1275 lines
47 KiB
Text
1275 lines
47 KiB
Text
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#">
|
||
<head>
|
||
<!-- Google Tag Manager -->
|
||
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':
|
||
new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],
|
||
j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=
|
||
'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);
|
||
})(window,document,'script','dataLayer','GTM-MP7S353');</script>
|
||
<!-- End Google Tag Manager -->
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="Relapse to uncontrolled drinking after periods of sobriety is a defining characteristic of alcoholism and is often triggered by stress. A new study in rats reports that a specific receptor for a stress-response transmitter may play an important role in stress-induced relapse. The study, a collaboration between scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), and at Camerino University, Italy, appears online in the Early Edition of the Proceedings of the National Academy of Sciences on October 2, 2006." />
|
||
<link rel="canonical" href="https://www.niaaa.nih.gov/news-events/news-releases/study-links-receptor-stress-induced-alcohol-relapse" />
|
||
<meta name="google-site-verification" content="D6PddlP4x_B-aaYH1GdtXWLMtqqDRm1KB76zwXU94r0" />
|
||
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
|
||
<meta name="MobileOptimized" content="width" />
|
||
<meta name="HandheldFriendly" content="true" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<meta http-equiv="x-ua-compatible" content="ie=edge" />
|
||
<link rel="icon" href="/sites/default/themes/solstice/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
<link rel="alternate" hreflang="und" href="https://www.niaaa.nih.gov/news-events/news-releases/study-links-receptor-stress-induced-alcohol-relapse" />
|
||
|
||
<title>Study Links Receptor to Stress-Induced Alcohol Relapse | National Institute on Alcohol Abuse and Alcoholism (NIAAA)</title>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_3jqSjunUwI7WktROG0Eute4UvTfE7JnUEOI-esMGxkQ.css?delta=0&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_284cOjFlGt6BbVNygt8wCcMAVOImI5Qo3eLcYPtTvXw.css?delta=1&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="print" href="/sites/default/files/css/css_Ki7WmdMheyToDR_iZ4-TUWAd6Z_Ji9D5oheAUfVPDGQ.css?delta=2&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_ZURahwWpOtPq2J3aEz1C3IyNMbNi6vxbJc3xYRtyniA.css?delta=3&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
|
||
|
||
</head>
|
||
<body class="page-node-342 path-node page-node-type-news body">
|
||
<!-- Google Tag Manager (noscript) -->
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MP7S353"
|
||
height="0" width="0" style="display:none;visibility:hidden" title="hhsgtmcontainer"></iframe></noscript>
|
||
<!-- End Google Tag Manager (noscript) -->
|
||
<a href="#main-content" class="visually-hidden focusable">
|
||
Skip to main content
|
||
</a>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<section class="usa-banner">
|
||
<section class="usa-banner" aria-label="Official website of the United States government">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner__header">
|
||
<div class="usa-banner__inner">
|
||
<div class="grid-col-auto">
|
||
<img aria-hidden="true" class="usa-banner__header-flag" src="/sites/default/themes/solstice/assets/uswds/img/us_flag_small.png" alt=""/>
|
||
</div>
|
||
<div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true">
|
||
<p class="usa-banner__header-text">
|
||
An official website of the United States government
|
||
</p>
|
||
<p class="usa-banner__header-action">Here’s how you know</p>
|
||
</div>
|
||
<button type="button" class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default-default">
|
||
<span class="usa-banner__button-text">Here’s how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default" hidden>
|
||
<div class="grid-row grid-gap-lg">
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/sites/default/themes/solstice/assets/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/>
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Official websites use .gov</strong><br/>A
|
||
<strong>.gov</strong>
|
||
website belongs to an official government
|
||
organization in the United States.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/sites/default/themes/solstice/assets/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/>
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Secure .gov websites use HTTPS</strong><br/>A
|
||
<strong>lock</strong>
|
||
(
|
||
