1275 lines
47 KiB
Text
1275 lines
47 KiB
Text
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#">
|
||
<head>
|
||
<!-- Google Tag Manager -->
|
||
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':
|
||
new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],
|
||
j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=
|
||
'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);
|
||
})(window,document,'script','dataLayer','GTM-MP7S353');</script>
|
||
<!-- End Google Tag Manager -->
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="A study in the current Archives of General Psychiatry (Volume 56, pages 719-724) shows that nalmefene, an opioid antagonist that is not now commercially available in the oral form studied, is effective in preventing relapse to heavy drinking in alcohol dependent individuals. Barbara J. Mason, Ph.D., and colleagues at the University of Miami School of Medicine found from a 12-week double-blind, placebo-controlled clinical trial that patients who received nalmefene were 2.4 times less likely to relapse to heavy drinking than those who received a placebo." />
|
||
<link rel="canonical" href="https://www.niaaa.nih.gov/news-events/news-releases/alcohol-researchers-identify-new-medication-lessens-relapse-risk" />
|
||
<meta name="google-site-verification" content="D6PddlP4x_B-aaYH1GdtXWLMtqqDRm1KB76zwXU94r0" />
|
||
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
|
||
<meta name="MobileOptimized" content="width" />
|
||
<meta name="HandheldFriendly" content="true" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<meta http-equiv="x-ua-compatible" content="ie=edge" />
|
||
<link rel="icon" href="/sites/default/themes/solstice/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
<link rel="alternate" hreflang="und" href="https://www.niaaa.nih.gov/news-events/news-releases/alcohol-researchers-identify-new-medication-lessens-relapse-risk" />
|
||
|
||
<title>Alcohol Researchers Identify New Medication That Lessens Relapse Risk | National Institute on Alcohol Abuse and Alcoholism (NIAAA)</title>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_3jqSjunUwI7WktROG0Eute4UvTfE7JnUEOI-esMGxkQ.css?delta=0&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_284cOjFlGt6BbVNygt8wCcMAVOImI5Qo3eLcYPtTvXw.css?delta=1&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="print" href="/sites/default/files/css/css_Ki7WmdMheyToDR_iZ4-TUWAd6Z_Ji9D5oheAUfVPDGQ.css?delta=2&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_ZURahwWpOtPq2J3aEz1C3IyNMbNi6vxbJc3xYRtyniA.css?delta=3&language=en&theme=solstice&include=eJxFyUEOgCAMRNELoZypyEiIhRqnRrm9Lkxc_vc56GgxCRFoSq8LYlFLohN9aO3l99W6ywVaQ8Dt79xiPs5ddP7yAeDrH1E" />
|
||
|
||
|
||
</head>
|
||
<body class="page-node-436 path-node page-node-type-news body">
|
||
<!-- Google Tag Manager (noscript) -->
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MP7S353"
|
||
height="0" width="0" style="display:none;visibility:hidden" title="hhsgtmcontainer"></iframe></noscript>
|
||
<!-- End Google Tag Manager (noscript) -->
|
||
<a href="#main-content" class="visually-hidden focusable">
|
||
Skip to main content
|
||
</a>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<section class="usa-banner">
|
||
<section class="usa-banner" aria-label="Official website of the United States government">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner__header">
|
||
<div class="usa-banner__inner">
|
||
<div class="grid-col-auto">
|
||
<img aria-hidden="true" class="usa-banner__header-flag" src="/sites/default/themes/solstice/assets/uswds/img/us_flag_small.png" alt=""/>
|
||
</div>
|
||
<div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true">
|
||
<p class="usa-banner__header-text">
|
||
An official website of the United States government
|
||
</p>
|
||
<p class="usa-banner__header-action">Here’s how you know</p>
|
||
</div>
|
||
<button type="button" class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default-default">
|
||
<span class="usa-banner__button-text">Here’s how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default" hidden>
|
||
<div class="grid-row grid-gap-lg">
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/sites/default/themes/solstice/assets/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/>
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Official websites use .gov</strong><br/>A
|
||
<strong>.gov</strong>
|
||
website belongs to an official government
|
||
organization in the United States.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="/sites/default/themes/solstice/assets/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/>
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Secure .gov websites use HTTPS</strong><br/>A
|
||
<strong>lock</strong>
