1273 lines
46 KiB
Text
1273 lines
46 KiB
Text
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#">
|
||
<head>
|
||
<!-- Google Tag Manager -->
|
||
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':
|
||
new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],
|
||
j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=
|
||
'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);
|
||
})(window,document,'script','dataLayer','GTM-MP7S353');</script>
|
||
<!-- End Google Tag Manager -->
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="An experimental compound repaired a defective alcohol metabolism enzyme that affects an estimated 1 billion people worldwide, according to research supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The findings, published Jan. 10, 2010 in the advance online edition of Nature Structural and Molecular Biology, suggest the possibility of a treatment to reduce the health problems associated with the enzyme defect." />
|
||
<link rel="canonical" href="https://www.niaaa.nih.gov/news-events/news-releases/molecule-repairs-alcohol-metabolism-enzyme" />
|
||
<meta name="google-site-verification" content="D6PddlP4x_B-aaYH1GdtXWLMtqqDRm1KB76zwXU94r0" />
|
||
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
|
||
<meta name="MobileOptimized" content="width" />
|
||
<meta name="HandheldFriendly" content="true" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<meta http-equiv="x-ua-compatible" content="ie=edge" />
|
||
<link rel="icon" href="/sites/default/themes/solstice/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
<link rel="alternate" hreflang="und" href="https://www.niaaa.nih.gov/news-events/news-releases/molecule-repairs-alcohol-metabolism-enzyme" />
|
||
|
||
<title>Molecule Repairs Alcohol Metabolism Enzyme | National Institute on Alcohol Abuse and Alcoholism (NIAAA)</title>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_3jqSjunUwI7WktROG0Eute4UvTfE7JnUEOI-esMGxkQ.css?delta=0&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_284cOjFlGt6BbVNygt8wCcMAVOImI5Qo3eLcYPtTvXw.css?delta=1&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="print" href="/sites/default/files/css/css_Ki7WmdMheyToDR_iZ4-TUWAd6Z_Ji9D5oheAUfVPDGQ.css?delta=2&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_ZURahwWpOtPq2J3aEz1C3IyNMbNi6vxbJc3xYRtyniA.css?delta=3&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
|
||
|
||
</head>
|
||
<body class="page-node-314 path-node page-node-type-news body">
|
||
<!-- Google Tag Manager (noscript) -->
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MP7S353"
|
||
height="0" width="0" style="display:none;visibility:hidden" title="hhsgtmcontainer"></iframe></noscript>
|
||
<!-- End Google Tag Manager (noscript) -->
|
||
<a href="#main-content" class="visually-hidden focusable">
|
||
Skip to main content
|
||
</a>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<section class="usa-banner">
|
||
<section class="usa-banner" aria-label="Official website of the United States government">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner__header">
|
||
<div class="usa-banner__inner">
|
||
<div class="grid-col-auto">
|
||
<img aria-hidden="true" class="usa-banner__header-flag" src="/sites/default/themes/solstice/assets/uswds/img/us_flag_small.png" alt=""/>
|
||
</div>
|
||
<div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true">
|
||
<p class="usa-banner__header-text">
|
||
An official website of the United States government
|
||
</p>
|
||
<p class="usa-banner__header-action">Here’s how you know</p>
|
||
</div>
|
||
<button type="button" class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default-default">
|
||
<span class="usa-banner__button-text">Here’s how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default" hidden>
|
||
<div class="grid-row grid-gap-lg">
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/sites/default/themes/solstice/assets/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/>
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Official websites use .gov</strong><br/>A
|
||
<strong>.gov</strong>
|
||
website belongs to an official government
|
||
organization in the United States.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/sites/default/themes/solstice/assets/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/>
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Secure .gov websites use HTTPS</strong><br/>A
|
||
<strong>lock</strong>
|
||
(
