
579 lines
46 KiB
Text
<!DOCTYPE html>
|
||
<html class="no-js" lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ rdfs: http://www.w3.org/2000/01/rdf-schema# sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema#">
|
||
<head>
|
||
<title>Protein involved in hearing loss recovery | National Institutes of Health (NIH)</title>
|
||
<meta charset="utf-8" />
|
||
<script type="text/javascript">
|
||
//<![CDATA[
|
||
var usasearch_config = { siteHandle:"nih" };
|
||
|
||
var script = document.createElement("script");
|
||
script.type = "text/javascript";
|
||
script.src = "//search.usa.gov/javascripts/remote.loader.js";
|
||
document.getElementsByTagName("head")[0].appendChild(script);
|
||
|
||
//]]>
|
||
</script><link rel="shortcut icon" href="https://www.nih.gov/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
<meta name="google-site-verification" content="rjIoO4vW0AYgltSYvxM1L_CzGIkq28kHf9gHIASKx8s" />
|
||
<link rel="profile" href="http://www.w3.org/1999/xhtml/vocab" />
|
||
<meta http-equiv="cleartype" content="on" />
|
||
<link rel="apple-touch-icon" href="https://www.nih.gov/sites/all/themes/nih/apple-touch-icon.png" />
|
||
<meta name="description" content="A study with mice found that a protein called FOXO3 is involved in recovery from noise-induced hearing loss. The results suggest new potential treatments approaches." />
|
||
<meta name="keywords" content="Noise-induced hearing loss, NIHL, hair cell, Forkhead Box O3, Foxo3, stereocilia, Patricia White, Scientific Reports" />
|
||
<meta name="robots" content="follow, index" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<meta name="generator" content="Drupal 7 (http://drupal.org)" />
|
||
<link rel="canonical" href="https://www.nih.gov/news-events/nih-research-matters/protein-involved-hearing-loss-recovery" />
|
||
<link rel="shortlink" href="https://www.nih.gov/node/33956" />
|
||
<meta http-equiv="content-language" content="EN" />
|
||
<meta property="og:site_name" content="National Institutes of Health (NIH)" />
|
||
<meta property="og:type" content="article" />
|
||
<meta property="og:title" content="Protein involved in hearing loss recovery" />
|
||
<meta property="og:url" content="https://www.nih.gov/news-events/nih-research-matters/protein-involved-hearing-loss-recovery" />
|
||
<meta property="og:description" content="A study with mice found that a protein called FOXO3 is involved in recovery from noise-induced hearing loss. The results suggest new potential treatments approaches." />
|
||
<meta property="og:updated_time" content="2018-02-22T10:07:09-05:00" />
|
||
<meta property="og:image" content="https://www.nih.gov/sites/default/files/news-events/research-matters/2017/20170509-hearing.jpg" />
|
||
<meta name="twitter:card" content="summary_large_image" />
|
||
<meta name="twitter:url" content="https://www.nih.gov/news-events/nih-research-matters/protein-involved-hearing-loss-recovery" />
|
||
<meta name="twitter:title" content="Protein involved in hearing loss recovery" />
|
||
<meta name="twitter:description" content="A study with mice found that a protein called FOXO3 is involved in recovery from noise-induced hearing loss. The results suggest new potential treatments approaches." />
|
||
<meta name="twitter:image" content="https://www.nih.gov/sites/default/files/news-events/research-matters/2017/20170509-hearing.jpg" />
|
||
<meta property="article:published_time" content="2017-05-08T14:49:27-04:00" />
|
||
<meta property="article:modified_time" content="2018-02-22T10:07:09-05:00" />
|
||
<meta name="owner" content="OD" />
|
||
<meta name="published_date" content="2017-05-08T14:49:27-04:00" />
|
||
<meta name="last_revision" content="2018-02-22T10:07:09-05:00" />
|
||
<link type="text/css" rel="stylesheet" href="https://www.nih.gov/sites/default/files/css/css_PfvPCWanzn7FjDwZqwAHhPoOxYKwkQP-RZSK1pFFG0s.css" media="all" />
|
||
<link type="text/css" rel="stylesheet" href="https://www.nih.gov/sites/default/files/css/css__mIWP9gcStq74isjZVoAAsiih8VXwJoN75Nyw_BXrj0.css" media="screen" />
|
||
<style media="print">#sb-container{position:relative;}#sb-overlay{display:none;}#sb-wrapper{position:relative;top:0;left:0;}#sb-loading{display:none;}
|
||
</style>
|
||
<link type="text/css" rel="stylesheet" href="https://www.nih.gov/sites/default/files/css/css_jENQOQqZCRFGZK__DTefxYiXR2RUf03k1ugj3_Vg7vk.css" media="all" />
|
||
<link type="text/css" rel="stylesheet" href="//cdn.jsdelivr.net/qtip2/3.0.3/jquery.qtip.min.css" media="all" />
|
||
<link type="text/css" rel="stylesheet" href="https://www.nih.gov/sites/default/files/css/css_3yt-b0M1HNJsvKsXwYjh5TEtX2lJGAvJvtmVAfORYZs.css" media="all" />
|
||
<link type="text/css" rel="stylesheet" href="//fonts.googleapis.com/css?family=Droid+Sans:700,regular|Droid+Serif:italic,regular&subset=latin" media="all" />
|
||
<link type="text/css" rel="stylesheet" href="https://www.nih.gov/sites/default/files/css/css_E4VlyxyL3JMcT6dslWLGb0uQdoI2bh_Xj0N65V-bcWo.css" media="all" />
|
||