|
||
(
|
||
<span class="icon-lock">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewbox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-description-default" focusable="false">
|
||
<title id="banner-lock-title-default">Lock</title>
|
||
<desc id="banner-lock-description-default">Locked padlock icon</desc>
|
||
<path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z"/>
|
||
</svg>
|
||
</span>) or
|
||
<strong>https://</strong>
|
||
means you’ve safely connected to
|
||
the .gov website. Share sensitive information only on official,
|
||
secure websites.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
</section>
|
||
|
||
|
||
|
||
|
||
<div class="usa-overlay" id="overlay" aria-hidden="true"></div>
|
||
<header class="usa-header usa-header--extended" id="header" role="banner">
|
||
|
||
|
||
<div class="region region-header usa-navbar">
|
||
<div class="usa-logo site-logo" id="logo">
|
||
|
||
<em class="usa-logo__text">
|
||
<a class="logo-img" href="/" accesskey="1" title="Home" aria-label="Home">
|
||
<img src="/sites/default/themes/solstice/niaaa-logo.png" alt="Home" />
|
||
</a>
|
||
|
||
|
||
</em>
|
||
|
||
</div>
|
||
<button class="usa-menu-btn" type="button">Menu</button>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<nav class="usa-nav" role="navigation">
|
||
<div class="usa-nav__inner">
|
||
|
||
<button type="button" class="usa-nav__close">
|
||
<img src="/sites/default/themes/solstice/assets/uswds/img/usa-icons/close.svg" alt="close"/>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<ul class="usa-nav__primary usa-accordion">
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-1">
|
||
<span>Alcohol's Effects on Health</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-1" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health" title="Alcohol's Effects on Health" class="link" data-drupal-link-system-path="node/5491">Alcohol's Effects on Health</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-topics-a-to-z" class="link" data-drupal-link-system-path="node/10109">Alcohol Topics</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/brochures-and-fact-sheets/treatment-alcohol-problems-finding-and-getting-help" class="link" data-drupal-link-system-path="node/5011">Getting Help</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-topics/alcohol-facts-and-statistics" class="link" data-drupal-link-system-path="node/13706">Alcohol Facts and Statistics</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/niaaa-short-takes-video-series" class="link">NIAAA Short Takes Video Series</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/alcohols-effects-health/alcohol-interventions-young-adults" class="link" data-drupal-link-system-path="node/12656">Alcohol Interventions for Young Adults</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/niaaa-publications-order-form" class="link" data-drupal-link-system-path="node/5266">Order Publications</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-2">
|
||
<span>Health Professionals & Communities</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-2" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities" title="Health Professionals & Communities" class="link" data-drupal-link-system-path="node/5526">Health Professionals & Communities</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/native-air" class="link" data-drupal-link-system-path="node/15486">Native Communities: Alcohol Intervention Review (NativeAIR)</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/core-resource-on-alcohol" class="link" data-drupal-link-system-path="node/12236">The Healthcare Professional's Core Resource on Alcohol</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="https://www.collegedrinkingprevention.gov/CollegeAIM/Default.aspx" class="link">Resources from the NIAAA College Task Force</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities/alcohol-interventions-young-adults-healthcare-professionals" class="link" data-drupal-link-system-path="node/12661">Alcohol Interventions for Young Adults</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/clinical-guides-and-manuals/alcohol-screening-and-brief-intervention-youth" class="link">Alcohol Screening & Brief Intervention for Youth</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/publications/surveillance-reports" class="link" data-drupal-link-system-path="node/12301">Surveillance Reports</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/health-professionals-communities#additional-reports" class="link" data-drupal-link-system-path="node/5526">Additional Reports and Resources</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-3">
|
||
