2143 lines
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<span class="a2a_kit a2a_kit_size_32 addtoany_list" data-a2a-url="https://www.nibib.nih.gov/labs-at-nibib/besip/besip-projects-2024/platt-2024" data-a2a-title="Platt – 2024"><a class="a2a_button_email"><span class="a2a_svg a2a_s_a2a a2a_s_email a2a-box"><img src="/themes/custom/nibib/assets/img/email-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_facebook"><span class="a2a_svg a2a_s_a2a a2a_s_facebook a2a-box"><img src="/themes/custom/nibib/assets/img/facebook-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_linkedin"><span class="a2a_svg a2a_s_a2a a2a_s_linkedin a2a-box"><img src="/themes/custom/nibib/assets/img/linkedin-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span></a><a class="a2a_button_twitter"><span class="a2a_svg a2a_s_a2a a2a_s_x a2a-box"><img src="/themes/custom/nibib/assets/img/x-a2a.svg" border="0" alt="Facebook" width="27" height="27"></span
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<article data-history-node-id="150081" about="/labs-at-nibib/besip/besip-projects-2024/platt-2024" class="besip-project is-promoted full clearfix node--besip-project">
|
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<h1 class="margin-0 page-header">Platt – 2024</h1>
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<div class="field__item"> <div class="paragraph paragraph--type--mentor paragraph--view-mode--default mentor">
|
||
<b>Mentor:</b> Manu Platt Ph.D. | <a href="mailto:manu.platt@nih.gov">manu.platt@nih.gov</a>
|
||
<br/><span class="field-linked-mentor-lab"><b>Lab:</b> <a href="/labs-at-nibib/section-mechanics-tissue-remodeling-integrating-computational-experimental-systems" target="_blank" title="Click to view lab">Mechanics And Tissue Remodeling for Computational and Experimental Systems (MATRICES)</a></span>
|
||
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<div class="field__item"> <div class="paragraph paragraph--type--mentor paragraph--view-mode--default mentor">
|
||
<b>Mentor:</b> Hannah Song Lee, Ph.D. | <a href="mailto:hannah.lee2@nih.gov">hannah.lee2@nih.gov</a>
|
||
<br/><span class="field-linked-mentor-lab"><b>Lab:</b> <a href="/labs-at-nibib/section-mechanics-tissue-remodeling-integrating-computational-experimental-systems" target="_blank" title="Click to view lab">Mechanics And Tissue Remodeling for Computational and Experimental Systems (MATRICES)</a></span>
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<div class="besip-project-description">
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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p><strong>Note: The project listed below may be modified by summer. If you are interested, contact Dr. Platt to get more information.</strong></p>
|
||
<h3>Magnetic Resonance Angiography to Assess Sickle Cell Disease Mediated Carotid and Cerebral Artery Damage</h3>
|
||
<figure role="group" class="align-left">
|
||
<img alt="Image of an MRA and 3D rendering of brain arteries" data-entity-type="file" data-entity-uuid="ef80734b-7f9d-4661-a664-bedc418483ee" height="221" src="/sites/default/files/inline-images/BESIP-MATRICES.png" width="367" loading="lazy"></p>
|
||
<figcaption>Figure 1: (A) Maximum intensity projection of SS arteries shows kinking in the left common carotid artery. (B) Arteries are reconstructed in 3D using Slicer to be used for CFD modeling</figcaption>
|
||
</figure>
|
||
<p>Sickle cell disease is a genetic blood disorder affecting 100,000 Americans. 11% of children with this disease will suffer a major stroke and 37% will suffer a silent stroke to cognitive regions of the brain. Arterial damage and stroke can occur as early as 2 years of age.</p>
|
||
<p>In order to analyze the mechanisms that cause arterial damage in SCD, a combination of both in vitro and in silico studies will be used to investigate the morphology and hemodynamics of carotid arteries.</p>
|
||
<p>A student who joins this project will work on reconstructing and analyzing images of the arteries collected from MRI scans of our humanized mouse model of sickle cell disease. Software will be used to virtually segment and reconstruct the carotid arteries in 3D, then arterial morphological data can be extracted from the images. </p>
|
||
<p>Secondarily, pathological fluid flow profiles indicate arterial damage. To assess this, computer renderings of the cerebral arteries will be generated from MR scans of sickle and non-sickle mice and implemented into an in-silico model using computational fluid dynamics. </p>
|
||
<p>Sickle red blood cells also can aggregate and accumulate inside of the blood vessels. We also have projects investigating the biophysics and attachments of these cells at the multi-cellular level in regions of extremely low flow. Mathematics, computer science, and biophysics principles are applied to model this system and develop predictions of cell behaviors and effective treatments to modify those behaviors.</p>
|
||
<p>Interested students should have an interest or background in any of the following areas: cardiovascular disease, blood flow, computational fluid dynamics, sickle cell, complicated health disparities.</p>
|
||
<p>Skillsets that are helpful but not required include MATLAB, Python, R, Ansys, or other coding packages.</p>
|
||
<p>Our team is willing to teach what you do not know, so don’t let experience stop you! Motivation and willpower go a long way.</p>
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</div>
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<div class="besip-project-interns">
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<div class="field field--name-field-intern-name field--type-string field--label-inline clearfix">
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||
<div class="title display-inline">Intern Name</div>
|
||
<div class="field__item display-inline">Sreenidhi Elayaperumal</div>
|
||
</div>
|
||
|
||
<b>Intern Institution:</b> University of North Carolina at Chapel Hill<br/>
|
||
<b>Project Title:</b> Cathepsin K-Mediated Arterial Remodeling Contributes to Disturbed Flow in Mice with Sickle Cell Disease
|
||
</div>
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</div>
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<div class="field__item"> <div class="paragraph paragraph--type--besip-intern paragraph--view-mode--default">
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<div class="field field--name-field-intern-name field--type-string field--label-inline clearfix">
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<div class="title display-inline">Intern Name</div>
|
||
<div class="field__item display-inline">Jeremy Hannon</div>
|
||
</div>
|
||
|
||
<b>Intern Institution:</b> Emory University<br/>
|
||
<b>Project Title:</b> Shear Stress-Mediated Inflammation Regulates BMPRII and Cathepsin expression in the Abdominal Aorta of mice with Sickle Cell Disease
|
||
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