<span class="icon-lock">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewbox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-description-default" focusable="false">
|
||
<title id="banner-lock-title-default">Lock</title>
|
||
<desc id="banner-lock-description-default">Locked padlock icon</desc>
|
||
<path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z"/>
|
||
</svg>
|
||
</span>) or
|
||
<strong>https://</strong>
|
||
means you’ve safely connected to
|
||
the .gov website. Share sensitive information only on official,
|
||
secure websites.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
</section>
|
||
|
||
|
||
|
||
|
||
<div class="usa-overlay" id="overlay" aria-hidden="true"></div>
|
||
<header class="usa-header usa-header--extended" id="header" role="banner">
|
||
|
||
|
||
<div class="region region-header usa-navbar">
|
||
<div class="usa-logo site-logo" id="logo">
|
||
|
||
<em class="usa-logo__text">
|
||
<a class="logo-img" href="/" accesskey="1" title="Home" aria-label="Home">
|
||
<img src="/sites/default/themes/solstice/niaaa-logo.png" alt="Home" />
|
||
</a>
|
||
|
||
|
||
</em>
|
||
|
||
</div>
|
||
<button class="usa-menu-btn" type="button">Menu</button>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<nav class="usa-nav" role="navigation">
|
||
<div class="usa-nav__inner">
|
||
|
||
<button type="button" class="usa-nav__close">
|
||
<img src="/sites/default/themes/solstice/assets/uswds/img/usa-icons/close.svg" alt="close"/>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<ul class="usa-nav__primary usa-accordion">
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-1">
|
||
<span>Alcohol's Effects on Health</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-1" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health" title="Alcohol's Effects on Health" class="link" data-drupal-link-system-path="node/5491">Alcohol's Effects on Health</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-topics-a-to-z" class="link" data-drupal-link-system-path="node/10109">Alcohol Topics</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/brochures-and-fact-sheets/treatment-alcohol-problems-finding-and-getting-help" class="link" data-drupal-link-system-path="node/5011">Getting Help</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-topics/alcohol-facts-and-statistics" class="link" data-drupal-link-system-path="node/13706">Alcohol Facts and Statistics</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/niaaa-short-takes-video-series" class="link">NIAAA Short Takes Video Series</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-interventions-young-adults" class="link" data-drupal-link-system-path="node/12656">Alcohol Interventions for Young Adults</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/niaaa-publications-order-form" class="link" data-drupal-link-system-path="node/5266">Order Publications</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-2">
|
||
<span>Health Professionals & Communities</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-2" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities" title="Health Professionals & Communities" class="link" data-drupal-link-system-path="node/5526">Health Professionals & Communities</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/native-air" class="link" data-drupal-link-system-path="node/15486">Native Communities: Alcohol Intervention Review (NativeAIR)</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/core-resource-on-alcohol" class="link" data-drupal-link-system-path="node/12236">The Healthcare Professional's Core Resource on Alcohol</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="https://www.collegedrinkingprevention.gov/CollegeAIM/Default.aspx" class="link">Resources from the NIAAA College Task Force</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/alcohol-interventions-young-adults-healthcare-professionals" class="link" data-drupal-link-system-path="node/12661">Alcohol Interventions for Young Adults</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/clinical-guides-and-manuals/alcohol-screening-and-brief-intervention-youth" class="link">Alcohol Screening & Brief Intervention for Youth</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/surveillance-reports" class="link" data-drupal-link-system-path="node/12301">Surveillance Reports</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities#additional-reports" class="link" data-drupal-link-system-path="node/5526">Additional Reports and Resources</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-3">
|
||