<span>Research</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-3" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research" title="Research" class="link" data-drupal-link-system-path="node/83">Research</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/major-initiatives" class="link" data-drupal-link-system-path="node/112">Major Research Initiatives</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/extramural-research" class="link" data-drupal-link-system-path="node/1115">Extramural Research Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/division-intramural-clinical-and-biological-research" class="link">Intramural Research Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/alcohol-research-resource-r24-and-r28-awards" class="link" data-drupal-link-system-path="node/3531">Alcohol Research Resource (R24) Awards</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/niaaa-sbir" class="link" data-drupal-link-system-path="node/5556">NIAAA SBIR/ STTR Program</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/data-archive-and-resources" class="link" data-drupal-link-system-path="node/15236">Data Archive and Resources</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-4">
|
||
<span>Research Training</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-4" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research-training-and-career-development" title="Research Training" class="link" data-drupal-link-system-path="node/3546">Research Training</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/research-training-and-career-development/training-opportunities-education-level" class="link" data-drupal-link-system-path="node/3556">Training Grants by Eligibility</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research/research-training-and-career-development/training-opportunities-grant-mechanism" class="link" data-drupal-link-system-path="node/3561">Training Grants by Mechanism</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/training-resources" class="link">Research Training Programs</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/research-training-and-career-development/centers-and-training-working-group-roster" class="link" data-drupal-link-system-path="node/3551">Centers and Training Working Group Roster</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-5">
|
||
<span>Grants & Funding</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-5" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/grant-funding" title="Grants & Funding" class="link" data-drupal-link-system-path="node/84">Grants & Funding</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/application-process" class="link">How to Apply for a Grant</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/funding-opportunities" class="link">Funding Opportunities</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/grant-funding/management-reporting" class="link" data-drupal-link-system-path="node/166">Management & Reporting</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-6">
|
||
<span>News & Events</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-6" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events" title="News & Events" class="link" data-drupal-link-system-path="node/47">News & Events</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/news" class="link" data-drupal-link-system-path="node/5521">News</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/meetings-events-exhibits" class="link" data-drupal-link-system-path="node/5525">Events</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/press-room" class="link" data-drupal-link-system-path="node/636">Press Room</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/news-events/niaaa-social-media" class="link" data-drupal-link-system-path="node/11396">Social Media</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="https://www.spectrum.niaaa.nih.gov/" class="link">Spectrum</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__primary-item flex-fill">
|
||
|
||
<button class="usa-accordion__button usa-nav__link " aria-expanded="false" aria-controls="basic-nav-section-7">
|
||
<span>About NIAAA</span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
<ul id="basic-nav-section-7" class="usa-nav__submenu" hidden="" >
