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<h1 itemprop="name">Kidney Disease Centers</h1>
<p class="abstract">
Enhancing the effectiveness of research related to nephrology by encouraging collaboration among investigators from relevant disciplines.
</p>
<div class="program-staff">
<h2>NIDDK Program Staff</h2>
<ul>
<li>
<a href="/about-niddk/staff-directory/biography/gipson-debbie">Debbie Gipson, M.D., M.S.</a>
Precision Clinical Trials; Clinical and Translational Studies; Chronic Kidney Diseases; OBrien Kidney Resource Alliance; Pediatric Centers of Excellence in Nephrology; Kidney Precision Medicine Project; NIDDK Central Repository; and Pediatric Urology
</li>
<li>
<a href="/about-niddk/staff-directory/biography/maric-bilkan-christine">Christine Maric-Bilkan, Ph.D.</a>
Basic Renal Disease; Basic Science of Polycystic Kidney Disease
</li>
<li>
<a href="/about-niddk/staff-directory/biography/mendley-susan">Susan R. Mendley, M.D.</a>
Clinical and Translational PKD; Polycystic Kidney Disease Research Resource Consortium; Pediatric Kidney Disease; Pediatric Centers of Excellence in Nephrology; and Chronic Kidney Disease
</li>
<li>
<a href="/about-niddk/staff-directory/biography/nihalani-deepak">Deepak Nihalani, Ph.D.</a>
OBrien Kidney Centers; Kidney HIV/AIDS; Clinical Translational Studies; Urology HIV/AIDS
</li>
<li>
<a href="/about-niddk/staff-directory/biography/schulman-ivonne">Ivonne H. Schulman, M.D.</a>
OBrien Kidney Centers; Translational and Clinical Studies of Acute Kidney Injury
</li>
</ul>
</div>
<div >
<h2>Funding for Kidney Disease Centers</h2>
<p>NIDDK funds Pediatric Centers of Excellence in Nephrology via <a href="/research-funding/process/apply/funding-mechanisms/p50">P50</a>. The O'Brien Kidney Centers are funded via <a href="/research-funding/process/apply/funding-mechanisms/u54">U54</a>&nbsp;and are supported by a U24&nbsp;Coordinating Center. The Polycystic Kidney Disease Centers are funded via <a href="/research-funding/process/apply/funding-mechanisms/u54">U54</a>&nbsp;and are also supported by a U24 Coordinating Center. For information on current funded Centers, please visit the <a href="https://reporter.nih.gov/">NIH RePORTer website</a>.</p>
<p>
Centers are funded for project periods of five years. Current project periods and funding levels can be ascertained using the <a href="https://report.nih.gov/">RePORTer tool</a>. NIDDK plans for re-competitions at the end of each project period pending consideration and concurrence by the National Diabetes and Digestive and Kidney Diseases Advisory Council. Approved Center concepts can be found on <a href="/about-niddk/advisory-coordinating-committees/national-diabetes-digestive-kidney-diseases-advisory-council/concept-clearances">this page</a>.</p>
<h2>
Resources and Services Available from Kidney Disease Centers</h2>
<p>There are seven Kidney Disease Centers also known as National Resource Centers (NRC). These centers will lead a nationwide effort in supporting kidney research by generating investigative resources that will be made available to the broader research community. These centers have integrated teams of investigators from a wide range of disciplines, share specialized equipment, and will serve as national resources. The coordinated efforts of all kidney centers will be managed and organized by a National Coordinating Center (NCC). All centers will participate in supporting an opportunity pool program that will be executed by the NCC and will focus on seeking and supporting new or early-stage investigators or investigators new to kidney research, who will address the scientific and technological gaps within the Consortium.</p>
<h3>O'Brien Kidney Centers</h3>
<p><strong><a href="https://www.uab.edu/okra/">UAB National Coordinating Center (NCC) for the George M. O'Brien Kidney National Resource Centers</a></strong><a href="https://www.uab.edu/okra/"><strong> (U24)</strong>&nbsp;</a></p>
<ul>
<li><strong>Goals and Specific Aims:</strong>&nbsp;The UAB NCC has the primary task of leading, coordinating, managing, and harmonizing all aspects of the work conducted by the Consortium to advance kidney research. The NCC will support the NRCs in their efforts to nationally share specialized resources including tools, technologies, services, and expertise beyond those typically available in an individual lab or institutional core. The UAB NCC has five aims including:
<ul>
<li>Providing administrative support, facilitating communication and coordination, and enhancing synergy by implementing standard operating procedures and sub-committees for the OBrien consortium</li>
<li>Expanding the UAB DMAC to provide a portal for sharing protocols, data, tools and other resources for the OBrien consortium</li>
<li>Implementing a training plan that includes team science workshops, hierarchical, peer and near-peer mentoring, and virtual office hours for early-stages investigators to collaborate with the OBrien NRCs</li>
<li>Engaging patient viewpoints, priorities and preferences through focus groups and active scientist patient interaction to inform the OBrien NRCs and consortium</li>
<li>Administering a national pilot program with pre-submission scientific and biostatistics consultation, rigorous peer review, and ongoing mentorship to support early-stage investigators, investigators new to kidney research and collaborations with the broader kidney community. The UAB NCC will support NIDDK and the OBrien Kidney Consortium to advance kidney research nationwide maximizing the impact on improving kidney health.</li>