|
||
<span class="icon-lock">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewbox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-description-default" focusable="false">
|
||
<title id="banner-lock-title-default">Lock</title>
|
||
<desc id="banner-lock-description-default">Locked padlock icon</desc>
|
||
<path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z"/>
|
||
</svg>
|
||
</span>) or
|
||
<strong>https://</strong>
|
||
means you’ve safely connected to
|
||
the .gov website. Share sensitive information only on official,
|
||
secure websites.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
</section>
|
||
|
||
|
||
|
||
|
||
<div class="usa-overlay" id="overlay" aria-hidden="true"></div>
|
||
<header class="usa-header usa-header--extended" id="header" role="banner">
|
||
|
||
|
||
<div class="region region-header usa-navbar">
|
||
<div class="usa-logo site-logo" id="logo">
|
||
|
||
<em class="usa-logo__text">
|
||
<a class="logo-img" href="/" accesskey="1" title="Home" aria-label="Home">
|
||
<img src="/sites/default/themes/solstice/niaaa-logo.png" alt="Home" />
|
||
</a>
|
||
|
||
|
||
</em>
|
||
|
||
</div>
|
||
<button class="usa-menu-btn" type="button">Menu</button>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<nav class="usa-nav" role="navigation">
|
||
<div class="usa-nav__inner">
|
||
|
||
<button type="button" class="usa-nav__close">
|
||
<img src="/sites/default/themes/solstice/assets/uswds/img/usa-icons/close.svg" alt="close"/>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<ul class="usa-nav__primary usa-accordion">
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-1">
|
||
<span>Alcohol's Effects on Health</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-1" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health" title="Alcohol's Effects on Health" class="link" data-drupal-link-system-path="node/5491">Alcohol's Effects on Health</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-topics-a-to-z" class="link" data-drupal-link-system-path="node/10109">Alcohol Topics</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/brochures-and-fact-sheets/treatment-alcohol-problems-finding-and-getting-help" class="link" data-drupal-link-system-path="node/5011">Getting Help</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-topics/alcohol-facts-and-statistics" class="link" data-drupal-link-system-path="node/13706">Alcohol Facts and Statistics</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/niaaa-short-takes-video-series" class="link">NIAAA Short Takes Video Series</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-interventions-young-adults" class="link" data-drupal-link-system-path="node/12656">Alcohol Interventions for Young Adults</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/niaaa-publications-order-form" class="link" data-drupal-link-system-path="node/5266">Order Publications</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-2">
|
||
<span>Health Professionals & Communities</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-2" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities" title="Health Professionals & Communities" class="link" data-drupal-link-system-path="node/5526">Health Professionals & Communities</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/native-air" class="link" data-drupal-link-system-path="node/15486">Native Communities: Alcohol Intervention Review (NativeAIR)</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/core-resource-on-alcohol" class="link" data-drupal-link-system-path="node/12236">The Healthcare Professional's Core Resource on Alcohol</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="https://www.collegedrinkingprevention.gov/CollegeAIM/Default.aspx" class="link">Resources from the NIAAA College Task Force</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/alcohol-interventions-young-adults-healthcare-professionals" class="link" data-drupal-link-system-path="node/12661">Alcohol Interventions for Young Adults</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/clinical-guides-and-manuals/alcohol-screening-and-brief-intervention-youth" class="link">Alcohol Screening & Brief Intervention for Youth</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/surveillance-reports" class="link" data-drupal-link-system-path="node/12301">Surveillance Reports</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities#additional-reports" class="link" data-drupal-link-system-path="node/5526">Additional Reports and Resources</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-3">