<link type="text/css" rel="stylesheet" href="https://www.nih.gov/sites/default/files/css/css_5rDMv37-JxnNA70cRr_1jlAjVs56DCb8EN4XB2QLl0c.css" media="all" />
|
||
|
||
<!--[if lte IE 8]>
|
||
<link type="text/css" rel="stylesheet" href="https://www.nih.gov/sites/default/files/css/css_aLJB_yHt22A_mQek4IRDNsur5tEkCpqLe72j_w6QHQ0.css" media="all" />
|
||
<![endif]-->
|
||
<link type="text/css" rel="stylesheet" href="https://www.nih.gov/sites/default/files/css/css_KviiBystpJcQq4MplcQZvCFxnu9V763f5bPq_AKh4xM.css" media="all" />
|
||
<script src="https://www.nih.gov/sites/default/files/js/js_mQAv54bz2JVXcwS5QWlz0fVY9Os67zeu9bgNqtlVLPY.js"></script>
|
||
<script src="//code.jquery.com/jquery-2.2.4.min.js"></script>
|
||
<script>window.jQuery || document.write("<script src='/sites/all/modules/contrib/jquery_update/replace/jquery/2.2/jquery.min.js'>\x3C/script>")</script>
|
||
<script>jQuery.migrateMute=true;jQuery.migrateTrace=false;</script>
|
||
<script src="//code.jquery.com/jquery-migrate-1.4.1.min.js"></script>
|
||
<script>window.jQuery && window.jQuery.migrateWarnings || document.write("<script src='/sites/all/modules/contrib/jquery_update/replace/jquery-migrate/1.4.1/jquery-migrate.min.js'>\x3C/script>")</script>
|
||
<script src="https://www.nih.gov/sites/default/files/js/js_9sGTPBGcOGZjLiSLGrYEnuUf8VdvLmL_DEZNNNbnHXk.js"></script>
|
||
<script src="https://www.nih.gov/sites/default/files/js/js_hNnF7a_sbk6nZ2-mOamHzalYND7HBHDLRInsaU93HDk.js"></script>
|
||
<script>document.createElement( "picture" );</script>
|
||
<script src="https://www.nih.gov/sites/default/files/js/js_gHk2gWJ_Qw_jU2qRiUmSl7d8oly1Cx7lQFrqcp3RXcI.js"></script>
|
||
<script src="//cdn.jsdelivr.net/qtip2/3.0.3/jquery.qtip.min.js"></script>
|
||
<script defer="defer" src="//script.crazyegg.com/pages/scripts/0011/2616.js"></script>
|
||
<script src="https://www.nih.gov/sites/default/files/js/js_3s0l7MQ3oYmGkNAypyzCJq3a0wT85XX_P1SLgnph5K4.js"></script>
|
||
<script>
|
||
Shadowbox.path = "/sites/all/libraries/shadowbox/";
|
||
</script>
|
||
<script>jQuery.extend(Drupal.settings, {"basePath":"\/","pathPrefix":"","setHasJsCookie":0,"instances":"{\u0022default\u0022:{\u0022content\u0022:{\u0022text\u0022:\u0022\u0022},\u0022style\u0022:{\u0022tip\u0022:false,\u0022classes\u0022:\u0022\u0022},\u0022position\u0022:{\u0022at\u0022:\u0022bottom right\u0022,\u0022adjust\u0022:{\u0022method\u0022:\u0022\u0022},\u0022my\u0022:\u0022top left\u0022,\u0022viewport\u0022:false},\u0022show\u0022:{\u0022event\u0022:\u0022mouseenter \u0022},\u0022hide\u0022:{\u0022event\u0022:\u0022mouseleave \u0022}}}","qtipDebug":"{\u0022leaveElement\u0022:0}","shadowbox":{"animate":true,"animateFade":true,"animSequence":"wh","auto_enable_all_images":1,"auto_gallery":1,"autoplayMovies":true,"continuous":false,"counterLimit":10,"counterType":"default","displayCounter":true,"displayNav":true,"enableKeys":true,"fadeDuration":0.34999999999999998,"handleOversize":"resize","handleUnsupported":"link","initialHeight":160,"initialWidth":320,"language":"en","modal":false,"overlayColor":"#000","overlayOpacity":0.80000000000000004,"resizeDuration":0.55000000000000004,"showMovieControls":true,"slideshowDelay":0,"viewportPadding":20,"useSizzle":false},"picture":{"mappings":[["Sidebar media mappings","sidebar_media_mappings"],["Floated media mappings","floated_media_mappings"],["Not Set","not_set"]],"label":"Image size (required)"},"extlink":{"extTarget":"_blank","extClass":"ext","extLabel":"(link is external)","extImgClass":0,"extIconPlacement":0,"extSubdomains":1,"extExclude":"(.\\.nih\\.gov.)|(.\\.cancer\\.gov.)|(.\\.genome\\.gov.)|(.\\.drugabuse\\.gov.)|(locatorplus\\.gov.)|(.\\.govdelivery\\.com.)|(.\\.hatchbuck\\.com.)|(nihseniorhealth\\.gov.)|(clinicaltrials\\.gov.)|(search\\.usa\\.gov\\\/search\\?affiliate\\=hip.)|(search\\.gov\\\/search\\?affiliate\\=hip.)|(drugabuse\\.gov.)|(medlineplus\\.gov.)|(collegedrinkingprevention\\.gov.)|(smokefree\\.gov.)|(arpa-h\\.gov.)|(nih\\.sharepoint\\.com)","extInclude":"(.\\.pagefreezer\\.com.)","extCssExclude":".media, .emergency-message, .slideshow-main, .bean-home-slideshow-2l-block","extCssExplicit":"","extAlert":"_blank","extAlertText":"You are leaving the NIH website.\r\n\r\nThis external link provides additional information that is consistent with the intended purpose of this site. NIH cannot attest to the accuracy of a non-federal site.\r\n\r\nLinking to a non-federal site does not constitute an endorsement by NIH or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site\u2019s privacy policy when you follow the link.","mailtoClass":"mailto","mailtoLabel":"(link sends e-mail)","extUseFontAwesome":0}});</script>
|
||
|
||
<script type="application/javascript" id="uws-snippet">
|
||
// Verint Unified WebSDK Integration Snippet v2.3
|
||
//
|
||
// Instructions: please embed this snippet directly into every page of your website template.
|
||
// For optimal performance, this should be embedded directly into the template, not referenced as
|
||
// an external file.
