2176 lines
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<div class="usa-nav__submenu-item">
|
||
<span class="nolink"> <span class="usa-nav__submenu-heading">EXPLORE and LEARN</span>
|
||
</span>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
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|
||
<ul id="basic-nav-section-3" class="usa-nav__submenu-list">
|
||
|
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|
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|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/Understanding-Medical-Scans-App" target="_self" class="link" data-drupal-link-system-path="node/68546"> <span>Medical Imaging App</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/science-education/beams-challenge" class="link" data-drupal-link-system-path="node/143486"> <span>Lesson Plans</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/science-education/meet-a-scientist" class="link" data-drupal-link-system-path="node/141721"> <span>Meet a Scientist</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="https://www.youtube.com/playlist?list=PLYH1eUq1QYrqrvA6HRRgKHcPsoJoJA6Kj" target="_blank" class="link"> <span>Featured Videos</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/science-education/glossary" target="_self" class="link" data-drupal-link-system-path="science-education/glossary"> <span>Glossary</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
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|
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</li>
|
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|
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|
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|
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<li class="usa-nav__primary-item">
|
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|
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<button type="button" class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="extended-mega-nav-section-5">
|
||
<span>News & Events </span>
|
||
</button>
|
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|
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|
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|
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|
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<div id="extended-mega-nav-section-5" class="usa-nav__submenu usa-megamenu" hidden="">
|
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|
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<div class="grid-row mm-container">
|
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<div class="desktop:grid-col flex-auto duplicated-parent">
|
||
<div class="usa-nav__submenu-item">
|
||
<span><a href="/news-events" target="_self" class="link" data-drupal-link-system-path="node/156671">News & Events</a> <span class="uswds-arrow-forward"></span></span>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
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<div class="grid-row mm-container">
|
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|
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|
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|
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<div class="desktop:grid-col-4 submenu-list-container">
|
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|
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<div class="usa-nav__submenu-item">
|
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<span target="_self" class="nolink"> <span class="usa-nav__submenu-heading">NEWS</span>
|
||
</span>
|
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</div>
|
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|
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|
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|
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|
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|
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|
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|
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<ul id="basic-nav-section-1" class="usa-nav__submenu-list">
|
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|
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|
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|
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|
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|
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<li class="usa-nav__submenu-item">
|
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|
||
|
||
|
||
|
||
<a href="/news-events/newsroom" class="link" data-drupal-link-system-path="news-events/newsroom"> <span>Newsroom</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
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|
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|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
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|
||
|
||
<a href="/news-events/press-releases" target="_self" class="link" data-drupal-link-system-path="news-events/press-releases"> <span>Press Releases</span>
|
||
</a>
|
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|
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</li>
|
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|
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|
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|
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|
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<li class="usa-nav__submenu-item">
|
||
|
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|
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|
||
|
||
<a href="/news-events/science-highlights" target="_self" class="link" data-drupal-link-system-path="news-events/science-highlights"> <span>Science Highlights</span>
|
||
</a>
|
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|
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</li>
|
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|
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|
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|
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|
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<li class="usa-nav__submenu-item">
|
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|
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|
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|
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|
||
