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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/nih-research-matters">NIH Research Matters</a></div> <div class="l-region l-region--section-header">
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<div about="/news-events/nih-research-matters/2007-research-highlights-clinical-breakthroughs" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-research-matters view-mode-full node--full node--nih-research-matters--full clearfix">
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2007-12-31T00:00:00-05:00" class="date-display-single">December 31, 2007</span></p><div class='syndicate'><h1>2007 Research Highlights — Clinical Breakthroughs</h1><div class="callout callout-with-border"><h3>Prevention, Diagnosis and Treatment of Human Disease</h3>
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<p>NIH has nearly 6,000 NIH staff scientists and supports more than 325,000 researchers with competitive grants to all 50 states, the territories and more than 90 countries around the world. Here's just a small sampling of the accomplishments made by NIH-supported scientists in 2007.</p>
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<div class="teaser">
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-12871" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2007/20070219-infertility.jpg">20070219-infertility.jpg</a></h2>
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<div class="content">
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<img height="150" width="150" alt="A young woman smiling" title="A young woman smiling" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2007/20070219-infertility.jpg?itok=sPzKuCSC" /> </div>
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</div>
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</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/established-drug-bests-newcomer-treating-female-infertility">Established Drug Bests Newcomer in Treating Female Infertility</a></h4>
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||
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||
<p class="teaser-description">Researchers reported that infertility arising from polycystic ovary syndrome (PCOS) is better treated with an established ovulation-inducing drug (clomiphene) than with an increasingly popular alternative (metformin). The NIH-funded study was the largest, most comprehensive effort to date comparing the 2 drugs' abilities to promote pregnancy in women with PCOS, a hormonal disorder that affects about 1 in 15 women and is the leading cause of infertility. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17287476?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVLinkOut" title="PubMed Abstract: Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.">Pubmed Abstract »</a></p>
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||
</div>
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<div class="teaser">
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-12906" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2007/20070205-asthma.jpg">20070205-asthma.jpg</a></h2>
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<div class="content">
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<img height="150" width="150" alt="A young boy using an inhaler" title="A young boy using an inhaler" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2007/20070205-asthma.jpg?itok=oakn5o_m" /> </div>
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</div>
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</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/inhaled-steroids-best-treatment-children-asthma">Inhaled Steroids Best Treatment for Children With Asthma</a></h4>
|
||
|
||
<p class="teaser-description">An NIH-funded study tested the effectiveness and safety of 3 different asthma medicines in nearly 300 school-age children. The scientists found that inhaled corticosteroids are the most effective initial daily therapy for children with mild to moderate persistent asthma. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17140647?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" title="PubMed Abstract: Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial.">Pubmed Abstract »</a></p>
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<div class="teaser">
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-13051" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2007/20070416-breast.jpg">20070416-breast.jpg</a></h2>
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<div class="content">
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<img height="150" width="150" alt="Doctor consulting with patient" title="Doctor consulting with patient" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2007/20070416-breast.jpg?itok=rXdPs71f" /> </div>
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||
<h4 class="teaser-title"><a href="/news-events/nih-research-matters/mri-increases-detection-second-cancer-opposite-breast">MRI Increases Detection of Second Cancer in Opposite Breast</a></h4>
|
||
|
||
<p class="teaser-description">When a woman is newly diagnosed with cancer in one breast, there's up to a 10% chance that clinical exams and mammography will miss a tumor growing in the opposite breast. An NIH-funded study found that magnetic resonance imaging (MRI) can help to detect these overlooked cancers in the opposite breast at the time of initial diagnosis, which may also lead to earlier treatment. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17392300?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" title="PubMed Abstract: MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer.">Pubmed Abstract »</a></p>
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</div>
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<div class="teaser">
|
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-13396" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2007/20071009-treatment-cropped.jpg">20071009-treatment-cropped.jpg</a></h2>
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<img height="150" width="150" alt="Photo of a teenage girl gazing out the window - Cropped" title="Photo of a teenage girl gazing out the window - Cropped" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2007/20071009-treatment-cropped.jpg?itok=xhreJyuL" /> </div>
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</div>
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</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/depressed-adolescents-respond-best-combination-treatment">Depressed Adolescents Respond Best to Combination Treatment</a></h4>
|
||
|
||
<p class="teaser-description">A major clinical trial found that a combination of antidepressant medication and “talk therapy,” or psychotherapy, appears to be more effective for treating teens with major depressive disorder than medication or psychotherapy alone. The NIH-funded study enrolled 439 adolescents who had major depression. At both 4 months and 9 months after therapy began, response rates to the combination treatment significantly outpaced the 2 single-treatment approaches. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17909125?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" title="PubMed Abstract: The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes.">Pubmed Abstract »</a></p>
|
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</div>
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|
