2132 lines
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2132 lines
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<a href="/programs/radx-innovation-funnel" class="link" data-drupal-link-system-path="node/146966"> <span>RADx Tech Innovation Funnel</span>
|
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|
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<a href="/Understanding-Medical-Scans-App" target="_self" class="link" data-drupal-link-system-path="node/68546"> <span>Medical Imaging App</span>
|
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</a>
|
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|
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|
||
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|
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<a href="/science-education/meet-a-scientist" class="link" data-drupal-link-system-path="node/141721"> <span>Meet a Scientist</span>
|
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|
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<a href="/science-education/glossary" target="_self" class="link" data-drupal-link-system-path="science-education/glossary"> <span>Glossary</span>
|
||
</a>
|
||
|
||
</li>
|
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|
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</div>
|
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|
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|
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<a href="/science-education/science-topics" target="_self" class="link" data-drupal-link-system-path="node/131271"> <span>Science Topics</span>
|
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</a>
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<a href="mailto:nibibpress@mail.nih.gov" target="_self" class="link"> <span>Contact Us</span>
|
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</a>
|
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|
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|
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</div>
|
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</div>
|
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<li class="usa-nav__primary-item">
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<span>About NIBIB </span>
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<span><a href="/about-nibib" target="_self" class="link" data-drupal-link-system-path="node/156676">About NIBIB</a> <span class="uswds-arrow-forward"></span></span>
|
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</div>
|
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</div>
|
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</div>
|
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<div class="grid-row mm-container">
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<div class="desktop:grid-col-4 submenu-list-container">
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<span target="_self" class="nolink"> <span class="usa-nav__submenu-heading">WHO WE ARE</span>
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<ul id="basic-nav-section-1" class="usa-nav__submenu-list">
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<a href="/about-nibib/mission" target="_self" class="link" data-drupal-link-system-path="node/79861"> <span>Mission & History</span>
|
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<a href="/about-nibib/directors-corner" target="_self" class="link" data-drupal-link-system-path="node/121791"> <span>Director's Corner</span>
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<a href="/about-nibib/advisory-council" target="_self" class="link" data-drupal-link-system-path="node/876"> <span>Advisory Council</span>
|
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<a href="/about-nibib/careers-at-NIBIB" target="_self" class="link" data-drupal-link-system-path="node/131241"> <span>Jobs @ NIBIB</span>
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</a>
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<span target="_self" class="nolink"> <span class="usa-nav__submenu-heading">WHAT WE DO</span>
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</span>
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<ul id="basic-nav-section-2" class="usa-nav__submenu-list">
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<a href="/about-nibib/strategic-plan" target="_self" class="link" data-drupal-link-system-path="node/11846"> <span>Strategic Plan</span>
|
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</a>
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<a href="/about-nibib/budget" target="_self" class="link" data-drupal-link-system-path="node/911"> <span>Budget</span>
|
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</a>
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</li>
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</ul>
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|
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</div>
|
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|
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</div>
|
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</div>
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|
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</li>
|
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<div class="usa-nav__secondary">
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<div>
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<section aria-label="search component" id="nibib-header-search" data-drupal-selector="search-block-form" role="search">
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<form id="search-block-form" accept-charset="UTF-8" class="usa-search usa-search--small" role="search" action="/searching" method="get">
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<label class="usa-sr-only" for="search-field-en-small">Search</label>
