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<p class="publishdate"><span class="tag-term">News Release</span></p><p class="publishdate"><span property="dc:date" datatype="xsd:dateTime" content="2015-03-31T12:00:00-04:00" class="date-display-single">Tuesday, March 31, 2015</span></p><h1>Repurposed experimental cancer drug restores brain function in mouse models of Alzheimer’s disease</h1><p class="subtitle">
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NIH-supported research enables clinical trial to explore treatment for most common form of dementia.</p><div class="featured-media"><div class="ds-1col file file-image file-image-jpeg view-mode-featured_media clearfix">
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<picture title="Image of mouse brain in Alzheimer’s model">
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-large/public/news-events/news-releases/2015/20150331-mouse-brain.jpg?itok=1HY1bbuY&timestamp=1436276396 1x" media="screen and (min-width: 960px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/news-events/news-releases/2015/20150331-mouse-brain.jpg?itok=cOaNIrcw&timestamp=1436276396 1x" media="screen and (min-width: 800px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-small/public/news-events/news-releases/2015/20150331-mouse-brain.jpg?itok=s3iL0kNA&timestamp=1436276396 1x" media="screen and (min-width: 480px)" />
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<source srcset="https://www.nih.gov/sites/default/files/styles/featured_media__breakpoint-tiny_/public/news-events/news-releases/2015/20150331-mouse-brain.jpg?itok=WXvOUNq0&timestamp=1436276396 1x" media="screen and (min-width: 0)" />
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<img src="https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/news-events/news-releases/2015/20150331-mouse-brain.jpg?itok=cOaNIrcw&timestamp=1436276396" alt="Image of mouse brain in Alzheimer’s model" title="Image of mouse brain in Alzheimer’s model" />
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</picture><span class="caption">In a mouse model of Alzheimer’s disease, amyloid beta clusters (red) build up among neurons (green) in a memory-related area of the brain. </span><span class="credit">(Strittmatter Laboratory, Yale University Photo/Adam Kaufman) </span></div>
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</div><p>Scientists have found that a compound originally developed as a cancer therapy potentially could be used to treat Alzheimer’s disease. The team demonstrated that the drug, saracatinib, restores memory loss and reverses brain problems in mouse models of Alzheimer’s, and now the researchers are testing saracatinib’s effectiveness in humans. The study was funded by the National Institutes of Health as part of an innovative crowdsourcing initiative to repurpose experimental drugs.</p>
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||
<p>Researchers from the Yale University School of Medicine, New Haven, Connecticut, conducted the animal study, published for early view on <a href="http://onlinelibrary.wiley.com/doi/10.1002/ana.24394/full" target="_blank">March 21 in the Annals of Neurology</a>, with support from the National Center for Advancing Translational Sciences (NCATS) through its <a href="http://www.ncats.nih.gov/therapeutics.html">Discovering New Therapeutic Uses for Existing Molecules</a> (New Therapeutic Uses) program. Launched in May 2012, this program matches scientists with a selection of pharmaceutical industry assets that have undergone significant research and development by industry, including safety testing in humans, to test potential ideas for new therapeutic uses.</p>
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<p>Alzheimer’s disease is the most common form of dementia, a group of disorders that cause progressive loss of memory and other mental processes. An estimated 5 million Americans have Alzheimer’s disease, which causes clumps of amyloid beta protein to build up in the brain, and these protein clusters damage and ultimately kill brain cells (neurons). Alzheimer’s disease also leads to loss of synapses, which are the spaces between neurons through which the cells talk to each other and form memories. Current Alzheimer’s drug therapies can only ease symptoms without stopping disease progression. New treatments are needed that can halt the condition by targeting its underlying mechanisms.</p>
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||
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||
<p>Through NCATS’ New Therapeutic Uses program, Yale neurobiology researcher, neurologist and senior author of the study Stephen Strittmatter, M.D., Ph.D., and his colleagues obtained saracatinib (AZD0530), which the biopharmaceutical company AstraZeneca previously developed to treat cancer. Strittmatter and his team knew from previous studies that a protein called Fyn kinase plays a central role in how amyloid beta clusters damage brain cells. Saracatinib targets the same Fyn protein and already had cleared several key steps in the development process, giving Strittmatter’s team a critical head start on the research.</p>
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<p>“The investigational drug already had been developed, optimized and studied in animals as well as tested for safety in humans, so our ability to obtain this asset through NCATS and AstraZeneca gave us an incredible shortcut in the drug development process,” Strittmatter explained.</p>
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||
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<p>Typically, drug development can take at least a decade from the discovery of a therapeutic target to an experimental compound’s entry into a Phase 2a human clinical trial to test effectiveness. In the case of saracatinib, the research team completed required preclinical and clinical safety studies and began a Phase 2a trial within about 18 months.</p>