|
||
<span>Research</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-3" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research" title="Research" class="link" data-drupal-link-system-path="node/83">Research</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/major-initiatives" class="link" data-drupal-link-system-path="node/112">Major Research Initiatives</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/extramural-research" class="link" data-drupal-link-system-path="node/1115">Extramural Research Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/division-intramural-clinical-and-biological-research" class="link">Intramural Research Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/alcohol-research-resource-r24-and-r28-awards" class="link" data-drupal-link-system-path="node/3531">Alcohol Research Resource (R24) Awards</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/niaaa-sbir" class="link" data-drupal-link-system-path="node/5556">NIAAA SBIR/ STTR Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/data-archive-and-resources" class="link" data-drupal-link-system-path="node/15236">Data Archive and Resources</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-4">
|
||
<span>Research Training</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-4" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research-training-and-career-development" title="Research Training" class="link" data-drupal-link-system-path="node/3546">Research Training</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/research-training-and-career-development/training-opportunities-education-level" class="link" data-drupal-link-system-path="node/3556">Training Grants by Eligibility</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/research-training-and-career-development/training-opportunities-grant-mechanism" class="link" data-drupal-link-system-path="node/3561">Training Grants by Mechanism</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/training-resources" class="link">Research Training Programs</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research-training-and-career-development/centers-and-training-working-group-roster" class="link" data-drupal-link-system-path="node/3551">Centers and Training Working Group Roster</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-5">
|
||
<span>Grants & Funding</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-5" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/grant-funding" title="Grants & Funding" class="link" data-drupal-link-system-path="node/84">Grants & Funding</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/application-process" class="link">How to Apply for a Grant</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/funding-opportunities" class="link">Funding Opportunities</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/grant-funding/management-reporting" class="link" data-drupal-link-system-path="node/166">Management & Reporting</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-6">
|
||
<span>News & Events</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-6" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events" title="News & Events" class="link" data-drupal-link-system-path="node/47">News & Events</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/news" class="link" data-drupal-link-system-path="node/5521">News</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/meetings-events-exhibits" class="link" data-drupal-link-system-path="node/5525">Events</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/press-room" class="link" data-drupal-link-system-path="node/636">Press Room</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/niaaa-social-media" class="link" data-drupal-link-system-path="node/11396">Social Media</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="https://www.spectrum.niaaa.nih.gov/" class="link">Spectrum</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-7">
|
||