<span>Research</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-3" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research" title="Research" class="link" data-drupal-link-system-path="node/83">Research</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/major-initiatives" class="link" data-drupal-link-system-path="node/112">Major Research Initiatives</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/extramural-research" class="link" data-drupal-link-system-path="node/1115">Extramural Research Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/division-intramural-clinical-and-biological-research" class="link">Intramural Research Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/alcohol-research-resource-r24-and-r28-awards" class="link" data-drupal-link-system-path="node/3531">Alcohol Research Resource (R24) Awards</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/niaaa-sbir" class="link" data-drupal-link-system-path="node/5556">NIAAA SBIR/ STTR Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/data-archive-and-resources" class="link" data-drupal-link-system-path="node/15236">Data Archive and Resources</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-4">
|
||
<span>Research Training</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-4" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research-training-and-career-development" title="Research Training" class="link" data-drupal-link-system-path="node/3546">Research Training</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/research-training-and-career-development/training-opportunities-education-level" class="link" data-drupal-link-system-path="node/3556">Training Grants by Eligibility</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/research-training-and-career-development/training-opportunities-grant-mechanism" class="link" data-drupal-link-system-path="node/3561">Training Grants by Mechanism</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/training-resources" class="link">Research Training Programs</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research-training-and-career-development/centers-and-training-working-group-roster" class="link" data-drupal-link-system-path="node/3551">Centers and Training Working Group Roster</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-5">
|
||
<span>Grants & Funding</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-5" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/grant-funding" title="Grants & Funding" class="link" data-drupal-link-system-path="node/84">Grants & Funding</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/application-process" class="link">How to Apply for a Grant</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/funding-opportunities" class="link">Funding Opportunities</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/grant-funding/management-reporting" class="link" data-drupal-link-system-path="node/166">Management & Reporting</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-6">
|
||
<span>News & Events</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-6" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events" title="News & Events" class="link" data-drupal-link-system-path="node/47">News & Events</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/news" class="link" data-drupal-link-system-path="node/5521">News</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/meetings-events-exhibits" class="link" data-drupal-link-system-path="node/5525">Events</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/press-room" class="link" data-drupal-link-system-path="node/636">Press Room</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/niaaa-social-media" class="link" data-drupal-link-system-path="node/11396">Social Media</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="https://www.spectrum.niaaa.nih.gov/" class="link">Spectrum</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-7">
|
||
<span>About NIAAA</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-7" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa" title="About NIAAA" class="link" data-drupal-link-system-path="node/86">About NIAAA</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/advisory-council" class="link" data-drupal-link-system-path="node/181">NIAAA Advisory Council</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/strategic-plan-fiscal-years-2024-2028" class="link" data-drupal-link-system-path="node/14961">Strategic Plan: Fiscal Years 2024–2028</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-work" class="link" data-drupal-link-system-path="node/176">Our