|
||
//
|
||
// DO NOT MODIFY BELOW THIS LINE *****************************************
|
||
(function () {
|
||
var cookies = document.cookie.split("; ").reduce(function (o, i) { var p = i.split("="); o[p[0]] = p[1]; return o; }, {});
|
||
var containerValue = cookies.uws_container_override && JSON.parse(decodeURIComponent(cookies.uws_container_override));
|
||
var config = {
|
||
moduleHost: "ucm-us.verint-cdn.com",
|
||
configHost: "ucm-us.verint-cdn.com",
|
||
siteKey: "nih-gov",
|
||
container: containerValue || "live",
|
||
loadTime: Date.now()
|
||
};
|
||
var readyCallbacks = []; window.uwsReady = function (callback) { readyCallbacks.push(callback); };
|
||
var sdkPath = "//" + [config.moduleHost, "files/sites", config.siteKey, config.container, "sdk.js"].join("/");
|
||
var script = document.createElement("script"); script.src = sdkPath; script.async = true; script.type = "module";
|
||
script.addEventListener("load", function () { window.unifiedSDK.start(config, readyCallbacks); });
|
||
document.head.appendChild(script);
|
||
})();
|
||
// DO NOT MODIFY ABOVE THIS LINE *****************************************
|
||
</script>
|
||
|
||
</head>
|
||
<body class="html not-front not-logged-in page-node page-node- page-node-33956 node-type-nih-research-matters section navigation-nih-research-matters section-news-events">
|
||
<a href="#main-content" class="element-invisible element-focusable">Skip to main content</a>
|
||
<noscript aria-hidden="true"><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5CBCNW2" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
||
<div class="l-page has-one-sidebar has-sidebar-second">
|
||
|
||
<div class="l-page-content">
|
||
|
||
<header class="l-header" role="banner">
|
||
<div class="l-ribbon-wrapper">
|
||
<ul class="l-ribbon">
|
||
<li><span class="ribbon-hhs"></span><a href="https://www.hhs.gov">U.S. Department of Health & Human Services</a><span class="ribbon-right"></span></li>
|
||
</ul>
|
||
</div> <div class="l-banner-wrapper">
|
||
<div class="l-banner">
|
||
<div class="l-branding">
|
||
<a class="nih-logo icon-nih-logo" href="/" title="National Institutes of Health (NIH) - Turning Discovery into Health" rel="home"><img src="/sites/all/themes/nih/images/nih-logo-color.png" width="390" height="60" alt="National Institutes of Health (NIH) - Turning Discovery into Health" /></a>
|
||
</div>
|
||
<!-- DigitalGov Search -->
|
||
<form accept-charset="UTF-8" action="https://search.nih.gov/search" id="search" class="search-form site-search" method="get">
|
||
<div style="margin:0;padding:0;display:inline"><input name="utf8" type="hidden" value="✓" /></div>
|
||
<input id="affiliate" name="affiliate" type="hidden" value="nih" />
|
||
<label for="query" class="hide">Search the NIH Website</label>
|
||
<input autocomplete="on" class="usagov-search-autocomplete form-field form-field-site-search" id="query" name="query" type="text" placeholder="Search NIH" /><input type="submit" name="commit" value="Search" class="form-button form-button-site-search" />
|
||
</form>
|
||
<ul class="banner-utilities">
|
||
<li><a href="/virtual-tour">Virtual Tour</a></li>
|
||
<li><a href="https://ned.nih.gov/">Staff Directory</a></li>
|
||
<li><a href="https://salud.nih.gov">En Español</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</header>
|
||
|
||
<div class="l-navigation-wrapper">
|
||
<!-- ****************** SITE MENU ****************** -->
|
||
<h2 class="element-invisible">Site Menu</h2>
|
||
<nav class="l-menu-wrapper">
|
||
<ul class="l-menu">
|
||
<!-- ********* HOME TAB (Mobile view only) ********* -->
|
||
<li class="tab-wrapper tab-wrapper-home">
|
||
<div class="tab home"><a href="/"><span>Home</span></a></div>
|
||
</li>
|
||
<!-- ********* HEALTH INFO TAB ********* -->
|
||
<li class="tab-wrapper tab-wrapper-healthinfo tab-wrapper-left">
|
||
<div class="tab"><a href="/health-information"><span>Health Information</span></a></div>
|
||
<div class="megamenu">
|
||
<div class="megamenu-col megamenu-leftcol">
|
||
<ul class="sub-menu">
|
||
<li><a href="https://www.hhs.gov/programs/social-services/health-care-facilities/index.html">Health Care Providers & Facilities</a></li>
|
||
<li><a href="/health-information/health-info-lines">Health Info Lines</a></li>
|
||
<li><a href="https://www.healthcare.gov">HealthCare.gov</a></li>
|
||
<li><a href="/research-training/science-education">Science Education Resources</a></li>
|
||
<li><a href="/health-information/nih-clinical-research-trials-you">NIH Clinical Research Trials and You</a></li>
|
||
<li><a href="/institutes-nih/nih-office-director/office-communications-public-liaison/clear-communication/talking-your-doctor">Talking to Your Doctor</a></li>
|
||
<!--<li><a href="/institutes-nih/nih-office-director/office-communications-public-liaison/clear-communication/clear-health-nih" title="">Clear Health A–Z</a></li>-->
|
||
</ul>
|
||
<p class="more-wrapper"><a class="button gold" href="/health-information" title="More Health Information">More »</a></p>
|
||
</div>
|
||
<div class="megamenu-col megamenu-rightcol">
|
||
<form id="hipsearch" accept-charset="UTF-8" action="https://search.nih.gov/search" method="get" class="search-form">
|
||
<p class="subhead"><label for="query2">Search Health Topics</label></p>
|
||
<div class="input-wrapper">
|
||
<div style="margin:0;padding:0;display:inline"><input name="utf8" type="hidden" value="✓" /></div>
|
||
<input id="affiliate" name="affiliate" type="hidden" value="hip" />
|
||
<input type="hidden" name="dc" value="940" />
|
||
<input autocomplete="on" maxlength="50" class="usagov-search-autocomplete form-field form-field-search" id="query2" name="query" type="text" />
|
||
<input name="commit" type="submit" value="Go" id="searchbutton" class="form-button" />
|
||
</div>
|
||
</form>
|
||
