2143 lines
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2143 lines
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<meta name="description" content="Parinaz Fathi, Ph.D., an early career researcher at NIBIB, leads an intramural research unit in the institute’s Section on Immunoengineering. The unit develops miniature organ models to study immune-related conditions and evaluates the role of biological nanoparticles in autoimmune diseases and cancer." />
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<title>Parinaz Fathi, Ph.D., is fulfilling a life-long career goal at NIBIB—conducting independent research | National Institute of Biomedical Imaging and Bioengineering</title>
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<a href="/science-education/beams-challenge" class="link" data-drupal-link-system-path="node/143486"> <span>Lesson Plans</span>
|
||
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|
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<a href="/science-education/meet-a-scientist" class="link" data-drupal-link-system-path="node/141721"> <span>Meet a Scientist</span>
|
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|
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<a href="/science-education/glossary" target="_self" class="link" data-drupal-link-system-path="science-education/glossary"> <span>Glossary</span>
|
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</a>
|
||
|
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</li>
|
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|
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|
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|
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<a href="/news-events/newsroom" class="link" data-drupal-link-system-path="news-events/newsroom"> <span>Newsroom</span>
|
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<a href="/science-education/science-topics" target="_self" class="link" data-drupal-link-system-path="node/131271"> <span>Science Topics</span>
|
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<a href="mailto:nibibpress@mail.nih.gov" target="_self" class="link"> <span>Contact Us</span>
|
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</a>
|
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|
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</div>
|
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</div>
|
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<span>About NIBIB </span>
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|
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|
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|
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<ul id="basic-nav-section-1" class="usa-nav__submenu-list">
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<a href="/about-nibib/mission" target="_self" class="link" data-drupal-link-system-path="node/79861"> <span>Mission & History</span>
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<a href="/about-nibib/directors-corner" target="_self" class="link" data-drupal-link-system-path="node/121791"> <span>Director's Corner</span>
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<a href="/about-nibib/careers-at-NIBIB" target="_self" class="link" data-drupal-link-system-path="node/131241"> <span>Jobs @ NIBIB</span>
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<span target="_self" class="nolink"> <span class="usa-nav__submenu-heading">WHAT WE DO</span>
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<a href="/about-nibib/strategic-plan" target="_self" class="link" data-drupal-link-system-path="node/11846"> <span>Strategic Plan</span>
|
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<a href="/about-nibib/budget" target="_self" class="link" data-drupal-link-system-path="node/911"> <span>Budget</span>
|
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</a>
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</div>
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</div>
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</div>
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</li>
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<div class="usa-nav__secondary">
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<div>
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<section aria-label="search component" id="nibib-header-search" data-drupal-selector="search-block-form" role="search">
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<form id="search-block-form" accept-charset="UTF-8" class="usa-search usa-search--small" role="search" action="/searching" method="get">
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<label class="usa-sr-only" for="search-field-en-small">Search</label>
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<button class="usa-button js-form-submit form-submit" name="search_btn" type="submit" value="Search" tabindex="-1">
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<img src="/themes/custom/nibib/assets/uswds/img/usa-icons-bg/search--white.svg" class="usa-search__submit-icon" alt="Search" />
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<a href="/es/nibib-en-espanol"> En Español
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<a target="_blank" class="link-list-serve" href="https://public.govdelivery.com/accounts/USNIBIB/subscriber/edit?preferences=true#tab1"> Join LISTSERV
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|
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|
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<a href="/science-education" class="usa-breadcrumb__link"><span>Science Education</span></a>
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<a href="/science-education/meet-a-scientist" class="usa-breadcrumb__link"><span>Meet a Scientist</span></a>