<a href="/news-events/nibib-news" target="_self" class="link" data-drupal-link-system-path="news-events/nibib-news"> <span>NIBIB in the News</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
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</div>
|
||
|
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|
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|
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|
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<div class="desktop:grid-col-4 submenu-list-container">
|
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|
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<div class="usa-nav__submenu-item">
|
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<span class="nolink"> <span class="usa-nav__submenu-heading">EVENTS</span>
|
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</span>
|
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</div>
|
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|
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|
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|
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|
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|
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|
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<ul id="basic-nav-section-2" class="usa-nav__submenu-list">
|
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|
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|
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|
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|
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<li class="usa-nav__submenu-item">
|
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|
||
|
||
|
||
|
||
<a href="/news-events/meetings-events/upcoming-events" class="link" data-drupal-link-system-path="news-events/meetings-events/upcoming-events"> <span>Upcoming Events</span>
|
||
</a>
|
||
|
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</li>
|
||
|
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|
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|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/meetings-events/past-events" class="link" data-drupal-link-system-path="news-events/meetings-events/past-events"> <span>Past Events</span>
|
||
</a>
|
||
|
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</li>
|
||
|
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|
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|
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|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/meetings-events/photo-galleries" class="link" data-drupal-link-system-path="news-events/meetings-events/photo-galleries"> <span>Event Photos</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
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<div class="desktop:grid-col-4 submenu-list-container">
|
||
|
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<div class="usa-nav__submenu-item">
|
||
<span target="_self" class="nolink"> <span class="usa-nav__submenu-heading">MEDIA RESOURCES</span>
|
||
</span>
|
||
</div>
|
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|
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|
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|
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|
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|
||
|
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|
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<ul id="basic-nav-section-3" class="usa-nav__submenu-list">
|
||
|
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|
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|
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|
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|
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<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/science-education/science-topics" target="_self" class="link" data-drupal-link-system-path="node/131271"> <span>Science Topics</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="mailto:nibibpress@mail.nih.gov" target="_self" class="link"> <span>Contact Us</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item">
|
||
|
||
<button type="button" class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="extended-mega-nav-section-6">
|
||
<span>About NIBIB </span>
|
||
</button>
|
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|
||
|
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|
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|
||
|
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|
||
<div id="extended-mega-nav-section-6" class="usa-nav__submenu usa-megamenu" hidden="">
|
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|
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<div class="grid-row mm-container">
|
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<div class="desktop:grid-col flex-auto duplicated-parent">
|
||
<div class="usa-nav__submenu-item">
|
||
<span><a href="/about-nibib" target="_self" class="link" data-drupal-link-system-path="node/156676">About NIBIB</a> <span class="uswds-arrow-forward"></span></span>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="grid-row mm-container">
|
||
|
||
|
||
|
||
|
||
<div class="desktop:grid-col-4 submenu-list-container">
|
||
|
||
<div class="usa-nav__submenu-item">
|
||
<span target="_self" class="nolink"> <span class="usa-nav__submenu-heading">WHO WE ARE</span>
|
||
</span>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
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|
||
<ul id="basic-nav-section-1" class="usa-nav__submenu-list">
|
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|
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|
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|
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|
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|
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<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-nibib/mission" target="_self" class="link" data-drupal-link-system-path="node/79861"> <span>Mission & History</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
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|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-nibib/directors-corner" target="_self" class="link" data-drupal-link-system-path="node/121791"> <span>Director's Corner</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-nibib/organizational-chart" target="_self" class="link" data-drupal-link-system-path="node/18836"> <span>Organization Chart</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-nibib/advisory-council" target="_self" class="link" data-drupal-link-system-path="node/876"> <span>Advisory Council</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-nibib/careers-at-NIBIB" target="_self" class="link" data-drupal-link-system-path="node/131241"> <span>Jobs @ NIBIB</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="desktop:grid-col-4 submenu-list-container">