<span>About NIAAA</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-7" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa" title="About NIAAA" class="link" data-drupal-link-system-path="node/86">About NIAAA</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/advisory-council" class="link" data-drupal-link-system-path="node/181">NIAAA Advisory Council</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/strategic-plan-fiscal-years-2024-2028" class="link" data-drupal-link-system-path="node/14961">Strategic Plan: Fiscal Years 2024–2028</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-work" class="link" data-drupal-link-system-path="node/176">Our Work</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/our-funding" class="link" data-drupal-link-system-path="node/189">Our Funding</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-staff" class="link" data-drupal-link-system-path="node/190">Our Staff</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/career-and-training-opportunities" class="link" data-drupal-link-system-path="node/191">Careers & Training</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/contact-us" class="link" data-drupal-link-system-path="node/201">Contact Us</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-work/history-niaaa" class="link">History</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class='usa-nav__secondary top-search-bar'>
|
||
|
||
|
||
<ul class="usa-nav__secondary-links">
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/join-study" title="" class="link" data-drupal-link-system-path="node/153">Join a Clinical Study</a>
|
||
</li>
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/alcohols-effects-health/alcohol-topics/health-topics-treatment-alcohol-problems" class="link" data-drupal-link-system-path="node/13376">Getting Help</a>
|
||
</li>
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/our-work/donations-niaaa" class="link" data-drupal-link-system-path="node/540">Donate</a>
|
||
</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
<form action="/search" method="get" id="views-exposed-form-acquia-search-page" accept-charset="UTF-8" class="usa-search usa-search--small" role="search">
|
||
<label class="usa-sr-only" for="extended-search-field-small">Search</label>
|
||
<input class="usa-input" id="extended-search-field-small" maxlength="128" type="search" name="search"/>
|
||
<button class="usa-button" type="submit">
|
||
<span class="usa-sr-only">Search</span>
|
||
<svg class="usa-icon" aria-hidden="true" focusable="false" role="img">
|
||
<use xlink:href="/sites/default/themes/solstice/assets/uswds/img/sprite.svg#search"></use>
|
||
</svg>
|
||
</button>
|
||
</form>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</nav>
|
||
|
||
|
||
</header>
|
||
|
||
|
||
<div class="above-content">
|
||
<div>
|
||
|
||
|
||
<div class="page-banner">
|
||
<div class="l-inner">
|
||
<p class="h1 heading-1 text-reverse">News & Events</p>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div id="block-solstice-breadcrumbs">
|
||
|
||
|
||
|
||
<div class="breadcrumb-container">
|
||
<nav role="navigation" class="usa-breadcrumb usa-breadcrumb--wrap" aria-labelledby="system-breadcrumb">
|
||
<h2 id="system-breadcrumb" class="usa-sr-only">Breadcrumb</h2>
|
||
<ol class="usa-breadcrumb__list">
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/" class="usa-breadcrumb__link">Home</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/news-events" class="usa-breadcrumb__link">News & Events</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/news-events/news-releases" class="usa-breadcrumb__link">News Releases</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
Molecule Repairs Alcohol Metabolism Enzyme
|
||
</li>
|
||
</ol>
|
||
</nav>
|
||
</div>
|
||
|
||
</div>
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="usa-section">
|
||
<div class="main--container">
|
||
<div class="grid-row grid-gap">
|
||
<main class="main--content grid-col" id="main-content">
|
||
<div id="block-solstice-content">
|
||
|
||
|
||
|
||
<article>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="content-river">
|
||
<div>
|
||
<h1>
|
||
<span>Molecule Repairs Alcohol Metabolism Enzyme</span>
|
||
</h1>
|
||
<div class="news-type">News Release</div>
|
||
<p><time datetime="2010-01-10T12:00:00Z">Sunday, January 10, 2010</time>
|
||
</p>
|
||
<p>An experimental compound repaired a defective alcohol metabolism enzyme that affects an estimated 1 billion people worldwide, according to research supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The findings, published Jan. 10, 2010 in the advance online edition of Nature Structural and Molecular Biology, suggest the possibility of a treatment to reduce the health problems associated with the enzyme defect.</p>
|
||
