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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/nih-research-matters">NIH Research Matters</a></div> <div class="l-region l-region--section-header">
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2014-12-22T00:00:00-05:00" class="date-display-single">December 22, 2014</span></p><div class='syndicate'><h1>2014 Research Highlights — Clinical Advances</h1><div class="callout callout-with-border"><h3>Prevention, Diagnosis, and Treatment of Human Disease</h3>
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<p>With NIH support, scientists across the country and the world conduct wide-ranging research to improve the health of the nation. Groundbreaking NIH-funded research often receives top scientific honors. In 2014, these honors included support for 1 of 3 Nobel laureates in chemistry and 4 NIH-funded recipients of awards from the Lasker Foundation. Here's just a small sampling of the research accomplishments made by NIH-supported scientists in 2014.</p>
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-6406" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2014/20140915-ebola-lowres.jpg">20140915-ebola-lowres.jpg</a></h2>
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<img height="150" width="150" alt="Strand-like Ebola Virons" title="Strand-like Ebola Virons" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2014/20140915-ebola-lowres_0.jpg?itok=nNIRHAtv" /> </div>
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</div></div>
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<h4 class="teaser-title">Ebola Research</h4>
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<p class="teaser-description">The 2014 Ebola outbreak in West Africa is the largest such outbreak in history. More than 17,000 cases and 6,000 deaths have been reported. NIH-funded scientists <a href="/news-events/nih-research-matters/genetics-2014-ebola-outbreak">used genomic sequencing technologies</a> to identify the origin and track transmission of the Ebola virus in the current outbreak. Other NIH-funded researchers <a href="/news-events/nih-research-matters/computer-models-can-help-guide-ebola-response">used computer model projections</a> to provide insight into the dynamics of the outbreak. NIH has also intensified efforts to <a href="/news-events/nih-research-matters/ebola-vaccine-prompts-immune-response">develop a protective vaccine</a>. The vaccine was tested at the NIH Clinical Center, which also provided state-of-the-art care to a nurse who had contracted the Ebola virus.</p>
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</div>
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-6551" class="file file-video file-video-youtube">
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<h2 class="element-invisible"><a href="/file/6551">20140414 - Voluntary training with spinal stimulation. Video courtesy of the University of Louisville.</a></h2>
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<div class="content">
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<img height="150" width="150" alt="20140414 - Voluntary training with spinal stimulation. Video courtesy of the University of Louisville." class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/video_thumbnail/public/media-youtube/dJYzwuYKijU.jpg?itok=qbCQ8zpI" /> </div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/paralyzed-men-regain-movement-spinal-stimulation">Paralyzed Men Regain Movement With Spinal Stimulation</a></h4>
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||
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<p class="teaser-description">Four young men paralyzed below the chest because of spinal cord injuries were able to regain control of some movement after receiving an experimental spinal stimulation therapy from a team of NIH-funded researchers. If confirmed in larger studies, this type of treatment may one day improve outcomes for people living with paralysis.</p>
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-5886" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2014/20140407-childhood.jpeg">20140407-childhood.jpeg</a></h2>
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<img height="150" width="150" alt="Caregivers clapping with baby." title="Caregivers clapping with baby" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2014/20140407-childhood_0.jpeg?itok=lenLJFhL" /> </div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/adult-health-improved-early-childhood-programs">Adult Health Improved by Early Childhood Programs</a></h4>
|
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|
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<p class="teaser-description">An early childhood program (birth through age 5) has been shown to bring higher academic achievement and career benefits later in life. According to a follow-up NIH-funded study, it can also help prevent disease. By their mid-30s, those who’d participated in the program—especially males—had significantly fewer risk factors for cardiovascular and metabolic diseases compared to a control group.</p>
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-5806" class="file file-image file-image-jpeg">
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<img height="150" width="150" alt="Nurse helping hospital patient." title="Nurse helping hospital patient" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2014/20140310-nurse.jpg?itok=YPMbdG4R" /> </div>
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</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/nurse-staffing-education-affect-patient-safety">Nurse Staffing, Education Affect Patient Safety</a></h4>
|
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<p class="teaser-description">Patient deaths in hospitals might be reduced by easing nurses’ workloads and emphasizing education in hiring, an NIH-funded study suggested. Researchers estimated that each additional patient in a nurse’s workload increased the likelihood of a patient dying. An increase in nurses with bachelor’s degrees lowered the likelihood of patient death. These findings can help administrators make informed staffing decisions.</p>