|
||
|
||
<div class="usa-nav__submenu-item">
|
||
<span target="_self" class="nolink"> <span class="usa-nav__submenu-heading">WHAT WE DO</span>
|
||
</span>
|
||
</div>
|
||
|
||
|
||
|
||
|
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|
||
|
||
|
||
<ul id="basic-nav-section-2" class="usa-nav__submenu-list">
|
||
|
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|
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|
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|
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|
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<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-nibib/strategic-plan" target="_self" class="link" data-drupal-link-system-path="node/11846"> <span>Strategic Plan</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-nibib/budget" target="_self" class="link" data-drupal-link-system-path="node/911"> <span>Budget</span>
|
||
</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="usa-nav__secondary">
|
||
<div>
|
||
<section aria-label="search component" id="nibib-header-search" data-drupal-selector="search-block-form" role="search">
|
||
<form id="search-block-form" accept-charset="UTF-8" class="usa-search usa-search--small" role="search" action="/searching" method="get">
|
||
<label class="usa-sr-only" for="search-field-en-small">Search</label>
|
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<input aria-label="Search" class="usa-input" id="edit-keys" data-drupal-selector="edit-keys" data-original-title="Enter the terms you wish to search for." data-toggle="tooltip" type="search" name="q" value="" tabindex="-1"/>
|
||
<button class="usa-button js-form-submit form-submit" name="search_btn" type="submit" value="Search" tabindex="-1">
|
||
<img src="/themes/custom/nibib/assets/uswds/img/usa-icons-bg/search--white.svg" class="usa-search__submit-icon" alt="Search" />
|
||
</button>
|
||
</form>
|
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</section>
|
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</div>
|
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|
||
|
||
|
||
<ul class="header-nav__secondary-list">
|
||
<li class="header-nav__secondary-item">
|
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<a href="/es/nibib-en-espanol"> En Español
|
||
</a>
|
||
</li>
|
||
<li class="header-nav__secondary-item">
|
||
<a target="_blank" class="link-list-serve" href="https://public.govdelivery.com/accounts/USNIBIB/subscriber/edit?preferences=true#tab1"> Join LISTSERV
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
|
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</div>
|
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</div>
|
||
</nav>
|
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</header>
|
||
|
||
<main class="main-content usa-layout-docs usa-section " role="main" id="main-content">
|
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<div class="grid-container">
|
||
<div class="grid-row breadcrumb-social-share-bar">
|
||
<div class="tablet:grid-col-6 desktop:grid-col-8">
|
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<div>
|
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|
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<div id="block-breadcrumbs" class="block block-system block-system-breadcrumb-block">
|
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|
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|
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<nav class="usa-breadcrumb--wrap" role="navigation" aria-label="breadcrumb">
|
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<ol class="usa-breadcrumb__list">
|
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<li class="usa-breadcrumb__list-item">
|
||
<a href="/" class="usa-breadcrumb__link"><span>Home</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/news-events" class="usa-breadcrumb__link"><span>News & Events</span></a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/news-events/newsroom" class="usa-breadcrumb__link"><span>Newsroom</span></a>
|
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</li>
|
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</ol>
|
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</nav>
|
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|
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|
||
</div>
|
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</div>
|
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|
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</div>
|
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<div class="tablet:grid-col-6 desktop:grid-col-4">
|
||
<div>
|
||
|
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<div id="block-addtoanysharebuttons" class="block block-addtoany block-addtoany-block">
|
||
|
||
|
||
<span class="a2a_kit a2a_kit_size_32 addtoany_list" data-a2a-url="https://www.nibib.nih.gov/news-events/newsroom/engineering-smile" data-a2a-title="Engineering a smile"><a class="a2a_button_email"><span class="a2a_svg a2a_s_a2a a2a_s_email a2a-box"><img src="/themes/custom/nibib/assets/img/email-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_facebook"><span class="a2a_svg a2a_s_a2a a2a_s_facebook a2a-box"><img src="/themes/custom/nibib/assets/img/facebook-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_linkedin"><span class="a2a_svg a2a_s_a2a a2a_s_linkedin a2a-box"><img src="/themes/custom/nibib/assets/img/linkedin-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_twitter"><span class="a2a_svg a2a_s_a2a a2a_s_x a2a-box"><img src="/themes/custom/nibib/assets/img/x-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span
|
||
</a><a class="a2a_button_whatsapp"><span class="a2a_svg a2a_s_a2a a2a_s_whatsapp a2a-box"><img src="/themes/custom/nibib/assets/img/whatsapp-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_dd addtoany_share"><span class="a2a_svg a2a_s_a2a a2a_s_share a2a-box"><img src="/themes/custom/nibib/assets/img/share-a2a.svg" border="0" alt="Share" width="27" height="27"></span></a></span>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="">
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
|
