2253 lines
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<span class="a2a_kit a2a_kit_size_32 addtoany_list" data-a2a-url="https://www.nibib.nih.gov/programs/molecular-imaging" data-a2a-title="Molecular Probes and Imaging Agents"><a class="a2a_button_email"><span class="a2a_svg a2a_s_a2a a2a_s_email a2a-box"><img src="/themes/custom/nibib/assets/img/email-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_facebook"><span class="a2a_svg a2a_s_a2a a2a_s_facebook a2a-box"><img src="/themes/custom/nibib/assets/img/facebook-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_linkedin"><span class="a2a_svg a2a_s_a2a a2a_s_linkedin a2a-box"><img src="/themes/custom/nibib/assets/img/linkedin-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_twitter"><span class="a2a_svg a2a_s_a2a a2a_s_x a2a-box"><img src="/themes/custom/nibib/assets/img/x-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span
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<h1 class="margin-0 page-header">
|
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<span>Molecular Probes and Imaging Agents</span>
|
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</h1>
|
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|
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<div id="block-nibib-content" class="block block-system block-system-main-block">
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|
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|
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|
||
<article data-history-node-id="147266" about="/programs/molecular-imaging" class="nibib-site-page node--nibib-site-page node--type-nibib-site-page">
|
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<!-- First goes the subtitle -->
|
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<!-- Lets put the banner in -->
|
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<!-- Now the content -->
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<!-- Staff Contact -->
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|
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<div data-history-node-id="63816" about="/about-nibib/staff/tatjana-atanasijevic" class="node--staff--secondary-block staff-card-container" >
|
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|
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|
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|
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<span class="staff-card--header--name"><a href="/about-nibib/staff/tatjana-atanasijevic" title="View Tatjana Atanasijevic's profile">Tatjana Atanasijevic</a>
|
||
, Ph.D.
|
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<a href="mailto:atanasijevict@mail.nih.gov" title="Email Tatjana Atanasijevic" >
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<div class="field field--name-field-staff-title field--type-entity-reference field--label-hidden field__item">Program Director</div>
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<span>Division of Applied Science & Technology (Biomedical Imaging)</span>
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<span><b>Program Area:</b> Molecular Probes and Imaging Agents</span>
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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="spotlight_full_width">This program supports development and biomedical application of molecular probes and imaging agents across all imaging modalities for the visualization, characterization and quantification of normal biological and pathophysiological processes and anatomy in living organisms at the molecular, cellular and organ levels.</div>
|
||
<h2>Emphasis</h2>
|
||
<p>The emphasis is on engineering of targeting and responsive molecular probes of high sensitivity and specificity for PET and SPECT (radiotracers), MR (T1, T2, CEST, hyperpolarized agents), EPR, CT, optical (fluorescent and bioluminescent probes), ultrasound (microbubbles) and photoacoustic imaging. The imaging agents may be based on nano- and micro-particles, liposomes, dendrimers, proteins, small organic and inorganic molecules etc., and detectable by one or more imaging modalities. Imaging agent development through methodologies such as chemical synthesis, biological mutagenesis, microfabrication, etc., may be pursued with an intent of leading to in vivo biomedical application.</p>
|
||
<h2>Outcome</h2>
|
||
<p>The goal of this program is to generate robust molecular probes, imaging agents and platforms for biomedical application across all disease areas to facilitate diagnostics and improve understanding of disease state, progression, and therapeutic response.</p>
|
||
<h2>Additional emphasis</h2>
|
||
<p>This program also supports the development of other imaging agents, for example:</p>
|
||
<ul>
|
||
<li>multimodal molecular probes (PET/MRI, PET/fluorescent, etc.)</li>
|
||
<li>imaging reporter genes and reporter gene/imaging probe duos</li>
|
||
<li>molecular probes as part of theranostic systems or biosensors</li>
|
||
<li>imaging agents for cell labelling and in vivo tracking</li>
|
||
<li>molecular probes for image-guided interventions</li>
|
||
</ul>
|
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<h2>Note</h2>
|
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<p>The following related scientific areas are supported by other NIBIB programs:</p>
|
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|
||
<li>development of biomaterials is supported by the <a href="/programs/biomaterials">Biomaterials and Biomolecular Constructs</a> program</li>
|
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<li>synthetic biology approaches are supported by the <a href="/programs/synthetic-biology-technology-development">Synthetic Biology for Technology Development</a> program</li>
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<li>development of associated imaging methods and related hardware/software is supported by NIBIB programs for <a href="/programs/division-applied-science-technology-dast">specific imaging modalities</a></li>
|
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<li>image processing technology is supported by the <a href="/programs/image-processing-visual-perception-and-display">Image Processing, Visualization, Perception and Display</a></li>
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A tiny, four-fingered “hand” folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, University of Illinois Urbana-Champaign researchers report. Source: <a href="https://news.illinois.edu/view/6367/1787912283">University of Illinois Urbana-Champaign News Bureau</a>
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