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa" title="About NIAAA" class="link" data-drupal-link-system-path="node/86">About NIAAA</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/advisory-council" class="link" data-drupal-link-system-path="node/181">NIAAA Advisory Council</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/strategic-plan-fiscal-years-2024-2028" class="link" data-drupal-link-system-path="node/14961">Strategic Plan: Fiscal Years 2024–2028</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-work" class="link" data-drupal-link-system-path="node/176">Our Work</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/our-funding" class="link" data-drupal-link-system-path="node/189">Our Funding</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-staff" class="link" data-drupal-link-system-path="node/190">Our Staff</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/career-and-training-opportunities" class="link" data-drupal-link-system-path="node/191">Careers & Training</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/about-niaaa/contact-us" class="link" data-drupal-link-system-path="node/201">Contact Us</a>
|
||
|
||
</li>
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__submenu-item">
|
||
|
||
|
||
|
||
|
||
<a href="/our-work/history-niaaa" class="link">History</a>
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class='usa-nav__secondary top-search-bar'>
|
||
|
||
|
||
<ul class="usa-nav__secondary-links">
|
||
|
||
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/join-study" title="" class="link" data-drupal-link-system-path="node/153">Join a Clinical Study</a>
|
||
</li>
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/alcohols-effects-health/alcohol-topics/health-topics-treatment-alcohol-problems" class="link" data-drupal-link-system-path="node/13376">Getting Help</a>
|
||
</li>
|
||
|
||
|
||
|
||
<li class="usa-nav__secondary-item">
|
||
<a href="/our-work/donations-niaaa" class="link" data-drupal-link-system-path="node/540">Donate</a>
|
||
</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
<form action="/search" method="get" id="views-exposed-form-acquia-search-page" accept-charset="UTF-8" class="usa-search usa-search--small" role="search">
|
||
<label class="usa-sr-only" for="extended-search-field-small">Search</label>
|
||
<input class="usa-input" id="extended-search-field-small" maxlength="128" type="search" name="search"/>
|
||
<button class="usa-button" type="submit">
|
||
<span class="usa-sr-only">Search</span>
|
||
<svg class="usa-icon" aria-hidden="true" focusable="false" role="img">
|
||
<use xlink:href="/sites/default/themes/solstice/assets/uswds/img/sprite.svg#search"></use>
|
||
</svg>
|
||
</button>
|
||
</form>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</nav>
|
||
|
||
|
||
</header>
|
||
|
||
|
||
<div class="above-content">
|
||
<div>
|
||
|
||
|
||
<div class="page-banner">
|
||
<div class="l-inner">
|
||
<p class="h1 heading-1 text-reverse">News & Events</p>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div id="block-solstice-breadcrumbs">
|
||
|
||
|
||
|
||
<div class="breadcrumb-container">
|
||
<nav role="navigation" class="usa-breadcrumb usa-breadcrumb--wrap" aria-labelledby="system-breadcrumb">
|
||
<h2 id="system-breadcrumb" class="usa-sr-only">Breadcrumb</h2>
|
||
<ol class="usa-breadcrumb__list">
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/" class="usa-breadcrumb__link">Home</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/news-events" class="usa-breadcrumb__link">News & Events</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
<a href="/news-events/news-releases" class="usa-breadcrumb__link">News Releases</a>
|
||
</li>
|
||
<li class="usa-breadcrumb__list-item">
|
||
Alcohol Researchers Identify New Medication That Lessens Relapse Risk
|
||
</li>
|
||
</ol>
|
||
</nav>
|
||
</div>
|
||
|
||
</div>
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="usa-section">
|
||
<div class="main--container">
|
||
<div class="grid-row grid-gap">
|
||
<main class="main--content grid-col" id="main-content">
|
||
<div id="block-solstice-content">
|
||
|
||
|
||
|
||
<article>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="content-river">
|
||
<div>
|
||
<h1>
|
||
<span>Alcohol Researchers Identify New Medication That Lessens Relapse Risk</span>
|
||
</h1>
|
||
<div class="news-type">News Release</div>
|
||
<p><time datetime="1999-08-30T12:00:00Z">Monday, August 30, 1999</time>
|
||
</p>
|
||
<p>A study in the current <em>Archives of General Psychiatry</em> (Volume 56, pages 719-724) shows that nalmefene, an opioid antagonist that is not now commercially available in the oral form studied, is effective in preventing relapse to heavy drinking in alcohol dependent individuals. Barbara J. Mason, Ph.D., and colleagues at the University of Miami School of Medicine found from a 12-week double-blind, placebo-controlled clinical trial that patients who received nalmefene were 2.4 times less likely to relapse to heavy drinking than those who received a placebo.</p>
|
||
<p>"This study again demonstrates the promise of pharmacologic agents to work with standard behavioral treatments in the treatment of alcoholism. Prospects for improving treatment outcome have never been better," said Enoch Gordis, M.D., Director, National Institute on Alcohol Abuse and Alcoholism, a component of the National Institutes of Health.</p>
