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<article class="dk-content">
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<h1 itemprop="name">Obesity, Pregnancy, & the Intrauterine Environment</h1>
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<p class="abstract">
|
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Impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of mother and offspring.
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</p>
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<div class="expandable" data-collapse="both" >
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<p><span style="color: rgb(87, 87, 87);">The Obesity, Pregnancy, and Intrauterine Environment program supports basic and clinical research to understand the impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of both mother and offspring. The program supports observational and interventional clinical studies on the adverse effects of obesity and gestational/type 2 diabetes during pregnancy on mothers and their offspring beyond the immediate neonatal period. NIDDK does not generally support research focusing on the primary prevention or treatment of gestational diabetes directed at the immediate pregnancy outcomes/complications in women or their newborns. Interventional studies may involve, but are not limited to, diet (including food components/dietary supplements), physical activity programs, medications, or bariatric surgery that aim to mitigate or prevent adverse effects of over-nutrition and dysglycemia during and after pregnancy/delivery in both the mothers and their offspring beyond the immediate neonatal period. The program also supports basic and clinical research investigating the mechanisms by which the intrauterine environment alters metabolic responses in offspring. A particular focus is on the role of the pathophysiological consequences of obesity and/or diabetes on the offspring. The long-term goal of this program is to identify molecular targets that could be therapeutically altered in order to prevent or ameliorate the increasing incidence and deleterious effects of obesity and type 2 diabetes.</span></p>
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<p> </p>
|
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<p> </p>
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</div>
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<div class="program-staff">
|
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<h2>NIDDK Program Staff</h2>
|
||
<ul>
|
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<li>
|
||
<a href="/about-niddk/staff-directory/biography/evans-mary">Mary Evans, Ph.D.</a>
|
||
Multi-center Clinical Studies in Nutrition & Obesity; Nutrition Obesity Research Centers; Diet & Physical Activity Assessment Methodology
|
||
</li>
|
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<li>
|
||
<a href="/about-niddk/staff-directory/biography/lawrence-jean">Jean M. Lawrence, Sc.D., M.P.H., MSW</a>
|
||
Type 2 diabetes risk and prevention after gestational diabetes; Studies of adults with diabetes/pre-diabetes using secondary data and observational designs, and natural experiments
|
||
</li>
|
||
<li>
|
||
<a href="/about-niddk/staff-directory/biography/linder-barbara">Barbara Linder, M.D., Ph.D.</a>
|
||
Type 2 diabetes in children and youth; human studies of metabolic imprinting
|
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</li>
|
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<li>
|
||
<a href="/about-niddk/staff-directory/biography/silva-corinne">Corinne M. Silva, Ph.D.</a>
|
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Circadian rhythms, Metabolic Signaling Pathways, Clock Protein Role in Gene Expression, Diabetes, Obesity
|
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</li>
|
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</ul>
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</div>
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<section class="fs-results" aria-live="polite">
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<h2>Recent Funding Opportunities</h2>
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<a class="cta" href="/research-funding/current-opportunities?rd=nu&rd=ob&rd=db&rd=em">View More Recent Funding Opportunities</a>
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<div class="top">
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<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-10">1/10/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/par-25-090.html" class="no-disclaimer">PAR-25-090</a>
|
||
</div>
|
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<h3>NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional)</h3>
|
||
|
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<div class="bottom"><a href="/research-funding/current-opportunities/par-25-090">Summary</a></div>
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<div class="top">
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<span>
|
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<label>Posted:</label>
|
||
<time datetime="2025-01-10">1/10/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/par-25-091.html" class="no-disclaimer">PAR-25-091</a>
|
||
</div>
|
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<h3>Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)</h3>
|
||
|
||
<div class="bottom"><a href="/research-funding/current-opportunities/par-25-091">Summary</a></div>
|
||
</li>
|
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<li data-filters="rd=db,dg,em,hm,kd,lv,nu,ob,pn,ur&at=par&cl=ei,jf&ac=rp">
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<div class="top">
|
||
<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-10">1/10/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/par-25-312.html" class="no-disclaimer">PAR-25-312</a>
|
||
</div>
|
||
<h3>Time-Sensitive Evaluation of Policies Affecting Health Behaviors and Chronic Disease Risk (R01-Clinical Trial Not Allowed)</h3>
|
||
|
||
<div class="bottom"><a href="/research-funding/current-opportunities/par-25-312">Summary</a></div>
|
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</li>
|
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<li data-filters="rd=db,dg,em,hm,kd,lv,nu,ob,pn,ur&at=pas&cl=ei,jf&ac=rp">
|
||
<div class="top">
|
||
<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-08">1/8/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/pas-25-073.html" class="no-disclaimer">PAS-25-073</a>
|
||
</div>
|
||
<h3>Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)</h3>
|
||
|
||
<div class="bottom"><a href="/research-funding/current-opportunities/pas-25-073">Summary</a></div>
|
||
</li>
|
||
<li data-filters="rd=db,dg,em,hm,kd,lv,nu,ob,pn,ur&at=pas&cl=ei,jf&ac=rp">
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<div class="top">
|
||
<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-08">1/8/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/pas-25-102.html" class="no-disclaimer">PAS-25-102</a>
|