<p class="subhead">Quick Links</p>
|
||
<ul class="sub-menu">
|
||
<li><a class="minibadge minibadge-medlineplus" href="https://medlineplus.gov/"><span class="minibadge-text">MedlinePlus Health Info</span></a></li>
|
||
<li><a class="minibadge minibadge-newsinhealth" href="https://newsinhealth.nih.gov/"><span class="minibadge-text">NIH News in Health</span></a></li>
|
||
<li><a class="minibadge minibadge-wellnesstoolkits" href="/health-information/your-healthiest-self-wellness-toolkits"><span class="minibadge-text">Wellness Toolkits</span></a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<!-- ********* GRANTS TAB ********* -->
|
||
<li class="tab-wrapper tab-wrapper-grants tab-wrapper-left">
|
||
<div class="tab"><a href="/grants-funding"><span>Grants & Funding</span></a></div>
|
||
<div class="megamenu">
|
||
<div class="megamenu-col megamenu-leftcol">
|
||
<ul>
|
||
<li><a href="https://grants.nih.gov">Grants Home Page</a></li>
|
||
<li><a href="https://grants.nih.gov/funding/index.htm">Find Funding</a></li>
|
||
<li><a href="https://grants.nih.gov/grants/how-to-apply-application-guide/due-dates-and-submission-policies/due-dates.htm">Due Dates</a></li>
|
||
<li><a href="https://grants.nih.gov/grants/how-to-apply-application-guide.html">How to Apply</a></li>
|
||
<li><a href="https://grants.nih.gov/grants/about_grants.htm">About Grants</a></li>
|
||
<li><a href="https://grants.nih.gov/policy/index.htm">Policy & Compliance</a></li>
|
||
<li><a href="https://nexus.od.nih.gov/all/">Grants News/Blog</a></li>
|
||
<li><a href="https://grants.nih.gov/funding/contracts.htm">Contracts</a></li>
|
||
<li><a href="https://www.lrp.nih.gov/">Loan Repayment</a></li>
|
||
</ul>
|
||
<p class="more-wrapper"><a class="button gold" href="/grants-funding" title="More Grants & Funding Information">More »</a></p>
|
||
</div>
|
||
<div class="megamenu-col megamenu-rightcol">
|
||
<p class="subhead">Quick Links</p>
|
||
<ul>
|
||
<li><a class="minibadge minibadge-report" href="https://report.nih.gov/"><span class="minibadge-text">RePORT</span></a></li>
|
||
<li><a class="minibadge minibadge-era" href="https://commons.era.nih.gov/commons/"><span class="minibadge-text">eRA Commons</span></a></li>
|
||
<li><a class="minibadge minibadge-commonfund" href="https://commonfund.nih.gov/"><span class="minibadge-text">NIH Common Fund</span></a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<!-- ********* NEWS TAB ********* -->
|
||
<li class="tab-wrapper tab-wrapper-news tab-wrapper-left">
|
||
<div class="tab"><a href="/news-events"><span>News & Events</span></a></div>
|
||
<div class="megamenu">
|
||
<div class="megamenu-col megamenu-leftcol">
|
||
<ul>
|
||
<li><a href="/news-events/news-releases">News Releases</a></li>
|
||
<li><a href="/news-events/digital-media-kits">Digital Media Kits</a></li>
|
||
<li><a href="/news-events/media-resources">Media Resources</a></li>
|
||
<li><a href="/news-events/media-contacts">Media Contacts</a></li>
|
||
<li><a href="/news-events/images-b-roll">Images and B-roll</a></li>
|
||
<li><a href="/news-events/events">Events</a></li>
|
||
<li><a href="/news-events/social-media-outreach">Social Media</a></li>
|
||
</ul>
|
||
<p class="more-wrapper"><a class="button gold" href="/news-events" title="More News & Events">More »</a></p>
|
||
</div>
|
||
<div class="megamenu-col megamenu-rightcol">
|
||
<p class="subhead">Quick Links</p>
|
||
<ul>
|
||
<li><a class="minibadge minibadge-newsinhealth" href="https://newsinhealth.nih.gov/"><span class="minibadge-text">NIH News in Health</span></a></li>
|
||
<li><a class="minibadge minibadge-researchmatters" href="/news-events/nih-research-matters"><span class="minibadge-text">NIH Research Matters</span></a></li>
|
||
<li><a class="minibadge minibadge-nihrecord" href="https://nihrecord.nih.gov/"><span class="minibadge-text">NIH Record</span></a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<!-- ********* RESEARCH TAB ********* -->
|
||
<li class="tab-wrapper tab-wrapper-research tab-wrapper-right">
|
||
<div class="tab"><a href="/research-training"><span>Research & Training</span></a></div>
|
||
<div class="megamenu">
|
||
<div class="megamenu-col megamenu-leftcol">
|
||
<ul>
|
||
<li><a href="/research-training/medical-research-initiatives">Medical Research Initiatives</a></li>
|
||
<li><a href="/research-training/science-highlights">Science Highlights</a></li>
|
||
<li><a href="/research-training/science-education">Science Education</a></li>
|
||
<li><a href="/research-training/research-nih-labs-clinics">Research in NIH Labs & Clinics</a></li>
|
||
<li><a href="/research-training/training-opportunities">Training Opportunities</a></li>
|
||
<li><a href="/research-training/library-resources">Library Resources</a></li>
|
||
<li><a href="/research-training/research-resources">Research Resources</a></li>
|
||
<li><a href="/research-training/clinical-research-resources">Clinical Research Resources</a></li>
|
||
<li><a href="/research-training/safety-regulation-guidance">Safety, Regulation and Guidance</a></li>
|
||
</ul>
|
||
<p class="more-wrapper"><a class="button gold" href="/research-training" title="More Research & Training">More »</a></p>
|
||
</div>
|
||
<div class="megamenu-col megamenu-rightcol">
|
||
<p class="subhead">Quick Links</p>
|
||
<ul>
|
||
<li><a class="minibadge minibadge-pubmed" href="https://pubmed.ncbi.nlm.nih.gov"><span class="minibadge-text">PubMed</span></a></li>
|
||
<li><a class="minibadge minibadge-stemcell" href="https://stemcells.nih.gov"><span class="minibadge-text">Stem Cell Information</span></a></li>
|
||
<li><a class="minibadge minibadge-oppnet" href="https://oppnet.nih.gov"><span class="minibadge-text">OppNet</span></a></li>
|
||
<li><a class="minibadge minibadge-nidb" href="https://intramural.nih.gov"><span class="minibadge-text">NIDB</span></a></li>
|
||