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<span class="a2a_kit a2a_kit_size_32 addtoany_list" data-a2a-url="https://www.nibib.nih.gov/science-education/meet-a-scientist/parinaz-fathi-phd" data-a2a-title="Parinaz Fathi, Ph.D., is fulfilling a life-long career goal at NIBIB—conducting independent research"><a class="a2a_button_email"><span class="a2a_svg a2a_s_a2a a2a_s_email a2a-box"><img src="/themes/custom/nibib/assets/img/email-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_facebook"><span class="a2a_svg a2a_s_a2a a2a_s_facebook a2a-box"><img src="/themes/custom/nibib/assets/img/facebook-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_linkedin"><span class="a2a_svg a2a_s_a2a a2a_s_linkedin a2a-box"><img src="/themes/custom/nibib/assets/img/linkedin-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_twitter"><span class="a2a_svg a2a_s_a2a a2a_s_x a2a-box"><img src="/themes/custom/nibib/assets/img/x-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span
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</a><a class="a2a_button_whatsapp"><span class="a2a_svg a2a_s_a2a a2a_s_whatsapp a2a-box"><img src="/themes/custom/nibib/assets/img/whatsapp-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_dd addtoany_share"><span class="a2a_svg a2a_s_a2a a2a_s_share a2a-box"><img src="/themes/custom/nibib/assets/img/share-a2a.svg" border="0" alt="Share" width="27" height="27"></span></a></span>
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<div class="">
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<div data-drupal-messages-fallback class="hidden"></div>
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|
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|
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<h1 class="margin-0 page-header">
|
||
<span>Parinaz Fathi, Ph.D., is fulfilling a life-long career goal at NIBIB—conducting independent research</span>
|
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</h1>
|
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|
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|
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<div id="block-nibib-content" class="block block-system block-system-main-block">
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|
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|
||
<article data-history-node-id="156251" about="/science-education/meet-a-scientist/parinaz-fathi-phd" class="nibib-site-page node--nibib-site-page node--type-nibib-site-page">
|
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<!-- First goes the subtitle -->
|
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<!-- Lets put the banner in -->
|
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<!-- Now the content -->
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<div class="page-body clearfix">
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<!-- Staff Contact -->
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<!-- CONTENT -->
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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><a href="/about-nibib/staff/parinaz-fathi">Parinaz Fathi, Ph.D.</a>, an early career researcher at NIBIB, has already achieved a professional milestone─she leads an intramural research unit in the institute’s <a href="/labs-at-nibib/section-immunoengineering#:~:text=The%20Section%20on%20Immunoengineering%20develops,of%20tissue%20homeostasis%20and%20disease.">Section on Immunoengineering</a>. The unit develops miniature organ models to study immune-related conditions and evaluates the role of biological nanoparticles in autoimmune diseases and cancer.</p>
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<div class="field__item"> <img loading="lazy" src="/sites/default/files/2024-10/Fathi-501x268.jpg" width="501" height="286" alt="A photo of a woman sitting next to a computer in a laboratory" typeof="foaf:Image">
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<figcaption>Parinaz Fathi, Ph.D., working in her Unit for Nanoengineering and Microphysiological Systems (UNEMPS) at NIBIB. Credit: Vanathi Sundaresan, NIBIB</figcaption>
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</figure>
|
||
<p>Fathi has run her Unit for Nanoengineering and Microphysiological Systems (UNEMPS) since 2022 when she became an <a href="https://irp.nih.gov/careers/trans-nih-scientific-recruitments/independent-research-scholar#:~:text=The%20Independent%20Research%20Scholar%20%28IRS%29%20program%20seeks%20to,scholars%20are%20independent%2C%20non-tenure%20track%20Principal%20Investigators%20%28PI%29.">NIH Independent Research Scholar</a> (IRS), a non-tenure-track primary investigator. Researchers are selected for the program based on their readiness to conduct independent research and their commitment to enhancing diversity within the biomedical workforce.</p>
|
||
<p>“Being an independent researcher was something I had dreamt of for years. My selection for this position is a major step towards fulfilling that goal,” said Fathi. </p>
|
||
<p>The resources from the IRS program enabled Fathi’s group (she’s hired two post-baccalaureate scholars) to study autoimmune diseases and cancer from two perspectives: modeling certain organs, such as the thyroid, to better understand disease and studying extracellular vesicles (EVs), secreted biological nanoparticles that are used in communication between different cell types. </p>
|
||
<p>“My group is interested in EVs secreted by bacteria that alter the immune system and create disease states. We want to explore this mechanism, and eventually use that knowledge to develop therapeutic interventions. As part of this, we also develop organ models, with the goal of using them to study the EVs,” said Fathi.</p>
|
||
<p><strong>Budding engineer </strong></p>
|
||