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</div>
|
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<h3>Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required)</h3>
|
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|
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<div class="bottom"><a href="/research-funding/current-opportunities/pas-25-102">Summary</a></div>
|
||
</li>
|
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</ol>
|
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<a class="cta" href="/research-funding/current-opportunities?rd=nu&rd=ob&rd=db&rd=em">View More Recent Funding Opportunities</a>
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</section> <div >
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<div class="title"><a href="https://clinicaltrials.gov/search?cond=pregnancy&spons=NIDDK&aggFilters=status:not+rec+act&viewType=Table">NIDDK Active Trials in Pregnancy Health</a></div>
|
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|
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|
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|
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|
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Study sections conduct initial peer review of applications in a designated scientific area.
|
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Visit the NIH’s Center for Scientific Review website to search for study sections.
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|
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|
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NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
|
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|
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|
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|
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<a href="/research-funding/human-subjects-research/ancillary-major-ongoing-clinical-studies">Ancillary Studies to Major Ongoing Clinical Studies</a> to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
|
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|
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|
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<a href="https://repository.niddk.nih.gov/home/">NIDDK Central Repository</a> for access to clinical resources including data and biospecimens from NIDDK-funded studies.
|
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|
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|
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<a href="https://dknet.org/">NIDDK Information Network (dkNET)</a> for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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These programs support innovative research conducted by small businesses that has the potential for
|
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commercialization.
|
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|
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<a class="cta" href="/research-funding/research-programs/small-business">Learn about NIDDK Small Business Programs</a>
|
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|
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<h4><a href="/research-funding/human-subjects-research">Human Subjects Research</a></h4>
|
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<p>
|
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NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
|
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</p>
|
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<a class="cta" href="/research-funding/human-subjects-research">Learn about Human Subjects Research</a>
|
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<h3>Translational<i class="hide-mobile"> Research</i></h3>
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|
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<p>
|
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NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
|
||
into novel therapeutics.
|
||
</p>
|
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<a class="cta" href="/research-funding/research-programs/translational-research-therapeutic-discovery-development">Learn about NIDDK Translational Research Opportunities</a>
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NIDDK New PI Workshop
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<time datetime="2025-03-13">March 13</time>
|
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- <time datetime="2025-03-14">14, 2025</time>
|
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<br />
|
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Rockville, MD <br />
|
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Webinar
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</div>
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</a>
|
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<div class="sc-card">
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<a href="https://www.niddk.nih.gov/news/meetings-workshops/2025/data-standards-2025">
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<div class="sc-card-image">
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<img src="/-/media/Images/News/Meetings/2024-Meetings/Gaps-Challenges-Opportunities-Meeting_Rotator.jpg" alt="Data Standards 2025 Rotator" width="400" height="300" />
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</div>
|
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<div class="sc-card-header">
|
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Addressing Gaps, Challenges, and Opportunities Related to Data and Metadata Standards for NIDDK Research Priorities
|
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</div>
|
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<div class="sc-card-copy">
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<p>
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<time datetime="2025-03-25">March 25</time>
|
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- <time datetime="2025-03-26">26, 2025</time>
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<br />
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Webinar
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</div>
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</a>
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2025 NIDDK K Awardees Workshop
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<div class="sc-card-copy">
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<p>
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<time datetime="2025-04-03">April 3</time>
|
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- <time datetime="2025-04-04">4, 2025</time>
|
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<br />
|
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Bethesda, MD <br />
|
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</p>
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