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<article class="dk-content">
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<h1 itemprop="name">Nutrient Metabolism, Status, & Assessment</h1>
|
||
<p class="abstract">
|
||
Basic, clinical, and translational research on the requirements, bioavailability, and metabolism of nutrients and other dietary components.
|
||
</p>
|
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<div class="expandable" data-collapse="both" >
|
||
<p><span>The
|
||
Nutrient Metabolism, Status, and Assessment program supports basic and clinical
|
||
studies related to the absorption, metabolism, bioavailability, and
|
||
requirements of nutrients and other dietary components. This includes
|
||
research on processes at the organ, cellular, and subcellular levels in normal
|
||
and diseased states. Suitable studies include those that explore how
|
||
the nutritional status of an organism, such as over-nutrition and
|
||
under-nutrition, affects physiological and metabolic functions contributing to
|
||
the pathophysiology of diseases of interest to the NIDDK. Specific areas
|
||
of interest include the role of gut-brain signals in nutrient sensing;
|
||
mechanisms of action/interaction of nutrients within the body; the process of
|
||
food digestion in the gastrointestinal tract; and the absorption and transport
|
||
of water, ions, sugars, amino acids/peptides, lipids, vitamins, minerals, and
|
||
other macromolecules and bioactive components. Other supported studies
|
||
include those that explore modifications of nutrient metabolism and/or status due
|
||
to genetic variation, altered gut barrier function, and/or in response to
|
||
stress, circadian and diurnal variations, drug use, toxicants, bariatric
|
||
surgery and physical activity in health and disease. The program also
|
||
supports studies that explore how dietary modifications affect gene regulation
|
||
and expression at the transcriptional, translational, epigenetic, and
|
||
functional level, including relevant nutrigenetic and nutrigenomic approaches. </span></p>
|
||
<p><span>Appropriate
|
||
studies explore the impact of dietary modification on the human gut microbiome
|
||
and/or dysregulation of gut microbiome on nutrient absorption, gut
|
||
barrier function, and permeability and metabolism. Mechanistic
|
||
studies that explore the role of prebiotic and probiotic metabolism
|
||
on microbiome compositional and functional changes and host physiology are also
|
||
appropriate.</span></p>
|
||
<p><span>This
|
||
program also supports studies that explore mathematical models contributing to
|
||
the understanding of whole-body energy balance and metabolism, and of metabolic
|
||
fluxes in cells, tissues, and organs. A particular focus of interest
|
||
is on models that allow the integration of data gained from a variety of
|
||
technological approaches, such as tracer studies, calorimetry, plasma
|
||
hormone/cytokines, metabolomics, genomics, epigenomics, and proteomics, and on
|
||
those models that would be of clinical utility, including prediction of plasma
|
||
glucose levels in diabetes, nutritional partitioning, nutritional status, and
|
||
weight management.</span></p>
|
||
|
||
<p><span>The
|
||
program supports research on specific metabolic considerations related to
|
||
alternative forms of nutrient delivery and use, such as total parenteral and
|
||
enteral nutrition. Other supported studies involve research for
|
||
improving methods to determine dietary intake and compliance, including dietary
|
||
recall methodologies and questionnaires; novel approaches for collecting
|
||
information on dietary intake, identification and development of biomarkers of
|
||
intake and exposure; and the development of methods and assays for assessing
|
||
nutritional status and for determining specific nutritional requirements in
|
||
health and disease.</span></p>
|
||
</div>
|
||
<div class="program-staff">
|
||
<h2>NIDDK Program Staff</h2>
|
||
<ul>
|
||
<li>
|
||
<a href="/about-niddk/staff-directory/biography/evans-mary">Mary Evans, Ph.D.</a>
|
||
Multi-center Clinical Studies in Nutrition & Obesity; Nutrition Obesity Research Centers; Diet & Physical Activity Assessment Methodology
|
||
</li>
|
||
<li>
|
||
<a href="/about-niddk/staff-directory/biography/maruvada-padma">Padma Maruvada, Ph.D.</a>
|
||
Nutrient Metabolism; Clinical Obesity and Nutrition
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
<section class="fs-results" aria-live="polite">
|
||
<h2>Recent Funding Opportunities</h2>
|
||
