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<title>New color vision pathway unveiled | National Institutes of Health (NIH)</title>
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2016-04-26T00:00:00-04:00" class="date-display-single">April 26, 2016</span></p><div class='syndicate'><h1>New color vision pathway unveiled </h1><div class="callout callout-with-border"><h3>At a Glance</h3>
<ul>
<li>Researchers discovered how dim-light detecting cells are used for color vision in mice.</li>
<li>The findings shed light on a color vision circuit in mice that may explain aspects of color processing in the human eye and brain.</li>
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2016/20160426-vision-cropped.jpg?itok=03yipGG5&amp;timestamp=1461676468" alt="Urine and plant seeds appear in dishes with high contrast" title="Simulated mouse view of soiled bedding and plant seeds" />
</picture><span class="caption">Bedding soiled with urine (left) and plant seeds (right) shown through filters that simulate mouse rod and cone cells light-detection levels.</span><span class="credit">M. Meister Laboratory/Caltech</span></div>
</div><p>Color enhances our ability to perceive the world around us. Which colors humans and other animals see depends on the light-sensing cells, or photoreceptors, in the eye. There are 2 types of photoreceptors: rods, which detect dim light and are used for night vision, and cones, which detect different colors and require brightly lit environments.</p>
<p>Humans have 3 distinct color-sensing cones—for red, green, and blue light. By combining these cells signals, the brain can distinguish thousands of different colors. Most other mammals only have 2 types of cone cells, for green and blue/ultraviolet (UV) light. Unlike humans, mice and other small mammals cone cells are segregated in the retina, the light-sensitive tissue at the back of the eye. Because of their locations, the cone cell signals cant be compared in the same way as they are in people to determine color. So researchers believe another mechanism for color vision must exist.</p>
<p>Dr. Markus Meister at California Institute of Technology and Dr. Maximilian Joesch at Harvard University wanted to find out what that pathway might be. They investigated how cells across the mouse retina respond to different colored lights. The research was funded in part by NIHs National Eye Institute (NEI). Results were published in <em>Nature</em> on April 14, 2016.</p>
<p>The researchers surveyed retinal ganglion cells, which integrate signals from cone cells and transmit information about color to the brain, by measuring their responses to different colored lights. They discovered a type of ganglion cell that was excited by green light but suppressed by UV light. The upper part of a mouses visual field holds blue/UV cones and the lower part has green cones. The scientists presumed ganglion cells would only respond to colors detected by nearby cones. However, these ganglion cells responded to green light even where green cone cells were absent.</p>
<p>Rod cells havent been thought to play a role in color vision, but they do contain a pigment thats sensitive to green light. A careful series of experiments revealed that rod cells activate horizontal cells, which inhibit cone cell signaling to retinal ganglion cells. Thus, the ganglion cells can integrate both green light information coming from rod cells and blue/UV light information coming from cone cells in order to send information about color to the brain.</p>
<p>To explore the potential benefits of such a circuit, the researchers used camera filters to simulate mouse rod and cone cells light-detection levels. They imaged UV-green colored objects that mice commonly encounter and found that urine markings (used for social communication in mice) and plant seeds (a food source) were easier to distinguish.</p>
<p>The human retina has all of the components for this circuit as well. The researchers suggest this might explain why humans perceive the color blue during twilight hours. “In really dim light, our cones don't receive enough photons to work, but they continue to emit a low-level baseline signal to the rest of the retina that is independent of light,” Meister says. “The rods are active, however, and through the horizontal cell they inhibit both the red and green cones. Because this baseline signal from the red and green cones is suppressed, it looks like the blue cones are more active. To the rest of the retina, it seems like everything in the field of vision is blue.”</p>
<p>—by Tianna Hicklin, Ph.D.</p>
</div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/gene-therapy-corrects-monkey-color-blindness" target="_top">Gene Therapy Corrects Monkey Color Blindness</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/genetically-altered-mice-see-more-colorful-world" target="_top">Genetically Altered Mice See a More Colorful World</a></li><li><a href="https://newsinhealth.nih.gov/issue/Jan2011/Feature1" target="_top">Your Aging Eyes</a></li><li><a href="https://nei.nih.gov/healthyeyes" target="_top">Healthy Eyes</a></li><li><a href="https://ghr.nlm.nih.gov/condition/color-vision-deficiency" target="_top">Color Vision Deficiency</a></li><li><a href="https://nei.nih.gov/health/color_blindness" target="_top">Color Blindness</a></li></ul><p class="footnote"><strong class="label-inline">References:&nbsp;</strong><a href="http://www.ncbi.nlm.nih.gov/pubmed/27049951">A neuronal circuit for colour vision based on rod-cone opponency.</a> Joesch M, Meister M. <em>Nature</em>. 2016 Apr 14; 532(7598):236-9. doi: 10.1038/nature17158. Epub 2016 Apr 6. PMID: 27049951.</p><p class="footnote"><strong class="label-inline">Funding:&nbsp;</strong>NIHs National Eye Institute (NEI) and the International Human Frontier Science Program Organization.</p>
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