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<div about="/news-events/news-releases/nih-fund-collaborations-industry-identify-new-uses-existing-compounds" typeof="sioc:Item foaf:Document" class="ds-1col node node--nih-news-release news-release view-mode-full node--full node--nih-news-release--full clearfix">
<p class="publishdate"><span class="tag-term">News Release</span></p><p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2013-06-18T11:30:00-04:00" class="date-display-single">Tuesday, June 18, 2013</span></p><h1>NIH to fund collaborations with industry to identify new uses for existing compounds</h1><p class="subtitle">
Crowdsourcing initiative will enable exploration of potential treatments in eight disease areas.</p><p>The National Institutes of Health has awarded $12.7 million to match nine academic research groups with a selection of pharmaceutical industry compounds to explore new treatments for patients in eight disease areas, including Alzheimers disease, Duchenne muscular dystrophy and schizophrenia. The collaborative pilot initiative, called <a href="http://www.ncats.nih.gov/research/reengineering/rescue-repurpose/therapeutic-uses/therapeutic-uses.html">Discovering New Therapeutic Uses for Existing Molecules</a>, is led by the National Center for Advancing Translational Sciences (NCATS) and funded by the NIH Common Fund.</p>
<p>The process of developing a new therapeutic is long and difficult. The average length of time from target discovery to approval of a new drug is more than 13 years, and the failure rate exceeds 95 percent. This failure rate means, however, that many existing partially developed compounds could be advanced to clinical trials more quickly than starting from scratch.</p>
<p><a href="https://ncats.nih.gov/files/NTU-Miller.mp3" target="_blank">Dr. Jordan Miller, Ph.D., Mayo Clinic, Rochester, Min., discusses his teams research effort to test the safety of an investigational drug in heart valve disease patients in slowing progression of stenosis, an abnormal narrowing of vessels or other structures. (MP3 - 34:00, 670 KB)</a> [<a href="https://ncats.nih.gov/files/NTU-Miller-transcript.txt" target="_blank">Transcript</a>]</p>
<p>“With thousands of diseases remaining untreatable, there is a sense of urgency to accelerate the pace at which discoveries are transformed into therapies for patients,” said Health and Human Services Secretary Kathleen Sebelius. “This program helps forge partnerships between the pharmaceutical industry and the biomedical research community to work together to tackle problems that are beyond the scope of any one organization or sector.”</p>
<p>“Innovative, collaborative approaches that improve the therapeutic pipeline are crucial for success,” said NIH Director Francis S. Collins, M.D., Ph.D. “This unique collaboration between academia and industry holds the promise of trimming years from the long and expensive process of drug development.”</p>
<p>AbbVie (formerly Abbott); AstraZeneca; Bristol-Myers Squibb Company; Eli Lilly and Company; GlaxoSmithKline; Janssen Research &amp; Development, LLC; Pfizer; and Sanofi are participating in the pilot phase of the program.</p>
<p>NCATS launched this initiative in 2012 to help re-engineer the research pipeline using an innovative strategy to identify new uses for compounds that have undergone significant research and development by industry, including safety testing in humans. The center crowdsourced the industry compounds to academic researchers nationwide to gain ideas for new therapeutic uses with the ultimate goal of developing new treatments for patients.</p>
<p>The program also tested newly created <a href="http://www.ncats.nih.gov/research/reengineering/rescue-repurpose/therapeutic-uses/agreements.html">template agreements</a>, which enabled negotiations to be completed in fewer than 11 weeks, versus a typical timeline of a year or more.</p>
<p>“Public-private collaborations are crucial for successful translation; no one organization can succeed alone,” said NCATS Director Christopher P. Austin, M.D. “This initiative has created a marketplace to connect academic researchers with potential new drugs, as well as template agreements that streamline the process by limiting the amount of negotiation required before a project can begin.”</p>
<p>Each award recipient will test a selected compound for its effectiveness against a previously unexplored disease or condition. The eight disease areas represented are alcohol dependence, Alzheimers disease, calcific aortic valve stenosis (a condition in which the heart valve hardens and makes it difficult to pump blood out of the heart), nicotine dependence, peripheral artery disease, schizophrenia and two rare diseases: Duchenne muscular dystrophy and the progressive lung disease lymphangioleiomyomatosis. For more details about each project, please visit <a href="http://www.ncats.nih.gov/therapeutics-projects.html">http://www.ncats.nih.gov/therapeutics-projects.html</a>. The projects, award recipient principal investigators and industry partners are:</p>
<p>The efficacy and safety of a selective estrogen receptor beta agonist (LY500307)<br />
Academic Partner: Alan Breier, M.D., Indiana University, Indianapolis<br />
Industry Partner: Eli Lilly and Company</p>
<p>Fyn inhibition by AZD0530 for Alzheimers disease<br />
Academic Partners: Stephen M. Strittmatter, M.D., Ph.D.; Haakon Berge Nygaard, M.D., Ph.D.; and Christopher H. Van Dyck, M.D., Yale University, New Haven, Conn.<br />
Industry Partner: AstraZeneca</p>
<p>Medication development of a novel therapeutic for smoking cessation<br />