<p>Fathi was interested in engineering from a young age, which her parents encouraged, having science and math backgrounds themselves. She participated in local science fairs and looked up to her older brother who obtained an engineering degree. </p>
|
||
<p>As an undergraduate student at the University of Maryland, she majored in mechanical engineering and minored in nanoscale science and technology. Taking classes in nanomaterials, microfluidics, and biomaterials led her to want to study nanoparticles further. </p>
|
||
<p>Her undergraduate lab experiences exposed her to bioengineering, a field she thought would be more rewarding than mechanical engineering. She switched to bioengineering for her graduate studies at the University of Illinois at Urbana-Champaign. “I liked that we could create technology that could improve people’s health and well-being,” she said. </p>
|
||
<p><strong>Building her research career</strong></p>
|
||
<p>She sought a variety of research opportunities early on, which exposed her to different senior researchers and mentors, and new ways of doing things. </p>
|
||
<p>She gained experience in research labs at the undergraduate and graduate institutions she attended and at federal health agencies. She completed an Oak Ridge Institute for Science and Education (ORISE) post-bac fellowship at the U.S. Food and Drug Administration (FDA), a graduate research fellowship for Science, Technology, Engineering, and Math (STEM) Diversity at the National Institute of Standards and Technology, and more recently an <a href="https://oir.nih.gov/sourcebook/personnel/ipds-appointment-mechanisms/intramural-research-training-award-irta-hiring-mechanism-postdoctoral-pre">NIH post-doctoral intramural research fellowship</a> in NIBIB’s Section on Immunoengineering. </p>
|
||
<p><a href="/about-nibib/staff/kaitlyn-sadtler">Kaitlyn Sadtler, Ph.D.</a>, a tenure-track investigator who leads the section and mentors Fathi, said, “Parinaz came into our group right after COVID hit and had to focus on pandemic-related research rather than her research interests. She rose to the occasion and quickly became a respected member of the group for her advice on different research techniques and her organization in the lab was second to none. It was clear from the start that she was on an upward trajectory, and I wanted to support that,” said Sadtler, who nominated her for the independent researcher scholar position. </p>
|
||
<p><strong>Rewards, challenges, and lessons learned </strong></p>
|
||
<p>The rewarding aspect of Fathi’s research is knowing that it could lead to a better understanding of diseases and ultimately treatments that could improve people’s lives. </p>
|
||
<p>Conducting new research is both exciting and challenging because there’s no roadmap to follow, which leads to more trial and error, said Fathi. </p>
|
||
<p>When her experiments fail, she has learned to take it in stride. “I learn whatever I can from each experiment and use that knowledge to inform the next experiment. I have learned to separate my sense of self-worth from the success of experiments.” </p>
|
||
<p>She adopted the same mindset about papers she submits to journals. “When I received a rejection in graduate school, I would take it personally. Now, if I get a rejection, I think ‘where am I going to submit the paper next?’”</p>
|
||
<p><strong>Her hobbies: STEM outreach and scientific art </strong></p>
|
||
<p>Fathi is passionate about STEM outreach and increasing the participation of women and other under-represented groups in the biomedical workforce. She has volunteered at NIH in different roles; as a post-doctoral scholar, she was the intramural research program fellow representative in the <a href="https://orwh.od.nih.gov/career-development-education/nih-working-group-on-women-in-biomedical-careers">NIH Working Group for Women in Biomedical Careers</a>. Last summer, her intramural research unit hosted two interns participating in the <a href="https://www.training.nih.gov/research-training/hs/hs-sip/histep/">NIH High School Scientific Training and Enrichment Program</a> (HiSTEP). Fathi also plans to mentor diverse college graduates participating in the <a href="https://www.training.nih.gov/research-training/pb/pb/">NIH Intramural Research Training Award program</a>. </p>
|
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|
||
<div class="field__item"> <img loading="lazy" src="/sites/default/files/2024-10/Fathi-rose-501x268.jpg" width="501" height="268" alt="A photo of a microscopic structure that is colored yellow and orange" typeof="foaf:Image">
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<figcaption>Caption: In this false color scanning electron microscopy image, a metal surface was modified to form microscopic “roses” and “thorns.” These types of metal surfaces could be applied to the detection, prevention, or treatment of diseases. This image was a semi-finalist in the 2020 UIUC Image of Research Competition. Credit: Parinaz Fathi, Ph.D.</figcaption>
|
||
</figure>
|
||
<p>When she’s not volunteering, Fathi enjoys creating scientific art inspired by her research. Her images have been finalists or winners in art competitions or featured in art exhibits.</p>
|
||
<p>“These are typically by-products of lab experiments that I thought looked cool and wanted other people to see. I realized that many people don't get to see the beautiful things that we see as scientists. Also, scientific art can be a great way to communicate our science to the public and potentially interest them in our work,” said Fathi.</p>
|
||
<p>Since this article was published, Fathi was honored with making the <a href="https://www.forbes.com/profile/parinaz-fathi/?list=30under30-science/">Forbes Under 30 list for 2025 in Science. </a><br> </p>
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