</ul>
</li>
</ul>
<p><strong><a href="https://medicine.iu.edu/internal-medicine/research/centers/advanced-microscopic-analysis-kidney">Indiana Center for Advanced Renal Microscopy and Molecular Imaging</a></strong></p>
<ul>
<li><strong>Research Aims:</strong>&nbsp;The goals of this Center are to
<ul>
<li>Provide quantitative intravital microcopy of mice and rats as a service to renal researchers. Provide hands-on training to encourage dissemination of intravital microscopy as an effective research tool.</li>
<li>Provide quantitative, large-scale microscopy of the kidney as a service to renal researchers. Three-dimensional confocal tissue cytometry, CODEX multiplexed cytometry and Spatial Transcriptomics will be offered individually or in combination, supporting uniquely comprehensive molecular characterizations.</li>
<li>Develop and implement methods of tissue clearing, light-sheet microscopy and digital image analysis to expand the scale of quantitative microscopy of renal tissues, based upon a unique multiscale/multi-resolution strategy and state-of-the-art methods of digital image analysis.</li>
</ul>
</li>
</ul>
<p><strong><a href="https://www.fcvrri.northwestern.edu/centers/kidney-research-therapeutics/index.html">Northwestern University O'Brien Kidney National Resource Center (NU-NRC)</a></strong></p>
<ul>
<li><strong>Research Aims:&nbsp;</strong>The overarching theme of the NU-NRC is to adapt powerful physical sciences theory, tools, platforms, and approaches to advance kidney investigation in a Physical Sciences-Kidney Resource Center. The major goals of the Center are:
<ul>
<li>harness physical science advances to provide new approaches to solve unmet challenges in kidney research and discovery.</li>
<li>to provide easy access to physical science tools, reagents and platforms to the broader kidney community to catalyze their research and spur innovation.</li>
</ul>
</li>
<li><strong>The Center has following Aims</strong>:
<ul>
<li>Establish a Biomedical Resource Core focused on established nanotechnology methods for cell-specific delivery of therapeutic and diagnostic payloads (small molecules and biologics).</li>
<li>Establish a Resource Development Core focused on nascent technologies in diverse areas of physical sciences to catalyze kidney research.</li>
<li>Establish an Administrative Core to oversee all operations of the Center and ensure new technologies are made readily available to the kidney research community.</li>
<li>Provide an immersive summer SciHigh research program for high school students.&nbsp;</li>
</ul>
</li>
</ul>
<p><strong><a href="https://nephrology.wustl.edu/research/washington-university-kidney-obrien-center-for-chronic-kidney-disease-research/">Washington University Chronic Kidney Disease National Resource Center</a></strong></p>
<ul>
<li><strong>Research Aims:&nbsp;</strong>this NRC will address the fundamental challenge of providing better access to cutting-edge techniques in single cell omics, genetics, and metabolism to the kidney research community to facilitate advances in CKD research. The Center has following Aims:
<ul>
<li>Oversee distribution of funds across the Cores, communicate with the National OBrien Consortium, manage the Summer Student Enrichment Program, and promote the involvement of early-stage investigators and a diverse workforce.</li>
<li>Provide genetic variants validation services through the Variant Validation Core, to investigate the pathogenicity of genetic variants of uncertain significance using CRISPR/Cas9-gene editing, in silico approaches, and tailored in vitro assays.</li>
<li>Provide consultation for users and access to a number of metabolic assays to interrogate changes in kidney metabolism relevant to CKD through their Metabolism Core services. These assays include Seahorse bioflux analysis,</li>
<li>radioactive substrate oxidation assays of tissue ex vivo, untargeted metabolomics, and stable isotope tracer studies.</li>
</ul>
</li>
</ul>
<h3 id="neph">
Pediatric Centers of Excellence in Nephrology </h3>
<p>The goals of the Pediatric Centers of Excellence in Nephrology (PCEN) program are: 1. to attract new scientific expertise to the study of human pediatric renal physiology, kidney development, and pediatric kidney disorders; 2. to encourage multidisciplinary research in these areas; and 3. to develop the pediatric nephrology research community through a national research symposium, broad sharing of research resources, and a national Pilot and Feasibility grant program. The 3 funded centers will work collaboratively to reach the goals of the program.</p>
<p><strong><a href="https://www.research.chop.edu/pediatric-center-of-excellence-in-nephrology">Children's Hospital of Philadelphia</a></strong></p>
<ul>
<li>
<strong>Research Aims:</strong> The CHOP PCEN facilitates extensive collaborative research around the causes, diagnoses, and treatment of kidney diseases in children and aims to break down barriers to clinical trials implementation.</li>
<li><strong>Activities &amp; Services</strong>
<ul>