<li><a class="minibadge minibadge-nihblueprint" href="https://neuroscienceblueprint.nih.gov"><span class="minibadge-text">NIH Blueprint for Neuroscience Research</span></a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<!-- ********* INSTITUTES TAB ********* -->
|
||
<li class="tab-wrapper tab-wrapper-institutes tab-wrapper-right">
|
||
<div class="tab"><a href="/institutes-nih"><span>Institutes at NIH</span></a></div>
|
||
<div class="megamenu">
|
||
<div class="megamenu-col megamenu-leftcol">
|
||
<ul>
|
||
<li><a href="/institutes-nih/list-institutes-centers">List of Institutes and Centers</a></li>
|
||
<li><a href="/institutes-nih/nih-office-director">NIH Office of the Director</a></li>
|
||
<li><a href="/institutes-nih/directors-nih-institutes-centers">Directors of NIH Institutes and Centers</a></li>
|
||
<li><a href="/institutes-nih/nih-institute-center-contact-information">NIH Institute and Center Contact Information</a></li>
|
||
</ul>
|
||
<p class="more-wrapper"><a class="button gold" href="/institutes-nih" title="More About the Institutes at NIH">More »</a></p>
|
||
</div>
|
||
<div class="megamenu-col megamenu-rightcol">
|
||
<p class="subhead">Quick Links</p>
|
||
<ul class="ic-acronymn-list">
|
||
<li><a href="https://www.cancer.gov" title="National Cancer Institute">NCI</a></li>
|
||
<li><a href="https://nei.nih.gov" title="National Eye Institute">NEI</a></li>
|
||
<li><a href="https://www.nhlbi.nih.gov" title="National Heart, Lung, and Blood Institute">NHLBI</a></li>
|
||
<li><a href="https://www.genome.gov" title="National Human Genome Research Institute">NHGRI</a></li>
|
||
<li><a href="https://www.nia.nih.gov" title="National Institute on Aging">NIA</a></li>
|
||
<li><a href="https://www.niaaa.nih.gov" title="National Institute on Alcohol Abuse and Alcoholism">NIAAA</a></li>
|
||
<li><a href="https://www.niaid.nih.gov" title="National Institute of Allergy and Infectious Diseases">NIAID</a></li>
|
||
<li><a href="https://www.niams.nih.gov" title="National Institute of Arthritis and Musculoskeletal and Skin Diseases">NIAMS</a></li>
|
||
<li><a href="https://www.nibib.nih.gov" title="National Institute of Biomedical Imaging and Bioengineering">NIBIB</a></li>
|
||
<li><a href="https://www.nichd.nih.gov" title="Eunice Kennedy Shriver National Institute of Child Health and Human Development">NICHD</a></li>
|
||
<li><a href="https://www.nidcd.nih.gov" title="National Institute on Deafness and Other Communication Disorders">NIDCD</a></li>
|
||
<li><a href="https://www.nidcr.nih.gov" title="National Institute of Dental and Craniofacial Research">NIDCR</a></li>
|
||
<li><a href="https://www.niddk.nih.gov" title="National Institute of Diabetes and Digestive and Kidney Diseases">NIDDK</a></li>
|
||
<li><a href="https://nida.nih.gov" title="National Institute on Drug Abuse">NIDA</a></li>
|
||
<li><a href="https://www.niehs.nih.gov" title="National Institute of Environmental Health Sciences">NIEHS</a></li>
|
||
<li><a href="https://www.nigms.nih.gov" title="National Institute of General Medical Sciences">NIGMS</a></li>
|
||
<li><a href="https://www.nimh.nih.gov" title="National Institute of Mental Health">NIMH</a></li>
|
||
<li><a href="https://www.nimhd.nih.gov" title="National Institute on Minority Health and Health Disparities">NIMHD</a></li>
|
||
<li><a href="https://www.ninds.nih.gov" title="National Institute of Neurological Disorders and Stroke">NINDS</a></li>
|
||
<li><a href="https://www.ninr.nih.gov" title="National Institute of Nursing Research">NINR</a></li>
|
||
<li><a href="https://www.nlm.nih.gov" title="National Library of Medicine">NLM</a></li>
|
||
<li><a href="https://www.cc.nih.gov" title="NIH Clinical Center">CC</a></li>
|
||
<li><a href="https://www.cit.nih.gov" title="Center for Information Technology">CIT</a></li>
|
||
<li><a href="https://www.csr.nih.gov" title="Center for Scientific Review">CSR</a></li>
|
||
<li><a href="https://www.fic.nih.gov" title="Fogarty International Center">FIC</a></li>
|
||
<li><a href="https://ncats.nih.gov" title="National Center for Advancing Translational Sciences">NCATS</a></li>
|
||
<li><a href="https://nccih.nih.gov" title="National Center for Complementary and Integrative Health">NCCIH</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
<!-- ********* ABOUT TAB ********* -->
|
||
<li class="tab-wrapper tab-wrapper-about tab-wrapper-right">
|
||
<div class="tab"><a href="/about-nih"><span>About NIH</span></a></div>
|
||
<div class="megamenu">
|
||
<div class="megamenu-col megamenu-leftcol">
|
||
<ul>
|
||
<li><a href="/about-nih/who-we-are">Who We Are</a></li>
|
||
<li><a href="/about-nih/what-we-do">What We Do</a></li>
|
||
<li><a href="https://hr.nih.gov/jobs">Jobs at NIH</a></li>
|
||
<li><a href="/about-nih/visitor-information">Visitor Information</a></li>
|
||
<li><a href="/about-nih/frequently-asked-questions">Frequently Asked Questions</a></li>
|
||
<li><a href="/about-nih/contact-us">Contact Us</a></li>
|
||
<!--<li><a href="/about-nih/explore-nih">Explore NIH</a></li>-->
|
||
</ul>
|
||
<p class="more-wrapper"><a class="button gold" href="/about-nih" title="More About NIH">More »</a></p>
|
||
</div>
|
||
<div class="megamenu-col megamenu-rightcol">
|
||
<p class="subhead">Quick Links</p>
|
||
<ul>
|
||
<li><a href="/about-nih/who-we-are/nih-director">The NIH Director</a></li>
|
||
<li><a href="/virtual-tour">Take the Virtual Tour</a></li>
|
||
<li><a href="/about-nih/what-we-do/nih-turning-discovery-into-health">NIH…Turning Discovery Into Health<sup>®</sup></a></li>
|
||
<li><a href="/about-nih/what-we-do/impact-nih-research">Impact of NIH Research</a></li>
|
||
<li><a href="/about-nih/what-we-do/science-health-public-trust">Science, Health, and Public Trust</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</li>
|
||
</ul>
|
||
