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<div about="/news-events/news-releases/surgery-beneficial-some-children-mild-sleep-disordered-breathing" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-news-release news-release view-mode-full node--full node--nih-news-release--full clearfix">
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<p class="publishdate"><span class="tag-term">News Release</span></p><p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2023-12-05T15:00:00-05:00" class="date-display-single">Tuesday, December 5, 2023</span></p><h1>Surgery beneficial for some children with mild sleep-disordered breathing </h1><p class="subtitle">
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NIH-supported study shows better sleep, blood pressure after adenotonsillectomy.</p><p>Surgical removal of the tonsils and adenoids in children with snoring and mild breathing problems during sleep appears to improve their sleep, quality of life, and blood pressure a year after surgery, a clinical trial supported by the National Institutes of Health has found. The study, funded by the National Heart, Lung, and Blood Institute (NHLBI), part of NIH, is believed to be the first large, randomized trial to address the effects of adenotonsillectomy on children with mild sleep-disordered breathing (SDB). Adenotonsillectomy is among the most common surgical procedures in children, and mild SDB is an issue for a large proportion of these patients. The findings were published in the <a href="https://jamanetwork.com/journals/jama/fullarticle/2812479"><em>Journal of the American Medical Association</em></a>.</p>
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<p>“Our data suggest that for children with no symptoms other than snoring, it's reasonable to monitor them over time without proceeding to surgery,” said study leader Susan Redline, M.D., M.P.H., of Brigham and Women’s Hospital and Harvard Medical School, both in Boston. “However, for children who are having issues with disturbed sleep, daytime sleepiness, and behavioral problems, our data suggest that surgery may be a very reasonable option.”</p>
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<p>SDB refers to breathing disturbances during sleep that can range from loud snoring to <a href="https://www.nhlbi.nih.gov/health/sleep-apnea">sleep apnea</a>. SDB affects 6-17% of typically developing children in the United States. Some research indicates that if left untreated, the condition may increase the risk for behavioral problems, reduced quality of life, and cardiovascular diseases, including heart disease and high blood pressure. Researchers and parents are showing increasing interest in how sleep problems such as sleep apnea might also affect brain development, cognition, and academic performance.</p>
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<p>Adenotonsillectomy, or removal of enlarged tonsils and adenoids, is a standard treatment for children with moderate to severe SDB and is aimed at reducing snoring and improving breathing in those with the condition. However, data are unclear whether the surgery is beneficial for children with mild forms of SDB.</p>
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<p>The Pediatric Adenotonsillectomy Trial for Snoring (PATS) was a randomized clinical trial that involved 459 children and adolescents with mild SDB who were enrolled at seven academic sleep centers in the United States between 2016 to 2021. The participants were ages 3 to 12, racially diverse, and followed for a year. The study did not include children with moderate to severe SDB.</p>
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<p>During the trial, half the participants received an adenotonsillectomy and the other half received supportive care without surgery, which included standardized education on healthy sleep and lifestyle and referral for untreated allergies or asthma. Researchers then evaluated neurodevelopmental, behavioral, health, and sleep-related outcomes in these groups, using measurements of attention and executive function, which includes a set of cognitive skills that help children manage everyday activities. Sleep outcomes were measured by <a href="https://medlineplus.gov/ency/article/003932.htm">polysomnography</a>, a standard sleep test that measures breathing, heart rate, eye movement, and other factors. </p>
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<p>At the end of the study period, cognition and attention improved in both groups, but improvement was not significantly greater in the children who were treated with surgery compared to the group who did not receive surgery. However, the secondary results of the study did show several beneficial changes in the surgery group. These included less daytime sleepiness, reduced SDB, less snoring, fewer behavioral problems, better quality of life, and lower blood pressure. The children treated with surgery were also less likely to show disease progression into full-blown sleep apnea, the researchers said.</p>
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<p>Researchers plan to explore the long-term impacts of surgery in this population and note the need to develop improved screening tools that better identify which children are most likely to benefit from adenotonsillectomy.</p>
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<p>“It is clear that adenotonsillectomy can help some children with mild sleep-disordered breathing. However, it may not be appropriate for everyone,” said Marishka Brown, Ph.D., director of the National Center on Sleep Disorder’s Research within the NHLBI. “Parents with concern over their children's nighttime breathing should discuss options with their pediatrician to develop a plan of action.”</p>
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<p>This work was supported by NHLBI cooperative agreements 1U01HL125307 and 1U01HL125295. Clinical trial: NCT02562040</p>
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<p><strong>About the National Heart, Lung, and Blood Institute (NHLBI):</strong> NHLBI is the global leader in conducting and supporting research in heart, lung, and blood diseases and sleep disorders that advances scientific knowledge, improves public health, and saves lives. For more information, visit <a href="https://www.nhlbi.nih.gov/">www.nhlbi.nih.gov</a>.</p><p><strong>About the National Institutes of Health (NIH):</strong>
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NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <a href="/">www.nih.gov</a>.</p>
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<h3>Study</h3><p>Redline, S, et al. <em>Adenotonsillectomy for snoring and mild sleep apnea in children: A randomized clinical trial. Journal of the American Medical Association. </em>DOI: <a href="https://jamanetwork.com/journals/jama/fullarticle/2812479">10.1001/jama.2023.22114</a></p></div>
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