|
||
<p>Naltrexone, another opioid antagonist that is selective for the mu receptor, was approved by the U.S. Food and Drug Administration in 1994 for use in alcoholism treatment. The newer nalmefene is a "universal" opioid antagonist that works on all opioid receptors.</p>
|
||
<p>Men and women aged 18-65 years who met <em>Diagnostic and Statistical Manual, Third Edition, Revised</em> criteria for alcohol dependence participated in the study. Dr. Mason and her colleagues randomly assigned 105 of the 162 individuals screened to oral nalmefene at a dose of either 20 mg or 80 mg per day, or to placebo. All patients received professionally delivered, manual-guided, cognitive-behavioral therapy designed to increase their ability to avoid or cope with high-risk situations that can precipitate drinking.</p>
|
||
<p>The researchers found no significant differences between the 20 mg and 80 mg nalmefene groups and, therefore, presented their results as nalmefene versus placebo comparisons. Although one-third of the nalmefene patients relapsed to heavy drinking at least once during the 12-week trial, significantly more nalmefene than placebo patients altogether avoided relapse. Of patients who relapsed, those on nalmefene had fewer subsequent heavy-drinking episodes. Patients on nalmefene showed no evidence of medically serious adverse drug experiences and had high rates of medication compliance and treatment completion. The nalmefene and placebo groups did not differ in rates of abstinent days or self-reported craving severity.</p>
|
||
<p>"Alcohol consumption is mediated by multiple neurotransmitters and neuromodulators, including nonopioid systems, so that an opioid antagonist alone would not necessarily eliminate alcohol drinking in all alcohol dependent persons," said Dr. Mason. "But any agent that can reduce relapse would be a useful addition in treating alcoholic patients, approximately one-half of whom relapse within the first few months of most behavioral treatments." Several pharmaceutical companies have approached the University of Miami to review the nalmefene data in support of a new drug application to the FDA, Dr. Mason said.</p>
|
||
<p>"As neuroscience research advances knowledge of how alcohol acts on the brain, that knowledge will continue to be applied to develop new medications," said Richard Fuller, M.D., Director, Division of Clinical and Prevention Research, NIAAA. "Medications development is a top NIAAA priority."</p>
|
||
<p>"A Double-Blind, Placebo-Controlled Study of Oral Nalmefene for Alcohol Dependence" was conducted at the University of Miami School of Medicine Alcohol Disorders Research Clinic, Jackson Memorial Medical Center, Miami, Florida, with support from NIAAA. Through grants to researchers in medical and academic institutions, NIAAA supports an estimated 90 percent of alcohol research conducted in the United States.</p>
|
||
<p>To arrange an interview with Dr. Mason, contact Judy Lozano (telephone 305/243-4059). To arrange an interview with Dr. Gordis or Dr. Fuller or for additional alcohol research information, contact NIAAA Press (telephone 301/443-3860) or visit <a href="http://www.niaaa.nih.gov/">http://www.niaaa.nih.gov/</a>.</p>
|
||
</div>
|
||
</div>
|
||
</article>
|
||
|
||
</div>
|
||
<div id="block-newsreleasecontact">
|
||
|
||
|
||
<div class="contact-info content-river">
|
||
|
||
<div><div class="contact-info content-river l-skinny">
|
||
<p><strong>About the National Institute on Alcohol Abuse and Alcoholism (NIAAA):</strong><br>
|
||
The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, is the primary U.S. agency for conducting and supporting research on the causes, consequences, diagnosis, prevention, and treatment of alcohol use disorder. NIAAA also disseminates research findings to general, professional, and academic audiences. Additional alcohol research information and publications are available at <a href="/" rel="nofollow noreferrer">www.niaaa.nih.gov</a>.</p>
|
||
|
||
<p><strong>About the National Institutes of Health (NIH):</strong><br>
|
||
NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <a href="https://www.nih.gov/" rel="noreferrer noopener">www.nih.gov</a>.</p>
|
||
|
||
<p><strong>Contact info</strong>:<br>
|
||
NIAAA Press Office<br>
|
||
301-443-2857<br>
|
||
<a href="mailto:NIAAAPressOffice@mail.nih.gov">NIAAAPressOffice@mail.nih.gov</a></p>
|
||
</div>
|
||
</div>
|
||
|
||
<div>
|
||
</div>
|
||
|
||
|
||
</main>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<footer class="usa-footer usa-footer--big" role="contentinfo">
|
||