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-6496" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2014/20141103-exome.jpg">20141103-exome.jpg</a></h2>
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<img height="150" width="150" alt="Mother and son." title="Mother and son" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2014/20141103-exome.jpg?itok=GvgclHze" /> </div>
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</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/clinical-exome-sequencing-detects-disease-causing-glitches">Clinical Exome Sequencing Detects Disease-Causing Glitches</a></h4>
|
||
|
||
<p class="teaser-description">In 2 NIH-supported studies, a fast, powerful technique called whole-exome sequencing provided a molecular diagnosis for about 1 in 4 people suspected of having a genetic disorder. Whole-exome sequencing focuses only on the DNA in the 1% of the human genome that codes for proteins, in contrast to the whole genome. The new tool may help doctors pinpoint the underlying causes of many rare and hard-to-diagnose genetic conditions.</p>
|
||
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<div class="teaser">
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<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-6526" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2014/20141208-hemophilia.jpg">20141208-hemophilia.jpg</a></h2>
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<div class="content">
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<img height="150" width="150" alt="Illustration of a blood clot." title="Illustration of a blood clot" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2014/20141208-hemophilia.jpg?itok=jwafcsvj" /> </div>
|
||
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</div>
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</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/gene-therapy-used-treat-hemophilia">Gene Therapy Used to Treat Hemophilia</a></h4>
|
||
|
||
<p class="teaser-description">Hemophilia is a rare bleeding disorder in which blood doesn’t clot normally. The primary treatment for people with severe hemophilia B is frequent injections of factor IX, a protein that helps blood clot, for a lifetime. An experimental gene therapy with the human factor IX gene improved symptoms for as long as 4 years in men with severe hemophilia. The NIH-funded study shows the potential for gene therapy as a safe, effective approach.</p>
|
||
</div>
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||
<div class="teaser">
|
||
<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-5801" class="file file-image file-image-jpeg">
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<h2 class="element-invisible"><a href="/2014/20140317-alzheimers.jpg">20140317-alzheimers.jpg</a></h2>
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<div class="content">
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<img height="150" width="150" alt="Scientist taking a blood sample tube from a rack." title="Scientist taking a blood sample tube from a rack" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2014/20140317-alzheimers.jpg?itok=VGzDF5XD" /> </div>
|
||
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||
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</div>
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||
</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/study-points-possible-blood-test-memory-decline-alzheimers">Study Points to Possible Blood Test For Memory Decline, Alzheimer’s</a></h4>
|
||
|
||
<p class="teaser-description">Many experts believe that successful treatment of Alzheimer’s disease will depend on early intervention before symptoms appear, but there isn’t yet any sure way to detect that stage. NIH-funded researchers identified a set of 10 compounds in the blood that might be used to distinguish older adults at risk for developing memory deficits or Alzheimer’s disease. More research is needed to confirm the findings, but the study suggests one possible approach.</p>
|
||
</div>
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||
|
||
<div class="teaser">
|
||
<div class="teaser-thumbnail"><div class="media media-element-container media-thumbnail"><div id="file-6156" class="file file-image file-image-jpeg">
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||
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<h2 class="element-invisible"><a href="/2014/20140714-sickle-cropped.jpg">20140714-sickle-cropped.jpg</a></h2>
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||
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||
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||
<div class="content">
|
||
<img height="150" width="150" alt="Torus-shaped cells." title="Torus-shaped cells" class="media-element file-thumbnail" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/thumbnail/public/news-events/research-matters/2014/20140714-sickle-cropped.jpg?itok=1nl7drlS" /> </div>
|
||
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</div>
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</div></div>
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<h4 class="teaser-title"><a href="/news-events/nih-research-matters/stem-cell-transplant-reverses-sickle-cell-disease-adults">Stem Cell Transplant Reverses Sickle Cell Disease in Adults</a></h4>
|
||
|
||
<p class="teaser-description">There is no widely available cure for the inherited blood disorder sickle cell disease. Some children have been successfully treated with blood stem cell, or bone marrow, transplants. This approach was thought to be too toxic for adults. NIH researchers successfully treated adults with severe sickle cell disease using a modified stem cell transplant approach that doesn’t require extensive immune-suppressing drugs. Further follow-up and testing will be needed to assess the therapy.</p>
|
||
</div>
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||
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