<li><strong>Learning Health System Core (LHS Core):</strong> This core leverages PEDSnet expertise and infrastructure to provide methodologic, informatics, and study development support to Center investigators and to expand the broad PEDSnet database to meet the needs of PCEN-sponsored studies.</li>
<li><strong>Molecular Precision Nephrology Core (MPN Core): </strong>The overall goal of the MPN Core is to develop and maintain a tissue bank of human kidney samples that can be analyzed and translated into a kidney tissue reference resource atlas.</li>
<li><strong>Enrichment Program: </strong>Aims to equip the research base with additional skill sets and maximizes interactions and intellectual discourse within the PCEN through early career engagement; career development and collaborations; and patient, family, and community engagement.</li>
<li><strong>Opportunity Pool Pilot &amp; Feasibility Program:</strong> Aims to support studies that promote synergistic interactions with the Cores, and brings new talent, scientific methods, and expertise to research focused on advancing clinical trials in childhood kidney disease.
</li>
</ul>
</li>
</ul>
<div><strong><a href="https://med.virginia.edu/pcen/">University of Virginia</a></strong>
</div>
<ul>
<li><strong>Research Aims:</strong>&nbsp;<span>Provide a coordinated, interdisciplinary approach to study the development of the kidney vasculature during embryonic, fetal and postnatal life. The main theme of this Research Center is “Regulation of Cell Fate during Kidney Development and Disease.” Broadly, the proposed research (Projects 1 and 2) deals with fundamental questions of clinical relevance in Pediatric Nephrology such as the understanding of the proper development, and the structural and functional maintenance of the kidney vasculature in health and disease. Foster advances in knowledge, new methodologies, training and collaborations in an inclusive and diverse multidisciplinary environment to improve the management of infants and children with renal and urological diseases.</span></li>
<li><strong>Activities &amp; Services</strong>
<ul>
<li>Educational Enrichment Program&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<ul>
<li>Inspire, attract, and stimulate the interest of young individuals in Pediatric Nephrology research.</li>
<li>Make new knowledge, technologies, expertise, and reagents available to all scientists worldwide.</li>
<li>Pursue collaborations with the broader research community.</li>
<li>Engage and educate the public and health professionals regarding recent advances in pediatric renal research.</li>
</ul>
</li>
<li><a href="https://research.med.virginia.edu/pcen/main-projects/pilot-program/">Pilot &amp; Feasibility Program</a>
<ul>
<li> Encourages <span>young and established investigators to take up research relevant to kidney development and disease and speed the acquisition of knowledge that can be applied to treatment of children with renal and urological diseases. This is in coordination with the other 2 PCENs.</span><br />
</li>
</ul>
</li>
</ul>
</li>
</ul>
<div>&nbsp;<a href="https://medicine.wustl.edu/news/pediatric-center-of-excellence-in-nephrology-established-with-nih-funding/" style="font-size: 1rem;"><strong>Washington University Pediatric Center of Excellence</strong></a>
<ul style="list-style-type: disc;">
<li><b>Research Aims:&nbsp;&nbsp;</b>The objective of the Washington University Kidney Single Cell Atlas Project (pKidCAP) is to create spatially resolved single cell molecular maps of pediatric reference and diseased kidneys at several time points across the pediatric lifespan. Discovery of regulatory factors associated with maturity and maladaptive or injury states will not only inform on therapeutic strategies but also in tissue engineering efforts.Project 1 of pKidCAP will construct a multimodal atlas of spatially resolved single nucleus gene expression and chromatin state maps with accompanying genomic variants at key stages of pediatric kidney development by using unique and innovatively collected high quality pediatric kidney samples from the Biomedical Core (pKidBIO).Project 2 will investigate the role of a new genetic driver of FSGS.Here single cell datasets as above will be generated at time points approximating the human postnatal development in control mice (for cross-species comparisons) and mouse model of FSGS (to find similarities in gene regulatory circuits with human FSGS). Through unique and innovative approaches and resources, WU Pediatric Center of Excellence will deliver novel concepts, knowledge and insights into the biology of kidney maturation and function in health and disease.</li>
<li><b>Activities &amp; Services</b>
<ul style="list-style-type: circle;">
<li>Educational Enrichment Program
<ul style="list-style-type: square;">
<li>We will institute a summer research series for selected undergraduates/medical students to perform research in Center members' laboratories/clinical service, and in affiliated labs that will be enhanced by dedicated lectures and discussions with clinical and research faculty across various aspects of kidney development, engineering and disease.</li>
<li>Visiting lecture seminar series by leading experts in pediatric nephrology and single cell studies</li>
</ul>
</li>
<li>Research Cores provide essential services, techniques, and resources to Center projects and Center participants, enabling them to conduct their research more efficiently, effectively, and in a cost-sensitive manner.
