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<p class="pretitle"><a href="/about-nih/what-we-do/impact-nih-research/revolutionizing-science">Revolutionizing Science</a></p><div class='syndicate'><h1>Partnerships</h1><div><p>NIH catalyzes the research enterprise by fostering partnerships to advance research fields in new ways and new directions.</p>
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<h3>ACTIV</h3>
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<p></p><div class="media media-element-container media-feature_teaser"><div id="file-78766" class="file file-image file-image-jpeg">
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-medium/public/about-nih/impact/partnerships--activ.jpg?itok=xHEzvIkB&timestamp=1702071284 1x" media="screen and (min-width: 800px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-medium-small/public/about-nih/impact/partnerships--activ.jpg?itok=bk0RlMaL&timestamp=1702071284 1x" media="screen and (min-width: 600px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-small/public/about-nih/impact/partnerships--activ.jpg?itok=xAGpVGCc&timestamp=1702071284 1x" media="screen and (min-width: 480px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-tiny/public/about-nih/impact/partnerships--activ.jpg?itok=CSXEkj9U&timestamp=1702071284 1x" media="screen and (min-width: 0)"></source>
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<img class="media-element" src="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-medium/public/about-nih/impact/partnerships--activ.jpg?itok=xHEzvIkB&timestamp=1702071284" alt="Three scientists wearing lab coats are standing near a lab bench and looking at a tool. " title="Three scientists at lab bench" />
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<p>NIH rapidly pivoted to combat COVID-19, establishing an unprecedented public-private partnership, Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV), by April 2020. ACTIV enabled the rapid and open exchange of information between government agencies, industry, and researchers to speed up research and clinical development of COVID-19 vaccines and therapeutics.</p>
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<p class="credit">Image credit: Lesnick Photo</p>
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<li>ACTIV established common research protocols for COVID-19 interventions so that researchers working on the same types of interventions were working toward the same measurable endpoints. This approach enabled rapid testing of possible vaccines and therapeutics and swift elimination of those that were not effective.</li>
|
||
<li>ACTIV brought together groups of scientific experts with different backgrounds to survey, assess, and evaluate the impact of viral evolution on vaccines and therapeutics. This illustrates what a team of dedicated experts from across sectors can accomplish and serves as a model for future partnerships.</li>
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<h3>COVID-19 Diagnostics</h3>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-medium/public/about-nih/impact/partnerships--covid-19-diagnostics.jpg?itok=jQSFPUoW&timestamp=1675176033 1x" media="screen and (min-width: 800px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-medium-small/public/about-nih/impact/partnerships--covid-19-diagnostics.jpg?itok=Mj5ff95D&timestamp=1675176033 1x" media="screen and (min-width: 600px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-small/public/about-nih/impact/partnerships--covid-19-diagnostics.jpg?itok=gjOo-Pbn&timestamp=1675176033 1x" media="screen and (min-width: 480px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-tiny/public/about-nih/impact/partnerships--covid-19-diagnostics.jpg?itok=XITaG0Gb&timestamp=1675176033 1x" media="screen and (min-width: 0)"></source>
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<img class="media-element" src="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-medium/public/about-nih/impact/partnerships--covid-19-diagnostics.jpg?itok=jQSFPUoW&timestamp=1675176033" alt="Woman swabs her own nose for an at-home COVID-19 test." title="COVID-19 Diagnostics" />
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<p>NIH facilitated the high-speed development of COVID-19 diagnostic technologies by applying a new model for innovation and collaboration between government, academia, and the private sector that can shape how technologies are developed in the future and be leveraged for other public health problems.</p>
|
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<p class="credit">Image credit: iStock</p>
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<li>The Rapid Acceleration of Diagnostics (RADx®) initiative enabled the accelerated development of COVID-19 diagnostic tests, reducing development timelines from years down to months.</li>
|
||
<li>As of November 2021, the RADx® initiative received over 800 submissions for COVID-19 testing technologies and supported more than 100 companies. </li>
|
||
<li>As of November 2021, support from the initiative led to 35 FDA emergency use authorizations (EUAs), including the first over-the-counter EUA for at-home COVID-19 tests. The cumulative capacity of manufactured tests and test products exceeds 950 million.</li>
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<h3>Alzheimer’s Disease Neuroimaging</h3>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-medium-small/public/about-nih/impact/partnerships--alzheimers-disease-neuroimaging.jpg?itok=25uJi7pQ&timestamp=1675176033 1x" media="screen and (min-width: 600px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-small/public/about-nih/impact/partnerships--alzheimers-disease-neuroimaging.jpg?itok=64f6DS86&timestamp=1675176033 1x" media="screen and (min-width: 480px)"></source>