Work</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/our-funding" class="link" data-drupal-link-system-path="node/189">Our Funding</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-staff" class="link" data-drupal-link-system-path="node/190">Our Staff</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/career-and-training-opportunities" class="link" data-drupal-link-system-path="node/191">Careers & Training</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/contact-us" class="link" data-drupal-link-system-path="node/201">Contact Us</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-work/history-niaaa" class="link">History</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class='usa-nav__secondary top-search-bar'>
|
||
|
||
|
||
<ul class="usa-nav__secondary-links">
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/join-study" title="" class="link" data-drupal-link-system-path="node/153">Join a Clinical Study</a>
|
||
</li>
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/alcohols-effects-health/alcohol-topics/health-topics-treatment-alcohol-problems" class="link" data-drupal-link-system-path="node/13376">Getting Help</a>
|
||
</li>
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/our-work/donations-niaaa" class="link" data-drupal-link-system-path="node/540">Donate</a>
|
||
</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
<form action="/search" method="get" id="views-exposed-form-acquia-search-page" accept-charset="UTF-8" class="usa-search usa-search--small" role="search">
|
||
<label class="usa-sr-only" for="extended-search-field-small">Search</label>
|
||
<input class="usa-input" id="extended-search-field-small" maxlength="128" type="search" name="search"/>
|
||
<button class="usa-button" type="submit">
|
||
<span class="usa-sr-only">Search</span>
|
||
<svg class="usa-icon" aria-hidden="true" focusable="false" role="img">
|
||
<use xlink:href="/sites/default/themes/solstice/assets/uswds/img/sprite.svg#search"></use>
|
||
</svg>
|
||
</button>
|
||
</form>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</nav>
|
||
|
||
|
||
</header>
|
||
|
||
|
||
<div class="above-content">
|
||
<div>
|
||
|
||
|
||
<div class="page-banner">
|
||
<div class="l-inner">
|
||
<p class="h1 heading-1 text-reverse">News & Events</p>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div id="block-solstice-breadcrumbs">
|
||
|
||
|
||
|
||
<div class="breadcrumb-container">
|
||
<nav role="navigation" class="usa-breadcrumb usa-breadcrumb--wrap" aria-labelledby="system-breadcrumb">
|
||
<h2 id="system-breadcrumb" class="usa-sr-only">Breadcrumb</h2>
|
||
<ol class="usa-breadcrumb__list">
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/" class="usa-breadcrumb__link">Home</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/news-events" class="usa-breadcrumb__link">News & Events</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/news-events/news-releases" class="usa-breadcrumb__link">News Releases</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
Study Links Receptor to Stress-Induced Alcohol Relapse
|
||
</li>
|
||
</ol>
|
||
</nav>
|
||
</div>
|
||
|
||
</div>
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="usa-section">
|
||
<div class="main--container">
|
||
<div class="grid-row grid-gap">
|
||
<main class="main--content grid-col" id="main-content">
|
||
<div id="block-solstice-content">
|
||
|
||
|
||
|
||
<article>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="content-river">
|
||
<div>
|
||
<h1>
|
||
<span>Study Links Receptor to Stress-Induced Alcohol Relapse</span>
|
||
</h1>
|
||
<div class="news-type">News Release</div>
|
||
<p><time datetime="2006-10-02T12:00:00Z">Monday, October 2, 2006</time>
|
||
</p>
|
||
<p>Relapse to uncontrolled drinking after periods of sobriety is a defining characteristic of alcoholism and is often triggered by stress. A new study in rats reports that a specific receptor for a stress-response transmitter may play an important role in stress-induced relapse. The study, a collaboration between scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), and at Camerino University, Italy, appears online in the Early Edition of the Proceedings of the National Academy of Sciences on October 2, 2006.</p>
|
||
<p>“This finding helps untangle the complex interplay of genetic and environmental factors that influence relapse,” says NIAAA Director T.-K. Li, M.D. “It also points to potential approaches for treating individuals at risk for relapse.”</p>
|
||
<p>Anita C. Hansson, Ph.D., a fellow in NIAAA’s Laboratory of Clinical and Translational Studies, and other NIAAA scientists worked with CamerinoUniversity scientists to examine stress-induced relapse in rats that were bred to have a greater-than-normal preference for alcohol.</p>