<ul style="list-style-type: square;">
<li>Pediatric Kidney Tissue Core</li>
<li>Human iPSC Core</li>
</ul>
</li>
<li>Pilot &amp; Feasibility Program<br />
<ul style="margin-top: 0.3em; margin-bottom: 0.3em; margin-left: 1.3em; list-style-type: square;">
<li style="margin-top: 0.3em;">This Pilot and Feasibility program will encourage young and established investigators to undertake research relevant to kidney development, engineering and disease multiomics to accelerate the acquisition of knowledge that can be applied to treatment of children with renal and urological diseases and engineer devices to replenish kidney function.</li>
</ul>
</li>
</ul>
</li>
</ul>
</div>
<h3>
Polycystic Kidney Disease Research Resource Consortium
</h3>
<p>The vision of the Polycystic Kidney Disease-Research Resource Consortium (RRC) is to accelerate discovery in polycystic kidney disease through innovation and resource sharing. The PKD- RRC was established in September 2020 as a collaborative team of Principal investigators (PIs) at three PKD Research and Translation Core Centers (RTCCs), the Central Coordinating Site (CCS) and the NIDDK. The RTCCs are located at the University of Maryland, the Johns Hopkins School of Medicine, University of Kansas Medical Center, and the University of Alabama at Birmingham/Childrens Hospital of Philadelphia. The CCS is located at University of Maryland.</p>
<p>Resources available through the PKD-RRC are available through <a href="https://www.pkd-rrc.org/">pkd-rrc.org</a>.</p>
</div>
<h2 id="related-links">Related Links</h2>
<ul class="thumbnail-list">
<li><i class="stack-icon circle orange funding"></i>
<div class="title"><a rel="noopener noreferrer" href="https://isac-kuh.org/" target="_blank">Innovative Science Accelerator (ISAC) Program</a></div>
<div>
<p>&nbsp;</p>
</div>
</li>
<li>
<i class="stack-icon square indigo dna"></i>
<div class="title"><a href="http://www.cristudy.org/Chronic-Kidney-Disease/Chronic-Renal-Insufficiency-Cohort-Study/">Chronic Renal Insufficiency Cohort (CRIC)</a></div>
<div>
</div>
</li>
<li>
<i class="stack-icon blue circle dna"></i>
<div class="title"><a href="https://statepi.jhsph.edu/ckid/">A Prospective Cohort Study of Kidney Disease in Children (CKiD)</a></div>
<div>
</div>
</li>
<li>
<i class="stack-icon square person-presenting orange"></i>
<div class="title"><a href="/about-niddk/strategic-plans-reports/usrds">United States Renal Data System (USRDS)</a></div>
<div>
</div>
</li>
<li><i class="stack-icon pentagon-arrow medical-microscope indigo"></i>
<div class="title"><a href="https://clinicaltrials.gov/search?cond=kidney+disease&spons=NIDDK&aggFilters=status:not+rec+act&viewType=Table">NIDDK Active Trials in Kidney Disease</a></div>
<div>
<p>View related clinical trials from ClinicalTrials.gov.</p>
</div>
</li>
<li><i class="stack-icon pentagon-arrow blue people-funding"></i>
<div class="title"><a href="https://public.csr.nih.gov/StudySections">NIH Study Sections</a></div>
<div>
<p>Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIHs Center for Scientific Review website to search for study sections. </p>
</div>
</li>
</ul><hr>
<h2 id="resources">Research Resources</h2>
<p>
NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
</p>
<ul>
<li>
<a href="/research-funding/human-subjects-research/ancillary-major-ongoing-clinical-studies">Ancillary Studies to Major Ongoing Clinical Studies</a> to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
</li>
<li>
<a href="https://repository.niddk.nih.gov/home/">NIDDK Central Repository</a> for access to clinical resources including data and biospecimens from NIDDK-funded studies.