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<input aria-label="Search" class="usa-input" id="edit-keys" data-drupal-selector="edit-keys" data-original-title="Enter the terms you wish to search for." data-toggle="tooltip" type="search" name="q" value="" tabindex="-1"/>
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<button class="usa-button js-form-submit form-submit" name="search_btn" type="submit" value="Search" tabindex="-1">
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<img src="/themes/custom/nibib/assets/uswds/img/usa-icons-bg/search--white.svg" class="usa-search__submit-icon" alt="Search" />
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<a href="/es/nibib-en-espanol"> En Español
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|
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<a target="_blank" class="link-list-serve" href="https://public.govdelivery.com/accounts/USNIBIB/subscriber/edit?preferences=true#tab1"> Join LISTSERV
|
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</a>
|
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|
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</nav>
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<div class="grid-row breadcrumb-social-share-bar">
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<div class="tablet:grid-col-6 desktop:grid-col-8">
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<div>
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<a href="/news-events" class="usa-breadcrumb__link"><span>News & Events</span></a>
|
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</li>
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<div id="block-addtoanysharebuttons" class="block block-addtoany block-addtoany-block">
|
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|
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|
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<span class="a2a_kit a2a_kit_size_32 addtoany_list" data-a2a-url="https://www.nibib.nih.gov/news-events/newsroom/beat-goes-%E2%80%94-even-258-miles-above-earth" data-a2a-title="The beat goes on — even 258 miles above Earth"><a class="a2a_button_email"><span class="a2a_svg a2a_s_a2a a2a_s_email a2a-box"><img src="/themes/custom/nibib/assets/img/email-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_facebook"><span class="a2a_svg a2a_s_a2a a2a_s_facebook a2a-box"><img src="/themes/custom/nibib/assets/img/facebook-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_linkedin"><span class="a2a_svg a2a_s_a2a a2a_s_linkedin a2a-box"><img src="/themes/custom/nibib/assets/img/linkedin-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_twitter"><span class="a2a_svg a2a_s_a2a a2a_s_x a2a-box"><img src="/themes/custom/nibib/assets/img/x-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span
|
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</a><a class="a2a_button_whatsapp"><span class="a2a_svg a2a_s_a2a a2a_s_whatsapp a2a-box"><img src="/themes/custom/nibib/assets/img/whatsapp-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_dd addtoany_share"><span class="a2a_svg a2a_s_a2a a2a_s_share a2a-box"><img src="/themes/custom/nibib/assets/img/share-a2a.svg" border="0" alt="Share" width="27" height="27"></span></a></span>
|
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|
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</div>
|
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</div>
|
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|
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</div>
|
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</div>
|
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|
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<div class="">
|
||
<div data-drupal-messages-fallback class="hidden"></div>
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|
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</div>
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<div class="grid-row ">
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</div>
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<div class="grid-row grid-gap">
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<div class="usa-layout-docs__main desktop:grid-col-fill">
|
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<div id="block-nibib-page-title" class="block--page-title-block">
|
||
|
||
|
||
<h1 class="margin-0 page-header">
|
||
<span>The beat goes on — even 258 miles above Earth</span>
|
||
</h1>
|
||
|
||
</div>
|
||
|
||
<div id="block-nibib-content" class="block block-system block-system-main-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<article data-history-node-id="116656" about="/news-events/newsroom/beat-goes-%E2%80%94-even-258-miles-above-earth" class="news node node--type-news is-promoted full clearfix">
|
||
<div class="content">
|
||
<div class="grid-row">
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<div class="grid-col flex-auto news--type-date"><strong>
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<div class="field field--name-field-publication-date field--type-datetime field--label-hidden field__item">May 4, 2020</div>
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<p>Raymond MacDougall<br/>
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<a href="mailto:nibibpress@mail.nih.gov">nibibpress@mail.nih.gov</a><br/>
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<a href="tel:301-496-3500">301-496-3500</a><br/>
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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
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white">At little after 3:30 p.m. EDT on April 7, 2020, the SpaceX Dragon spacecraft splashed down in the Pacific Ocean, returning to Earth after nearly a month attached to the International Space Station (ISS). The spacecraft brought back a number of physical and life sciences research projects, including heart and gut tissue chip projects that traveled to the ISS as part of the Tissue Chips in Space initiative.</p>