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<div class="teaser">
|
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-13091" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2007/20070430-sodium-cropped.jpg">20070430-sodium-cropped.jpg</a></h2>
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<div class="content">
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<img height="150" width="150" alt="Photo of a salt shaker and spilled salt - Cropped" title="Photo of a salt shaker and spilled salt - Cropped" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2007/20070430-sodium-cropped_0.jpg?itok=27JoCtWN" /> </div>
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</div>
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</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/lower-sodium-decreases-long-term-risk-cardiovascular-disease">Lower Sodium Decreases Long-Term Cardiovascular Risk</a></h4>
|
||
|
||
<p class="teaser-description">Several studies had already shown that lowering your salt intake helps to prevent high blood pressure, or hypertension. But a new NIH-funded analysis found that less sodium can also prevent heart disease. The researchers examined clinical trial data from studies of more than 3,000 adults with pre-hypertension. Men and women who reduced their salt intake had a 25% lower risk of total cardiovascular disease over the next 10 to 15 years. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17449506?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" title="PubMed Abstract: Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP).">Pubmed Abstract »</a></p>
|
||
</div>
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||
|
||
<div class="teaser">
|
||
<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-13216" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2007/20070716-autism.jpg">20070716-autism.jpg</a></h2>
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<div class="content">
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||
<img height="150" width="150" alt="Picture of a little girl standing by the ocean" title="Picture of a little girl standing by the ocean" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2007/20070716-autism.jpg?itok=oizfnVVA" /> </div>
|
||
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</div>
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||
</div></div>
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||
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||
<h4 class="teaser-title"><a href="/news-events/nih-research-matters/learning-diagnose-autism-spectrum-disorders">Diagnosing Autism Spectrum Disorder</a></h4>
|
||
|
||
<p class="teaser-description">Autism is rarely diagnosed before 3 years of age, but the sooner it is identified and treated the better the outcome for the child. NIH-supported scientists found that it's possible to detect autism in some children as young as 14 months of age, the earliest the disorder has ever been diagnosed. In other children, definite signs of autism can be seen by about 2, the researchers said. Their diagnoses were based on close assessment of the children's social and communication skills. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17606819?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" title="PubMed Abstract: Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders.">Pubmed Abstract »</a></p>
|
||
</div>
|
||
|
||
<div class="teaser">
|
||
<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-12996" class="file file-image file-image-jpeg">
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||
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<h2 class="element-invisible"><a href="/2007/20070312-vaccine.jpg">20070312-vaccine.jpg</a></h2>
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||
|
||
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||
<div class="content">
|
||
<img height="150" width="150" alt="Image with a large cluster of circular viruses" title="Image with a large cluster of circular viruses" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2007/20070312-vaccine.jpg?itok=4VeXOQPZ" /> </div>
|
||
|
||
|
||
</div>
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||
</div></div>
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||
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||
<h4 class="teaser-title"><a href="/news-events/nih-research-matters/vaccine-shows-promise-preventing-hepatitis-e">Vaccine Shows Promise in Preventing Hepatitis E</a></h4>
|
||
|
||
<p class="teaser-description">An experimental vaccine—originally created and tested over the past 2 decades by NIH scientists—appears safe and effective in preventing hepatitis E, a sometimes-deadly viral disease prevalent in developing countries. A clinical trial involving nearly 2,000 healthy adults in Nepal, where the virus is widespread, found that the vaccine was nearly 96% effective in preventing hepatitis E during a follow-up period of about 2 years. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17329696?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" title="PubMed Abstract: Safety and efficacy of a recombinant hepatitis E vaccine.">Pubmed Abstract »</a></p>
|
||
</div>
|
||
|
||
<div class="teaser">
|
||
<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-13116" class="file file-image file-image-jpeg">
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||
|
||
<h2 class="element-invisible"><a href="/2007/20070514-bipolar-cropped.jpg">20070514-bipolar-cropped.jpg</a></h2>
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||
|
||
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<img height="150" width="150" alt="Photo of a depressed man - Cropped" title="Photo of a depressed man - Cropped" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2007/20070514-bipolar-cropped.jpg?itok=xxfclIgG" /> </div>
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<h4 class="teaser-title"><a href="/news-events/news-releases/intensive-psychotherapy-more-effective-brief-therapy-treating-bipolar-depression">Treating Depression in Patients with Bipolar Disorder</a></h4>
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<p class="teaser-description">Patients with bipolar disorder have severe mood swings between mania and depression. Treatment typically involves mood-stabilizing drugs like lithium or valproate. Two separate reports—both part of a large-scale NIH-funded study of bipolar disorder—looked at how well patients with depression responded when additional treatments were added to their mood-stabilizing therapy. One found that adding an antidepressant medication was no more effective than a sugar pill in reducing depression. (<a href="/news-events/news-releases/study-sheds-light-medication-treatment-options-bipolar-disorder">NIH news release </a>| <a href="http://www.ncbi.nlm.nih.gov/pubmed/17392295?ordinalpos=27&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" title="PubMed Abstract: Effectiveness of adjunctive antidepressant treatment for bipolar depression.">PubMed Abstract</a>). The other reported that patients tended to get well faster and stay well if they received intensive psychotherapy for several months. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17404119?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" title="PubMed Abstract: Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program.">Pubmed Abstract »</a></p>
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