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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/nih-research-matters">NIH Research Matters</a></div> <div class="l-region l-region--section-header">
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2015-03-09T00:00:00-04:00" class="date-display-single">March 9, 2015</span></p><div class='syndicate'><h1>Human Epigenome Map Yields Insights into Development, Disease</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
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<ul class="spaced">
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<li>Scientists generated and analyzed more than 100 reference human epigenomes from a broad range of cell and tissue types.</li>
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<li>Early results revealed epigenomic factors associated with age, sex, tissue type, and various diseases.</li>
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-large/public/news-events/research-matters/2015/03-09-2015-epigenome-lowres.jpg?itok=8TJd1yPi&timestamp=1430847345 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2015/03-09-2015-epigenome-lowres.jpg?itok=06oIsU6V&timestamp=1430847345 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2015/03-09-2015-epigenome-lowres.jpg?itok=UapAByMP&timestamp=1430847345 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2015/03-09-2015-epigenome-lowres.jpg?itok=H1m2KCyl&timestamp=1430847345 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2015/03-09-2015-epigenome-lowres.jpg?itok=F_5p88BS&timestamp=1430847345 1x" media="screen and (min-width: 0)" />
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<!--[if IE 9]></video><![endif]-->
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<img src="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2015/03-09-2015-epigenome-lowres.jpg?itok=06oIsU6V&timestamp=1430847345" alt="A rectangular prism made up of many color lines." title="A rectangular prism made up of many color lines" />
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</picture><span class="caption">Graphic representation of the massive amount of data from just one type of lung cell illustrates genome-wide measurements (X axis) from 127 reference genomes (Y axis) in 33 data sets (Z axis).</span><span class="credit">Image by the researchers, courtesy of Nature</span></div>
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</div><p>The sequencing of the human genome—the complete set of DNA in our cells—laid the foundation for understanding how variation in the genetic code can affect human health. The “epigenome” refers to the chemical modifications that affect how cells in different parts of the body use the same genome to form countless different types of cells and tissues. Epigenomic modifications don’t affect the DNA sequence itself. Rather, these alterations influence when specific genes are turned on and off, or “expressed.” These changes to DNA and its associated proteins tell cells what to do, where to do it, and when.</p>
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<p>To gain a systematic understanding of how epigenomics contributes to human biology and disease, hundreds of researchers in labs around the world generated and analyzed over 100 reference human epigenomes from a broad range of cells and tissues. This is the largest collection to date of reference human epigenomes. The work was supported by the NIH Common Fund’s Roadmap Epigenomics Program. An overview of the effort was published on February 19, 2015, in <em>Nature</em>. More than 20 additional papers in <em>Nature</em> and <em>Nature</em>-associated journals showed how this information can be used to gain insights into human biology.</p>
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||
<p>The researchers examined several types of epigenomic factors. These included DNA methylation (when chemical tags called methyl groups are attached to DNA directly), histone modifications (when methyl or acetyl groups are added to specific spots on histones, the proteins that package DNA), gene expression levels, and more.</p>
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||
<p>This extensive resource will help scientists understand how epigenomic elements regulate gene expression to create different cell types and tissues, guide human development, and affect disease. Among the companion papers were epigenomic explorations that deepen our understanding of autoimmune disorders, Alzheimer’s disease, and cancer.</p>
|
||
|
||
<p>“What the Roadmap Epigenomics Program has delivered is a way to look at the human genome in its living, breathing nature from cell type to cell type,” says senior author Dr. Manolis Kellis at the Massachusetts Institute of Technology.</p>
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<p>“Today, sequencing the human genome can be done rapidly and cheaply, but interpreting the genome remains a challenge,” says Dr. Bing Ren at the University of California, San Diego, co-author of the <em>Nature</em> paper and several of the associated papers. “These maps are like snapshots of the human genome in action.” </p>
|
||
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||
<p>All the data sets, standards, and protocols are publicly available through Web portals as a resource to spur future research. In addition to helping scientists understand how epigenomics affects human health and disease, this resource can be used to develop better ways to identify early signs of disease and targets for therapeutics.</p>
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<p>—by Harrison Wein, Ph.D.</p>
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</div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/epigenetic-clock-marks-age-human-tissues-cells" target="_top">Epigenetic Clock Marks Age of Human Tissues and Cells</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/genetic-variations-affect-control-genome" target="_top">Genetic Variations Affect Control of the Genome</a></li><li><a href="http://www.genome.gov/27532724" target="_top">Epigenomics</a></li><li><a href="http://commonfund.nih.gov/epigenomics/index" target="_top">Roadmap Epigenomics Program</a></li><li><a href="http://www.ihec-epigenomes.org" target="_top">International Human Epigenome Consortium</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="http://www.ncbi.nlm.nih.gov/pubmed/25693563">Integrative analysis of 111 reference human epigenomes.</a> Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. <em>Nature</em>. 2015 Feb 19;518(7539):317-30. doi: 10.1038/nature14248. PMID: 25693563.</p><p class="footnote"><strong class="label-inline">Funding: </strong>NIH Common Fund, NIH’s National Institute of Environmental Health Sciences (NIEHS), National Institute on Drug Abuse (NIDA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Human Genome Research Institute (NHGRI), National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Aging (NIA), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and National Heart, Lung, and Blood Institute (NHLBI); and National Science Foundation.</p>
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