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<p>“This work demonstrates what can happen when NIH, the biopharmaceutical industry and academia innovate and collaborate to share resources and knowledge,” said NCATS Director Christopher P. Austin, M.D. “The speed with which this compound moved to human trials validates our New Therapeutic Uses program model and serves NCATS’ mission to deliver more treatments to more patients more quickly.”</p>
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<p>“No one individual or group has complete knowledge of disease pathways and treatment targets,” said Craig D. Wegner, Ph.D., head, Boston Emerging Innovations Unit, Scientific Partnering & Alliances within AstraZeneca’s Innovative Medicines and Early Development Biotech Unit. “This program enabled us to pair AstraZeneca’s data on this compound with the Strittmatter group’s specialized Alzheimer’s disease knowledge to uncover a potential new therapeutic use for saracatinib. It’s a great example of how scientists from industry and academia can synergistically work together to push the boundaries of medical science.”</p>
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<p>In the animal study, the Yale team gave the experimental drug to mice with Alzheimer’s-like symptoms, such as memory loss and age-related buildup of abnormal amyloid beta clusters, modeling the development of the disease in humans. After four weeks, the Alzheimer’s mice showed complete reversal of spatial learning and memory loss. When the scientists examined the brains of the mice, they found that the characteristic synapse loss had been fully restored, providing a biological explanation for the memory improvement. The treatment also reduced several other Alzheimer’s-related biochemical changes in the mice and did not appear to be toxic.</p>
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||
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||
<p>Already, the Yale scientists have completed a successful Phase 1b safety trial in humans with Alzheimer’s disease (NCT01864655). Now the team is enrolling more participants in a larger, multisite Phase 2a trial (NCT02167256) to assess safety, tolerability and effectiveness of the experimental compound. A total of 152 participants will receive saracatinib or placebo for one year, and the researchers expect to have final results within two years. Individuals interested in participating in the trial can find more information at <a href="https://clinicaltrials.gov/ct2/show/NCT02167256?term=Alzheimer+AND+Fyn&rank=2">https://clinicaltrials.gov/ct2/show/NCT02167256?term=Alzheimer+AND+Fyn&rank=2</a>.</p>
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<p>Both human trials were funded by the New Therapeutic Uses program (Phase 1b: 1UH2TR000967-01; Phase 2a: 4UH3TR000967-02). The Phase 2a study will take place at multiple clinical sites as part of the <a href="http://www.adcs.org" target="_blank">Alzheimer’s Disease Cooperative Study</a>, an initiative for multisite clinical studies sponsored by the National Institute on Aging (NIA) to facilitate the development and testing of new therapeutics for the condition.</p>
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<p>In addition to NCATS, the NIH Common Fund (IUH2TR000967-01), NIA (5R01AG034924-05), BrightFocus Foundation, Alzheimer’s Association and Falk Medical Research Trust provided funding for the animal study.</p>
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||
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<p>Learn more about NCATS’ New Therapeutic Uses program at <a href="http://www.ncats.nih.gov/therapeutics.html">http://www.ncats.nih.gov/therapeutics.html</a>. </p>
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<p>The National Center for Advancing Translational Sciences is a distinctly different entity in the research ecosystem. Rather than targeting a particular disease or fundamental science, NCATS focuses on what is common across diseases and the translational process. The Center emphasizes innovation and deliverables, relying on the power of data and new technologies to develop, demonstrate and disseminate advancements in translational science that bring about tangible improvements in human health. For more information, visit <a href="http://www.ncats.nih.gov/">http://www.ncats.nih.gov</a>.</p>
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<p>About the National Institute on Aging: The NIA leads the federal government effort conducting and supporting research on aging and the health and well-being of older people. It provides information on age-related cognitive change and neurodegenerative disease specifically at its Alzheimer’s Disease Education and Referral (ADEAR) Center at <a href="http://www.nia.nih.gov/alzheimers">http://www.nia.nih.gov/alzheimers</a>.</p>
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<p>The NIH Common Fund supports a series of exceptionally high-impact research programs that are broadly relevant to health and disease. Common Fund programs are designed to overcome major research barriers and pursue emerging opportunities for the benefit of the biomedical research community at large. The research products of the Common Fund programs are expected to catalyze disease-specific research supported by the NIH Institutes and Centers. To learn more about the NIH Common Fund, visit <a href="http://commonfund.nih.gov">http://commonfund.nih.gov</a>.</p>
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<p><strong>About the National Institutes of Health (NIH):</strong>
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