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|
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</div>
|
||
|
||
<div class="grid-row ">
|
||
|
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</div>
|
||
|
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<div class="grid-row grid-gap">
|
||
|
||
<div class="usa-layout-docs__main desktop:grid-col-fill">
|
||
|
||
<div id="block-nibib-page-title" class="block--page-title-block">
|
||
|
||
|
||
<h1 class="margin-0 page-header">
|
||
<span>Engineering a smile</span>
|
||
</h1>
|
||
|
||
</div>
|
||
|
||
<div id="block-nibib-content" class="block block-system block-system-main-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
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<article data-history-node-id="157021" about="/news-events/newsroom/engineering-smile" class="news node node--type-news full clearfix">
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<div class="grid-col flex-auto news--type-date"><strong>
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<div class="field field--name-field-news-type field--type-entity-reference field--label-hidden field__item">Science Highlights</div>
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<div class="grid-col flex-auto news--type-date"><strong>
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<div class="field field--name-field-publication-date field--type-datetime field--label-hidden field__item">December 23, 2024</div>
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<h3> NIH-funded researchers restore facial nerve function in animals with stem cell-based conduits </h3>
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<div id="node--news--more-from-author">
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<h3>Media Contacts</h3>
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<p>Jonathan Griffin<br/>
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<a href="mailto:nibibpress@mail.nih.gov">nibibpress@mail.nih.gov</a><br/>
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<a href="tel:301-496-3500">301-496-3500</a><br/>
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<a href="/more-content-by/jonathan-griffin">More by this author</a></p>
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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A gesture as simple as a smile can often convey what words cannot. This is part of why nonverbal communication is so central to human interaction. It is also why facial nerve disorders and injuries can be devastating.</p>
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<p>These conditions are typically <a href="https://pubmed.ncbi.nlm.nih.gov/31273975/">treated with nerve tissue</a> taken from elsewhere in a patient’s body, known as autografts. This technique for repairing injured nerves presents issues for patients, such as damage to the donor site and the odds of functional recovery being nearly a coin toss. Synthetic alternatives have been explored in the past but have yet to live up to the performance of autografts. </p>
|
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<p>Bioengineers at the University of Pittsburgh may have developed a new solution with the help of some of nature’s best engineers — stem cells. Leveraging these cells’ ability to create a restorative environment, the team produced implantable conduits to act as bridges, providing directional, mechanical, and biochemical guidance for injured nerves to regenerate across large gaps. Experiments in the facial nerves of rats showed that the technology matched autografts. These results were published in the <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11406051/"><em>Journal of Neural Engineering</em></a>. </p>
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<div class="field__item"> <img loading="lazy" src="/sites/default/files/2024-12/nerve-conduit-1040x568.png" width="1040" height="568" alt="A graphic illustrating a facial nerve injury, treatment with an autograft, and treatment with an engineered nerve conduit" typeof="foaf:Image">
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<figcaption>Facial nerve injuries are often treated with tissue taken from a patient’s body, called autografts. Alternatively, researchers are developing engineered conduits which could potentially be more accessible. Credit: NIBIB. Created with BioRender.com.</figcaption>
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<p>“We leaned into the idea that the cells know what they're doing, and they know how to make tissue,” said oral and craniofacial sciences and bioengineering professor Fatima Syed-Picard, Ph.D., the senior author of the study. “These engineered tissues ended up being more biomimetic than many other synthetically derived scaffolds used in tissue engineering.” </p>
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<p><em>Getting neurons in line </em></p>
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<p>For nerves to be repaired, the long projections that extend from neurons, called axons, need to both regrow and reconnect to the appropriate tissue. With autografts, the former is slow, and the latter is no guarantee, as many patients experience unwanted muscle activity due to regrown nerves connecting to the wrong tissue. </p>
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<p>Researchers have <a href="https://pubmed.ncbi.nlm.nih.gov/31254439/">wielded specific cell populations</a> to accelerate growth, such as neural support cells and stem cells, which produce biomolecules that aid neural tissue regeneration. To orient growing tissue so that axons reach the proper targets, researchers have designed synthetic tissue scaffolds with features, such as grooves, that act as guiderails to regenerating neurons. </p>
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<p>“It’s difficult to embed and distribute cells evenly in synthetic scaffolds without harming them. Another concern is trying to get these scaffolds to match the structural complexity of innate tissue,” said first author Michelle Drewry, Ph.D., who conducted this research while a graduate student* at the University of Pittsburgh. </p>
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<div class="field__item"> <img loading="lazy" src="/sites/default/files/2024-12/nerve-conduit-768x418.png" width="768" height="418" alt="A photograph of a cell-made nerve conduit in a well plate" typeof="foaf:Image">