<div class="usa-footer__return-to-top return-to-top-stick">
|
||
<a href="#">Return to top</a>
|
||
</div>
|
||
|
||
<div class="usa-footer__primary-section">
|
||
|
||
<div class="usa-footer__primary-content">
|
||
<div class="grid-container">
|
||
<div class="grid-row grid-gap">
|
||
|
||
<div class="tablet:grid-col-8">
|
||
<nav class="usa-footer__nav" aria-label="Footer navigation">
|
||
<div class="grid-row grid-gap-4">
|
||
<div id="block-footermenu" class="mobile-lg:grid-col-6 desktop:grid-col">
|
||
<section class="usa-footer__primary-content usa-footer__primary-content--collapsible">
|
||
|
||
<h4 class="usa-footer__primary-link">NIAAA</h4>
|
||
|
||
<ul class="usa-list usa-list--unstyled">
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/sitemap" title="" class="link" data-drupal-link-system-path="sitemap">Site Map</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/about-niaaa/contact-us" title="" class="link" data-drupal-link-system-path="node/201">Contact Us</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/disclaimer" title="" class="link" data-drupal-link-system-path="node/616">Disclaimer</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</section>
|
||
</div>
|
||
<div id="block-solstice-otherniaaasites" class="mobile-lg:grid-col-6 desktop:grid-col">
|
||
<section class="usa-footer__primary-content usa-footer__primary-content--collapsible">
|
||
|
||
<h4 class="usa-footer__primary-link">Other NIAAA Sites</h4>
|
||
|
||
<ul class="usa-list usa-list--unstyled">
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://alcoholpolicy.niaaa.nih.gov/" title="Alcohol Policy Information System" class="link">Alcohol Policy Information System</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://arcr.niaaa.nih.gov/" title="Alcohol Research: Current Reviews (ARCR)" class="link">Alcohol Research: Current Reviews (ARCR)</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://alcoholtreatment.niaaa.nih.gov/" title="Alcohol Treatment Navigator" class="link">Alcohol Treatment Navigator</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://www.collegedrinkingprevention.gov/" class="link">College Drinking Prevention</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://niaaaforteens.niaaa.nih.gov/" class="link">NIAAA Facts About Teen Drinking</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="/news-events/niaaa-spectrum-webzine" title="NIAAA Spectrum" class="link" data-drupal-link-system-path="node/169">NIAAA Spectrum</a>
|
||
</li>
|
||
|
||
|
||
<li class="usa-footer__secondary-link">
|
||
<a href="https://rethinkingdrinking.niaaa.nih.gov/" class="link">Rethinking Drinking</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</section>
|
||
</div>
|
||
|
||
<div>
|
||
</nav>
|
||
</div>
|
||
|
||
|
||
<div class="tablet:grid-col-4">
|
||
<div>
|
||
<div id="block-solstice-govdeliveryformblock">
|
||
|
||
|
||
<div class="usa-sign-up">
|
||
<h4 class="usa-sign-up__heading">Get Email Updates</h4>
|
||
<form class="usa-form" action="https://public.govdelivery.com/accounts/USNIAAA/subscribers/qualify" accept-charset="UTF-8" method="post" data-drupal-form-fields="email" target="_blank">
|
||
<input name="utf8" type="hidden" value="✓">
|
||
<input type="hidden" name="authenticity_token" value="myTqrfcKP26ImObkqXpLlCJwJeMr6pdTfN5L19Lw964CAojxidv3kEZTy3NuaWCFS9OWuYPTy20qtVl1JsD9hQ==">
|
||
<label class="usa-label" for="email">Your email address</label>
|
||
<input class="usa-input" id="email" name="email" type="email"/>
|
||
<button class="usa-button" type="submit">Sign up</button>
|
||
</form>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="usa-footer__secondary-section">
|
||
<div class="grid-container">
|
||
<div class="grid-row grid-gap">
|
||
<div class="usa-footer__logo grid-row mobile-lg:grid-col-6 mobile-lg:grid-gap-2">
|
||
|
||
<a href="https://www.niaaa.nih.gov/">
|
||
|
||
<div class="mobile-lg:grid-col-auto">
|
||
<img class="usa-footer__logo-img" src="/sites/default/themes/solstice/assets/img/niaaa-logo.png" alt="Agency logo">
|
||
</div>
|
||
|
||
|
||
</a>
|
||
|
||
</div>
|
||
|
||
<div class="usa-footer__contact-links desktop:grid-col-6">
|
||
<div class="usa-footer__social-links grid-row grid-gap-1">
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--facebook" href="https://www.facebook.com/NIAAAgov/" target="_blank">
|
||
<i class="fa-brands fa-facebook-f"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--instagram" href="https://instagram.com/NIAAAnews" target="_blank">
|
||
<i class="fa-brands fa-instagram"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--twitter" href="https://twitter.com/NIAAAnews" target="_blank">
|
||
