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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/nih-research-matters">NIH Research Matters</a></div> <div class="l-region l-region--section-header">
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<div about="/news-events/nih-research-matters/nanoparticles-target-transform-fat-tissue" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-research-matters view-mode-full node--full node--nih-research-matters--full clearfix">
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2016-05-24T00:00:00-04:00" class="date-display-single">May 24, 2016</span></p><div class='syndicate'><h1>Nanoparticles target, transform fat tissue</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
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<ul>
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<li>Nanoparticles designed to target white fat and convert it to calorie-burning brown fat slowed weight gain in obese mice without affecting food intake.</li>
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<li>This proof-of-concept work could lead to new therapies to treat obesity.</li>
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<picture title="Targeted nanoparticles">
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<!--[if IE 9]><video style="display: none;"><![endif]-->
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/research-matters/2016/20160524-nanoparticle.jpg?itok=T8ZQTLTV&timestamp=1464095530 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2016/20160524-nanoparticle.jpg?itok=CRKXfVrf&timestamp=1464095530 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2016/20160524-nanoparticle.jpg?itok=rICR3Mh7&timestamp=1464095530 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2016/20160524-nanoparticle.jpg?itok=aN56pcZu&timestamp=1464095530 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2016/20160524-nanoparticle.jpg?itok=qjcTAL6r&timestamp=1464095530 1x" media="screen and (min-width: 0)" />
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<!--[if IE 9]></video><![endif]-->
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2016/20160524-nanoparticle.jpg?itok=CRKXfVrf&timestamp=1464095530" alt="Image of several small spheres." title="Targeted nanoparticles" />
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</picture><span class="caption">The targeted nanoparticles used in the study, visualized by transmission electron microscopy.</span><span class="credit">Langer and Farokhzad labs, PNAS</span></div>
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</div><p>More than 2 in 3 adults nationwide are considered overweight or obese. In recent years, researchers have gained insights into the roles of different types of fat tissue in weight control. Adults have mostly white fat, in which excess calories are stored as chemicals called fatty acids. Too much white fat increases the risk of several metabolic disorders.</p>
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<p>Brown fat, in contrast, burns energy to create heat and help maintain body temperature. Infants have brown fat when they're born, but we lose it as we age. Brown fat was <a href="/news-events/nih-research-matters/overlooked-brown-fat-tied-obesity">only recently</a> proven to exist in adults. Since brown fat cells are able to burn calories, they could potentially play a role in strategies to reduce obesity and its associated disorders.</p>
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||
<p>Fat tissue and its supporting blood vessel network can change over time. Compounds such as rosiglitazone (Rosi) and prostaglandin E2 analog (PGE2) have been shown to have “browning” effects on white fat tissue—increasing metabolism and the growth of new blood vessels. However, such drugs may have unwanted effects on other tissues.</p>
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<p>Nanometer-sized particles, or nanoparticles, can be designed to target specific organs or tissues. The technology is current being explored in cancer and other therapies. A team led by Dr. Robert Langer at MIT and Dr. Omid Farokhzad at Brigham and Women’s Hospital designed nanoparticles to target browning agents to fat tissue. The study, funded in part by NIH’s National Institute of Biomedical Imaging and Bioengineering (NIBIB), appeared on May 17, 2016, in <em>Proceedings of the National Academy of Sciences</em>.</p>
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||
<p>The researchers developed nanoparticles with a core containing Rosi or PGE2 along with a polymer called PLGA that enables slow release of the drug. To target the nanoparticles to fat tissue, the outer surface was made of a polymer called PEG attached to either iRGD or P3—compounds that bind to molecules inside the blood vessels of fat tissue. The particles were delivered to the mice by intravenous injection.</p>
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||
<p>Compared to control mice given the drugs free in solution or in nontargeted nanoparticles, the mice treated with the targeted nanoparticles had darker white fat. Under the microscope, their fat cells appeared smaller and there were more blood vessels. Expression of UCP1, a marker of brown fat cells, was significantly raised by the targeted nanoparticles as well.</p>
|
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||
<p>The researchers next tested the Rosi nanoparticles in obese mice fed a high-fat diet. The targeted nanoparticles inhibited body weight gain by about 10% compared to untreated mice, or to mice treated with Rosi in solution or in nontargeted nanoparticles. Mice treated with targeted nanoparticles had smaller fat cells, more blood vessels, and higher levels of brown fat markers. Notably, the groups had similar food intakes. These findings show that the targeted Rosi nanoparticles reduced weight gain by browning fat tissue.</p>
|
||
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||
<p>This study focused on Rosi as a proof of concept. In the clinic, Rosi has serious side effects, but agents other than Rosi or PGE2 could be loaded into the nanoparticles. “The advantage here is now you have a way of targeting it to a particular area and not giving the body systemic effects,” Langer says. “You can get the positive effects that you’d want in terms of anti-obesity but not the negative ones that sometimes occur.”</p>
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<p>—by Harrison Wein, Ph.D.</p>
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</div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/injectable-nanoparticles-deliver-cancer-therapy-mice" target="_top">Injectable Nanoparticles Deliver Cancer Therapy in Mice</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/insights-into-energy-burning-fat-cells" target="_top">Insights into Energy-Burning Fat Cells</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/cool-temperature-alters-human-fat-metabolism" target="_top">Cool Temperature Alters Human Fat and Metabolism</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/shivering-triggers-brown-fat-produce-heat-burn-calories" target="_top">Shivering Triggers Brown Fat to Produce Heat and Burn Calories</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/way-burn-more-calories" target="_top">A Way to Burn More Calories?</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/overlooked-brown-fat-tied-obesity" target="_top">Overlooked “Brown Fat” Tied to Obesity</a></li><li><a href="https://search.nih.gov/search?utf8=%E2%9C%93&affiliate=hip&query=obesity" target="_top">NIH Health Information: Obesity</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/27140638">Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles.</a> Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R. <em>Proc Natl Acad Sci U S A</em>. 2016 May 17;113(20):5552-7. doi: 10.1073/pnas.1603840113. Epub 2016 May 2. PMID: 27140638.</p><p class="footnote"><strong class="label-inline">Funding: </strong>NIH’s National Institute of Biomedical Imaging and Bioengineering (NIBIB) and National Cancer Institute (NCI); Koch–Prostate Cancer Foundation Award in Nanotherapeutics; and Swedish Research Council.</p>
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NIH Research Matters<br />
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Bldg. 31, Rm. 5B52, MSC 2094<br />
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Bethesda, MD 20892-2094</p></div>
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<h3 class="block__title">Popular Stories</h3>
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<div about="/block/research-matters---popular-stori" class="ds-1col entity entity-bean bean-research-matters-block view-mode-default clearfix">
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-can-we-slow-aging">Research in Context: Can we slow aging?</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/brain-changes-observed-during-pregnancy">Brain changes observed during pregnancy</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-detecting-cancer">Research in Context: Detecting cancer</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/risk-future-burden-dementia-united-states">Risk and future burden of dementia in the United States </a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/complete-wiring-map-adult-fruit-fly-brain">Complete wiring map of an adult fruit fly brain</a></p>
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<h3 class="block__title">About NIH Research Matters</h3>
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<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
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<p><strong>Assistant Editors:</strong> Vicki Contie and Brian Doctrow, Ph.D.</p>
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<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
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<p>ISSN 2375-9593</p>
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