|
||
<p>“These animals provide an excellent model for identifying genes involved in stress-mediated relapse,” says Dr. Hansson. “Not only do they voluntarily consume large amounts of alcohol they also display anxiety and depression-like traits, characteristics that are common among human alcoholics and which indicate a maladaptive response to stress.”</p>
|
||
<p>A series of behavioral experiments confirmed that the alcohol-preferring rats were more sensitive to stressful situations. For example, they explored a new environment significantly less than did the normal rats, and also remained immobile longer than normal rats did in the novel environment. Each group of rats then learned that, by pressing a bar, they gained access to as much alcohol as they cared to drink. Under these conditions, the alcohol-preferring rats consume more than twice the amount of regular rats, and do so in order to obtain the intoxicating effects of alcohol. This behavior was extinguished, or unlearned, by a 15-day period during which bar-pressing yielded no alcohol, thus allowing the alcohol-preferring rats to achieve a state of sobriety.</p>
|
||
<p>Investigators then assessed whether a stressful stimulus – mild electric foot shock – would induce the rats to again seek alcohol by resuming the bar- pressing behavior. Alcohol-seeking was reinstated in the alcohol-preferring rats by foot shocks of much lower intensity than normal rats required.</p>
|
||
<p>“The resumption of alcohol-seeking by alcohol-preferring rats under these conditions is analogous to stress-induced relapse to drinking by human alcoholics,” says NIAAA Clinical Director Markus Heilig, M.D., Ph.D., a senior author of the paper.</p>
|
||
<p>To determine if a particular gene or genes might underlie the stress-induced drinking of the alcohol-preferring rats, the researchers compared gene expression patterns in the brains of rats from each group. They focused on several families of known stress-related genes, including those associated with corticotropin-releasing hormone (CRH), which influences behavioral responses to stress through a number of different receptors. They found that alcohol-preferring rats had higher expression levels of Crhr1, a gene encoding the corticotropin-releasing hormone receptor 1 (CRH-R1). Subsequent experiments showed that antalarmin, a compound that blocks CRH-R1, suppressed alcohol drinking and completely blocked stress-induced reinstatement of drinking in alcohol-preferring rats, but had no effect on normal rats. Dr. Heilig notes that NIAAA and other NIH institutes have begun to develop antalarmin for human use.</p>
|
||
<p>“Our findings demonstrate that the Crhr1 genotype and its expression interact with environmental stress to reinstate alcohol-seeking behavior in this animal model of excessive drinking,” says Dr. Hansson. She and her colleagues conclude that their data, “provide a functional validation for antagonism at CRH-R1 receptors as a mechanism for novel treatments aimed at relapse prevention in susceptible individuals.”</p>
|
||
</div>
|
||
</div>
|
||
</article>
|
||
|
||
</div>
|
||
<div id="block-newsreleasecontact">
|
||
|
||
|
||
<div class="contact-info content-river">
|
||
|
||
<div><div class="contact-info content-river l-skinny">
|
||
<p><strong>About the National Institute on Alcohol Abuse and Alcoholism (NIAAA):</strong><br>
|
||
The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, is the primary U.S. agency for conducting and supporting research on the causes, consequences, diagnosis, prevention, and treatment of alcohol use disorder. NIAAA also disseminates research findings to general, professional, and academic audiences. Additional alcohol research information and publications are available at <a href="/" rel="nofollow noreferrer">www.niaaa.nih.gov</a>.</p>
|
||
|
||
<p><strong>About the National Institutes of Health (NIH):</strong><br>
|
||
NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <a href="https://www.nih.gov/" rel="noreferrer noopener">www.nih.gov</a>.</p>
|
||
|
||
<p><strong>Contact info</strong>:<br>
|
||
NIAAA Press Office<br>
|
||
301-443-2857<br>
|
||
<a href="mailto:NIAAAPressOffice@mail.nih.gov">NIAAAPressOffice@mail.nih.gov</a></p>
|
||
</div>
|
||
</div>
|
||
|
||
<div>
|
||
</div>
|
||
|
||
|
||
</main>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<footer class="usa-footer usa-footer--big" role="contentinfo">
|
||
<div class="usa-footer__return-to-top return-to-top-stick">
|
||