|
||
<figure role="group" class="align-right">
|
||
<img alt="astronaut with tissue chip experiment" data-entity-type="file" data-entity-uuid="e492decb-2a24-448c-8af3-94167529c257" height="225" src="/sites/default/files/inline-images/TissueChipinline400x266.jpg" width="339" loading="lazy"></p>
|
||
<figcaption>NASA astronaut Jessica Meir works with heart tissue chip experiment aboard the ISS. Sensors attached to the chambers containing the heart tissue chips detected changes in magnetic force as the tissues’ contractions moved posts with embedded magnets. The data were transmitted back to Earth, allowing researchers on the ground to monitor the strength of the contractions while the experiment was on the International Space Station. <em>NASA photo</em></figcaption>
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</figure>
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<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
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||
white">The initiative is an ambitious collaborative endeavor that brings the National Center for Advancing Translational Sciences (NCATS), the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and the ISS U.S. National Laboratory together to rapidly advance tissue chip technology for biomedical research.</p>
|
||
<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
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white">The chips contain miniature models of living tissues built from human cells. Because tissue chips accurately model the structure and function of human organs and systems, researchers could use them to predict — more quickly and effectively than current methods allow — whether a candidate drug, vaccine or biologic agent is safe or toxic in humans. Tissue chips also can provide new opportunities for researchers to study biological processes in the extreme environment of microgravity aboard the ISS.</p>
|
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<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
||
white">Prolonged exposure to microgravity — as is experienced by the astronauts on the ISS — is known to cause changes to many aspects of the functioning of the human body, including in the heart and cardiovascular system. Many of the changes caused by microgravity look similar to those caused by accelerated disease and aging processes. Using tissue chips on the ISS provides a unique opportunity for researchers to model and study conditions related to diseases and aging over weeks or months, rather than the years that it would take for these conditions to develop on Earth.</p>
|
||
<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
||
white">A research team led by Deok-Ho Kim, Ph.D., at Johns Hopkins University and comprising researchers from several academic institutions and other organizations developed heart tissue chips to study the structural and functional changes to the tissue caused by spending time in low gravity. The team also developed related technology needed to send the tissue chips safely into space, survive on board the ISS for nearly a month and return to Earth. The researchers hypothesized that during that period of time the tissues would undergo functional, visible and molecular changes that are similar to those that occur with illness or old age on Earth.</p>
|
||
<figure role="group" class="align-right">
|
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<img alt="astronaut and tissue chip experiement" data-entity-type="file" data-entity-uuid="7ac2b76e-7a28-475c-bf70-0b0d4d9a471b" height="264" src="/sites/default/files/inline-images/Tissuechipinline2400x304.jpg" width="348" loading="lazy"></p>
|
||
<figcaption>NASA astronaut Jessica Meir performs scientific procedure within the Life Sciences Glovebox aboard the ISS. <em>NASA photo</em></figcaption>
|
||
</figure>
|
||
<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
||
white">To create the heart tissue chips, the researchers coaxed human induced pluripotent stem cells, which have the potential to become almost any type of cell in the body, to form cardiomyocytes (heart muscle cells) that developed into small 3-D structures between two posts on a silicon scaffold. One of the posts, which was flexible and bent each time the tissue contracted, contained a small magnet. While on the ISS, the magnet’s movements were picked up by a sensor and transmitted to the researchers on the ground so they could collect data on the strength of the contractions—and any changes to that strength—remotely.</p>
|
||
<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
||
white">Now that the tissue chips have returned to Earth, the researchers will continue to analyze the data they collected while the tissue chips were on the ISS and compare them to data from a set of comparison chips that remained on Earth. The research team also will begin to assess the visible and molecular changes the tissue may have undergone as a result of spending time in microgravity.</p>
|
||
<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
||
white">On a future flight, the researchers will test methods to improve heart cell contractions, including mechanical stimulation, which mimics muscle conditioning, as well as drugs known to protect the heart from an irregular heartbeat or heart disease. Findings from the project may have implications both for improving the health of astronauts and for finding new ways to study and treat heart diseases related to aging on Earth.</p>
|
||
<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
||
white">For more photos, go to coverage by NCATS <a href="https://ncats.nih.gov/pubs/features/heart-chips-in-space">here</a>.</p>
|
||
<p class="MsoNormal" style="margin-bottom:7.5pt;line-height:normal;background:<br />
|
||
white">This work was funded with support from NIBIB and NCATS (UG3 EB028094).</p>
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