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<figcaption>The authors of the study created their nerve conduits by rolling up cell-made sheets of extracellular matrix. Credit: <em>Drewry et al. This image originally appeared in the Journal of Neural Engineering; see licensing information below.</em></figcaption>
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<p>Many cell types in the body frequently make or remodel the biomolecular scaffolding surrounding them, known as extracellular matrix (ECM). So, instead of making tissue scaffolds from scratch themselves, the researchers thought it might be better to let cells make their own. The authors of the study tested this hypothesis with dental pulp stem cells (DPSCs), a hardy and readily available cell population that produce proteins known to encourage nerve growth. After extracting these cells from adult wisdom teeth provided by the University of Pittsburgh School of Dental Medicine, the researchers put them to work. </p>
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<p>They wanted to give DPSCs the freedom to create ECM but, at the same time, nudge them into making an environment conducive to supporting aligned axons. To accomplish this, the researchers fabricated rubber molds with rows of 10 micrometer-wide grooves and then covered them with DPSCs. After several days, the DPSCs secreted aligned ECM around themselves, forming thin biological sheets. The authors then peeled the sheets from the rubber templates and rolled them up into cylindrical conduits. </p>
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<p>The researchers used this approach to make a type of bandage in a <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8616747/">previous study</a>, which successfully regenerated the axons of a crushed nerve. With their new work, they sought to clear a higher hurdle of using the conduit to bridge a 5-millimeter gap in the facial nerve of rats — a defect so large that the nerve would not be able to heal on its own. </p>
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<p>Specifically, they implanted their aligned conduits into gaps made in the buccal branch of the facial nerve. For comparison, the team also implanted autografts into another group of rats. </p>
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<p>“The buccal branch is the part of the facial nerve that helps with smiling. It's a big part of your quality of life because it’s a large piece of how you communicate with other people and how you're seen in the world. Injury to that nerve can have a life-changing effect,” Drewry said. </p>
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<p><em>Crossing the bridge </em></p>
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<p>Twelve weeks after implantation, the authors evaluated how well axons had regenerated, primarily through histology. They found that their cell-made conduits contained regenerated axons across their full length. And, in general, the density and number of axons were similar to what they found in autografts. </p>
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<p>Indicators of developing axons were prevalent in the conduits, suggesting that regeneration may have been more robust with additional time, Drewry noted. </p>
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<div class="field__item"> <img loading="lazy" src="/sites/default/files/2024-12/conduit-sem-501x268.png" width="501" height="268" alt="An SEM micrograph of a cell-made nerve conduit" typeof="foaf:Image">
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<figcaption>To confirm that their nerve conduits contained aligned grooves to guide nerve regeneration, the researchers used scanning electron microscopy. Credit: <em>Drewry et al. This image originally appeared in the Journal of Neural Engineering; see licensing information below.</em></figcaption>
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</figure>
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<p>But did all this regenerated tissue translate to improved function? To find out, the authors electrically stimulated the nerves on one end and measured the animals’ whisker movement on the other side. The tests showed that the motions of rats implanted with conduits were on par with those treated with autografts.</p>
|
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<p>Syed-Picard’s lab aims to better understand the roles the ECM and cells play in healing and then use that information to improve their technology. For example, in addition to encouraging regrowth directly, the conduits may also be helping by dampening inflammation, Syed-Picard explained. </p>
|
||
<p>Drewry’s work on this study was funded by the <a href="https://www.path.pitt.edu/training/research-opportunities/cater-training-program">Cellular Approaches to Tissue Engineering and Regeneration (CATER) Training Program</a> at the University of Pittsburgh, which is supported by NIBIB grant T32EB001026. </p>
|
||
<p>“This research exemplifies how our training programs lay a strong foundation for doctoral students. Trainees from this particular program have gone on to receive 58 subsequent NIH grants including fellowships, career awards, and research grants,” said Zeynep Erim, Ph.D., director of the Division of Interdisciplinary Training at the National Institute of Biomedical Imaging and Bioengineering (NIBIB). </p>
|
||
<p>The research was also supported by the National Institute of Dental and Craniofacial Research (NIDCR; R56DE030881). </p>
|
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<p><em>This science highlight describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process—each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.</em> </p>
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<p>*Drewry is now an associate program officer at the National Academies of Sciences, Engineering, and Medicine (NASEM). Her comments in this article reflect her personal views and not that of NASEM. </p>
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||
<p>About the graphics: These two images originally appeared in the <em>Journal of Neural Engineering</em> paper and are available under the <a href="https://creativecommons.org/licenses/by/4.0/">Creative Commons</a> license. Images have been adapted for the NIBIB website.</p>
|
||
<p>Study reference: Michelle Drewry et al. Enhancing facial nerve regeneration with scaffold-free conduits engineered using dental pulp stem cells and their endogenous, aligned extracellular matrix. <em>Journal of Neural Engineering</em> (2024) <a href="https://doi.org/10.1088/1741-2552/ad749d">https://doi.org/10.1088/1741-2552/ad749d</a> </p>
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