<a href="#">Return to top</a>
|
||
</div>
|
||
|
||
<div class="usa-footer__primary-section">
|
||
|
||
<div class="usa-footer__primary-content">
|
||
<div class="grid-container">
|
||
<div class="grid-row grid-gap">
|
||
|
||
<div class="tablet:grid-col-8">
|
||
<nav class="usa-footer__nav" aria-label="Footer navigation">
|
||
<div class="grid-row grid-gap-4">
|
||
<div id="block-footermenu" class="mobile-lg:grid-col-6 desktop:grid-col">
|
||
<section class="usa-footer__primary-content usa-footer__primary-content--collapsible">
|
||
|
||
<h4 class="usa-footer__primary-link">NIAAA</h4>
|
||
|
||
<ul class="usa-list usa-list--unstyled">
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/sitemap" title="" class="link" data-drupal-link-system-path="sitemap">Site Map</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/about-niaaa/contact-us" title="" class="link" data-drupal-link-system-path="node/201">Contact Us</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/disclaimer" title="" class="link" data-drupal-link-system-path="node/616">Disclaimer</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</section>
|
||
</div>
|
||
<div id="block-solstice-otherniaaasites" class="mobile-lg:grid-col-6 desktop:grid-col">
|
||
<section class="usa-footer__primary-content usa-footer__primary-content--collapsible">
|
||
|
||
<h4 class="usa-footer__primary-link">Other NIAAA Sites</h4>
|
||
|
||
<ul class="usa-list usa-list--unstyled">
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://alcoholpolicy.niaaa.nih.gov/" title="Alcohol Policy Information System" class="link">Alcohol Policy Information System</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://arcr.niaaa.nih.gov/" title="Alcohol Research: Current Reviews (ARCR)" class="link">Alcohol Research: Current Reviews (ARCR)</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://alcoholtreatment.niaaa.nih.gov/" title="Alcohol Treatment Navigator" class="link">Alcohol Treatment Navigator</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://www.collegedrinkingprevention.gov/" class="link">College Drinking Prevention</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://niaaaforteens.niaaa.nih.gov/" class="link">NIAAA Facts About Teen Drinking</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/news-events/niaaa-spectrum-webzine" title="NIAAA Spectrum" class="link" data-drupal-link-system-path="node/169">NIAAA Spectrum</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://rethinkingdrinking.niaaa.nih.gov/" class="link">Rethinking Drinking</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</section>
|
||
</div>
|
||
|
||
<div>
|
||
</nav>
|
||
</div>
|
||
|
||
|
||
<div class="tablet:grid-col-4">
|
||
<div>
|
||
<div id="block-solstice-govdeliveryformblock">
|
||
|
||
|
||
<div class="usa-sign-up">
|
||
<h4 class="usa-sign-up__heading">Get Email Updates</h4>
|
||
<form class="usa-form" action="https://public.govdelivery.com/accounts/USNIAAA/subscribers/qualify" accept-charset="UTF-8" method="post" data-drupal-form-fields="email" target="_blank">
|
||
<input name="utf8" type="hidden" value="✓">
|
||
<input type="hidden" name="authenticity_token" value="myTqrfcKP26ImObkqXpLlCJwJeMr6pdTfN5L19Lw964CAojxidv3kEZTy3NuaWCFS9OWuYPTy20qtVl1JsD9hQ==">
|
||
<label class="usa-label" for="email">Your email address</label>
|
||
<input class="usa-input" id="email" name="email" type="email"/>
|
||
<button class="usa-button" type="submit">Sign up</button>
|
||
</form>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="usa-footer__secondary-section">
|
||
<div class="grid-container">
|
||
<div class="grid-row grid-gap">
|
||
<div class="usa-footer__logo grid-row mobile-lg:grid-col-6 mobile-lg:grid-gap-2">
|
||
|
||
<a href="https://www.niaaa.nih.gov/">
|
||
|
||
<div class="mobile-lg:grid-col-auto">
|
||
<img class="usa-footer__logo-img" src="/sites/default/themes/solstice/assets/img/niaaa-logo.png" alt="Agency logo">
|
||
</div>
|
||
|
||
|
||
</a>
|
||
|
||
</div>
|
||
|
||
<div class="usa-footer__contact-links desktop:grid-col-6">
|
||
<div class="usa-footer__social-links grid-row grid-gap-1">
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--facebook" href="https://www.facebook.com/NIAAAgov/" target="_blank">
|
||
<i class="fa-brands fa-facebook-f"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--instagram" href="https://instagram.com/NIAAAnews" target="_blank">
|
||
<i class="fa-brands fa-instagram"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--twitter" href="https://twitter.com/NIAAAnews" target="_blank">
|
||