<a class="cta" href="/research-funding/current-opportunities?rd=dg">View More Recent Funding Opportunities</a>
|
||
<ol class="result-items funding-opportunities">
|
||
<li data-filters="rd=db,dg,em,hm,kd,lv,nu,ob,pn,ur&at=par&cl=ei&ac=rp">
|
||
<div class="top">
|
||
<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-10">1/10/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/par-25-090.html" class="no-disclaimer">PAR-25-090</a>
|
||
</div>
|
||
<h3>NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional)</h3>
|
||
|
||
<div class="bottom"><a href="/research-funding/current-opportunities/par-25-090">Summary</a></div>
|
||
</li>
|
||
<li data-filters="rd=db,dg,em,hm,kd,lv,nu,ob,pn,ur&at=par&cl=jf&ac=trn">
|
||
<div class="top">
|
||
<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-10">1/10/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/par-25-091.html" class="no-disclaimer">PAR-25-091</a>
|
||
</div>
|
||
<h3>Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)</h3>
|
||
|
||
<div class="bottom"><a href="/research-funding/current-opportunities/par-25-091">Summary</a></div>
|
||
</li>
|
||
<li data-filters="rd=db,dg,em,hm,kd,lv,nu,ob,pn,ur&at=par&cl=ei,jf&ac=rp">
|
||
<div class="top">
|
||
<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-10">1/10/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/par-25-312.html" class="no-disclaimer">PAR-25-312</a>
|
||
</div>
|
||
<h3>Time-Sensitive Evaluation of Policies Affecting Health Behaviors and Chronic Disease Risk (R01-Clinical Trial Not Allowed)</h3>
|
||
|
||
<div class="bottom"><a href="/research-funding/current-opportunities/par-25-312">Summary</a></div>
|
||
</li>
|
||
<li data-filters="rd=db,dg,em,hm,kd,lv,nu,ob,pn,ur&at=pas&cl=ei,jf&ac=rp">
|
||
<div class="top">
|
||
<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-08">1/8/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/pas-25-073.html" class="no-disclaimer">PAS-25-073</a>
|
||
</div>
|
||
<h3>Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)</h3>
|
||
|
||
<div class="bottom"><a href="/research-funding/current-opportunities/pas-25-073">Summary</a></div>
|
||
</li>
|
||
<li data-filters="rd=db,dg,em,hm,kd,lv,nu,ob,pn,ur&at=pas&cl=ei,jf&ac=rp">
|
||
<div class="top">
|
||
<span>
|
||
<label>Posted:</label>
|
||
<time datetime="2025-01-08">1/8/2025</time>
|
||
</span>
|
||
<a href="https://grants.nih.gov/grants/guide/pa-files/pas-25-102.html" class="no-disclaimer">PAS-25-102</a>
|
||
</div>
|
||
<h3>Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required)</h3>
|
||
|
||
<div class="bottom"><a href="/research-funding/current-opportunities/pas-25-102">Summary</a></div>
|
||
</li>
|
||
</ol>
|
||
<a class="cta" href="/research-funding/current-opportunities?rd=dg">View More Recent Funding Opportunities</a>
|
||
</section> <div >
|
||
|
||
</div>
|
||
<h2 id="related-links">Related Links</h2>
|
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<ul class="thumbnail-list">
|
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<li>
|
||
<i class="stack-icon pentagon-arrow indigo medical-microscope"></i>
|
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<div class="title"><a href="https://clinicaltrials.gov/search?cond=gastrointestinal+diseases&spons=NIDDK&aggFilters=status:not+rec+act&viewType=Table">NIDDK Active Trials in Digestive Disease</a></div>
|
||
<div>
|
||
<p>View related clinical trials from ClinicalTrials.gov.</p>
|
||
</div>
|
||
</li>
|
||
<li>
|
||
<i class="stack-icon pentagon-arrow blue people-funding"></i>
|
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<div class="title"><a href="https://public.csr.nih.gov/StudySections">NIH Study Sections</a></div>
|
||
<div>
|
||
<p>
|
||
Study sections conduct initial peer review of applications in a designated scientific area.
|
||
Visit the NIH’s Center for Scientific Review website to search for study sections.
|
||
</p>
|
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</div>
|
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</li>
|
||
</ul><hr>
|
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<h2 id="resources">Research Resources</h2>
|
||
|
||
<p>
|
||
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
|
||
</p>
|
||
<ul>
|
||
<li>
|
||
<a href="/research-funding/human-subjects-research/ancillary-major-ongoing-clinical-studies">Ancillary Studies to Major Ongoing Clinical Studies</a> to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
|
||
</li>
|
||
<li>
|
||
<a href="https://repository.niddk.nih.gov/home/">NIDDK Central Repository</a> for access to clinical resources including data and biospecimens from NIDDK-funded studies.