<div class="tab-bkgnd"></div><!-- For pixel rounding issue -->
|
||
</nav>
|
||
<!-- ****************** END SITE MENU ****************** -->
|
||
</div>
|
||
|
||
<div class="l-main-wrapper">
|
||
<div class="l-main" id="page-content">
|
||
<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/nih-research-matters">NIH Research Matters</a></div> <div class="l-region l-region--section-header">
|
||
<div id="block-block-101" class="block block--block sectionheader block--block-101" id="block-block-101" class="block block--block sectionheader block--block-101">
|
||
|
||
|
||
<div class="content" class="block__content">
|
||
<h2><a href="/news-events/nih-research-matters">NIH Research Matters</a></h2> </div>
|
||
</div>
|
||
</div>
|
||
<div class="l-content-wrapper">
|
||
<div class="l-content" role="main">
|
||
<a id="main-content"></a>
|
||
<div about="/news-events/nih-research-matters/protein-involved-hearing-loss-recovery" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-research-matters view-mode-full node--full node--nih-research-matters--full clearfix">
|
||
|
||
|
||
<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2017-05-12T00:00:00-04:00" class="date-display-single">May 12, 2017</span></p><div class='syndicate'><h1>Protein involved in hearing loss recovery</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
|
||
|
||
<ul>
|
||
<li>A study with mice found that a protein called FOXO3 is involved in recovery from noise-induced hearing loss.</li>
|
||
<li>Work is in progress to further describe the networks that help protect the inner ear from permanent noise-induced damage so that potential treatments might be developed.</li>
|
||
</ul>
|
||
</div><div class="media-float-right"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
|
||
|
||
|
||
<picture title="Construction worker holding ears on building site">
|
||
<!--[if IE 9]><video style="display: none;"><![endif]-->
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/research-matters/2017/20170509-hearing.jpg?itok=EnKJCl4N&timestamp=1494334597 1x" media="screen and (min-width: 960px)" />
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2017/20170509-hearing.jpg?itok=wfEm5alb&timestamp=1494334597 1x" media="screen and (min-width: 800px)" />
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2017/20170509-hearing.jpg?itok=a9ve-qie&timestamp=1494334597 1x" media="screen and (min-width: 600px)" />
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2017/20170509-hearing.jpg?itok=vqyJontL&timestamp=1494334597 1x" media="screen and (min-width: 480px)" />
|
||
<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2017/20170509-hearing.jpg?itok=kKyWXXse&timestamp=1494334597 1x" media="screen and (min-width: 0)" />
|
||
<!--[if IE 9]></video><![endif]-->
|
||
<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2017/20170509-hearing.jpg?itok=wfEm5alb&timestamp=1494334597" alt="Construction worker holding ears on building site" title="Construction worker holding ears on building site" />
|
||
</picture><span class="caption">Loud and long-lasting sounds, or ones that are extremely loud even for a brief time, can damage sensitive structures in the inner ear and cause noise-induced hearing loss.</span><span class="credit">Highwaystarz-Photography/ iStock/Thinkstock </span></div>
|
||
|
||
</div><p>The snail-shaped cochlea is an organ in the inner ear that helps us to hear sounds. Within the cochlea, thousands of sensory cells known as hair cells are arranged in inner and outer rows. Vibrations from sound waves cause these hair cells to move up and down and create an electrical signal that travels to the brain. Long or repeated exposure to loud noises can damage and even destroy hair cells. This noise-induced hearing loss can be permanent. Millions of Americans have noise-induced hearing loss.</p>
|
||
|
||
<p>Currently, devices such as assistive listening devices and hearing aids are used to help people with hearing loss. However, these don’t restore hearing and aren’t a cure. Because some people are more vulnerable than others to noise-induced hearing loss, researchers have sought to understand the genetic factors and mechanisms that may be protective. Ultimately, they hope these findings will lead to the development of treatments that can restore hearing.</p>
|
||
|
||
<p>A team led by Dr. Patricia White of the University of Rochester previously showed that a protein called Forkhead Box O3 (FOXO3) is expressed in both inner and outer hair cells. FOXO3 is a transcription factor—a type of protein that plays a role in gene regulation. Upon noise exposure, FOXO3 travels into the hair cell nucleus, suggesting it might play a role in the protective response to noise-induced damage. To test this hypothesis, the scientists used mice that had been genetically modified to lack the gene for FOXO3. The study was supported in part by NIH’s National Institute on Deafness and Other Communication Disorders (NIDCD). Results were published on April 21, 2017, in <em>Scientific Reports</em>.</p>
|
||
|
||
<p>The scientists first explored the effect of noise on hearing. For 30 minutes, two-month-old mice were exposed to 105 decibels, equivalent to a personal stereo at maximum volume. Thirty-five mice had FOXO3 and 36 did not. Before the loud noise, both groups of mice had the same ability to hear the five high frequencies tested (8, 12, 16, 24, and 32 KHz). One day afterward, the researchers found that the mice lacking FOXO3 had become profoundly deaf. The mice with FOXO3 also had hearing loss, but it was far less severe. Two weeks afterward, the mice lacking FOXO3 continued to have severe hearing loss, but the normal mice seemed to mostly recover their hearing. </p>
|
||
|
||