<i class="fa-brands fa-x-twitter"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--linkedin" href="https://www.linkedin.com/company/nih-national-institute-on-alcohol-abuse-and-alcoholism/" target="_blank">
|
||
<i class="fa-brands fa-linkedin"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--youtube" href="https://www.youtube.com/@NIAAANIH" target="_blank">
|
||
<i class="fa-brands fa-youtube"></i>
|
||
</a>
|
||
</div>
|
||
|
||
</div>
|
||
<address class="usa-footer__address">
|
||
<div class="usa-footer__contact-info grid-row grid-gap">
|
||
|
||
</div>
|
||
</address>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</footer>
|
||
|
||
|
||
<div class="usa-identifier">
|
||
<section
|
||
class="usa-identifier__section usa-identifier__section--masthead"
|
||
aria-label="">
|
||
<div class="usa-identifier__container"><div class="usa-identifier__identity" aria-label="">
|
||
<p class="usa-identifier__identity-domain">niaaa.nih.gov</p>
|
||
<p class="usa-identifier__identity-disclaimer">An official website of the <a href="https://www.nih.gov">National Institutes of Health</a> and the <a href="https://www.niaaa.nih.gov">National Institute on Alcohol Abuse and Alcoholism</a></p>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<nav class="usa-identifier__section usa-identifier__section--required-links" aria-label="Important Links">
|
||
<div class="usa-identifier__container">
|
||
<ul class="usa-identifier__required-links-list">
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/about-niaaa" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/86">About NIAAA</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/accessibility" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/92">Accessibility</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/freedom-information-act-foia" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/96">FOIA</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/privacy" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/93">Privacy Policy</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="usa-identifier__required-link usa-link">Vulnerability Disclosure</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</nav>
|
||
|
||
<section class="usa-identifier__section usa-identifier__section--usagov" aria-label="">
|
||
<div class="usa-identifier__container">
|
||
<div class="usa-identifier__usagov-description">Looking for U.S. government information and services?</div>
|
||
<a href="https://www.usa.gov/" class="usa-link">Visit USA.gov</a>
|
||
</div>
|
||
</section>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/342","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"data":{"extlink":{"extTarget":true,"extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":false,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":false,"extExclude":"(niaaa-dev\\.iq\\.iqsolutions\\.com)|(niaaa-demo\\.iqsolutions\\.com)|(dev\\.niaaa\\.nih\\.gov)|(stage\\.niaaa\\.nih\\.gov)|(content\\.niaaa\\.nih\\.gov)| (drupal1stg\\.prod\\.acquia-sites\\.com)|(addictionresearch\\.nih\\.gov)|(alcoholtreatment\\.niaaa\\.nih\\.gov)|(arcr\\.niaaa\\.nih\\.gov)|(pubs\\.niaaa\\.nih\\.gov)|(rethinkingdrinking\\.niaaa\\.nih\\.gov)|(collegedrinkingprevention\\.gov)|(niaaa\\.nih\\.gov)| (spectrum\\.niaaa\\.nih\\.gov)","extInclude":"(permanent\\.fdlp\\.gov\/*)","extCssExclude":".usa-social-link","extCssExplicit":"","extAlert":false,"extAlertText":"The link you have selected is located on a non-NIAAA website. The page will open in a new window. Click OK to proceed. Click Cancel to stay on the NIAAA website. For additional information, click the \u0022Disclaimer\u0022 link at the bottom of this webpage. NIAAA links to external websites to supplement the information found on the NIAAA website. However, NIAAA is not responsible for the information provided on external websites. Linking to a non-NIAAA website does not indicate an endorsement by NIAAA of the sponsors or of the information and products presented on the website. You will be subject to the external website\u0027s privacy policy when you leave NIAAA\u0027s website.","mailtoClass":"mailto","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"append","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"ajaxTrustedUrl":{"\/search":true},"user":{"uid":0,"permissionsHash":"4e30a5f49b5cb41f19ce8fc050778cbf4a3f6d15e6ea7ae3ecb470a24eb76f37"}}</script>
|
||
<script src="/sites/default/files/js/js_7EEwZdd8l1mj56dq3iNvu0yA35A65lrEovJK0yLC2Ks.js?scope=footer&delta=0&language=en&theme=solstice&include=eJxFiksOgCAMBS8EciaUSoi1Je0j6u11oXE5H1d2tIVSZZ0zR8fFTWrwz68qyAe57hToxBO3VGz0zNOL_2uEYRKh_Qbz6yKX"></script>
|
||
|
||
</body>
|
||
</html>
|