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Medical College of Georgia scientists searching for new treatment target for diabetic retinopathy
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<span>Medical College of Georgia scientists searching for new treatment target for diabetic retinopathy</span>
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September 12, 2024
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<a href="/about/news-and-events/news?topic=13" hreflang="en">Diabetic Eye Disease</a>
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<img src="https://www.nei.nih.gov/sites/default/files/styles/small/public/2024-09/Shruti%20Sharma_creditAugustaUniv.jpeg?itok=S4I8iv48" alt="Shruti Sharma in the laboratory." width="700" height="466">
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<p>Shruti Sharma, Ph.D. Image credit: Michael Holahan, Augusta University</p>
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<p>Scientists at the Medical College of Georgia at Augusta University are searching for a new treatment target for a common complication of diabetes that can cause retinal blood vessels to break down, leak or become blocked.</p><p>The current treatment standard is anti-VEGF, which targets and blocks the activity of vascular endothelial growth factor, a protein that promotes the growth of blood vessels and causes them to leak. But that treatment doesn’t work for everyone.</p><p>With a new $1.5 million grant from the National Eye Institute, vascular and endothelial biologist Shruti Sharma, PhD, and a team from the MCG Center for Biotechnology and Genomic Medicine, hope to zero in on a new treatment pathway. They suspect the key to that may be a protein called Interleukin-6 (IL-6), a versatile protein involved in both immunity and inflammation throughout the body.</p><p>She and her research team think the answer lies in how IL-6 signals or initiates physiological changes in the body.</p><p>In preliminary studies, she and her research team found that specifically blocking pro-inflammatory IL-6 signaling, with a drug called sgp130Fc, helped balance levels of two important proteins in the retina. They believe that disruption to that balance is what ultimately leads to the development of diabetic retinopathy.</p>
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<a href="https://jagwire.augusta.edu/mcg-scientists-secure-1-5-million-grant-to-treat-diabetic-retinopathy/" class="c-link__link">Read more at Augusta Jagwire</a>
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