<i class="fa-brands fa-x-twitter"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--linkedin" href="https://www.linkedin.com/company/nih-national-institute-on-alcohol-abuse-and-alcoholism/" target="_blank">
|
||
<i class="fa-brands fa-linkedin"></i>
|
||
</a>
|
||
</div>
|
||
|
||
<div class="grid-col-auto">
|
||
<a class="usa-social-link usa-social-link--youtube" href="https://www.youtube.com/@NIAAANIH" target="_blank">
|
||
<i class="fa-brands fa-youtube"></i>
|
||
</a>
|
||
</div>
|
||
|
||
</div>
|
||
<address class="usa-footer__address">
|
||
<div class="usa-footer__contact-info grid-row grid-gap">
|
||
|
||
</div>
|
||
</address>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</footer>
|
||
|
||
|
||
<div class="usa-identifier">
|
||
<section
|
||
class="usa-identifier__section usa-identifier__section--masthead"
|
||
aria-label="">
|
||
<div class="usa-identifier__container"><div class="usa-identifier__identity" aria-label="">
|
||
<p class="usa-identifier__identity-domain">niaaa.nih.gov</p>
|
||
<p class="usa-identifier__identity-disclaimer">An official website of the <a href="https://www.nih.gov">National Institutes of Health</a> and the <a href="https://www.niaaa.nih.gov">National Institute on Alcohol Abuse and Alcoholism</a></p>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<nav class="usa-identifier__section usa-identifier__section--required-links" aria-label="Important Links">
|
||
<div class="usa-identifier__container">
|
||
<ul class="usa-identifier__required-links-list">
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/about-niaaa" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/86">About NIAAA</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/accessibility" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/92">Accessibility</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/freedom-information-act-foia" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/96">FOIA</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="/privacy" class="usa-identifier__required-link usa-link" data-drupal-link-system-path="node/93">Privacy Policy</a>
|
||
</li>
|
||
|
||
<li class="usa-identifier__required-links-item">
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="usa-identifier__required-link usa-link">Vulnerability Disclosure</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</nav>
|
||
|
||
<section class="usa-identifier__section usa-identifier__section--usagov" aria-label="">
|
||
<div class="usa-identifier__container">
|
||
<div class="usa-identifier__usagov-description">Looking for U.S. government information and services?</div>
|
||
<a href="https://www.usa.gov/" class="usa-link">Visit USA.gov</a>
|
||
</div>
|
||
</section>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/436","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"data":{"extlink":{"extTarget":true,"extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":false,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":false,"extExclude":"(niaaa-dev\\.iq\\.iqsolutions\\.com)|(niaaa-demo\\.iqsolutions\\.com)|(dev\\.niaaa\\.nih\\.gov)|(stage\\.niaaa\\.nih\\.gov)|(content\\.niaaa\\.nih\\.gov)| (drupal1stg\\.prod\\.acquia-sites\\.com)|(addictionresearch\\.nih\\.gov)|(alcoholtreatment\\.niaaa\\.nih\\.gov)|(arcr\\.niaaa\\.nih\\.gov)|(pubs\\.niaaa\\.nih\\.gov)|(rethinkingdrinking\\.niaaa\\.nih\\.gov)|(collegedrinkingprevention\\.gov)|(niaaa\\.nih\\.gov)| (spectrum\\.niaaa\\.nih\\.gov)","extInclude":"(permanent\\.fdlp\\.gov\/*)","extCssExclude":".usa-social-link","extCssExplicit":"","extAlert":false,"extAlertText":"The link you have selected is located on a non-NIAAA website. The page will open in a new window. Click OK to proceed. Click Cancel to stay on the NIAAA website. For additional information, click the \u0022Disclaimer\u0022 link at the bottom of this webpage. NIAAA links to external websites to supplement the information found on the NIAAA website. However, NIAAA is not responsible for the information provided on external websites. Linking to a non-NIAAA website does not indicate an endorsement by NIAAA of the sponsors or of the information and products presented on the website. You will be subject to the external website\u0027s privacy policy when you leave NIAAA\u0027s website.","mailtoClass":"mailto","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"append","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"ajaxTrustedUrl":{"\/search":true},"user":{"uid":0,"permissionsHash":"4e30a5f49b5cb41f19ce8fc050778cbf4a3f6d15e6ea7ae3ecb470a24eb76f37"}}</script>
|
||
<script src="/sites/default/files/js/js_7EEwZdd8l1mj56dq3iNvu0yA35A65lrEovJK0yLC2Ks.js?scope=footer&delta=0&language=en&theme=solstice&include=eJxFiksOgCAMBS8EciaUSoi1Je0j6u11oXE5H1d2tIVSZZ0zR8fFTWrwz68qyAe57hToxBO3VGz0zNOL_2uEYRKh_Qbz6yKX"></script>
|
||
|
||
</body>
|
||
</html>
|