<p>“This intriguing finding could have broad public health implications,” said NIAAA Acting Director Kenneth R. Warren, Ph.D. “We look forward to further research aimed at translating these laboratory discoveries into possible treatments for people.”</p>
|
||
<p>“We recently identified a molecule called Alda-1 that activates the defective enzyme, and in the current study, we determined how this activation is achieved,” said the study’s senior author, Thomas D. Hurley, Ph.D., professor and associate chairman of biochemistry and molecular biology at Indiana University School of Medicine in Indianapolis. Initial investigations of Alda-1 were led by co-author Daria Mochly-Rosen, Ph.D., professor of chemical and systems biology at Stanford University School of Medicine.</p>
|
||
<p>After alcohol is consumed, it is first metabolized, or broken down, into acetaldehyde, a toxic chemical that causes DNA damage. Aldehyde dehydrogenase 2 (ALDH2) is the main enzyme responsible for breaking down acetaldehyde into acetate, a nontoxic metabolite in the body. It also removes other toxic aldehydes that can accumulate in the body.</p>
|
||
<p>About 40 percent of the East Asian population, and many people of East Asian descent throughout the world, carry a genetic mutation that produces an inactive form of ALDH2. When individuals with the ALDH2 mutation drink alcohol, acetaldehyde accumulates in the body, resulting in facial flushing, nausea, and rapid heartbeat. In addition to its link to increased cancer risk, the inactive form of ALDH2 also reduces the effectiveness of nitroglycerin. Nitroglycerin is a drug to treat angina, chest pain that occurs when the heart doesn't get enough oxygen-rich blood.</p>
|
||
<p>In a series of experiments that examined the interaction between Alda-1 and the defective ALDH2 enzyme, Dr. Hurley and his colleagues found that Alda-1 restored the structure of the inactive enzyme. The normal, active form of ALDH2 creates a catalytic tunnel, a space within the enzyme in which acetaldehyde is metabolized, explained Dr. Hurley. In the defective enzyme, the tunnel does not function properly. Alda-1 binds to the defective enzyme in a way that effectively reopens the catalytic tunnel and thus allows the enzyme to metabolize acetaldehyde.</p>
|
||
<p>“The manner in which Alda-1 binds to the structure of ALDH2 provides us with powerful insight into the relationships between activators and inhibitors of this crucial detoxifying enzyme,” says Dr. Hurley. “This insight will lead to the modification of Alda-1 to improve its potency, and also opens up the possibility of designing new analogs that can selectively affect the metabolism of other molecules that are detoxified by aldehyde dehydrogenase.”</p>
|
||
</div>
|
||
</div>
|
||
</article>
|
||
|
||
</div>
|
||
<div id="block-newsreleasecontact">
|
||
|
||
|
||
<div class="contact-info content-river">
|
||
|
||
<div><div class="contact-info content-river l-skinny">
|
||
<p><strong>About the National Institute on Alcohol Abuse and Alcoholism (NIAAA):</strong><br>
|
||
The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, is the primary U.S. agency for conducting and supporting research on the causes, consequences, diagnosis, prevention, and treatment of alcohol use disorder. NIAAA also disseminates research findings to general, professional, and academic audiences. Additional alcohol research information and publications are available at <a href="/" rel="nofollow noreferrer">www.niaaa.nih.gov</a>.</p>
|
||
|
||
<p><strong>About the National Institutes of Health (NIH):</strong><br>
|
||
NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <a href="https://www.nih.gov/" rel="noreferrer noopener">www.nih.gov</a>.</p>
|
||
|
||
<p><strong>Contact info</strong>:<br>
|
||
NIAAA Press Office<br>
|
||
301-443-2857<br>
|
||
<a href="mailto:NIAAAPressOffice@mail.nih.gov">NIAAAPressOffice@mail.nih.gov</a></p>
|
||
</div>
|
||
</div>
|
||
|
||
<div>
|
||
</div>
|
||
|
||
|
||
</main>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<footer class="usa-footer usa-footer--big" role="contentinfo">
|
||
<div class="usa-footer__return-to-top return-to-top-stick">
|
||
<a href="#">Return to top</a>
|
||
</div>
|
||
|
||
<div class="usa-footer__primary-section">
|
||
|
||
<div class="usa-footer__primary-content">
|
||
<div class="grid-container">
|
||
<div class="grid-row grid-gap">
|
||
|
||
<div class="tablet:grid-col-8">
|
||
<nav class="usa-footer__nav" aria-label="Footer navigation">