|
||
</li>
|
||
<li>
|
||
<a href="https://dknet.org/">NIDDK Information Network (dkNET)</a> for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
|
||
</li>
|
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</ul>
|
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|
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|
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<h2 id="additional-programs">Additional Research Programs</h2>
|
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<div class="tabs">
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<h3><i class="hide-mobile">Research </i>Training</h3>
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<figure class="fill">
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|
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<p>
|
||
NIDDK supports the training and career development of medical and graduate students, postdoctoral
|
||
fellows, and physician scientists through institutional and individual grants.
|
||
</p>
|
||
<a class="cta" href="/research-funding/training-career-development">Learn about NIDDK Research Training Programs</a>
|
||
<h3>Small Business</h3>
|
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<h4><a href="/research-funding/research-programs/small-business">Small Business Programs</a></h4>
|
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<p>
|
||
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology
|
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Transfer (STTR) programs.
|
||
These programs support innovative research conducted by small businesses that has the potential for
|
||
commercialization.
|
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</p>
|
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<a class="cta" href="/research-funding/research-programs/small-business">Learn about NIDDK Small Business Programs</a>
|
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<h3>Human Subjects<i class="hide-mobile"> Research</i></h3>
|
||
<h4><a href="/research-funding/human-subjects-research">Human Subjects Research</a></h4>
|
||
<p>
|
||
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
|
||
</p>
|
||
<a class="cta" href="/research-funding/human-subjects-research">Learn about Human Subjects Research</a>
|
||
<h3>Translational<i class="hide-mobile"> Research</i></h3>
|
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<figure class="fill">
|
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<a href="/research-funding/research-programs/translational-research-therapeutic-discovery-development"><img alt="Translational Research process graphic" src="/-/media/Images/Components/research-funding/translational-research.svg?h=133&w=760&hash=3953D09C6DDCB1B1A5D196FD8C011104" width="760" height="133" style="max-width: 760px;" /></a></figure>
|
||
<p>
|
||
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
|
||
into novel therapeutics.
|
||
</p>
|
||
<a class="cta" href="/research-funding/research-programs/translational-research-therapeutic-discovery-development">Learn about NIDDK Translational Research Opportunities</a>
|
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</div>
|
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|
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<div class="sc-card">
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<a href="https://www.niddk.nih.gov/news/meetings-workshops/2025/new-pi-workshop-2025">
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<div class="sc-card-image">
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<img src="/-/media/Images/News/Meetings/2024-Meetings/NIDDK_2025-New-PI-Web-Rotator_400x330_P3.png" alt="NIDDK New PI Rotator" width="400" height="300" />
|
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</div>
|
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<div class="sc-card-header">
|
||
NIDDK New PI Workshop
|
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</div>
|
||
<div class="sc-card-copy">
|
||
<p>
|
||
<time datetime="2025-03-13">March 13</time>
|
||
- <time datetime="2025-03-14">14, 2025</time>
|
||
<br />
|
||
Rockville, MD <br />
|
||
Webinar
|
||
</p>
|
||
</div>
|
||
|
||
</a>
|
||
</div>
|
||
<div class="sc-card">
|
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<a href="https://www.niddk.nih.gov/news/meetings-workshops/2025/k-awardees-2025">
|
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<div class="sc-card-image">
|
||
<img src="/-/media/Images/News/Meetings/2024-Meetings/K-Awardees-Web-Rotator_400x300_2025_P1.jpg" alt="K Awardees Workshop Rotator" width="400" height="300" />
|
||
</div>
|
||
<div class="sc-card-header">
|
||
2025 NIDDK K Awardees Workshop
|
||
</div>
|
||
<div class="sc-card-copy">
|
||
<p>
|
||
<time datetime="2025-04-03">April 3</time>
|
||
- <time datetime="2025-04-04">4, 2025</time>
|
||
<br />
|
||
Bethesda, MD <br />
|
||
</p>
|
||
</div>
|
||
|
||
</a>
|
||
</div>
|
||
<div class="sc-card">
|
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<a href="http://dknet.org">
|
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<div class="sc-card-image">
|
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<img src="/-/media/Images/Components/Cards/Featured-Cards/2020-Feature-Cards/dkNET-rotator-v3.jpg?as=0&h=300&iar=0&w=400&hash=D8E6EACC5FB46775B352E9D41EFF0854" alt="dkNET slider card." width="400" height="300" />
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