Academic Partners: Darlene H. Brunzell, Ph.D., Virginia Commonwealth University, Richmond and Kenneth Alan Perkins, Ph.D., University of Pittsburgh<br />
Industry Partner: Janssen Research &amp; Development, LLC</p>
<p>A novel compound for alcoholism treatment: A translational strategy<br />
Academic Partner: Fatemeh Akhlaghi, Pharm.D., Ph.D., University of Rhode Island, Kingston<br />
NIH Intramural Partner: Lorenzo Leggio, M.D., Ph.D., M.Sc., National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse<br />
Industry Partner: Pfizer</p>
<p>Partnering to treat an orphan disease: Duchenne muscular dystrophy<br />
Academic Partners: Kathryn R. Wagner, M.D., Ph.D., Kennedy Krieger Institute, Baltimore<br />
and Stanley C. Froehner, Ph.D., University of Washington, Seattle<br />
Industry Partner: Sanofi</p>
<p>Reuse of ZD4054 for patients with symptomatic peripheral artery disease (PAD)<br />
Academic Partner: Brian H. Annex, M.D., University of Virginia, Charlottesville<br />
Industry Partner: AstraZeneca</p>
<p>Therapeutic strategy for lymphangioleiomyomatosis (LAM)<br />
Academic Partner: N. Tony Eissa, M.D., Baylor College of Medicine, Houston<br />
Industry Partner: AstraZeneca</p>
<p>Therapeutic strategy to slow progression of calcific aortic valve stenosis<br />
Academic Partners: Jordan D. Miller, Ph.D.; Maurice Enriquez-Sarano, M.D.; and<br />
Hartzell V. Schaff, M.D., Mayo Clinic, Rochester, Minn.<br />
Industry Partner: Sanofi</p>
<p>Translational neuroscience optimization of GlyT1 inhibitor for cognitive impairments associated with schizophrenia<br />
Academic Partner: John H. Krystal, M.D., Yale University, New Haven, Conn.<br />
Industry Partner: Pfizer</p>
<p>These cooperative agreements will fund projects for researchers to conduct pre-clinical validation and additional safety studies as needed. If specific milestones are met, clinical feasibility studies or proof-of-concept clinical trials will be initiated to test whether the selected compounds may be effective as treatments for other diseases. The projects will be supported for up to three years.</p>
<p>NCATS leads this effort with additional scientific expertise provided by the National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; National Institute of Mental Health; and the National Institute of Neurological Disorders and Stroke.</p>
<p>For more information about the Discovering New Therapeutic Uses for Existing Molecules pilot initiative, visit <a href="http://ncats.nih.gov/therapeutics.html">http://ncats.nih.gov/therapeutics.html</a>. To submit comments regarding the pilot phase of the program, see the <a href="http://grants.nih.gov/grants/guide/notice-files/NOT-RM-13-021.html">RFI</a> at <a href="http://grants.nih.gov/grants/guide/notice-files/NOT-RM-13-021.html">http://grants.nih.gov/grants/guide/notice-files/NOT-RM-13-021.html</a>.</p>
<p>The National Center for Advancing Translational Sciences (NCATS) is a distinctly different entity in the research ecosystem. Rather than targeting a particular disease and fundamental science, NCATS focuses on what is common across diseases and the translational process. The Center emphasizes innovation and deliverables, relying on the power of data and new technologies to develop, demonstrate and disseminate improvements in translational science. For more information, visit <a href="http://www.ncats.nih.gov">http://www.ncats.nih.gov</a>.</p>
<p>The NIH Common Fund encourages collaboration and supports a series of exceptionally high-impact, trans-NIH programs. Common Fund programs are designed to pursue major opportunities and gaps in biomedical research that no single NIH Institute could tackle alone, but that the agency as a whole can address to make the biggest impact possible on the progress of medical research. Additional information about the NIH Common Fund can be found at <a href="http://commonfund.nih.gov">http://commonfund.nih.gov</a>.</p>
<p><strong>About the National Institutes of Health (NIH):</strong>
NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <a href="/">www.nih.gov</a>.</p>
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<div class="sb-image sb-individual"><a href="https://www.youtube.com/embed/C4XOI23v0SA?autoplay=1" rel="shadowbox; width=640; height=360" title="Dr. Kathryn Wagner, M.D., Ph.D., Kennedy Krieger Institute, Baltimore, talks about Duchenne muscular dystrophy and how the New Therapeutic Uses program can make a difference in potentially accelerating a treatment for this devastating disorder."><img class="image-video_sidebar" typeof="foaf:Image" src="https://www.nih.gov/sites/default/files/styles/video_sidebar/public/media-youtube/C4XOI23v0SA.jpg?itok=J4VI7lYR" width="640" height="427" alt="Dr. Kathryn Wagner, M.D., Ph.D., Kennedy Krieger Institute, Baltimore, talks about Duchenne muscular dystrophy and how the New Therapeutic Uses program can make a difference in potentially accelerating a treatment for this devastating disorder." title="Dr. Kathryn Wagner, M.D., Ph.D., Kennedy Krieger Institute, Baltimore, talks about Duchenne muscular dystrophy and how the New Therapeutic Uses program can make a difference in potentially accelerating a treatment for this devastating disorder." /></a></div><p class="caption">Dr. Kathryn Wagner, M.D., Ph.D., Kennedy Krieger Institute, Baltimore, talks about Duchenne muscular dystrophy and how the New Therapeutic Uses program can make a difference in potentially accelerating a treatment for this devastating disorder.</p></div>
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