<p>The team examined the effect of noise on structural damage to hair cells and other parts of the cochlea. They found that FOXO3 is needed for outer hair cell survival after loud noise. They linked the hearing loss in the FOXO3-deficient mice with outer hair cell loss and structural damage. Inner hair cells survived and appeared to be relatively undamaged. Finally, the scientists found FOXO3 in cochlear hair cells from a human cadaver, supporting the idea that it may also play a role in human hearing.</p>
|
||
|
||
<p>“Discovering that FOXO3 was important for the survival of outer hair cells is a significant advance,” White says. “We are also excited about the results because FOXO3 is a transcription factor, which regulates the expression of many target genes. We are currently investigating what its targets might be in the inner ear, and how they could act to protect the ear from damage."</p>
|
||
|
||
<p>White adds that they would also like to study whether increasing FOXO3 in cochlear hair cells would help protect against noise-induced hearing loss. “If it did, that could be very helpful for the active military as well as for people who work in noisy environments, such as miners,” she says.</p>
|
||
|
||
<p>—by Geri Piazza</p>
|
||
</div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/hearing-different-frequencies" target="_top">Hearing Different Frequencies</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/blueprint-cell-development-inner-ear" target="_top">A Blueprint of Cell Development in the Inner Ear</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/technique-forms-working-inner-ear-cells" target="_top">Technique Forms Working Inner Ear Cells</a></li><li><a href="https://www.nidcd.nih.gov/health/noise-induced-hearing-loss" target="_top">Noise-Induced Hearing Loss</a></li><li><a href="https://www.nidcd.nih.gov/health/age-related-hearing-loss" target="_top">Age-Related Hearing Loss</a></li><li><a href="https://www.nidcd.nih.gov/health/do-you-need-hearing-test" target="_top">Do You Need a Hearing Test?</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/28432353">Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure</a>. Gilels F, Paquette ST, Beaulac HJ, Bullen A, White PM. <em>Sci Rep.</em> 2017 Apr 21;7(1):1054. doi: 10.1038/s41598-017-01142-3. PMID: 28432353.</p><p class="footnote"><strong class="label-inline">Funding: </strong>This work was supported by NIH’s National Institute on Deafness and Other Communication Disorders (NIDCD) and the Biotechnology and Biological Sciences Research Council of the United Kingdom.</p>
|
||
|
||
</div>
|
||
|
||
<div class="lastupdated">
|
||
</div> </div>
|
||
<aside class="l-region l-region--sidebar-second masonry-container">
|
||
<div id="block-ds-extras-in-this-edition" class="block block--ds-extras box block--ds-extras-in-this-edition" id="block-ds-extras-in-this-edition" class="block block--ds-extras box block--ds-extras-in-this-edition">
|
||
|
||
<h3 class="block__title">In this Edition</h3>
|
||
|
||
<div class="content" class="block__content">
|
||
<div class="view view-nih-rm-in-this-edition view-id-nih_rm_in_this_edition view-display-id-default view-dom-id-4c597d79e6eab61a78967bd3efa0917c">
|
||
|
||
|
||
|
||
<div class="view-content">
|
||
<div>
|
||
|
||
<p><a href="/news-events/nih-research-matters/protein-involved-hearing-loss-recovery" class="active">Protein involved in hearing loss recovery</a></p> </div>
|
||
<div>
|
||
|
||
<p><a href="/news-events/nih-research-matters/enzyme-drives-middle-age-weight-fitness-changes">Enzyme drives middle-age weight and fitness changes</a></p> </div>
|
||
<div>
|
||
|
||
<p><a href="/news-events/nih-research-matters/3-d-model-human-brain-development-disease">3-D model of human brain development and disease</a></p> </div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div> </div>
|
||
</div>
|
||
<div id="block-bean-research-matters-search" class="block block--bean box block--bean-research-matters-search" id="block-bean-research-matters-search" class="block block--bean box block--bean-research-matters-search">
|
||
|
||
<h3 class="block__title">Search NIH Research Matters</h3>
|
||
|
||
<div class="content" class="block__content">
|
||
<div about="/block/research-matters---search" class="ds-1col entity entity-bean bean-research-matters-block view-mode-default clearfix">
|
||
|
||
|
||
|
||
<!-- DigitalGov Search -->
|
||
<form id="directorsearch" accept-charset="UTF-8" action="https://search.nih.gov/search/docs" method="get" class="search-form">
|
||
<div class="input-wrapper">
|
||
<div style="margin:0;padding:0;display:inline"><input name="utf8" type="hidden" value="✓" /></div>
|
||
<input id="affiliate" name="affiliate" type="hidden" value="nih" />
|
||
<input type="hidden" name="dc" value="678" />
|
||
<label for="query2" class="hide">Search NIH Research Matters' stories</label>
|
||
<input autocomplete="off" class="usagov-search-autocomplete form-field form-field-search" id="query2" name="query" type="text" />
|
||
<input name="commit" type="submit" value="Go" id="searchbutton" class="form-button" />
|
||
</div>
|
||
</form>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div id="block-bean-research-matters-contact-us" class="block block--bean box block--bean-research-matters-contact-us" id="block-bean-research-matters-contact-us" class="block block--bean box block--bean-research-matters-contact-us">
|
||
|
||
<h3 class="block__title">Connect with Us</h3>
|
||
|
||
<div class="content" class="block__content">
|
||
<div about="/block/research-matters---contact-us" class="ds-1col entity entity-bean bean-research-matters-block view-mode-default clearfix">
|
||
|
||
|
||
<p><a class="button-link" href="https://service.govdelivery.com/accounts/USNIH/subscriber/new?topic_id=USNIH_48" onclick="window.open(this.href,'popup','width=725,height=500,left=25,top=25,location=no,resizable=yes,scrollbars=yes,status=yes');return false;">Subscribe to get NIH Research Matters by email</a></p>