|
||
<div class="grid-row grid-gap-4">
|
||
<div id="block-footermenu" class="mobile-lg:grid-col-6 desktop:grid-col">
|
||
<section class="usa-footer__primary-content usa-footer__primary-content--collapsible">
|
||
|
||
<h4 class="usa-footer__primary-link">NIAAA</h4>
|
||
|
||
<ul class="usa-list usa-list--unstyled">
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/sitemap" title="" class="link" data-drupal-link-system-path="sitemap">Site Map</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/about-niaaa/contact-us" title="" class="link" data-drupal-link-system-path="node/201">Contact Us</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/disclaimer" title="" class="link" data-drupal-link-system-path="node/616">Disclaimer</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</section>
|
||
</div>
|
||
<div id="block-solstice-otherniaaasites" class="mobile-lg:grid-col-6 desktop:grid-col">
|
||
<section class="usa-footer__primary-content usa-footer__primary-content--collapsible">
|
||
|
||
<h4 class="usa-footer__primary-link">Other NIAAA Sites</h4>
|
||
|
||
<ul class="usa-list usa-list--unstyled">
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://alcoholpolicy.niaaa.nih.gov/" title="Alcohol Policy Information System" class="link">Alcohol Policy Information System</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://arcr.niaaa.nih.gov/" title="Alcohol Research: Current Reviews (ARCR)" class="link">Alcohol Research: Current Reviews (ARCR)</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://alcoholtreatment.niaaa.nih.gov/" title="Alcohol Treatment Navigator" class="link">Alcohol Treatment Navigator</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://www.collegedrinkingprevention.gov/" class="link">College Drinking Prevention</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://niaaaforteens.niaaa.nih.gov/" class="link">NIAAA Facts About Teen Drinking</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/news-events/niaaa-spectrum-webzine" title="NIAAA Spectrum" class="link" data-drupal-link-system-path="node/169">NIAAA Spectrum</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://rethinkingdrinking.niaaa.nih.gov/" class="link">Rethinking Drinking</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</section>
|
||
</div>
|
||
|
||
<div>
|
||
</nav>
|
||
</div>
|
||
|
||
|
||
<div class="tablet:grid-col-4">
|
||
<div>
|
||
<div id="block-solstice-govdeliveryformblock">
|
||
|
||
|
||
<div class="usa-sign-up">
|
||
<h4 class="usa-sign-up__heading">Get Email Updates</h4>
|
||
<form class="usa-form" action="https://public.govdelivery.com/accounts/USNIAAA/subscribers/qualify" accept-charset="UTF-8" method="post" data-drupal-form-fields="email" target="_blank">
|
||
<input name="utf8" type="hidden" value="✓">
|
||
<input type="hidden" name="authenticity_token" value="myTqrfcKP26ImObkqXpLlCJwJeMr6pdTfN5L19Lw964CAojxidv3kEZTy3NuaWCFS9OWuYPTy20qtVl1JsD9hQ==">
|
||
<label class="usa-label" for="email">Your email address</label>
|
||
<input class="usa-input" id="email" name="email" type="email"/>
|
||
<button class="usa-button" type="submit">Sign up</button>
|
||
</form>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="usa-footer__secondary-section">
|
||
<div class="grid-container">
|
||
<div class="grid-row grid-gap">
|
||
<div class="usa-footer__logo grid-row mobile-lg:grid-col-6 mobile-lg:grid-gap-2">
|
||
|
||
<a href="https://www.niaaa.nih.gov/">
|
||
|
||
<div class="mobile-lg:grid-col-auto">
|
||
<img class="usa-footer__logo-img" src="/sites/default/themes/solstice/assets/img/niaaa-logo.png" alt="Agency logo">
|
||
</div>
|
||
|
||
|
||
</a>
|
||
|
||
</div>
|
||
|
||
<div class="usa-footer__contact-links desktop:grid-col-6">
|
||
<div class="usa-footer__social-links grid-row grid-gap-1">
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--facebook" href="https://www.facebook.com/NIAAAgov/" target="_blank">
|
||
<i class="fa-brands fa-facebook-f"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--instagram" href="https://instagram.com/NIAAAnews" target="_blank">
|
||
<i class="fa-brands fa-instagram"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--twitter" href="https://twitter.com/NIAAAnews" target="_blank">
|
||
<i class="fa-brands fa-x-twitter"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--linkedin" href="https://www.linkedin.com/company/nih-national-institute-on-alcohol-abuse-and-alcoholism/" target="_blank">
|
||