</li>
<li>
<a href="https://dknet.org/">NIDDK Information Network (dkNET)</a> for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.
</li>
</ul>
<ul>
<li><a href="http://www.mmpc.org/">Mouse Phenotyping Centers</a></li>
<li><a href="https://iidp.coh.org/">Integrated Islet Distribution Program</a></li>
<li><a href="http://www.cysticfibrosiscenters.org">Cystic Fibrosis Centers</a></li>
</ul>
<h2 id="additional-programs">Additional Research Programs</h2>
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<h3><i class="hide-mobile">Research </i>Training</h3>
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<a href="/research-funding/training-career-development"><img alt="Funding Eligibility by Career Level arrow graphic" src="/-/media/Images/Components/research-funding/rtcd-career-arrow.svg?h=64&amp;w=670&amp;hash=2504F9BEAC7EC40339F51F64ED03BEA9" width="670" height="64" style="max-width: 670px;" /></a></figure>
<p>
NIDDK supports the training and career development of medical and graduate students, postdoctoral
fellows, and physician scientists through institutional and individual grants.
</p>
<a class="cta" href="/research-funding/training-career-development">Learn about NIDDK Research Training Programs</a>
<h3>Small Business</h3>
<h4><a href="/research-funding/research-programs/small-business">Small Business Programs</a></h4>
<p>
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology
Transfer (STTR) programs.
These programs support innovative research conducted by small businesses that has the potential for
commercialization.
</p>
<a class="cta" href="/research-funding/research-programs/small-business">Learn about NIDDK Small Business Programs</a>
<h3>Human Subjects<i class="hide-mobile"> Research</i></h3>
<h4><a href="/research-funding/human-subjects-research">Human Subjects Research</a></h4>
<p>
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
</p>
<a class="cta" href="/research-funding/human-subjects-research">Learn about Human Subjects Research</a>
<h3>Translational<i class="hide-mobile"> Research</i></h3>
<figure class="fill">
<a href="/research-funding/research-programs/translational-research-therapeutic-discovery-development"><img alt="Translational Research process graphic" src="/-/media/Images/Components/research-funding/translational-research.svg?h=133&amp;w=760&amp;hash=3953D09C6DDCB1B1A5D196FD8C011104" width="760" height="133" style="max-width: 760px;" /></a></figure>
<p>
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
into novel therapeutics.
</p>
<a class="cta" href="/research-funding/research-programs/translational-research-therapeutic-discovery-development">Learn about NIDDK Translational Research Opportunities</a>
</div>
<section class="sc-slider sc-events">
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<h2 id="meetings-workshops">Meetings &amp; Workshops</h2>
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Catalytic Tool and Technology Development Webinar Series: Kidney Imaging
</div>
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<p>
<time datetime="2025-04-01">April 1, 2025</time>
<br />
Webinar
</p>
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2025 NIDDK K Awardees Workshop
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<time datetime="2025-04-03">April 3</time>
- <time datetime="2025-04-04">4, 2025</time>
<br />
Bethesda, MD <br />
</p>
</div>
</a>
</div>
<div class="sc-card">
<a href="http://dknet.org">
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<img src="/-/media/Images/Components/Cards/Featured-Cards/2020-Feature-Cards/dkNET-rotator-v3.jpg?as=0&amp;h=300&amp;iar=0&amp;w=400&amp;hash=D8E6EACC5FB46775B352E9D41EFF0854" alt="dkNET slider card." width="400" height="300" />
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dkNET
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Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation. </p>
</div>
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<p>Learn about current projects and view funding opportunities sponsored by the <a href="https://commonfund.nih.gov">NIH Common Fund</a>.</p>
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<li>
<i class="stack-icon pentagon-arrow orange grant-apply"></i>
<div class="title">Planning to Apply? Register Early</div>
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<p>Registration is required at <a href="https://era.nih.gov">eRA Commons</a> and <a href="http://grants.gov">grants.gov</a> and can take 4 weeks.</p>
</div>
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<div class="dk-review-date">Last Reviewed April 2024</div>
</article>
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