|
||
|
||
<ul class="icon-list">
|
||
<li><a class="icon-link rss-monochrome" href="/nih-research-matters/feed.xml"><span class="icon"></span>RSS feed</a></li>
|
||
<li><a class="icon-link facebook-monochrome" href="https://www.facebook.com/ResearchMatters"><span class="icon"></span>Facebook</a></li>
|
||
<li><a class="icon-link email-monochrome" href="mailto:nihresearchmatters@od.nih.gov"><span class="icon"></span>Email us</a></li>
|
||
</ul>
|
||
|
||
<p><strong>Mailing Address:</strong><br />
|
||
NIH Research Matters<br />
|
||
Bldg. 31, Rm. 5B52, MSC 2094<br />
|
||
Bethesda, MD 20892-2094</p></div>
|
||
|
||
</div>
|
||
</div>
|
||
<div id="block-bean-research-matters-popular-stori" class="block block--bean box block--bean-research-matters-popular-stori" id="block-bean-research-matters-popular-stori" class="block block--bean box block--bean-research-matters-popular-stori">
|
||
|
||
<h3 class="block__title">Popular Stories</h3>
|
||
|
||
<div class="content" class="block__content">
|
||
<div about="/block/research-matters---popular-stori" class="ds-1col entity entity-bean bean-research-matters-block view-mode-default clearfix">
|
||
|
||
|
||
<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-can-we-slow-aging">Research in Context: Can we slow aging?</a></p>
|
||
|
||
<p><a href="https://www.nih.gov/news-events/nih-research-matters/brain-changes-observed-during-pregnancy">Brain changes observed during pregnancy</a></p>
|
||
|
||
<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-detecting-cancer">Research in Context: Detecting cancer</a></p>
|
||
|
||
<p><a href="https://www.nih.gov/news-events/nih-research-matters/risk-future-burden-dementia-united-states">Risk and future burden of dementia in the United States </a></p>
|
||
|
||
<p><a href="https://www.nih.gov/news-events/nih-research-matters/complete-wiring-map-adult-fruit-fly-brain">Complete wiring map of an adult fruit fly brain</a></p>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div id="block-bean-research-matters-about" class="block block--bean box block--bean-research-matters-about" id="block-bean-research-matters-about" class="block block--bean box block--bean-research-matters-about">
|
||
|
||
<h3 class="block__title">About NIH Research Matters</h3>
|
||
|
||
<div class="content" class="block__content">
|
||
<div about="/block/research-matters---about" class="ds-1col entity entity-bean bean-research-matters-block view-mode-default clearfix">
|
||
|
||
|
||
<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
|
||
|
||
<p><strong>Assistant Editors:</strong> Vicki Contie and Brian Doctrow, Ph.D.</p>
|
||
|
||
<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
|
||
|
||
<p>ISSN 2375-9593</p>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</aside>
|
||
</div>
|
||
<div class="l-connect-wrapper">
|
||
<div class="l-connect">
|
||
<h2 class="element-invisible">Connect with Us</h2>
|
||
<ul>
|
||
<li><a class="contactus-monochrome" href="/about-nih/contact-us"><span class="icon"></span>Contact Us</a></li>
|
||
<li><a class="twitter-monochrome" href="https://twitter.com/NIH"><span class="icon"></span>X</a></li>
|
||
<li><a class="facebook-monochrome" href="https://www.facebook.com/nih.gov"><span class="icon"></span>Facebook</a></li>
|
||
<li><a class="instagram-monochrome" href="https://www.instagram.com/nihgov/"><span class="icon"></span>Instagram</a></li>
|
||
<li><a class="youtube-monochrome" href="https://www.youtube.com/user/nihod"><span class="icon"></span>YouTube</a></li>
|
||
<li><a class="flickr-monochrome" href="https://www.flickr.com/photos/nihgov/"><span class="icon"></span>Flickr</a></li>
|
||
<li><a class="social-monochrome" href="/news-events/social-media-outreach"><span class="icon"></span>More Social Media from NIH</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="l-footer-wrapper">
|
||
<footer class="l-footer" role="contentinfo">
|
||
<h2 class="element-invisible">Footer</h2>
|
||
<ul>
|
||
<li><a href="/">NIH Home</a></li>
|
||
<li><a href="/virtual-tour">Virtual Tour</a></li>
|
||
<li><a href="https://salud.nih.gov">En Español</a></li>
|
||
<li><a href="/about-nih/visitor-information">Visitor Information</a></li>
|
||
<li><a href="/about-nih/frequently-asked-questions">Frequently Asked Questions</a></li>
|
||
<li><a href="/privacy-policy">Privacy Policy</a></li>
|
||
<li><a href="/disclaimers">Disclaimers</a></li>
|
||
<li><a href="/accessibility">Accessibility</a></li>
|
||
<li><a href="/nih-website-archives">NIH Website Archives</a></li>
|
||
</ul>
|
||
<ul>
|
||
<li><a href="/nondiscrimination-notice">Nondiscrimination Notice</a></li>
|
||
<li><a href="/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office">Freedom of Information Act</a></li>
|
||
<li><a href="https://www.edi.nih.gov/no-fear-act">No Fear Act</a></li>
|
||
<li><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html">HHS Vulnerability Disclosure</a></li>
|
||
<li><a href="https://oig.hhs.gov">Office of Inspector General</a></li>
|
||
<li><a class="lastTab" href="https://www.usa.gov/">USA.gov</a></li>
|
||
</ul>
|
||
<p>NIH…Turning Discovery Into Health<sup>®</sup></p>
|
||
<p>National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892</p>
|
||
<p><a href="https://www.hhs.gov">U.S. Department of Health and Human Services</a></p>
|
||
</footer>
|
||
</div>
|
||
|
||
<div class="back-to-top"><a href="#"><span class="icon-arrow-up"></span><span class="text">Back to Top</span></a></div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
<script src="https://www.nih.gov/sites/default/files/js/js_7Ukqb3ierdBEL0eowfOKzTkNu-Le97OPm-UqTS5NENU.js"></script>
|
||
<script src="https://www.nih.gov/sites/default/files/js/js_E9yUYWK8EMydR0HMIp2PahVxPAClXyH0Cnh782A15UM.js"></script>
|
||
</body>
|
||
</html>
|
||
|