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<meta name="keywords" content="Ear infection, acute otitis media, tympanostomy tubes, ear tubes, recurrent infection, antibiotics, medical management, otorrhea, antibiotic resistance, amoxicillin–clavulanate, Alejandro Hoberman, New England Journal of Medicine, NEJM." />
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<div about="/news-events/nih-research-matters/ear-tubes-or-antibiotics-repeat-infections-children" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-research-matters view-mode-full node--full node--nih-research-matters--full clearfix">
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2021-05-25T00:00:00-04:00" class="date-display-single">May 25, 2021</span></p><div class='syndicate'><h1>Ear tubes or antibiotics for repeat infections in children?</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
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<li>A study found that placing tympanostomy tubes in young children did not reduce the overall number of ear infections any more than oral antibiotic treatment.</li>
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<li>The findings may help to inform guidelines for treating children with recurrent ear infections.</li>
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</ul></div><div class="media-float-right"><div class="ds-1col file file-image file-image-jpeg view-mode-floated_media clearfix">
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<picture title="Boy’s ear being examined by a doctor with an otoscope">
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<!--[if IE 9]><video style="display: none;"><![endif]-->
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/research-matters/2021/20210525-tube.jpg?itok=elQQMvBu&timestamp=1621874379 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2021/20210525-tube.jpg?itok=Z7yQr_qj&timestamp=1621874379 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2021/20210525-tube.jpg?itok=0uoCPuXG&timestamp=1621874379 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2021/20210525-tube.jpg?itok=_PRqcQ2X&timestamp=1621874379 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2021/20210525-tube.jpg?itok=KVWU9oBI&timestamp=1621874379 1x" media="screen and (min-width: 0)" />
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<!--[if IE 9]></video><![endif]-->
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2021/20210525-tube.jpg?itok=Z7yQr_qj&timestamp=1621874379" alt="Boy’s ear being examined by a doctor with an otoscope" title="Boy’s ear being examined by a doctor with an otoscope" />
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</picture><span class="caption">The study compared two approaches to treating recurrent ear infections in children. </span><span class="credit">SolStock / E+ via Getty Images</span></div>
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</div><p>Ear infections are among the most common illnesses in U.S. children. They occur when bacteria or viruses infect the area behind the ear drum called the middle ear. Parts of the middle ear become swollen or blocked, trapping fluid behind the ear drum. This leads to pressure and pain, and can also affect hearing.</p>
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<p>Childhood ear infections are often treated with oral antibiotics. But using antibiotics too often can cause bacteria to become resistant, so doctors may wait to see if mild ear infections clear up on their own. Some children experience frequent ear infections. For them, doctors may recommend surgery to place a tiny tube in the ear drum, called a tympanostomy tube, to provide ventilation to the middle ear. This helps to drain fluid and prevent future buildup.</p>
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||
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||
<p>Studies comparing ear tubes to oral antibiotic treatment for recurring childhood ear infections have had mixed results. Most were conducted before the pneumococcal vaccine became standard for young children. This protects against strains of bacteria that commonly cause ear infections.</p>
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||
<p>A research team led by Drs. Alejandro Hoberman at the University of Pittsburgh and Diego Preciado of Children’s National Medical Center looked at whether tubes reduced the rate of ear infection compared with treating each infection with an oral antibiotic. The study was funded by NIH’s National Institute on Deafness and Other Communication Disorders (NIDCD) and National Center for Advancing Translational Sciences (NCATS). It appeared in the <em>New England Journal of Medicine</em> on May 13, 2021.</p>
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<p>Researchers randomly assigned 250 ear infection-prone children, 6 to 35 months of age, to receive either ear tubes and antibiotic ear drops or medical management with oral antibiotics. All children had a history of at least three ear infections within 6 months or at least four within 12 months prior to entering the study. They had also received the pneumococcal vaccine. The children were then followed for two years.</p>
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<p>The team found no difference in the study’s main measure, the total number of ear infections, between the groups. Though the children in the medical management group received more oral antibiotics, the researchers did not find evidence of increased bacterial resistance in their nose and throat samples. There were also no differences in the percentage of severe infections or impact on the children’s quality of life.</p>
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<p>Of the 121 children being managed with oral antibiotics, 54 underwent tube placement during the study—35 because of failure of medical management and 19 at the request of the parent. Of the 129 children assigned to receive ear tubes, the parents of 13 declined surgery. Because of these changes, the team conducted a secondary analysis limited to children who remained in their original treatment groups. This analysis found a small benefit to the surgical approach: there were an average of 1.47 ear infections per child in the surgical group compared to 1.72 among those receiving oral antibiotics.</p>
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||
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||
<p>Although the two approaches led to a similar number of ear infections, the team did find some advantages to ear tube placement. Children in this group had their first ear infection an average of two months later than those receiving oral antibiotics. They also had fewer days with symptoms related to their ear infection, other than drainage from the ear.</p>
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||
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||
<p>“We used to often recommend tubes to reduce the rate of ear infections, but in our study, episodic antibiotic treatment worked just as well for most children,” Hoberman explains.</p>
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||
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||
<p>Another theoretical reason to resort to tubes is to prevent the development of bacterial resistance, Hoberman adds, “but in this trial, we did not find increased resistance with oral antibiotic use.”</p>
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<p>—by Erin Bryant</p></div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/antibiotics-prescribed-more-often-during-telemedicine-visits" target="_top">Antibiotics Prescribed More Often During Telemedicine Visits</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/no-benefit-shortening-ear-infection-treatment" target="_top">No Benefit to Shortening Ear Infection Treatment</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/developing-novel-ear-infection-treatments" target="_top">Developing Novel Ear Infection Treatments</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/reducing-antibiotic-prescriptions" target="_top">Reducing Antibiotic Prescriptions</a></li><li><a href="https://www.nidcd.nih.gov/health/ear-infections-children" target="_top">Ear Infections in Children</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/33979487/">Tympanostomy Tubes or Medical Management for Recurrent Acute Otitis Media. </a>Hoberman A, Preciado D, Paradise JL, Chi DH, Haralam M, Block SL, Kearney DH, Bhatnagar S, Muñiz Pujalt GB, Shope TR, Martin JM, Felten DE, Kurs-Lasky M, Liu H, Yahner K, Jeong JH, Cohen NL, Czervionke B, Nagg JP, Dohar JE, Shaikh N. <em>N Engl J Med.</em> 2021 May 13;384(19):1789-1799. doi: 10.1056/NEJMoa2027278. PMID: 33979487.</p><p class="footnote"><strong class="label-inline">Funding: </strong>NIH’s National Institute on Deafness and Other Communication Disorders (NIDCD) and National Center for Advancing Translational Sciences (NCATS).</p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-can-we-slow-aging">Research in Context: Can we slow aging?</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/risk-future-burden-dementia-united-states">Risk and future burden of dementia in the United States </a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/complete-wiring-map-adult-fruit-fly-brain">Complete wiring map of an adult fruit fly brain</a></p>
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<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
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<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
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