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<source srcset="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-tiny/public/about-nih/impact/partnerships--alzheimers-disease-neuroimaging.jpg?itok=xp-2uznJ&timestamp=1675176033 1x" media="screen and (min-width: 0)"></source>
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<!--[if IE 9]></video><![endif]-->
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<img class="media-element" src="https://www.nih.gov/sites/default/files/styles/feature_teaser_breakpoint-medium/public/about-nih/impact/partnerships--alzheimers-disease-neuroimaging.jpg?itok=vVmEfXLX&timestamp=1675176033" alt="Illustration of amyloid plaques and tau tangles, colored in brown, surrounded by brain cells, colored in cyan and purple." title="Alzheimer’s Disease Neuroimaging" />
|
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<p>Launched in 2004, the NIH-funded Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a public-private partnership between NIH, nonprofits, and private industry designed to understand and develop tools to track the progression of Alzheimer’s disease. With 63 sites, ADNI aided the development of methods and tools that can detect the hallmark signs of this disease.</p>
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<p class="credit">Image credit: National Institute on Aging, NIH</p>
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<li>ADNI researchers aided the development and validation of methods and tools to detect the hallmark signs of Alzheimer’s disease that can be seen with PET scans of the brain and found in spinal fluid and blood.</li>
|
||
<li>An analysis in August 2020 revealed that open-access ADNI data had been requested by 24,500 users, resulting in 131 million downloads of data, and more than 4,700 scientific publications in a wide variety of fields.</li>
|
||
<li>The successful ADNI model inspired similar initiatives for Parkinson’s disease and multiple sclerosis.</li>
|
||
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</div>
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||
</div>
|
||
</div>
|
||
|
||
<h2>References</h2>
|
||
|
||
<h3>ACTIV</h3>
|
||
|
||
<ol>
|
||
<li>Accelerating Covid-19 Therapeutic Interventions and Vaccines (ACTIV): <a href="https://www.nih.gov/research-training/medical-research-initiatives/activ">https://www.nih.gov/research-training/medical-research-initiatives/activ</a></li>
|
||
<li>Tracking Resistance and Coronavirus Evolution (TRACE): <a href="https://www.nih.gov/research-training/medical-research-initiatives/activ/tracking-resistance-coronavirus-evolution-trace">https://www.nih.gov/research-training/medical-research-initiatives/activ/tracking-resistance-coronavirus-evolution-trace</a></li>
|
||
</ol>
|
||
|
||
<h3>COVID-19 Diagnostics</h3>
|
||
|
||
<ol>
|
||
<li>Rapid Acceleration of Diagnostics (RADx®) initiative: <a href="https://www.nih.gov/research-training/medical-research-initiatives/radx">https://www.nih.gov/research-training/medical-research-initiatives/radx</a></li>
|
||
<li>RADx® Tech and ATP Programs: <a href="https://www.nibib.nih.gov/covid-19/radx-tech-program">https://www.nibib.nih.gov/covid-19/radx-tech-program</a></li>
|
||
<li>RADx® Tech Dashboard: <a href="https://www.nibib.nih.gov/covid-19/radx-tech-program/radx-tech-dashboard">https://www.nibib.nih.gov/covid-19/radx-tech-program/radx-tech-dashboard</a></li>
|
||
<li>RADx® Tech and ATP Programs: Phase 2 Awards: <a href="https://www.nibib.nih.gov/covid-19/radx-tech-program/radx-tech-phase2-awards">https://www.nibib.nih.gov/covid-19/radx-tech-program/radx-tech-phase2-awards</a></li>
|
||
<li>Article: RADx One Year Later – A Sea Change for Diagnostics: <a href="https://www.nibib.nih.gov/about-nibib/directors-corner/corner-posts/radx-one-year-later-%E2%80%93-sea-change-diagnostics">https://www.nibib.nih.gov/about-nibib/directors-corner/corner-posts/radx-one-year-later-%E2%80%93-sea-change-diagnostics</a></li>
|
||
<li>Radical solutions. <em>Nat Biotechnol</em>. 2021;39(4):391. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/33824513/">33824513</a>.</li>
|
||
<li>Roback JD, et al. <em>Nat Biotechnol</em>. 2021;39(9):1060-1062. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/34404954/">34404954</a>.</li>
|
||
</ol>
|
||
|
||
<h3>Alzheimer’s Disease Neuroimaging</h3>
|
||
|
||
<ol>
|
||
<li>Alzheimer’s Disease Neuroimaging Initiative: <a href="http://adni.loni.usc.edu/">http://adni.loni.usc.edu/</a></li>
|
||
<li>Advances in Alzheimer’s Disease & Related Dementias Research: <a href="https://www.nia.nih.gov/about/advances-alzheimers-disease-related-dementias-research">https://www.nia.nih.gov/about/advances-alzheimers-disease-related-dementias-research</a></li>
|
||
<li>Weiner MW, et al. <em>Alzheimers Dement</em>. 2015;11(7):865-84. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/26194320/">26194320</a>.</li>
|
||
<li>Weiner MW, et al. <em>Alzheimers Dement</em>. 2017;13(5):561-571. PMID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536850/">27931796</a>.</li>
|
||
<li>Alzheimer’s Disease Neuroimaging Initiative 3: <a href="https://fnih.org/our-programs/alzheimers-disease-neuroimaging-initiative-3-adni-3">https://fnih.org/our-programs/alzheimers-disease-neuroimaging-initiative-3-adni-3</a></li>
|
||
</ol>
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</div></div>
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