<i class="fa-brands fa-linkedin"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--youtube" href="https://www.youtube.com/@NIAAANIH" target="_blank">
|
||
<i class="fa-brands fa-youtube"></i>
|
||
</a>
|
||
</div>
|
||
|
||
</div>
|
||
<address class="usa-footer__address">
|
||
<div class="usa-footer__contact-info grid-row grid-gap">
|
||
|
||
</div>
|
||
</address>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</footer>
|
||
|
||
|
||
<div class="usa-identifier">
|
||
<section
|
||
class="usa-identifier__section usa-identifier__section--masthead"
|
||
aria-label="">
|
||
<div class="usa-identifier__container"><div class="usa-identifier__identity" aria-label="">
|
||
<p class="usa-identifier__identity-domain">niaaa.nih.gov</p>
|
||
<p class="usa-identifier__identity-disclaimer">An official website of the <a href="https://www.nih.gov">National Institutes of Health</a> and the <a href="https://www.niaaa.nih.gov">National Institute on Alcohol Abuse and Alcoholism</a></p>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<nav class="usa-identifier__section usa-identifier__section--required-links" aria-label="Important Links">
|
||
<div class="usa-identifier__container">
|
||
<ul class="usa-identifier__required-links-list">
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/about-niaaa" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/86">About NIAAA</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/accessibility" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/92">Accessibility</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/freedom-information-act-foia" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/96">FOIA</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/privacy" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/93">Privacy Policy</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="usa-identifier__required-link usa-link">Vulnerability Disclosure</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</nav>
|
||
|
||
<section class="usa-identifier__section usa-identifier__section--usagov" aria-label="">
|
||
<div class="usa-identifier__container">
|
||
<div class="usa-identifier__usagov-description">Looking for U.S. government information and services?</div>
|
||
<a href="https://www.usa.gov/" class="usa-link">Visit USA.gov</a>
|
||
</div>
|
||
</section>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/314","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"data":{"extlink":{"extTarget":true,"extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":false,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":false,"extExclude":"(niaaa-dev\\.iq\\.iqsolutions\\.com)|(niaaa-demo\\.iqsolutions\\.com)|(dev\\.niaaa\\.nih\\.gov)|(stage\\.niaaa\\.nih\\.gov)|(content\\.niaaa\\.nih\\.gov)| (drupal1stg\\.prod\\.acquia-sites\\.com)|(addictionresearch\\.nih\\.gov)|(alcoholtreatment\\.niaaa\\.nih\\.gov)|(arcr\\.niaaa\\.nih\\.gov)|(pubs\\.niaaa\\.nih\\.gov)|(rethinkingdrinking\\.niaaa\\.nih\\.gov)|(collegedrinkingprevention\\.gov)|(niaaa\\.nih\\.gov)| (spectrum\\.niaaa\\.nih\\.gov)","extInclude":"(permanent\\.fdlp\\.gov\/*)","extCssExclude":".usa-social-link","extCssExplicit":"","extAlert":false,"extAlertText":"The link you have selected is located on a non-NIAAA website. The page will open in a new window. Click OK to proceed. Click Cancel to stay on the NIAAA website. For additional information, click the \u0022Disclaimer\u0022 link at the bottom of this webpage. NIAAA links to external websites to supplement the information found on the NIAAA website. However, NIAAA is not responsible for the information provided on external websites. Linking to a non-NIAAA website does not indicate an endorsement by NIAAA of the sponsors or of the information and products presented on the website. You will be subject to the external website\u0027s privacy policy when you leave NIAAA\u0027s website.","mailtoClass":"mailto","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"append","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"ajaxTrustedUrl":{"\/search":true},"user":{"uid":0,"permissionsHash":"4e30a5f49b5cb41f19ce8fc050778cbf4a3f6d15e6ea7ae3ecb470a24eb76f37"}}</script>
|
||
<script src="/sites/default/files/js/js_7EEwZdd8l1mj56dq3iNvu0yA35A65lrEovJK0yLC2Ks.js?scope=footer&delta=0&language=en&theme=solstice&include=eJxFiksOgCAMBS8EciaUSoi1Je0j6u11oXE5H1d2tIVSZZ0zR8fFTWrwz68qyAe57hToxBO3VGz0zNOL_2uEYRKh_Qbz6yKX"></script>
|
||
|
||
</body>
|
||
</html>
|