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<h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/news-events">News & Events</a> » <a href="/news-events/nih-research-matters">NIH Research Matters</a></div> <div class="l-region l-region--section-header">
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<p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2015-08-10T00:00:00-04:00" class="date-display-single">August 10, 2015</span></p><div class='syndicate'><h1>Muscle Mitochondria May Form Energy Power Grid</h1><div class="callout callout-with-border"><h3>At a Glance</h3>
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<li>Researchers found that mitochondria in mouse muscles not only produce energy, but can quickly distribute it across the muscle cell through a grid-like network.</li>
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<li>The findings reveal a major mechanism for energy distribution in skeletal muscle cells, and could provide new insights into diseases linked to energy use in muscle.</li>
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium/public/news-events/research-matters/2015/20150810-mitochondria_1.jpg?itok=jnct_qU_&timestamp=1440188024 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-medium-small/public/news-events/research-matters/2015/20150810-mitochondria_1.jpg?itok=IN349oKz&timestamp=1440188024 1x" media="screen and (min-width: 600px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-small/public/news-events/research-matters/2015/20150810-mitochondria_1.jpg?itok=yJknBksB&timestamp=1440188024 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/floated_media_breakpoint-tiny/public/news-events/research-matters/2015/20150810-mitochondria_1.jpg?itok=tb29obuG&timestamp=1440188024 1x" media="screen and (min-width: 0)" />
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</picture><span class="caption">This high-resolution 3-D microscopic image shows a network of interconnected mitochondria within a mouse muscle cell.</span><span class="credit">Brian Glancy and Chris Combs, NHLBI</span></div>
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</div><p>Skeletal muscles are made of long, thin cells that are packed with highly organized proteins and organelles. During strenuous exercise, the rate of energy use in skeletal muscles can increase by more than 100-fold almost instantly. To meet this energy demand, muscle cells contain mitochondria. These organelles, commonly referred to as the cell’s “power plants,” convert nutrients into the molecule ATP, which stores energy. In this process—known as cellular respiration or oxidative phosphorylation—the mitochondria act like small cellular batteries, using an electrical voltage across their membranes as an intermediate energy source to produce ATP.</p>
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<p>Scientists have long believed that the energy produced by mitochondria is distributed through muscle cells by some type of diffusion mechanism. However, studies have shown that these diffusion pathways alone are not sufficient to support normal muscle contraction.</p>
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<p>A team led by Drs. Robert S. Balaban and Sriram Subramaniam from NIH’s National Heart, Lung, and Blood Institute (NHLBI) and National Cancer Institute (NCI), respectively, hypothesized that some other faster, more efficient energy pathway must spread energy throughout muscle cells. Their research was conducted on the NIH campus in Bethesda, Maryland. Results were published on July 30, 2015, in <em>Nature</em>.</p>
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||
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<p>The group analyzed high-resolution 3-D images of mouse skeletal muscle. They used an imaging technique known as<strong> </strong>focused-ion beam scanning electron microscopy (FIB-SEM). Dr. Subramaniam and his team have used this approach, which they developed, to determine the structure of many key proteins, including <a href="/news-events/nih-research-matters/structural-states-brain-receptor-revealed">brain receptors</a> and the <a href="/news-events/nih-research-matters/key-hiv-protein-structure-revealed">virus that causes AIDS</a>.</p>
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<p>The researchers traced the paths of mitochondria and found that they formed a network, or reticulum. They hypothesized that these organelles might form a vast, interconnected network in a way that resembles electrical transmission lines in a municipal power grid.</p>
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||
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||
<p>To test the idea, they used specially designed optical probes to examine the electrical connections among mitochondria. They found that the mitochondrial “wires” were electrically conductive and that most of the mitochondria were in direct electrical communication through the interconnecting network. The mitochondria were electrically coupled and able to rapidly distribute the mitochondrial membrane voltage—the primary energy for ATP production—throughout the cell.</p>
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||
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<p>“The discovery of this mechanism for rapid distribution of energy throughout the muscle cell will change the way scientists think about muscle function and will open up a whole new area to explore in health and disease,” Balaban says.</p>
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</div><h2 class="label-above">Related Links</h2><ul class="spaced print-urls"><li><a href="https://www.nih.gov/news-events/nih-research-matters/mitochondrial-fusion-may-explain-alcohols-effect-muscle" target="_top">Mitochondrial Fusion May Explain Alcohol’s Effect on Muscle</a></li><li><a href="https://www.nih.gov/news-events/nih-research-matters/high-resolution-imaging-technique-may-advance-drug-design" target="_top">High-Resolution Imaging Technique May Advance Drug Design</a></li><li><a href="http://www.niams.nih.gov/Health_Info/Kids/healthy_muscles.asp" target="_top">Healthy Muscles Matter</a></li><li><a href="http://www.ninds.nih.gov/disorders/mitochondrial_myopathy/mitochondrial_myopathy.htm" target="_top">Mitochondrial Disorders</a></li><li><a href="https://newsinhealth.nih.gov/2010/April/feature1.htm" target="_top">When Cells Face an Energy Crisis</a></li></ul><p class="footnote"><strong class="label-inline">References: </strong><a href="http://www.ncbi.nlm.nih.gov/pubmed/26223627">Mitochondrial reticulum for cellular energy distribution in muscle.</a> Glancy B, Hartnell LM, Malide D, Yu ZX, Combs CA, Connelly PS, Subramaniam S, Balaban RS. <em>Nature.</em> 2015 Jul 30;523(7562):617-20. doi: 10.1038/nature14614. PMID: 26223627.</p><p class="footnote"><strong class="label-inline">Funding: </strong>NIH’s National Heart, Lung, and Blood Institute (NHLBI) and National Cancer Institute (NCI).</p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/brain-changes-observed-during-pregnancy">Brain changes observed during pregnancy</a></p>
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||
<p><a href="https://www.nih.gov/news-events/nih-research-matters/research-context-detecting-cancer">Research in Context: Detecting cancer</a></p>
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<p><a href="https://www.nih.gov/news-events/nih-research-matters/risk-future-burden-dementia-united-states">Risk and future burden of dementia in the United States </a></p>
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||
|
||
<p><a href="https://www.nih.gov/news-events/nih-research-matters/complete-wiring-map-adult-fruit-fly-brain">Complete wiring map of an adult fruit fly brain</a></p>
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<p><strong>Editor:</strong> Harrison Wein, Ph.D.</p>
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<p><strong><em>NIH Research Matters </em></strong>is a weekly update of NIH research highlights reviewed by NIH’s experts. It's published by the <a href="/institutes-nih/nih-office-director/office-communications-public-liaison">Office of Communications and Public Liaison</a> in the <a href="/institutes-nih/nih-office-director">NIH Office of the Director</a>.</p>
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