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<div about="/news-events/news-releases/biomedical-sti-prevention-evidence-inadequate-cisgender-women" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-news-release media-advisory featured-media-floated view-mode-full node--full node--nih-news-release--full clearfix">
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<p class="publishdate"><span class="tag-term">Media Advisory</span></p><p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2023-12-20T17:00:00-05:00" class="date-display-single">Wednesday, December 20, 2023</span></p><h1>Biomedical STI prevention evidence is inadequate for cisgender women</h1><p class="subtitle">
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NIH leadership calls for population-specific considerations in study design.</p><div class="featured-media"><div class="ds-1col file file-image file-image-jpeg view-mode-featured_media clearfix">
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<picture title="Scanning electron micrograph of Neisseria gonorrhoeae bacteria, which causes gonorrhea. Captured by the Research Technologies Branch (RTB) at the NIAID Rocky Mountain Laboratories (RML) in Hamilton, Montana.">
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media__breakpoint-tiny_/public/news-events/news-releases/2023/20231220-bacteria.jpg?itok=wZ-xT-mx&timestamp=1703101118 1x" media="screen and (min-width: 0)" />
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<img src="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/news-events/news-releases/2023/20231220-bacteria.jpg?itok=KOLqx5TU&timestamp=1703101118" alt="Scanning electron micrograph of Neisseria gonorrhoeae bacteria, which causes gonorrhea. Captured by the Research Technologies Branch (RTB) at the NIAID Rocky Mountain Laboratories (RML) in Hamilton, Montana." title="Scanning electron micrograph of Neisseria gonorrhoeae bacteria, which causes gonorrhea. Captured by the Research Technologies Branch (RTB) at the NIAID Rocky Mountain Laboratories (RML) in Hamilton, Montana." />
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</picture><span class="caption">Scanning electron micrograph of Neisseria gonorrhoeae bacteria, which causes gonorrhea. Captured by the Research Technologies Branch (RTB) at the NIAID Rocky Mountain Laboratories (RML) in Hamilton, Montana.</span><span class="credit">NIAID</span></div>
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</div><h3>What</h3>
|
||
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||
<p>Pivotal studies of some biomedical HIV and sexually transmitted infection (STI) prevention interventions have excluded cisgender women or demonstrated low efficacy among them, limiting their prevention options relative to other populations who experience high HIV and STI incidence. Findings from a NIAID-funded study published in <em>The</em> <em>New England Journal of Medicine</em> today show doxycycline postexposure prophylaxis (better known as DoxyPEP) did not prevent STI acquisition in cisgender women, despite showing <a href="https://www.niaid.nih.gov/news-events/nih-funded-study-finds-doxycycline-reduces-sexually-transmitted-infections-two-thirds">promising</a> results in gay, bisexual, and other men who have sex with men and transgender women in a previous study. Jeanne Marrazzo, M.D., M.P.H., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, discusses these disparities — and the opportunity to correct them — in an accompanying editorial<em>. </em></p>
|
||
|
||
<p>The study, conducted among Kenyan cisgender women, found no significant reduction in STI incidence among those taking DoxyPEP compared to a control group. This is in contrast to the findings from a U.S. study published earlier this year in which oral doxycycline given within 72 hours of condomless sex reduced the incidence of common bacterial STIs by two-thirds among gay, bisexual, and other men who have sex with men and transgender women. Investigators suggested these results may be due to low DoxyPEP use, high existing resistance to doxycycline among <em>Neisseria gonorrhoeae </em>bacteria, that cause gonorrhea, in the study location, and a local syphilis incidence too low to enable significant efficacy estimates.</p>
|
||
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<p>In the accompanying editorial, Dr. Marrazzo describes the need to better understand the biological and behavioral factors that influence STI acquisition in cisgender women, and to consider those factors when designing future biomedical prevention studies, rather than employing a “one-size-fits all” approach for all populations. Specifically, Dr. Marrazzo highlights insufficient evidence on how HIV and STI prophylaxis drugs perform in cervicovaginal versus rectal tissues. She also stresses the need for studies to reflect cisgender women’s sexual activity preferences, as well as common power dynamics with sex partners. Dr. Marrazzo explains that these knowledge gaps have implications for improving the efficacy and acceptability of biomedical prevention interventions among cisgender women. Finally, the editorial highlights the need to address these gaps given alarmingly high rates of congenital syphilis in the United States as well as steady HIV incidence and low HIV pre-exposure prophylaxis uptake among U.S. cisgender women.</p>
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<p>NIH strives to increase the meaningful inclusion of diverse and representative populations in the planning, conduct, and translation of clinical research so that everyone can enjoy the benefits of scientific progress and its applications.</p>
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<h3>Articles</h3>
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||
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<p>JM Marrazzo. Doxycycline Postexposure Prophylaxis for STIs in Women—Uncertain Benefit, Urgent Need. <em>The New England Journal of Medicine</em> DOI: 10.1056/NEJMe2311948 (2023).</p>
|
||
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||
<p>J Stewart <em>et al</em>. Doxycycline prophylaxis to prevent sexually transmitted infections in women. <em>The New England Journal of Medicine</em> DOI: 10.1056/NEJMoa2304007 (2023).</p>
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<p>NIAID Director Jeanne Marrazzo, M.D., M.P.H., is available to comment.</p>
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<p>NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the <a href="https://www.niaid.nih.gov/">NIAID website</a>.</p><p><strong>About the National Institutes of Health (NIH):</strong>
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